Cited by 141Probiotics and Fermented FoodsAnimal Nutrition and PhysiologyGut microbiota and health

Bacteriocin production: A relatively unharnessed probiotic trait?

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Hegarty, James W., Guinane, Caitriona M., Ross, R. Paul, Hill, Colin, Cotter, Paul D.·2016·F1000Research

Abstract

Probiotics are "live microorganisms which, when consumed in adequate amounts, confer a health benefit to the host". A number of attributes are highly sought after among these microorganisms, including immunomodulation, epithelial barrier maintenance, competitive exclusion, production of short-chain fatty acids, and bile salt metabolism. Bacteriocin production is also generally regarded as a probiotic trait, but it can be argued that, in contrast to other traits, it is often considered a feature that is desirable, rather than a key probiotic trait. As such, the true potential of these antimicrobials has yet to be realised.

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Crossref · 10.12688/f1000research.9615.1

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  • Several in vitro and in vivo studies have shown that bacteriocins produced by LAB can exert a protective effect on the gastrointestinal tract by excluding pathogens and promoting colonization of the gut.

    “Several in vitro and in vivo studies have shown that bacteriocins produced by LAB can exert a protective effect on the gastrointestinal tract by excluding pathogens and promoting the colonization of the gut [245].”

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Research works printed but not linked: 1

  1. [69]O'Shea EF Gardiner GE O'Connor PM: Characterization of enterocin- and salivaricin-producing lactic acid bacteria from the mammalian gastrointestinal tract. FEMS Microbiol Lett. 2009; 291(1): 24– 34. 10.1111/j.1574-6968.2008.01427.x 19076236 · DOI

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Authors
Hegarty, J. W., Guinane, C. M., Ross, R. P., Hill, C., & Cotter, P. D.
Affiliations
  • Teagasc - The Irish Agriculture and Food Development Authority (IE)
  • University College Cork (IE)
Corresponding author
Cotter, Paul D.
Venue
F1000Research
Published
2016-10-27
Volume
5
Pages
2587
ISSN
2046-1402 (ISSN-L)
OpenAlex
W2543921200
Cited by
141
References
75
Citations by year
2026: 6 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 20 · 2021: 20 · 2020: 21 · 2019: 15 · 2018: 14 · 2017: 6
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • F1000Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
Funders
Science Foundation Ireland (11/P1/1137)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
bacteriocin production, probiotics, antimicrobial peptides, competitive exclusion, immunomodulation, bile salt metabolism, short-chain fatty acids

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