The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
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Previous work has demonstrated that the character of mouse cortical interneuron subtypes can be directly related to their embryonic temporal and spatial origins. The relationship between embryonic origin and the character of mature interneurons is likely reflected by the developmental expression of genes that direct cell fate. However, a thorough understanding of the early genetic events that specify subtype identity has been hampered by the perinatal lethality resulting from the loss of genes implicated in the determination of cortical interneurons. Here, we employ a conditional loss-of-function approach to demonstrate that the transcription factor Nkx2-1 is required for the proper specification of specific interneuron subtypes. Removal of this gene at distinct neurogenic time points results in a switch in the subtypes of neurons observed at more mature ages. Our strategy reveals a causal link between the embryonic genetic specification by Nkx2-1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system.
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MGE/POA progenitor cells take on properties of the LGE and CGE in mice lacking Nkx2-1.
“MGE/POA progenitor cells take on properties of the LGE and CGE in mice lacking Nkx2-1”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Butt et al., 2008
MGE progenitors preferentially express Nkx2.1, which must be downregulated in migrating postmitotic cells for them to avoid the striatum and reach the cortex.
“MGE progenitors preferentially express the transcription factor Nkx2.1 (147, 148, 829, 1233), which must be downregulated in migrating postmitotic cells in order for them to avoid the striatum and reach the cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [148]
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Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954 · see citing works
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · see citing works
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416 · see citing works
Kimura, S., Hara, Y., Pineau, T., Fernández‐Salguero, P. M., Fox, C. H., Ward, J. M., & Gonzalez, F. J. (1996) · Genes & Development · doi:10.1101/gad.10.1.60 · Cited by 1,221 · see citing works
Self-citationEvidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.
Harfe, B., Scherz, P., Nissim, S., Tian, H., McMahon, A., & Tabin, C. (2004) · Cell · doi:10.1016/j.cell.2004.07.024 · Cited by 1,033 · see citing works
Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains
Feil, R., Wagner, J. D., METZGER, D., & Chambon, P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7124 · Cited by 992 · see citing works
Cell fate determination in the vertebrate retina.
Cepko, C. L., Austin, C. P., Yang, X.-J., Alexiades, M. R., & Ezzeddine, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.589 · Cited by 989 · see citing works
Somogyi, P., Tamás, G., Luján, R., & Buhl, E. H. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00061-1 · Cited by 875 · see citing works
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873 · see citing works
Self-citationLints, T., Parsons, L. M., Hartley, L., Lyons, I. G., & Harvey, R. P. (1993) · Development · doi:10.1242/dev.119.2.419 · Cited by 861 · see citing works
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T., Rubenstein, J., & Ericson, J. (1999) · Nature · doi:10.1038/19315 · Cited by 807 · see citing works
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722 · see citing works
Self-citationInductive interactions direct early regionalization of the mouse forebrain
Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 659 · see citing works
Origins of Cortical Interneuron Subtypes
Xu, Q., Cobos, I., De La Cruz, E., Rubenstein, J. L., & Anderson, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5667-03.2004 · Cited by 639 · see citing works
Origin and Molecular Specification of Striatal Interneurons
Marín, Ó., Anderson, S. A., & Rubenstein, J. L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 627 · see citing works
The temporal and spatial origins of cortical interneurons predict their physiological subtype
Butt, S. J. B., Fuccillo, M., Nery, S., Noctor, S., Kriegstein, A., Corbin, J. G., & Fishell, G. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.034 · Cited by 587 · see citing works
