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Cited by 269

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Bmp activity establishes a gradient of positional information throughout the entire neural plate

Barth, K. Anukampa, Kishimoto, Yasuyuki, Rohr, Klaus B., Seydler, Catrin, Schulte-Merker, Stefan, Wilson, Stephen W.·1999·Development
DOI 10.1242/dev.126.22.4977
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Abstract

Bone morphogenetic proteins (Bmps) are key regulators of dorsoventral (DV) patterning. Within the ectoderm, Bmp activity has been shown to inhibit neural development, promote epidermal differentiation and influence the specification of dorsal neurons and neural crest. In this study, we examine the patterning of neural tissue in mutant zebrafish embryos with compromised Bmp signalling activity. We find that although Bmp activity does not influence anteroposterior (AP) patterning, it does affect DV patterning at all AP levels of the neural plate. Thus, we show that Bmp activity is required for specification of cell fates around the margin of the entire neural plate, including forebrain regions that do not form neural crest. Surprisingly, we find that Bmp activity is also required for patterning neurons at all DV levels of the CNS. In swirl/bmp2b− (swr−) embryos, laterally positioned sensory neurons are absent whereas more medial interneuron populations are hugely expanded. However, in somitabun− (sbn−) embryos, which probably retain higher residual Bmp activity, it is the sensory neurons and not the interneurons that are expanded. Conversely, in severely Bmp depleted embryos, both interneurons and sensory neurons are absent and it is the most medial neurons that are expanded. These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm.

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Metadata

Authors
Barth, K. A., Kishimoto, Y., Rohr, K. B., Seydler, C., Schulte-Merker, S., & Wilson, S. W.
Venue
Development
Publisher
The Company of Biologists
Published
1999-11-15
Volume
126
Issue
22
Pages
4977-4987
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.126.22.4977
OpenAlex
W1929503316
Cited by
269
References
60
FWCI
6.20
Type
journal article
Language
en
Open access
closed

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