The microbiome of uncontacted Amerindians
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Fecal, oral, and skin biomes of isolated Amerindians show higher human bacterial diversity including antibiotic resistance genes.
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Comparison studies of non-Western and Western populations show significant differences in the relative abundances of common phyla and a much greater species diversity in non-Western populations.
“Although no living population today carries an ancestral microbiome, comparison studies of non-Western and Western populations show significant differences in the relative abundances of common phyla and a much greater species diversity in non-Western populations [126,127].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [127]
The Results (page not provided) report significantly greater fecal and skin diversity in Yanomami than in U.S. subjects, but not greater oral diversity; they do not establish greater diversity for all non-Western populations. The 16S rRNA analysis (page not provided) attributes the major Western–non-Western compositional differences to relative-abundance changes in Bacteroides and Prevotella within the Bacteroidetes phylum, rather than to differences in the relative abundances of common phyla. (LLM, conf=0.88)
Experimental — accuracy not yet measuredGut microbiota of eight hunter-gatherer or rural farming populations has greater bacterial diversity than Western populations.
“The gut microbiota of eight hunter–gatherer or rural farming populations in various parts of the world showed increased bacterial diversity compared with those of Western populations19,40,52–55.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [55]
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- Authors
- Clemente, J. C., Pehrsson, E. C., Blaser, M. J., Sandhu, K., Gao, Z., Wang, B., Magris, M., Hidalgo, G., Contreras, M., Noya-Alarcón, Ó., Lander, O., McDonald, J., Cox, M., Walter, J., Oh, P. L., Ruiz, J. F., Rodriguez, S., Shen, N., Song, S. J., Metcalf, J., Knight, R., Dantas, G., & Dominguez-Bello, M. G.
- Affiliations
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- Washington University in St. Louis (US)
- United States Department of Veterans Affairs (US)
- New York University (US)
- Amazonic Center for Research and Control of Tropical Diseases (CAICET), Puerto Ayacucho 7101, Venezuela.
- Venezuelan Institute for Scientific Research, Caracas 1020-A, Venezuela.
- Universidad Central de Venezuela (VE)
- AnMed Health (US)
- University of Nebraska–Lincoln (US)
- University of Puerto Rico at Río Piedras (PR)
- Icahn School of Medicine at Mount Sinai (US)
- University of Colorado Boulder (US)
- Howard Hughes Medical Institute (US)
- New York University School of Medicine, New York, NY 10016, USA.
- Corresponding author
- Pehrsson, Erica C.
- Sandhu, Kuldip
- Walter, Jens
- Knight, Rob
- ORCID
- Venue
- Science Advances
- Published
- 2015-04-03
- Volume
- 1
- Issue
- 3
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC4517851
- OpenAlex
- W1986189475
- Cited by
- 851
- References
- 74
- Citations by year
- 2026: 35 · 2025: 55 · 2024: 59 · 2023: 72 · 2022: 81 · 2021: 88 · 2020: 90 · 2019: 103 · 2018: 77 · 2017: 72 · 2016: 86 · 2015: 31
- FWCI
- 38.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Lincoln (University of Nebraska) (submittedVersion, cc-by-nc)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Funders
- C&D Research Fund (ID0EWFBG929)
- Emch Research Fund (ID0EBMBG930)
- NIH SCORE-PES RISE (ID0EMSBG931, 2R25GM061151-13)
- SUCCESS (ID0EZYBG932)
- Leona M. and Harry B. Helmsley Charitable Trust (ID0ET1BG933)
- NIH NIDDK (ID0EN3BG934, DK062429)
- NAKFI Synthetic Biology (ID0EJ5BG935, SB2, ID0ECAAI936)
- NIH Director’s New Innovator Award (ID0EYBAI937, NIDDK DP2-DK098089)
- NIH NIGMS (ID0EQDAI938, R01-GM099538)
- Washington University I-CARES (ID0EIFAI939)
- NIH NIAMS (ID0E5GAI940, UH2AR057506)
- Diane Belfer Program for Human Microbial Ecology (ID0EYIAI941)
- NDSEG (ID0EQKAI942)
- Howard Hughes Medical Institute (ID0EEMAI943)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- human microbiome, resistome, antibiotic resistance genes, Yanomami, isolated populations, Westernization, bacterial diversity, synthetic antibiotics, gut microbiota, oral microbiota, skin microbiome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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