Bacteriocin production: A relatively unharnessed probiotic trait?
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Probiotics are "live microorganisms which, when consumed in adequate amounts, confer a health benefit to the host". A number of attributes are highly sought after among these microorganisms, including immunomodulation, epithelial barrier maintenance, competitive exclusion, production of short-chain fatty acids, and bile salt metabolism. Bacteriocin production is also generally regarded as a probiotic trait, but it can be argued that, in contrast to other traits, it is often considered a feature that is desirable, rather than a key probiotic trait. As such, the true potential of these antimicrobials has yet to be realised.
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Several in vitro and in vivo studies have shown that bacteriocins produced by LAB can exert a protective effect on the gastrointestinal tract by excluding pathogens and promoting colonization of the gut.
“Several in vitro and in vivo studies have shown that bacteriocins produced by LAB can exert a protective effect on the gastrointestinal tract by excluding pathogens and promoting the colonization of the gut [245].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [245]
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- Authors
- Hegarty, J. W., Guinane, C. M., Ross, R. P., Hill, C., & Cotter, P. D.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Corresponding author
- Cotter, Paul D.
- Venue
- F1000Research
- Publisher
- F1000 Research Ltd
- Published
- 2016-10-27
- Volume
- 5
- Pages
- 2587
- ISSN
- 2046-1402 (ISSN-L)
- PMC
- PMC5089130
- OpenAlex
- W2543921200
- Cited by
- 141
- References
- 75
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 18 · 2022: 20 · 2021: 20 · 2020: 21 · 2019: 15 · 2018: 14 · 2017: 6
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- F1000Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Funders
- Science Foundation Ireland (11/P1/1137)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- bacteriocin production, probiotics, antimicrobial peptides, competitive exclusion, immunomodulation, bile salt metabolism, short-chain fatty acids
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