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Cited by 343

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET

Mosconi, L., Perani, D., Sorbi, S., Herholz, K., Nacmias, B., Holthoff, V., Salmon, E., Baron, J.-C., De Cristofaro, M. T.R., Padovani, A., Borroni, B., Franceschi, M., Bracco, L., Pupi, A.·2004·Neurology
DOI 10.1212/01.wnl.0000147469.18313.3b
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Abstract

OBJECTIVES: To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHOD: After 1 year, 8 of 37 patients with MCI converted to AD (22%). Differences in baseline regional glucose metabolic rate (rCMRglc) across groups were assessed on a voxel-based basis using a two-factor analysis of variance with outcome (converters [n = 8] vs nonconverters [n = 29]) and APOE genotype (E4 carriers [E4+] [n = 16] vs noncarriers [E4-] [n = 21]) as grouping factors. Results were considered significant at p < 0.05, corrected for multiple comparisons. RESULTS: All converters showed reduced rCMRglc in the inferior parietal cortex (IPC) as compared with the nonconverters. Hypometabolism in AD-typical regions, that is, temporoparietal and posterior cingulate cortex, was found for the E4+ as compared with the E4- patients, with the E4+/converters (n = 5) having additional rCMRglc reductions within frontal areas, such as the anterior cingulate (ACC) and inferior frontal (IFC) cortex. For the whole MCI sample, IPC rCMRglc predicted conversion to AD with 84% overall diagnostic accuracy (p = 0.003). Moreover, ACC and IFC rCMRglc improved prediction for the E4+ group, yielding 100% sensitivity, 90% specificity, and 94% accuracy (p < 0.0005), thus leading to an excellent discrimination. CONCLUSION: Fluoro-2-deoxy-d-glucose-PET measures may improve prediction of the conversion to Alzheimer disease, especially in combination with the APOE genotype.

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Metadata

Authors
Mosconi, L., Perani, D., Sorbi, S., Herholz, K., Nacmias, B., Holthoff, V., Salmon, E., Baron, J.-C., De Cristofaro, M. T. R., Padovani, A., Borroni, B., Franceschi, M., Bracco, L., & Pupi, A.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-12-28
Volume
63
Issue
12
Pages
2332-2340
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000147469.18313.3b
OpenAlex
W2170945547
Cited by
343
References
15
FWCI
11.58
Type
journal article
Language
en
Open access
closed

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