The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
Open accessAbstract
Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKbeta/NF-kappaB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked the beneficial effects of exercise on the re-balance of food intake and insulin and leptin resistance. This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10, a core inhibitor of IKKbeta/NF-kappaB signaling and ER stress. We report that exercise and recombinant IL-6 requires IL-10 expression to suppress hyperphagia-related obesity. Moreover, in contrast to control mice, exercise failed to reverse the pharmacological activation of IKKbeta and ER stress in C3H/HeJ mice deficient in hypothalamic IL-6 and IL-10 signaling. Hence, inflammatory signaling in the hypothalamus links beneficial physiological effects of exercise to the central action of insulin and leptin.
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BackgroundThe anti-inflammatory effect of exercise
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“. Since the discovery of interleukin (IL)-6 releases from contracting skeletal muscle, accumulating evidence indicates that exercise induces metabolic changes in other organs, such as the liver, the adipose tissue, and hypothalamus, in an IL-6 dependent manner. IL-6 is most often classified as a pro-inflammatory cytok…”
BackgroundInterleukin-6-deficient mice develop mature-onset obesity
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Self-citationHypothalamic inflammation and obesity: a mechanistic review
Seong, J., Kang, J. Y., Sun, J. S., & Kim, K. W. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01138-9 · Cited by 158
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Metadata
- Authors
- Ropelle, E. R., Flores, M. B., Cintra, D. E., Rocha, G. Z., Pauli, J. R., Morari, J., de Souza, C. T., Moraes, J. C., Prada, P. O., Guadagnini, D., Marin, R. M., Oliveira, A. G., Augusto, T. M., Carvalho, H. F., Velloso, L. A., Saad, M. J. A., & Carvalheira, J. B. C.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-24
- Volume
- 8
- Issue
- 8
- Pages
- e1000465
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2030818171
- Cited by
- 326
- References
- 8
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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