Effects of MDMA-assisted therapy for PTSD on self-experience
Open accessAbstract
INTRODUCTION: There is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical trial of participants with severe PTSD (NCT03537014) showed that MDMA-assisted therapy induced significant attenuation in the Clinician-Administered PTSD Scale for DSM-5 compared to Therapy with placebo. Deficits in emotional coping skills and altered self-capacities constitute major obstacles to successful completion of available treatments. The current analysis evaluated the differential effects of MDMA-assisted therapy and Therapy with placebo on 3 transdiagnostic outcome measures and explored the contribution of changes in self-experience to improvement in PTSD scores. METHODS: Participants were randomized to receive manualized therapy with either MDMA or placebo during 3 experimental sessions in combination with 3 preparation and 9 integration therapy visits. Symptoms were measured at baseline and 2 months after the last experimental session using the 20-item Toronto Alexithymia Scale (TAS-20), the 26-item Self Compassion Scale (SCS), and the 63-item Inventory of Altered Self-Capacities (IASC). RESULTS: 90 participants were randomized and dosed (MDMA-assisted therapy, n = 46; Therapy with placebo, n = 44); 84.4% (76/90) had histories of developmental trauma, and 87.8% (79/90) had suffered multiple traumas. MDMA-assisted therapy facilitated statistically significant greater improvement on the TAS-20, the SCS, and most IASC factors of interpersonal conflicts; idealization disillusionment; abandonment concerns; identity impairment; self-awareness; susceptibility to influence; affect dysregulation; affect instability; affect skill deficit; tension reduction activities; the only exception was identity diffusion. CONCLUSION: Compared with Therapy with placebo, MDMA-assisted therapy had significant positive effects on transdiagnostic mental processes of self-experience which are often associated with poor treatment outcome. This provides a possible window into understanding the psychological capacities facilitated by psychedelic agents that may result in significant improvements in PTSD symptomatology.
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MDMA enhances metacognitive capacity, promoting self-other differentiation and deeper emotional processing, crucial in working with narcissistic pathology.
“Additionally, MDMA has demonstrated it enhances metacognitive capacity, promoting self-other differentiation and deeper emotional processing, both of which are crucial in working with narcissistic pathology (137).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [137]
The Discussion reports that MDMA-assisted therapy improved emotional self-awareness and helped participants with PTSD access painful experiences, supporting the emotional-processing part of the claim. The paper does not demonstrate enhanced metacognitive capacity or self–other differentiation. It mentions an association between low self-compassion and narcissism, but does not study treatment of narcissistic pathology. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMDMA-AT improves emotional regulation and strengthens self-experience, particularly in individuals with impaired self-coherence, such as those with PN.
“MDMA-AT has also been shown to improve emotional regulation and strengthen self-experience, particularly in individuals with impaired self-coherence, such as those with PN (137).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [137]
The Results (Treatment effects on self-experience measures; page not provided) report greater improvements in measures of emotion regulation and self-experience with MDMA-assisted therapy than with therapy and placebo in participants with PTSD. The Discussion suggests benefits may be particularly relevant to people with clinically significant impairments in these areas, but the paper does not establish the effect in people with PN or show that they benefit particularly. (LLM, conf=0.89)
Experimental — accuracy not yet measuredMDMA facilitates emotional disclosure and increases comfort in discussing personal feelings.
“MDMA also facilitates emotional disclosure and increases comfort in discussing personal feelings (136, 137), which could be particularly important for narcissists with alexithymia, who struggle to identify and express their emotions.”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [137]
The Methods (Self-experience measures) describe the alexithymia scale as measuring difficulty verbalizing emotions, and the Results (Treatment effects on self-experience measures) report greater improvement with MDMA-assisted therapy than with therapy plus placebo. This supports a link to expressing feelings, but the paper does not directly report greater comfort discussing personal feelings or measure emotional disclosure during sessions; the Discussion notes that sessions often occurred in relative silence. (LLM, conf=0.82)
Experimental — accuracy not yet measured
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1 retracted
Jerome, L., Feduccia, A. A., Wang, J. B., Hamilton, S., Yazar-Klosinski, B., Emerson, A., Mithoefer, M. C., & Doblin, R. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05548-2 · Cited by 159 · cited 1× · see citing works
“A pooled analysis of six Phase 2 trials showed that 54% of patients assigned to the MDMA-assisted therapy group no longer met criteria for PTSD after 2 experimental sessions [3].”
MethodRetractedFelitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943 · cited 1× · see citing works
“…status, detailed trauma history, pre-study treatment, and base-line outcomes measures for the Adverse Childhood Experience Questionnaire (ACE) [37], Beck Depression Inventory II (BDI-II) [38], CAPS-5 total severity score [36], and lifetime suicidality assessment from the Columbia Suicide…”
MethodChild abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works
The Development and Validation of a Scale to Measure Self-Compassion
NEFF, K. D. (2003) · Self and Identity · doi:10.1080/15298860309027 · Cited by 6,436 · cited 1× · see citing works
“…(i) TAS-20 baseline measure of having no alexithymia ( � 50) and alexithymia ( > 51) [47]; (ii) SCS baseline measure of low (1–2.4) and moderate (2.5–3.4) or high (3.5–5.0) self-compassion [48]; (iii) and for each IASC factor base-line scores for each factor above and below the sample median.”
BackgroundInfluentialThe twenty-item Toronto Alexithymia scale—II. Convergent, discriminant, and concurrent validity
Bagby, R. M., Taylor, G. J., & Parker, J. D. A. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90006-x · Cited by 2,431 · cited 1× · see citing works
“…scores stratified by baseline cutoff scores; specifically: (i) TAS-20 baseline measure of having no alexithymia ( � 50) and alexithymia ( > 51) [47]; (ii) SCS baseline measure of low (1–2.4) and moderate (2.5–3.4) or high (3.5–5.0) self-compassion [48]; (iii) and for each IASC factor base-line…”
MethodInfluentialA Multidimensional Meta-Analysis of Psychotherapy for PTSD
Bradley, R., Greene, J., Russ, E., Dutra, L., & Westen, D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.214 · Cited by 1,938 · cited 1× · see citing works
“Trauma-focused psychotherapy is considered a first line treatment for PTSD [5, 6].”
BackgroundExploring compassion: A meta-analysis of the association between self-compassion and psychopathology
MacBeth, A., & Gumley, A. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.06.003 · Cited by 1,838 · see citing works
Weathers, F. W., Bovin, M. J., Lee, D. J., Sloan, D. M., Schnurr, P. P., Kaloupek, D. G., Keane, T. M., & Marx, B. P. (2018) · Psychological Assessment · doi:10.1037/pas0000486 · Cited by 1,799 · see citing works
Posttraumatic stress disorder in the world mental health surveys
Koenen, K. C., Ratanatharathorn, A., Ng, L., McLaughlin, K. A., Bromet, E. J., Stein, D. J., Karam, E. G., Meron Ruscio, A., Benjet, C., Scott, K., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717000708 · Cited by 1,453 · see citing works
Roberts, A. L., Gilman, S. E., Breslau, J., Breslau, N., & Koenen, K. C. (2010) · Psychological Medicine · doi:10.1017/s0033291710000401 · Cited by 1,083 · see citing works
Posner, K., Oquendo, M. A., Gould, M., Stanley, B., & Davies, M. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.1035 · Cited by 1,025 · see citing works
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
Mitchell, J. M., Bogenschutz, M., Lilienstein, A., Harrison, C., Kleiman, S., Parker-Guilbert, K., Ot’alora G., M., Garas, W., Paleos, C., Gorman, I., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01336-3 · Cited by 1,004 · cited 4× · see citing works
“Detailed sample characteristics of the mITT analysis set of n = 90 participants have been described in the primary outcome paper [4].”
BackgroundMethodInfluentialSelf-compassion: Theory, method, research, and intervention
Neff, K. D. (2023) · Annual Review of Psychology · doi:10.1146/annurev-psych-032420-031047 · Cited by 931 · cited 1× · see citing works
“A total score of 1–2.4 indicates “low,” 2.5–3.4 “moderate,” and 3.5–5.0 “high” SCS [45].”
InfluentialCampbell-Sills, L., Barlow, D. H., Brown, T. A., & Hofmann, S. G. (2006) · Behaviour Research and Therapy · doi:10.1016/j.brat.2005.10.001 · Cited by 845 · cited 1× · see citing works
“Emotion regulation deficits are major contributors to the development of a large variety of psychopathological conditions [66], including interference with being able to resolve the impact of traumatizing experience(s) [67–70].”