Self-citationNK-2Homeobox Genes and Heart Development
Harvey, R. P. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0212 · Cited by 579 · see citing works
The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations
Nery, S., Fishell, G., & Corbin, J. G. (2002) · Nature Neuroscience · doi:10.1038/nn971 · Cited by 558 · see citing works
Self-citationStenman, J. M., Toresson, H., & Campbell, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00167.2003 · Cited by 508 · see citing works
Takebayashi, H., Nabeshima, Y., Yoshida, S., Chisaka, O., Ikenaka, K., & Nabeshima, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00926-0 · Cited by 500 · see citing works
Three distinct families of GABAergic neurons in rat visual cortex
Gonchar, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.4.347 · Cited by 481 · see citing works
Bai, C. B., Stephen, D. N., & Joyner, A. L. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00394-0 · Cited by 440 · see citing works
Fogarty, M., Grist, M., Gelman, D., Marín, O., Pachnis, V., & Kessaris, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1629-07.2007 · Cited by 412 · see citing works
Muhr, J., Andersson, E., Persson, M., Jessell, T., & Ericson, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00283-5 · Cited by 412 · see citing works
Miyoshi, G., Butt, S. J. B., Takebayashi, H., & Fishell, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1807-07.2007 · Cited by 400 · see citing works
Self-citationGenetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2
Toresson, H., Potter, S. S., & Campbell, K. (2000) · Development · doi:10.1242/dev.127.20.4361 · Cited by 387 · see citing works
Progressive restriction in fate potential by neural progenitors during cerebral cortical development
Desai, A. R., & McConnell, S. K. (2000) · Development · doi:10.1242/dev.127.13.2863 · Cited by 385 · see citing works
Liodis, P., Denaxa, M., Grigoriou, M., Akufo-Addo, C., Yanagawa, Y., & Pachnis, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3055-06.2007 · Cited by 377 · see citing works
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Storm, E. E., Garel, S., Borello, U., Hébert, J. M., Martı́nez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R. (2006) · Development · doi:10.1242/dev.02324 · Cited by 361 · see citing works
Powell, E. M., Campbell, D. B., Stanwood, G. D., Davis, C., Noebels, J. L., & Levitt, P. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00622.2003 · Cited by 333 · see citing works
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
Krude, H., Schütz, B., Biebermann, H., von Moers, A., Schnabel, D., Neitzel, H., Tönnies, H., Weise, D., Lafferty, A. R. A., Schwarz, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14341 · Cited by 329 · see citing works
Chen, C. Y., & Schwartz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15628 · Cited by 287 · see citing works
Sander, M., Paydar, S., Ericson, J., Briscoe, J., Berber, E., German, M., Jessell, T. M., & Rubenstein, J. L. R. (2000) · Genes & Development · doi:10.1101/gad.820400 · Cited by 270 · see citing works
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
Krude, H., Schütz, B., Biebermann, H., von Moers, A., Schnabel, D., Neitzel, H., Tönnies, H., Weise, D., Lafferty, A., Schwarz, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214341 · Cited by 268 · see citing works
Nóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.024 · Cited by 256 · see citing works
Self-citationWeiss, J. B., Von Ohlen, T., Mellerick, D. M., Dressler, G., Doe, C. Q., & Scott, M. P. (1998) · Genes & Development · doi:10.1101/gad.12.22.3591 · Cited by 250 · cited 2× · see citing works
“Both the ventral nervous system defective (vnd) gene in Drosophila and the Nkx22, Nkx6-1, and Nkx6-2 genes in the mouse spinal cord act to direct progenitors to adopt specific ventral neural identities while repressing the fates of neighboring regions (Briscoe et al., 1999; Chu et al., 1998; McDonald et al., 1998; San…”
BackgroundZhao, Y., Marín, O., Hermesz, E., Powell, A., Flames, N., Palkovits, M., Rubenstein, J. L. R., & Westphal, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537759100 · Cited by 227 · see citing works
