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Cited by 12melanin and skin pigmentationZebrafish Biomedical Research ApplicationsDevelopmental Biology and Gene Regulation

Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects

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McCluskey, Braedan M., Liang, Yipeng, Lewis, Victor M., Patterson, Larissa B., Parichy, David M.·2021·Biology Open
DOI 10.1242/bio.058814PMC PMC8487636

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Abstract

Molecular and cellular mechanisms underlying variation in adult form remain largely unknown. Adult pigment patterns of fishes in the genus Danio, which includes zebrafish, Danio rerio, consist of horizontal stripes, vertical bars, spots and uniform patterns, and provide an outstanding opportunity to identify causes of species level variation in a neural crest derived trait. Understanding pigment pattern variation requires quantitative approaches to assess phenotypes, yet such methods have been mostly lacking for pigment patterns. We introduce metrics derived from information theory that describe patterns and pattern variation in Danio fishes. We find that these metrics used singly and in multivariate combinations are suitable for distinguishing general pattern types, and can reveal even subtle phenotypic differences attributable to mutations. Our study provides new tools for analyzing pigment pattern in Danio and potentially other groups, and sets the stage for future analyses of pattern morphospace and its mechanistic underpinnings.

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  • An ancestral state reconstruction suggests that the most plausible scenario for pattern diversification in Danio is repeated evolution from an inferred ancestral pattern of horizontal stripes reminiscent of zebrafish towards the various alternative pattern states now evident.

    “An ancestral state reconstruction suggests that the most plausible scenario for pattern diversification in Danio is repeated evolution from an inferred ancestral pattern of horizontal stripes reminiscent of zebrafish towards the various alternative pattern states now evident8.”

    From Genomic and genetic insights into speciation and pigment pattern diversification in <i>Danio</i> fishes (2025) · cites this paper as [8]

  • The ancestral pigmentation pattern of the Danio genus is likely horizontal stripes, while vertical bars and spotted patterns recurrently evolved in different Danio lineages over the course of evolution.

    “Our results, together with previous research8, provide evidence that the ancestral pigmentation pattern of the Danio genus is likely horizontal stripes, while vertical bars and spotted patterns recurrently evolved in different Danio lineages over the course of evolution.”

    From Genomic and genetic insights into speciation and pigment pattern diversification in <i>Danio</i> fishes (2025) · cites this paper as [8]

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Research works printed but not linked: 69

