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Novel Markers to Delineate Murine M1 and M2 Macrophages
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Further gene expression comparisons to MODEL-AD and DAM datasets showed significant shifts in microglial phenotypes.
“Further gene expression comparisons to MODEL-AD and DAM datasets showed significant shifts in microglial phenotypes [8, 15].”
From Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model (2025) · cites this paper as [15]
The Methods (§2.5) describe gene-expression profiling of mouse bone marrow-derived macrophages under M0, M1 and M2 conditions, and Results (§3.1) compare those conditions. Searches for MODEL-AD, DAM and disease-associated microglial datasets found no passage reporting the claimed dataset comparisons or shifts in microglial phenotypes. Page numbers are unavailable in our copy. (LLM, conf=0.76)
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“Indeed, M1 macrophages have been implicated in the pathogenesis of several inflammatory conditions including atherosclerosis, diabetes and glomerulonephritis [4,14].”
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“Indeed, M1 macrophages have been implicated in the pathogenesis of several inflammatory conditions including atherosclerosis, diabetes and glomerulonephritis [4,14].”
BackgroundResultTrophic macrophages in development and disease
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“Arginase-1 is up-regulated not only in the expected M2 macrophages but also in M1 spectrum macrophages [30,31].”
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Metadata
- Authors
- Jablonski, K. A., Amici, S. A., Webb, L. M., Ruiz-Rosado, J. D. D., Popovich, P. G., Partida-Sanchez, S., & Guerau-de-Arellano, M.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-12-23
- Volume
- 10
- Issue
- 12
- Pages
- e0145342
- ISSN
- 1932-6203
- PMC
- PMC4689374
- Cited by
- 978
- References
- 12
- Language
- en
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