Jeong, Y., El-Jaick, K. B., Roessler, E., Muenke, M., & Epstein, D. J. (2006) · Development · doi:10.1242/dev.02239 · Cited by 227 · see citing works
A spatial bias for the origins of interneuron subgroups within the medial ganglionic eminence
Wonders, C. P., Taylor, L. A., Welagen, J., Mbata, I. C., Xiang, J., & Anderson, S. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.11.018 · Cited by 224 · see citing works
Mutations in TITF-1 are associated with benign hereditary chorea
Breedveld, G. J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.8.971 · Cited by 223 · see citing works
NKX2.1 specifies cortical interneuron fate by activatingLhx6
Du, T., Xu, Q., Ocbina, P. J. R., & Anderson, S. A. (2008) · Development · doi:10.1242/dev.015123 · Cited by 220 · see citing works
Hanashima, C., Shen, L., Li, S. C., & Lai, E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06526.2002 · Cited by 194 · see citing works
Kohtz, J. D., Baker, D. P., Corte, G., & Fishell, G. (1998) · Development · doi:10.1242/dev.125.24.5079 · Cited by 181 · see citing works
Self-citationPohlenz, J., Dumitrescu, A. M., Zundel, D., Martiné, U., Schönberger, W., Koo, E., Weiss, R. E., Cohen, R., Kimura, S., & Refetoff, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14192 · Cited by 179 · see citing works
Self-citationRallu, M., Corbin, J. G., & Fishell, G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn989 · Cited by 173 · see citing works
Self-citationCellular Patterns of Transcription Factor Expression in Developing Cortical Interneurons
Cobos, I., Long, J. E., Thwin, M. T., & Rubenstein, J. L. R. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk003 · Cited by 167 · see citing works
Pohlenz, J., Dumitrescu, A. M., Zundel, D., Martiné, U., Schönberger, W., Koo, E., Weiss, R. E., Cohen, R., Kimura, S., & Refetoff, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214192 · Cited by 164 · see citing works
Self-citationMcDonald, J. A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C. Q., & Mellerick, D. M. (1998) · Genes & Development · doi:10.1101/gad.12.22.3603 · Cited by 162 · see citing works
FGF signalling generates ventral telencephalic cells independently of SHH
Gutin, G., Fernandes, M., Palazzolo, L., Paek, H., Yu, K., Ornitz, D. M., McConnell, S. K., & Hébert, J. M. (2006) · Development · doi:10.1242/dev.02465 · Cited by 152 · see citing works
Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesisPreprint
Chu, H., Parras, C. M., White, K., & Jiménez, F. (1998) · Genes & Development · doi:10.1101/gad.12.22.3613 · Cited by 113 · see citing works
Kusakabe, T., Kawaguchi, A., Hoshi, N., Kawaguchi, R., Hoshi, S., & Kimura, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0327 · Cited by 112 · see citing works
Self-citationRedundant Domains Contribute to the Transcriptional Activity of the Thyroid Transcription Factor 1
Felice, M. D., Damante, G., Zannini, M., Francis-Lang, H., & Lauro, R. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26649 · Cited by 111 · see citing works
Fragkouli, A., Hearn, C. J., Errington, M. L., Cooke, S. F., Grigoriou, M. E., Bliss, T., Stylianopoulou, F., & Pachnis, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04141.x · Cited by 103 · see citing works
Watada, H., Mirmira, R. G., Kalamaras, J., & German, M. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9443 · Cited by 101 · see citing works
Wang, H.-F., & Liu, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00590-x · Cited by 80 · see citing works
Moeller, L. C., Kimura, S., Kusakabe, T., Liao, X.-H., SANDE, J. V., & Refetoff, S. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0175 · Cited by 61 · see citing works
Self-citationDlx2 Progenitor Migration in Wild Type and Nkx2.1 Mutant Telencephalon
Nery, S. V. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.9.895 · Cited by 46 · see citing works
TheFugu rubripes tyrosinase gene promoter targets transgene expression to pigment cells in the mouse
Camacho-H�bner, A., Rossier, A., & Beermann, F. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 27 · see citing works
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Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828 · see citing works
Self-citationInterneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190 · see citing works
Interneuron cell types are fit to function