  1. Budi, E. H., Patterson, L. B. and Parichy, D. M. (2008). Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development 135, 2603- 2614. 10.1242/dev.019299 18508863 PMC2704560 · DOI · Paper page
  2. Budi, E. H., Patterson, L. B. and Parichy, D. M. (2011). Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genet. 7, e1002044. 10.1371/journal.pgen.1002044 21625562 PMC3098192 · DOI · Paper page
  3. Cooley, J. W., Lewis, P. A. and Welch, P. D. (1969). The fast fourier transform and its applications. IEEE Trans. Educ. 12, 27- 34. 10.1109/TE.1969.4320436 · DOI
  4. DiNapoli, S. E., Martinez-McFaline, R., Gribbin, C. K., Wrighton, P. J., Balgobin, C. A., Nelson, I., Leonard, A., Maskin, C. R., Shwartz, A., Quenzer, E. D. et al. (2020). Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic Acids Res. 48, e38. 10.1093/nar/gkaa085 32064511 PMC7144937 · DOI
  5. Dooley, C. M., Mongera, A., Walderich, B. and Nüsslein-Volhard, C. (2013). On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development 140, 1003- 1013. 10.1242/dev.087007 23364329 · DOI
  6. Engeszer, R. E., Wang, G., Ryan, M. J. and Parichy, D. M. (2008). Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proc. Natl. Acad. Sci. USA 105, 929- 933. 10.1073/pnas.0708778105 18199839 PMC2242707 · DOI · Paper page
  7. Eom, D. S., Bain, E. J., Patterson, L. B., Grout, M. E. and Parichy, D. M. (2015). Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLife 4, e12401. 10.7554/eLife.12401 26701906 PMC4764569 · DOI
  8. Eom, D. S., Patterson, L. B., Bostic, R. R. and Parichy, D. M. (2021). Immunoglobulin superfamily receptor junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes. Dev. Biol. 476, 314- 327. 10.1016/j.ydbio.2021.04.007 33933422 PMC10069301 · DOI · Paper page
  9. Fadeev, A., Krauss, J., Frohnhöfer, H. G., Irion, U. and Nüsslein-Volhard, C. (2015). Tight junction protein 1a regulates pigment cell organisation during zebrafish colour patterning. eLife 4, e06545. 10.7554/eLife.06545 PMC4446668 25915619 · DOI · Paper page
  10. Fisher, R. B., Perkins, S., Walker, A. and Wolfart, E. (1996). Hypermedia Image Processing Reference, New York: John Wiley & Sons, Ltd.
  11. Frohnhöfer, H. G., Krauss, J., Maischein, H.-M. and Nüsslein-Volhard, C. (2013). Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish. Development 140, 2997- 3007. 10.1242/dev.096719 23821036 PMC3912879 · DOI · Paper page
  12. Hamada, H., Watanabe, M., Lau, H. E., Nishida, T., Hasegawa, T., Parichy, D. M. and Kondo, S. (2014). Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development 141, 318- 324. 10.1242/dev.099804 24306107 PMC3879813 · DOI
  13. Hirata, M., Nakamura, K.-I., Kanemaru, T., Shibata, Y. and Kondo, S. (2003). Pigment cell organization in the hypodermis of zebrafish. Dev. Dyn. 227, 497- 503. 10.1002/dvdy.10334 12889058 · DOI
  14. Hoshijima, K., Jurynec, M. J., Klatt Shaw, D., Jacobi, A. M., Behlke, M. A. and Grunwald, D. J. (2019). Highly efficient CRISPR-Cas9-based methods for generating deletion mutations and F0 embryos that lack gene function in zebrafish. Dev. Cell 51, 645- 657.e4. 10.1016/j.devcel.2019.10.004 31708433 PMC6891219 · DOI
  15. Houde, A. E. (1997). Sex, Color, and Mate Choice in Guppies. Princeton, NJ: Princeton University Press.
  16. Irion, U., Singh, A. P. and Nüsslein-Volhard, C. (2016). The developmental genetics of vertebrate color pattern formation: lessons from zebrafish. Curr. Top. Dev. Biol. 117, 141- 169. 10.1016/bs.ctdb.2015.12.012 26969976 · DOI · Paper page
  17. Johnson, S. L., Africa, D., Walker, C. and Weston, J. A. (1995). Genetic control of adult pigment stripe development in zebrafish. Dev. Biol. 167, 27- 33. 10.1006/dbio.1995.1004 7851648 · DOI
  18. Johnson, S. L., Nguyen, A. T. N. and Lister, J. A. (2011). mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell. Dev. Biol. 350, 405- 413. 10.1016/j.ydbio.2010.12.004 21146516 PMC3040983 · DOI · Paper page
  19. Krauss, J., Geiger-Rudolph, S., Koch, I., Nüsslein-Volhard, C. and Irion, U. (2014). A dominant mutation in tyrp1A leads to melanophore death in zebrafish. Pigment Cell Melanoma Res. 27, 827- 830. 10.1111/pcmr.12272 24891189 · DOI
