Cited by 862Gut microbiota and healthAntibiotic Resistance in BacteriaMicrobial Community Ecology and Physiology

The microbiome of uncontacted Amerindians

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Clemente, Jose C., Pehrsson, Erica C., Blaser, Martin J., Sandhu, Kuldip, Gao, Zhan, Wang, Bin, Magris, Magda, Hidalgo, Glida +15 more·2015·Science Advances

Abstract

Fecal, oral, and skin biomes of isolated Amerindians show higher human bacterial diversity including antibiotic resistance genes.

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Crossref · 10.1126/sciadv.1500183

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  • Comparison studies of non-Western and Western populations show significant differences in the relative abundances of common phyla and a much greater species diversity in non-Western populations.

    “Although no living population today carries an ancestral microbiome, comparison studies of non-Western and Western populations show significant differences in the relative abundances of common phyla and a much greater species diversity in non-Western populations [126,127].”

    From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [127]

    The Results (page not provided) report significantly greater fecal and skin diversity in Yanomami than in U.S. subjects, but not greater oral diversity; they do not establish greater diversity for all non-Western populations. The 16S rRNA analysis (page not provided) attributes the major Western–non-Western compositional differences to relative-abundance changes in Bacteroides and Prevotella within the Bacteroidetes phylum, rather than to differences in the relative abundances of common phyla. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Gut microbiota of eight hunter-gatherer or rural farming populations has greater bacterial diversity than Western populations.

    “The gut microbiota of eight hunter–gatherer or rural farming populations in various parts of the world showed increased bacterial diversity compared with those of Western populations19,40,52–55.”

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Authors
Clemente, J. C., Pehrsson, E. C., Blaser, M. J., Sandhu, K., Gao, Z., Wang, B., Magris, M., Hidalgo, G., Contreras, M., Noya-Alarcón, Ó., Lander, O., McDonald, J., Cox, M., Walter, J., Oh, P. L., Ruiz, J. F., Rodriguez, S., Shen, N., Song, S. J., Metcalf, J., Knight, R., Dantas, G., & Dominguez-Bello, M. G.
Affiliations
  • Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Washington University in St. Louis (US)
  • United States Department of Veterans Affairs (US)
  • New York University (US)
  • Amazonic Center for Research and Control of Tropical Diseases (CAICET), Puerto Ayacucho 7101, Venezuela.
  • Venezuelan Institute for Scientific Research, Caracas 1020-A, Venezuela.
  • Universidad Central de Venezuela (VE)
  • AnMed Health (US)
  • University of Nebraska–Lincoln (US)
  • University of Puerto Rico at Río Piedras (PR)
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Colorado Boulder (US)
  • Howard Hughes Medical Institute (US)
  • New York University School of Medicine, New York, NY 10016, USA.
Corresponding author
  • Pehrsson, Erica C.
  • Sandhu, Kuldip
  • Walter, Jens
  • Knight, Rob
Venue
Science Advances
Published
2015-04-03
Volume
1
Issue
3
ISSN
2375-2548 (ISSN-L)
OpenAlex
W1986189475
Cited by
851
References
74
Citations by year
2026: 35 · 2025: 55 · 2024: 59 · 2023: 72 · 2022: 81 · 2021: 88 · 2020: 90 · 2019: 103 · 2018: 77 · 2017: 72 · 2016: 86 · 2015: 31
FWCI
38.52
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
  • Lincoln (University of Nebraska) (submittedVersion, cc-by-nc)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
Funders
  • C&D Research Fund (ID0EWFBG929)
  • Emch Research Fund (ID0EBMBG930)
  • NIH SCORE-PES RISE (ID0EMSBG931, 2R25GM061151-13)
  • SUCCESS (ID0EZYBG932)
  • Leona M. and Harry B. Helmsley Charitable Trust (ID0ET1BG933)
  • NIH NIDDK (ID0EN3BG934, DK062429)
  • NAKFI Synthetic Biology (ID0EJ5BG935, SB2, ID0ECAAI936)
  • NIH Director’s New Innovator Award (ID0EYBAI937, NIDDK DP2-DK098089)
  • NIH NIGMS (ID0EQDAI938, R01-GM099538)
  • Washington University I-CARES (ID0EIFAI939)
  • NIH NIAMS (ID0E5GAI940, UH2AR057506)
  • Diane Belfer Program for Human Microbial Ecology (ID0EYIAI941)
  • NDSEG (ID0EQKAI942)
  • Howard Hughes Medical Institute (ID0EEMAI943)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
human microbiome, resistome, antibiotic resistance genes, Yanomami, isolated populations, Westernization, bacterial diversity, synthetic antibiotics, gut microbiota, oral microbiota, skin microbiome

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