Kepecs, A., & Fishell, G. (2014) · Nature · doi:10.1038/nature12983 · Cited by 1,110 · see citing works
Self-citationHippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction
Goldberg, E. M., & Coulter, D. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3482 · Cited by 542 · see citing works
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
Self-citationWarburton, D., El-Hashash, A. H. K., Carraro, G., Tiozzo, C., Sala, F., Rogers, O., Langhe, S. D., Kemp, P. J., Riccardi, D., Torday, J. S., et al. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)90003-3 · Cited by 431 · see citing works
Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
Kwan, K. Y., Šestan, N., & Anton, E. S. (2012) · Development · doi:10.1242/dev.069963 · Cited by 414 · see citing works
Generating Neuronal Diversity in the Mammalian Cerebral Cortex
Lodato, S., & Arlotta, P. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125353 · Cited by 389 · see citing works
Genetic and activity-dependent mechanisms underlying interneuron diversity
Wamsley, B., & Fishell, G. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.30 · Cited by 290 · see citing works
Self-citationCharacterization of Nkx6-2-Derived Neocortical Interneuron Lineages
Sousa, V. H., Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., & Fishell, G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp038 · Cited by 328 · see citing works
Self-citationSubcortical origins of human and monkey neocortical interneurons
Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3536 · Cited by 322 · see citing works
Okaty, B. W., Miller, M. N., Sugino, K., Hempel, C. M., & Nelson, S. B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0105-09.2009 · Cited by 309 · see citing works
The spatial and temporal origin of chandelier cells in mouse neocortex
Taniguchi, H., Lu, J., & Huang, Z. J. (2013) · Science · doi:10.1126/science.1227622 · Cited by 278 · see citing works
Neuronal activity is required for the development of specific cortical interneuron subtypes
De Marco García, N. V., Karayannis, T., & Fishell, G. (2011) · Nature · doi:10.1038/nature09865 · Cited by 294 · see citing works
Self-citationA Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity
Tricoire, L., Pelkey, K. A., Erkkila, B. E., Jeffries, B. W., Yuan, X., & McBain, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-11.2011 · Cited by 292 · see citing works
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
Marques, S., van Bruggen, D., Vanichkina, D. P., Floriddia, E. M., Munguba, H., Väremo, L., Giacomello, S., Falcão, A. M., Meijer, M., Björklund, Å. K., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.005 · Cited by 290 · see citing works
Self-citationPyramidal cell regulation of interneuron survival sculpts cortical networks
Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O. (2018) · Nature · doi:10.1038/s41586-018-0139-6 · Cited by 286 · see citing works
Thyroid transcription factors in development, differentiation and disease
Fernández, L. P., López-Márquez, A., & Santisteban, P. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.186 · Cited by 258 · see citing works
Nóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.024 · Cited by 256 · see citing works
Self-citationPrototypic and arkypallidal neurons in the dopamine-intact external globus pallidus
Abdi, A., Mallet, N., Mohamed, F. Y., Sharott, A., Dodson, P. D., Nakamura, K. C., Suri, S., Avery, S. V., Larvin, J. T., Garas, F. N., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4662-14.2015 · Cited by 247 · see citing works
Lodato, S., Rouaux, C., Quast, K. B., Jantrachotechatchawan, C., Studer, M., Hensch, T. K., & Arlotta, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.015 · Cited by 244 · see citing works
Wirth, E. K., Conrad, M., Winterer, J., Wozny, C., Carlson, B. A., Roth, S., Schmitz, D., Bornkamm, G. W., Coppola, V., Tessarollo, L., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-143974 · Cited by 237 · see citing works
Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network
Batista‐Brito, R., & Fishell, G. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)01203-4 · Cited by 223 · see citing works
Self-citationXu, Q., Guo, L., Moore, H., Waclaw, R. R., Campbell, K., & Anderson, S. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.004 · Cited by 218 · see citing works