  20. Kullander, S. O. and Britz, R. (2015). Description of Danio absconditus, new species, and redescription of Danio feegradei (Teleostei: Cyprinidae), from the Rakhine Yoma hotspot in south-western Myanmar. Zootaxa 3948, 233- 247. 10.11646/zootaxa.3948.2.5 25947774 · DOI
  21. Kullander, S. O. and Norén, M. (2016). Danio htamanthinus (Teleostei: Cyprinidae), a new species of miniature cyprinid fish from the Chindwin River in Myanmar. Zootaxa 4178, 535- 546. 10.11646/zootaxa.4178.4.5 27811706 · DOI
  22. Lewis, V. M., Saunders, L. M., Larson, T. A., Bain, E. J., Sturiale, S. L., Gur, D., Chowdhury, S., Flynn, J. D., Allen, M. C., Deheyn, D. D. et al. (2019). Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proc. Natl. Acad. Sci. USA 116, 11806- 11811. 10.1073/pnas.1901021116 31138706 PMC6575160 · DOI · Paper page
  23. Li, H. and Zhang, Z. (2014). Research on palmprint identification method based on quantum algorithms. ScientificWorldJournal 2014, 670328. 10.1155/2014/670328 25105165 PMC4106095 · DOI
  24. Li, W., Zhang, D. and Xu, D. (1996). Palmprint identification by fourier transform. Intl. J. Pattern Recognit. Artif. Intel. 16, 417- 432. 10.1142/S0218001402001757 · DOI
  25. Lopes, S. S., Yang, X., Müller, J., Carney, T. J., McAdow, A. R., Rauch, G. J., Jacoby, A. S., Hurst, L. D., Delfino-Machín, M., Haffter, P. et al. (2008). Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genet. 4, e1000026. 10.1371/journal.pgen.1000026 18369445 PMC2265441 · DOI · Paper page
  26. Maan, M. E. and Sefc, K. M. (2013). Colour variation in cichlid fish: developmental mechanisms, selective pressures and evolutionary consequences. Semin. Cell Dev. Biol. 24, 516- 528. 10.1016/j.semcdb.2013.05.003 23665150 PMC3778878 · DOI
  27. Maderspacher, F. and Nüsslein-Volhard, C. (2003). Formation of the adult pigment pattern in zebrafish requires leopard and obelix dependent cell interactions. Development 130, 3447- 3457. 10.1242/dev.00519 12810592 · DOI · Paper page
  28. Mahalwar, P., Walderich, B., Singh, A. P. and Nusslein-Volhard, C. (2014). Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish. Science 345, 1362- 1364. 10.1126/science.1254837 25214630 · DOI
  29. Mahalwar, P., Singh, A. P., Fadeev, A., Nüsslein-Volhard, C. and Irion, U. (2016). Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish. Biol. Open 5, 1680- 1690. 10.1242/bio.022251 27742608 PMC5155543 · DOI · Paper page
  30. Marshall, N. J., Cortesi, F., de Busserolles, F., Siebeck, U. E. and Cheney, K. L. (2019). Colours and colour vision in reef fishes: past, present and future research directions. J. Fish Biol. 95, 5- 38. 10.1111/jfb.13849 30357835 · DOI
  31. McCann, L. I. and Carlson, C. C. (1982). Effect of cross-rearing on species identification in zebra fish and pearl danios. Dev. Psychobiol. 15, 71- 74. 10.1002/dev.420150110 7054017 · DOI
  32. McClure, M. and McCune, A. R. (2003). Evidence for developmental linkage of pigment patterns with body size and shape in danios (Teleostei: Cyprinidae). Evolution. Int. J. Org. Evol. 57, 1863- 1875. 10.1111/j.0014-3820.2003.tb00594.x 14503628 · DOI
  33. McCluskey, B. M. and Postlethwait, J. H. (2015). Phylogeny of Zebrafish, a “Model Species,” within Danio, a “Model Genus”. Mol. Biol. Evol. 32, 635- 652. 10.1093/molbev/msu325 25415969 PMC4327152 · DOI · Paper page
  34. McCluskey, B. M., Uji, S., Mancusi, J. L., Postlethwait, J. H. and Parichy, D. M. (2021). A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genet. 17, e1009364. 10.1371/journal.pgen.1009364 33901178 PMC8102007 · DOI · Paper page
  35. McMenamin, S. K., Bain, E. J., McCann, A. E., Patterson, L. B., Eom, D. S., Waller, Z. P., Hamill, J. C., Kuhlman, J. A., Eisen, J. S. and Parichy, D. M. (2014). Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science 345, 1358- 1361. 10.1126/science.1256251 25170046 PMC4211621 · DOI · Paper page
  36. Mills, M. G., Nuckels, R. J. and Parichy, D. M. (2007). Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes. Development 134, 1081- 1090. 10.1242/dev.02799 17287252 · DOI
