Neural Basis of Self and Other Representation in Autism: An fMRI Study of Self-Face Recognition
Open accessAbstract
BACKGROUND: Autism is a developmental disorder characterized by decreased interest and engagement in social interactions and by enhanced self-focus. While previous theoretical approaches to understanding autism have emphasized social impairments and altered interpersonal interactions, there is a recent shift towards understanding the nature of the representation of the self in individuals with autism spectrum disorders (ASD). Still, the neural mechanisms subserving self-representations in ASD are relatively unexplored. METHODOLOGY/PRINCIPAL FINDINGS: We used event-related fMRI to investigate brain responsiveness to images of the subjects' own face and to faces of others. Children with ASD and typically developing (TD) children viewed randomly presented digital morphs between their own face and a gender-matched other face, and made "self/other" judgments. Both groups of children activated a right premotor/prefrontal system when identifying images containing a greater percentage of the self face. However, while TD children showed activation of this system during both self- and other-processing, children with ASD only recruited this system while viewing images containing mostly their own face. CONCLUSIONS/SIGNIFICANCE: This functional dissociation between the representation of self versus others points to a potential neural substrate for the characteristic self-focus and decreased social understanding exhibited by these individuals, and suggests that individuals with ASD lack the shared neural representations for self and others that TD children and adults possess and may use to understand others.
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Individuals with ASD often show difficulty in evaluating social cues and in appropriately interpreting another person's experiences or emotions, and may display a preoccupation with self or limited interest in others.
“Individuals with ASD often show difficulty in evaluating social cues and in appropriately interpreting another person’s experiences or emotions, and may display a preoccupation with self or limited interest in others 14–19.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [18]
Individuals with ASD are often described as having inability to organize social information or appropriately interpret the state and experience of others.
“Individuals with ASD are often described as having inability to organize social information or appropriately interpret the state and experience of others 14–19.”
From Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time (2021) · cites this paper as [18]
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- Authors
- Uddin, L. Q., Davies, M. S., Scott, A. A., Zaidel, E., Bookheimer, S. Y., Iacoboni, M., & Dapretto, M.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Uddin, Lucina Q.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-10-29
- Volume
- 3
- Issue
- 10
- Pages
- e3526
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2568959
- OpenAlex
- W2005551003
- Cited by
- 118
- References
- 66
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 7 · 2012: 7
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Brain Mapping Support Foundation
- National Institutes of Health (RR13642)
- National Center for Research Resources (P41RR013642, RR12169, RR 13642, RR00865, M01RR000865, C06RR012169)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035470)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Keywords
- autism spectrum disorder, self-face recognition, self and other representations, face perception, self-focus, social cognition, children with autism
- MeSH terms
- Adolescent, Autistic Disorder, Behavior, Brain Mapping, Child, Face, Facial Expression, Humans, Magnetic Resonance Imaging, Male, Mental Processes, Pattern Recognition, Visual, Photic Stimulation, Self Concept, Social Perception
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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