The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development
Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis, V., & Fishell, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.005 · Cited by 214 · see citing works
Self-citationCortical interneuron development: a tale of time and space
Hu, J. S., Vogt, D., Sandberg, M., & Rubenstein, J. L. (2017) · Development · doi:10.1242/dev.132852 · Cited by 189 · see citing works
Five new TTF1/NKX2.1 mutations in brain-lung-thyroid syndrome: rescue by PAX8 synergism in one case
Carré, A., Szinnai, G., Castanet, M., Sura‐Trueba, S., Tron, E., Broutin, I., Barat, P., Goizet, C., Lacombe, D., Moutard, M., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp162 · Cited by 208 · see citing works
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development
Azim, E., Jabaudon, D., Fame, R. M., & Macklis, J. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2387 · Cited by 202 · see citing works
Baker, A. L., Kalmbach, B. E., Morishima, M., Kim, J., Juavinett, A., Li, N., & Dembrow, N. C. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0150-18.2018 · Cited by 198 · see citing works
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Fishell, G., & Kepecs, Á. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050421 · Cited by 208 · see citing works
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Wang, Y., Dye, C. A., Sohal, V. S., Long, J. E., Estrada, R. C., Roztocil, T., Lufkin, T., Deisseroth, K. A., Baraban, S. C., & Rubenstein, J. L. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5963-09.2010 · Cited by 186 · see citing works
Generation of interneuron diversity in the mouse cerebral cortex
Gelman, D. M., & Marín, O. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07267.x · Cited by 188 · see citing works
Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
Rossignol, E. (2011) · Neural Plasticity · doi:10.1155/2011/649325 · Cited by 192 · see citing works
Flandin, P., Kimura, S., & Rubenstein, J. L. R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4228-09.2010 · Cited by 176 · see citing works
Self-citationEvolution and development of interhemispheric connections in the vertebrate forebrain
Suárez, R., Gobius, I., & Richards, L. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00497 · Cited by 175 · see citing works
Development and specification of GABAergic cortical interneurons
Kelsom, C., & Lu, W. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-19 · Cited by 171 · see citing works
Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells
Tricoire, L., Pelkey, K. A., Daw, M. I., Sousa, V. H., Miyoshi, G., Jeffries, B., Cauli, B., Fishell, G., & McBain, C. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-09.2010 · Cited by 171 · see citing works
Self-citationGenomic Perspectives of Transcriptional Regulation in Forebrain Development
Nord, A. S., Pattabiraman, K., Visel, A., & Rubenstein, J. L. R. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.011 · Cited by 152 · see citing works
Floriddia, E., Lourenço, T., Zhang, S., van Bruggen, D., Hilscher, M., Kukanja, P., dos Santos, J. P. G., Altınkök, M., Yokota, C., Llorens-Bobadilla, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19453-x · Cited by 137 · see citing works
Flandin, P., Zhao, Y., Vogt, D., Jeong, J., Long, J., Potter, G., Westphal, H., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.020 · Cited by 155 · see citing works
McKinsey, G. L., Lindtner, S., Trzcinski, B., Visel, A., Pennacchio, L. A., Huylebroeck, D., Higashi, Y., & Rubenstein, J. L. R. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.035 · Cited by 153 · see citing works
Interneurons in the developing human neocortex
Zečević, N., Hu, F., & Jakovčevski, I. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20812 · Cited by 153 · see citing works
Clonal production and organization of inhibitory interneurons in the neocortex
Brown, K. N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Zhang, X.-J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., et al. (2011) · Science · doi:10.1126/science.1208884 · Cited by 152 · see citing works
Close, J., Xu, H., De Marco García, N., Batista-Brito, R., Rossignol, E., Rudy, B., & Fishell, G. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3583-12.2012 · Cited by 141 · see citing works