  37. Moreira, J. and Deutsch, A. (2005). Pigment pattern formation in zebrafish during late larval stages: a model based on local interactions. Dev. Dyn. 232, 33- 42. 10.1002/dvdy.20199 15543601 · DOI
  38. Nakamasu, A., Takahashi, G., Kanbe, A. and Kondo, S. (2009). Interactions between zebrafish pigment cells responsible for the generation of Turing patterns. Proc. Natl. Acad. Sci. USA 106, 8429- 8434. 10.1073/pnas.0808622106 19433782 PMC2689028 · DOI · Paper page
  39. Owen, J. P., Kelsh, R. N. and Yates, C. A. (2020). A quantitative modelling approach to zebrafish pigment pattern formation. eLife 9, e52998. 10.7554/eLife.52998 32716296 PMC7384860 · DOI
  40. Paradis, E. and Schliep, K. (2019). ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Bioinformatics 35, 526- 528. 10.1093/bioinformatics/bty633 30016406 · DOI
  41. Parichy, D. M. (2015). Advancing biology through a deeper understanding of zebrafish ecology and evolution. eLife 4, e05635. 10.7554/eLife.05635 PMC4373672 25807087 · DOI · Paper page
  42. Parichy, D. M. (2021). Evolution of pigment cells and patterns: recent insights from teleost fishes. Curr. Opin. Genet. Dev. 69, 88- 96. 10.1016/j.gde.2021.02.006 33743392 PMC8364858 · DOI · Paper page
  43. Parichy, D. M. and Turner, J. M. (2003a). Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development. Development 130, 817- 833. 10.1242/dev.00307 12538511 · DOI · Paper page
  44. Parichy, D. M. and Turner, J. M. (2003b). Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis. Dev. Biol. 256, 242- 257. 10.1016/S0012-1606(03)00015-0 12679100 · DOI
  45. Parichy, D. M., Rawls, J. F., Pratt, S. J., Whitfield, T. T. and Johnson, S. L. (1999). Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development 126, 3425- 3436. 10.1242/dev.126.15.3425 10393121 · DOI
  46. Parichy, D. M., Mellgren, E. M., Rawls, J. F., Lopes, S. S., Kelsh, R. N. and Johnson, S. L. (2000a). Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Dev. Biol. 227, 294- 306. 10.1006/dbio.2000.9899 11071756 · DOI · Paper page
  47. Parichy, D. M., Ransom, D. G., Paw, B., Zon, L. I. and Johnson, S. L. (2000b). An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development 127, 3031- 3044. 10.1242/dev.127.14.3031 10862741 · DOI · Paper page
  48. Parichy, D. M., Elizondo, M. R., Mills, M. G., Gordon, T. N. and Engeszer, R. E. (2009). Normal table of postembryonic zebrafish development: staging by externally visible anatomy of the living fish. Dev. Dyn. 238, 2975- 3015. 10.1002/dvdy.22113 19891001 PMC3030279 · DOI · Paper page
  49. Patterson, L. B. and Parichy, D. M. (2013). Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genet. 9, e1003561. 10.1371/journal.pgen.1003561 23737760 PMC3667786 · DOI · Paper page
  50. Patterson, L. B. and Parichy, D. M. (2019). Zebrafish pigment pattern formation: insights into the development and evolution of adult form. Annu. Rev. Genet. 53, 505- 530. 10.1146/annurev-genet-112618-043741 31509458 · DOI · Paper page
  51. Patterson, L. B., Bain, E. J. and Parichy, D. M. (2014). Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. Nat. Commun. 5, 5299. 10.1038/ncomms6299 25374113 PMC4224114 · DOI · Paper page
  52. Podobnik, M., Frohnhöfer, H. G., Dooley, C. M., Eskova, A., Nüsslein-Volhard, C. and Irion, U. (2020). Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish. Nat. Commun. 11, 6230. 10.1038/s41467-020-20021-6 33277491 PMC7718271 · DOI · Paper page
  53. Price, A. C., Weadick, C. J., Shim, J. and Rodd, F. H. (2008). Pigments, patterns, and fish behavior. Zebrafish 5, 297- 307. 10.1089/zeb.2008.0551 19133828 · DOI
  54. Quigley, I. K., Turner, J. M., Nuckels, R. J., Manuel, J. L., Budi, E. H., MacDonald, E. L. and Parichy, D. M. (2004). Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development 131, 6053- 6069. 10.1242/dev.01526 15537688 · DOI
  55. Quigley, I. K., Manuel, J. L., Roberts, R. A., Nuckels, R. J., Herrington, E. R., MacDonald, E. L. and Parichy, D. M. (2005). Evolutionary diversification of pigment pattern in Danio fishes:differential fms dependence and stripe loss in D. albolineatus. Development 132, 89- 104. 10.1242/dev.01547 15563521 · DOI · Paper page
