The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
Open accessAbstract
Identification of the signaling pathways that control the proliferation of stem cells (SCs), and whether they act in a cell or non-cell autonomous manner, is key to our understanding of tissue homeostasis and cancer. In the adult Drosophila midgut, the Jun N-Terminal Kinase (JNK) pathway is activated in damaged enterocyte cells (ECs) following injury. This leads to the production of Upd cytokines from ECs, which in turn activate the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway in Intestinal SCs (ISCs), stimulating their proliferation. In addition, the Hippo pathway has been recently implicated in the regulation of Upd production from the ECs. Here, we show that the Hippo pathway target, Yorkie (Yki), also plays a crucial and cell-autonomous role in ISCs. Activation of Yki in ISCs is sufficient to increase ISC proliferation, a process involving Yki target genes that promote division, survival and the Upd cytokines. We further show that prior to injury, Yki activity is constitutively repressed by the upstream Hippo pathway members Fat and Dachsous (Ds). These findings demonstrate a cell-autonomous role for the Hippo pathway in SCs, and have implications for understanding the role of this pathway in tumorigenesis and cancer stem cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
Huang, J., Wu, S., Barrera, J., Matthews, K., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,863
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,314
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
Evidence that stem cells reside in the adult Drosophila midgut epithelium
Micchelli, C. A., & Perrimon, N. (2006) · Nature · doi:10.1038/nature04371 · Cited by 1,131
Self-citationWu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,098
The adult Drosophila posterior midgut is maintained by pluripotent stem cells
Ohlstein, B., & Spradling, A. (2006) · Nature · doi:10.1038/nature04333 · Cited by 1,083
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.-T., Luk, J. M., Wigler, M., Hannon, G. J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.030 · Cited by 1,065
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,064
Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut
Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D. G., & Edgar, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.05.014 · Cited by 1,013
Zhou, D., Conrad, C., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 913
Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
Basler, K., & Struhl, G. (1994) · Nature · doi:10.1038/368208a0 · Cited by 833
Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804
Hamaratoglu, F., Willecke, M., Kango-Singh, M., Nolo, R., Hyun, E., Tao, C., Jafar-Nejad, H., & Halder, G. (2006) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767
Ohlstein, B., & Spradling, A. (2007) · Science · doi:10.1126/science.1136606 · Cited by 648
JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut
Biteau, B., Hochmuth, C. E., & Jasper, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.024 · Cited by 583
Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila
Amcheslavsky, A., Jiang, J., & Ip, Y. T. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.10.016 · Cited by 542
Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches
Song, X., Zhu, C.-H., Doan, C., & Xie, T. (2002) · Science · doi:10.1126/science.1069871 · Cited by 483
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
St John, M. A. R., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M. L., Brownstein, D. G., Parlow, A. F., McGrath, J., & Xu, T. (1999) · Nature Genetics · doi:10.1038/5965 · Cited by 439
Zeng, Q., & Hong, W. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.011 · Cited by 435
In vivo regulation of Yorkie phosphorylation and localization
Oh, H., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.015255 · Cited by 404
Saucedo, L. J., & Edgar, B. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2221 · Cited by 363
Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells
Lin, G., Xu, N., & Xi, R. (2008) · Nature · doi:10.1038/nature07329 · Cited by 343
The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size
Willecke, M., Hamaratoglu, F., Kango-Singh, M., Udan, R., Chen, C.-L., Tao, C., Zhang, X., & Halder, G. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.005 · Cited by 329
Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway
Bennett, F. C., & Harvey, K. F. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.045 · Cited by 314
Matakatsu, H., & Blair, S. S. (2004) · Development · doi:10.1242/dev.01254 · Cited by 301
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liver
Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 269
Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation
Staley, B. K., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.041 · Cited by 266
Morphogen Control of Wing Growth through the Fat Signaling Pathway
Rogulja, D., Rauskolb, C., & Irvine, K. D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.06.003 · Cited by 250
Beebe, K., Lee, W.-C., & Micchelli, C. A. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.045 · Cited by 227
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
Apidianakis, Y., Pitsouli, C., Perrimon, N., & Rahme, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911797106 · Cited by 220
Self-citationIn vivo analysis of Yorkie phosphorylation sites
Oh, H., & Irvine, K. D. (2009) · Oncogene · doi:10.1038/onc.2009.43 · Cited by 195
Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
Lee, W.-C., Beebe, K., Sudmeier, L., & Micchelli, C. A. (2009) · Development · doi:10.1242/dev.035196 · Cited by 181
Willecke, M., Hamaratoglu, F., Sansores-Garcia, L., Tao, C., & Halder, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805201105 · Cited by 166
Lin, G., Xu, N., & Xi, R. (2009) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjp028 · Cited by 147
Liu, W., Singh, S. R., & Hou, X. S. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22482 · Cited by 117
Cyclin D-Cdk4 and Cyclin E-Cdk2 Regulate the JAK/STAT Signal Transduction Pathway in Drosophila
Chen, X., Oh, S., Zheng, G. Z., Chen, H., Shin, H., & Hou, X. S. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00024-8 · Cited by 46
A Cellular View of Nf2 in Liver Homeostasis and Tumorigenesis
Breuhahn, K., & Schirmacher, P. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.015 · Cited by 5
Cited by
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206
The Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205
The Hippo Signaling Pathway in Development and Disease
Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Dey, A., Varelas, X., & Guan, K.-L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0070-z · Cited by 860
Metadata
- Authors
- Karpowicz, P., Perez, J., & Perrimon, N.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2010-12-15
- Volume
- 137
- Issue
- 24
- Pages
- 4135-4145
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2037598426
- Cited by
- 318
- References
- 41
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