Self-citationIntegrative Mechanisms of Oriented Neuronal Migration in the Developing Brain
Evsyukova, I. Y., Plestant, C., & Anton, E. S. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122400 · Cited by 151 · see citing works
Origin and molecular specification of globus pallidus neurons
Nóbrega-Pereira, S., Gelman, D., Bartolini, G., Pla, R., Pierani, A., & Marín, O. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4023-09.2010 · Cited by 142 · see citing works
Miyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z. J., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1164-15.2015 · Cited by 135 · see citing works
Self-citationTranscriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
Sandberg, M., Flandin, P., Silberberg, S., Su-Feher, L., Price, J. D., Hu, J. S., Kim, C., Visel, A., Nord, A. S., & Rubenstein, J. L. R. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.020 · Cited by 129 · see citing works
Genetic programs controlling cortical interneuron fate
Kessaris, N., Magno, L., Rubin, A. N., & Oliveira, M. G. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.12.012 · Cited by 122 · see citing works
Cortical interneuron specification: the juncture of genes, time and geometry
Bandler, R. C., Mayer, C., & Fishell, G. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.10.003 · Cited by 125 · see citing works
Self-citationMany specialists for suppressing cortical excitation
Burkhalter, A. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.026.2008 · Cited by 122 · see citing works
Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., Hippenmeyer, S., & Fishell, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.011 · Cited by 113 · see citing works
Self-citationThe Neuron Identity Problem: Form Meets Function
Fishell, G., & Heintz, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.035 · Cited by 115 · see citing works
Self-citationFuentealba, P., Klausberger, T., Karayannis, T., Suen, W. Y., Huck, J., Tomioka, R., Rockland, K., Capogna, M., Studer, M., Morales, M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4199-09.2010 · Cited by 113 · see citing works
Lodato, S., Tomassy, G. S., De Leonibus, E., Uzcategui, Y. G., Andolfi, G., Armentano, M., Touzot, A., Gaztelu, J. M., Arlotta, P., Menendez de la Prida, L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6580-10.2011 · Cited by 112 · see citing works
Rossignol, E., Kruglikov, I., van den Maagdenberg, A. M. J. M., Rudy, B., & Fishell, G. (2013) · Annals of Neurology · doi:10.1002/ana.23913 · Cited by 112 · see citing works
Self-citationWide dispersion and diversity of clonally related inhibitory interneurons
Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.030 · Cited by 106 · see citing works
Genetic dissection of GABAergic neural circuits in mouse neocortex
Taniguchi, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00008 · Cited by 106 · see citing works
Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Sousa, V. H., & Fishell, G. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.04.008 · Cited by 106 · see citing works
Self-citationPrenatal stress delays inhibitory neuron progenitor migration in the developing neocortex
Stevens, H. E., Su, T., Yanagawa, Y., & Vaccarino, F. M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.011 · Cited by 104 · see citing works
Primate-specific origins and migration of cortical GABAergic neurons
Petanjek, Z. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.026.2009 · Cited by 102 · see citing works
Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy
Jiang, X., Lachance, M., & Rossignol, E. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.012 · Cited by 98 · see citing works
Npas1 + -Nkx2.1 + Neurons Are an Integral Part of the Cortico-pallido-cortical Loop
Abecassis, Z. A., Berceau, B. L., Win, P. H., García, D., Xenias, H. S., Cui, Q., Pamukcu, A., Cherian, S., Hernández, V. M., Chon, U., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1199-19.2019 · Cited by 93 · see citing works
GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
Anastasiades, P. G., Marques-Smith, A., Lyngholm, D., Lickiss, T., Raffiq, S., Kätzel, D., Miesenböck, G., & Butt, S. J. B. (2016) · Nature Communications · doi:10.1038/ncomms10584 · Cited by 87 · see citing works