  56. Raup, D. M. (1961). The geometry of coiling in gastropods. Proc. Natl. Acad. Sci. USA 47, 602- 609. 10.1073/pnas.47.4.602 16578506 PMC221494 · DOI
  57. Rosenthal, G. G. and Ryan, M. J. (2005). Assortative preferences for stripes in danios. Anim. Behav. 70, 1063- 1066. 10.1016/j.anbehav.2005.02.005 · DOI · Paper page
  58. Shah, A. N., Davey, C. F., Whitebirch, A. C., Miller, A. C. and Moens, C. B. (2015). Rapid reverse genetic screening using CRISPR in zebrafish. Nat Methods 12, 535- 540. 25867848 PMC4667794
  59. Shannon, C. E. (1948). A mathematical theory of communication. Bell Syst. Tech. J. 27, 623- 656. 10.1002/j.1538-7305.1948.tb00917.x · DOI
  60. Singh, A. P., Frohnhöfer, H.-G., Irion, U. and Nüsslein-Volhard, C. (2015). Response to comment on “Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish”. Science 348, 297. 10.1126/science.aaa2804 25883351 · DOI
  61. Singh, A. P., Dinwiddie, A., Mahalwar, P., Schach, U., Linker, C., Irion, U. and Nüsslein-Volhard, C. (2016). Pigment cell progenitors in zebrafish remain multipotent through metamorphosis. Dev. Cell 38, 316- 330. 10.1016/j.devcel.2016.06.020 27453500 · DOI · Paper page
  62. Spiewak, J. E., Bain, E. J., Liu, J., Kou, K., Sturiale, S. L., Patterson, L. B., Diba, P., Eisen, J. S., Braasch, I., Ganz, J. et al. (2018). Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes. PLoS Genet. 14, e1007538. 10.1371/journal.pgen.1007538 30226839 PMC6161917 · DOI · Paper page
  63. Volkening, A. and Sandstede, B. (2015). Modelling stripe formation in zebrafish: an agent-based approach. J. R. Soc. Interface 12, 20150812. 10.1098/rsif.2015.0812 26538560 PMC4685853 · DOI
  64. Volkening, A. and Sandstede, B. (2018). Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns. Nat. Commun. 9, 3231. 10.1038/s41467-018-05629-z 30104716 PMC6089994 · DOI · Paper page
  65. Watanabe, M. and Kondo, S. (2015a). Comment on “Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish”. Science 348, 297-297. 10.1126/science.1261947 25883350 · DOI
  66. Watanabe, M. and Kondo, S. (2015b). Is pigment patterning in fish skin determined by the turing mechanism? Trends Genet. 31, 88- 96. 10.1016/j.tig.2014.11.005 25544713 · DOI
  67. Wierson, W. A., Welker, J. M., Almeida, M. P., Mann, C. M., Webster, D. A., Torrie, M. E., Weiss, T. J., Kambakam, S., Vollbrecht, M. K., Lan, M. et al. (2020). Efficient targeted integration directed by short homology in zebrafish and mammalian cells. eLife 9, e53968. 10.7554/eLife.53968 32412410 PMC7228771 · DOI
  68. Xu, B. (1996). Identifying fabric structures with fast Fourier transform techniques. Tex. Res. J. 66, 496- 506. 10.1177/004051759606600803 · DOI
  69. Yamanaka, H. and Kondo, S. (2014). In vitro analysis suggests that difference in cell movement during direct interaction can generate various pigment patterns in vivo. Proc. Natl. Acad. Sci. USA 111, 1867- 1872. 10.1073/pnas.1315416111 24449859 PMC3918784 · DOI

Cited by

Sorted by citations

Authors
McCluskey, B. M., Liang, Y., Lewis, V. M., Patterson, L. B., & Parichy, D. M.
Affiliations
  • University of Virginia (US)
  • Rhode Island College (US)
Corresponding author
Parichy, David M.
ORCID
Venue
Biology Open
Publisher
The Company of Biologists
Published
2021-09-15
Volume
10
Issue
9
ISSN
2046-6390 (ISSN-L)
DOI
10.1242/bio.058814
PMC
PMC8487636
OpenAlex
W3198812331
Cited by
12
References
2
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 4
FWCI
0.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Biology Open (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R35 GM122471)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
pigmentation patterns, Danio, zebrafish, morphospace, information theory metrics, phenotypic variability, evolutionary diversification, mutation effects
MeSH terms
Animals, Embryo, Nonmammalian, Biological Evolution, Metamorphosis, Biological, Mutation, Neural Crest, Phenotype, Pigmentation, Zebrafish, Embryonic Development

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