Self-citationPrenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders
Fine, R., Zhang, J., & Stevens, H. E. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.35 · Cited by 96 · see citing works
Liu, Y., Wang, Y., Ling, X. L., Yan, Z., Wu, D., Liu, J., & Lu, G. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c06479 · Cited by 94 · see citing works
Vasistha, N. A., Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M., García‐González, D., Malwade, S., Korshunova, I., Pfisterer, U., von Engelhardt, J., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0539-5 · Cited by 92 · see citing works
Molecules and Mechanisms Involved in the Generation and Migration of Cortical Interneurons
Hernandez-Miranda, L. R., Parnavelas, J. G., & Chiara, F. (2010) · ASN NEURO · doi:10.1042/an20090053 · Cited by 90 · see citing works
Revisiting enigmatic cortical calretinin-expressing interneurons
Cauli, B., Zhou, X., Tricoire, L., Toussay, X., & Staiger, J. F. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00052 · Cited by 86 · see citing works
Prospective Isolation of Cortical Interneuron Precursors from Mouse Embryonic Stem Cells
Maroof, A. M., Brown, K. N., Shi, S., Studer, L., & Anderson, S. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4255-09.2010 · Cited by 84 · see citing works
Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production
Tan, X., Liu, W. A., Zhang, X., Shi, W., Ren, S., Li, Z., Brown, K. N., & Shi, S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.023 · Cited by 83 · see citing works
Production and organization of neocortical interneurons
Sultan, K. T., Brown, K. N., & Shi, S.-H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00221 · Cited by 83 · see citing works
Olig1 Function Is Required to Repress Dlx1/2 and Interneuron Production in Mammalian Brain
Silbereis, J. C., Nobuta, H., Tsai, H., Heine, V. M., McKinsey, G. L., Meijer, D. H., Howard, M. A., Petryniak, M. A., Potter, G. B., Alberta, J. A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.024 · Cited by 77 · see citing works
Molecular regulation of neuronal migration during neocortical development
Huang, Z. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.06.003 · Cited by 87 · see citing works
Neurons on the Move: Migration and Lamination of Cortical Interneurons
Faux, C. H., Rakić, S., Andrews, W. D., & Britto, J. M. (2012) · Neurosignals · doi:10.1159/000334489 · Cited by 88 · see citing works
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis
Silva, C. G., Peyre, E., Adhikari, M. H., Tielens, S., Tanco, S., Damme, P. V., Magno, L., Krusy, N., Agirman, G., Magiera, M. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.031 · Cited by 74 · see citing works
Orduz, D., Benamer, N., Ortolani, D., Coppola, E., Vigier, L., Pierani, A., & Angulo, M. C. (2019) · Nature Communications · doi:10.1038/s41467-019-11904-4 · Cited by 75 · see citing works
Kourdougli, N., Suresh, A., Liu, B., Juárez, P., Lin, A., Chung, D. T., Sams, A. G., Gandal, M. J., Martínez‐Cerdeño, V., Buonomano, D. V., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.009 · Cited by 68 · see citing works
Neocortical neurogenesis and neuronal migration
Tan, X., & Shi, S. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.88 · Cited by 85 · see citing works
Spatio-temporal extension in site of origin for cortical calretinin neurons in primates
Hladnik, A., Džaja, D., Darmopil, S., Jovanov-MiloÅ¡ević, N., & Petanjek, Z. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00050 · Cited by 72 · see citing works
Frazer, S., Prados, J., Niquille, M., Cadilhac, C., Markopoulos, F., Gomez, L., Tomasello, U., Telley, L., Holtmaat, A., Jabaudon, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms14219 · Cited by 72 · see citing works
NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory
Magno, L., Barry, C., Schmidt‐Hieber, C., Theodotou, P., Häusser, M., & Kessaris, N. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.053 · Cited by 68 · see citing works
The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC)
Feliciano, D. M. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00039 · Cited by 69 · see citing works
Developmental specification of forebrain cholinergic neurons
Allaway, K. C., & Machold, R. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.007 · Cited by 68 · see citing works
Local Thyroid Hormone Action in Brain Development
Alcaide, M. A., & Mayerl, S. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512352 · Cited by 70 · see citing works
Chromatin Remodeling Proteins in Epilepsy: Lessons From CHD2-Associated Epilepsy
Lamar, K., & Carvill, G. L. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00208 · Cited by 66 · see citing works
MTOR controls genesis and autophagy of GABAergic interneurons during brain development
Ka, M., Smith, A. L., & Kim, W.-Y. (2017) · Autophagy · doi:10.1080/15548627.2017.1327927 · Cited by 65 · see citing works
Foxp2 regulates neuronal differentiation and neuronal subtype specification
Chiu, Y.-C., Li, M., Liu, Y., Ding, J., Yu, J., & Wang, T. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22166 · Cited by 61 · see citing works
Conserved rules in embryonic development of cortical interneurons
Laclef, C., & Métin, C. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.09.017 · Cited by 57 · see citing works
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62 · see citing works
Neves, G., Shah, M. M., Liodis, P., Achimastou, A., Denaxa, M., Roalfe, G., Sesay, A. K., Walker, M. C., & Pachnis, V. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs159 · Cited by 62 · see citing works
Patterning of ventral telencephalon requires positive function of Gli transcription factors
Yu, W., Wang, Y., McDonnell, K., Stephen, D. N., & Bai, C. B. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.07.026 · Cited by 62 · see citing works
Sonic hedgehogexpressing and responding cells generate neuronal diversity in the medial amygdala
Carney, R. S. E., Mangin, J., Hayes, L. N., Mansfield, K., Sousa, V. H., Fishell, G., Machold, R. P., Ahn, S., Gallo, V., & Corbin, J. G. (2010) · Neural Development · doi:10.1186/1749-8104-5-14 · Cited by 60 · see citing works
Self-citationNeuronal sources of hedgehog modulate neurogenesis in the adult planarian brain
Currie, K. W., Molinaro, A. M., & Pearson, B. J. (2016) · eLife · doi:10.7554/elife.19735 · Cited by 66 · see citing works
Cossart, R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.10.003 · Cited by 60 · see citing works
Meganathan, K., Lewis, E. M. A., Gontarz, P. M., Liu, S., Stanley, E. G., Elefanty, A. G., Huettner, J. E., Zhang, B., & Kroll, K. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712365115 · Cited by 58 · see citing works
Naegele, J. R., Maisano, X., Yang, J. N., Royston, S. E., & Ribeiro, E. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.019 · Cited by 58 · see citing works
Benign hereditary chorea: An update
Inzelberg, R., Weinberger, M., & Gak, E. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.01.002 · Cited by 57 · see citing works
- Authors
- Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G.
- Affiliations
- New York University (US)
- National Institutes of Health (US)
- Corresponding author
- Fishell, Gord
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 59
- Issue
- 5
- Pages
- 722-732
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2562525
- OpenAlex
- W2032232458
- Cited by
- 330
- References
- 58
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 11 · 2023: 21 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 21 · 2018: 23 · 2017: 15 · 2016: 18 · 2015: 13 · 2014: 24 · 2013: 27 · 2012: 15
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1780 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH068469, R01MH071679, R37MH071679)
- Fogarty International Center
- National Institute of Neurological Disorders and Stroke (R01NS032993, R01NS039007)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- TTF-1, temporal specifications, conditional knockout, neurogenesis, neuronal precursors, transcription factors, perinatal lethality, mouse brain development
- MeSH terms
- Thyroid Nuclear Factor 1, Age Factors, Animals, Animals, Newborn, beta-Galactosidase, Cell Differentiation, Cerebral Cortex, Electroencephalography, Embryo, Mammalian, Estrogen Antagonists, Female, Interneurons, Male, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Nuclear Proteins, Seizures, Stem Cells, Tamoxifen, Transcription Factors, Gene Expression Regulation, Developmental, Body Patterning, Green Fluorescent Proteins, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins
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