BackgroundThe Self-Compassion Scale is a Valid and Theoretically Coherent Measure of Self-Compassion
Neff, K. D. (2016) · Mindfulness · doi:10.1007/s12671-015-0479-3 · Cited by 805 · see citing works
Ehring, T., & Quack, D. (2010) · Behavior Therapy · doi:10.1016/j.beth.2010.04.004 · Cited by 668 · see citing works
Executive function and PTSD: disengaging from trauma.
Aupperle, R. L., Melrose, A. J., Stein, M. B., & Paulus, M. P. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.008 · Cited by 657 · cited 1× · see citing works
“Multiple studies have shown that reduced self-capacities interfere with successful completion of psychotherapy for PTSD [19, 20].”
BackgroundPredicting PTSD symptoms in victims of violent crime: The role of shame, anger, and childhood abuse.
Andrews, B., Brewin, C. R., Rose, S., & Kirk, M. (2000) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.109.1.69 · Cited by 615 · cited 4× · see citing works
“In non-PTSD studies MDMA has been shown to promote a general sense of interpersonal “connectedness” [49] “openness” [50, 51], and to enhance positive appraisal of favorable memories, while reducing negative evaluations of painful memories [51].”
BackgroundInfluentialThe long-term costs of traumatic stress: intertwined physical and psychological consequences
McFARLANE, A. C. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00254.x · Cited by 608 · cited 1× · see citing works
“Even patients who are considered responders often remain challenged by difficulties in emotion regulation, impulse con-trol and interpersonal functioning [10–12], all of which seem to continue relatively independent from PTSD symptomatology [13, 14].”
BackgroundInfluence of emotional engagement and habituation on exposure therapy for PTSD.
Jaycox, L. H., Foa, E. B., & Morral, A. R. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.66.1.185 · Cited by 507 · see citing works
Influence of emotional engagement and habituation on exposure therapy for PTSD
Jaycox, L. H., Foa, E. B., & Morral, A. R. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.1.185 · Cited by 507 · see citing works
Oehen, P., Traber, R., Widmer, V., & Schnyder, U. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112464827 · Cited by 402 · see citing works
MDMA enhances emotional empathy and prosocial behavior
Hysek, C. M., Schmid, Y., Simmler, L. D., Domes, G., Heinrichs, M., Eisenegger, C., Preller, K. H., Quednow, B. B., & Liechti, M. E. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst161 · Cited by 356 · see citing works
Self-compassion as an emotion regulation strategy in major depressive disorder
Diedrich, A., Grant, M., Hofmann, S. G., Hiller, W., & Berking, M. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.05.006 · Cited by 352 · see citing works
Twenty-five years with the 20-item Toronto Alexithymia Scale
Bagby, R. M., Parker, J. D. A., & Taylor, G. J. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.109940 · Cited by 334 · cited 2× · see citing works
“Alexithymia, deficits in being able to identify and describe emotions, is associated with posttraumatic pathology [22–24], and with a lack of habituation to emotionally distressing stimuli [25].”
BackgroundTull, M. T., Gratz, K. L., Salters, K., & Roemer, L. (2004) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000144694.30121.89 · Cited by 298 · cited 2× · see citing works
“Low self-compassion scores are associated with anxiety, depression, narcissism, self-criticism, and with poor treatment responses [30].”
BackgroundEhlers, A., Maercker, A., & Boos, A. (2000) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.109.1.45 · Cited by 274 · see citing works
Meta‐analysis of alexithymia in posttraumatic stress disorder
Frewen, P., Dozois, D. J. A., Neufeld, R. W. J., & Lanius, R. A. (2008) · Journal of Traumatic Stress · doi:10.1002/jts.20320 · Cited by 264 · see citing works
Psychedelics and connectedness
Carhart-Harris, R. L., Erritzøe, D., Haijen, E. C. H. M., Kaelen, M., & Watts, R. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4701-y · Cited by 262 · cited 1× · see citing works
“In non-PTSD studies MDMA has been shown to promote a general sense of interpersonal “connectedness” [49] “openness” [50, 51], and to enhance positive appraisal of favorable memories, while reducing negative evaluations of painful memories [51].”
BackgroundBedi, G., Hyman, D., & de Wit, H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.003 · Cited by 247 · cited 1× · see citing works
“It also has been shown to enhance extinction of fearful memories, modulate memory reconsolidation (possibly through an oxytocin-dependent mechanism), and to promote social behavior [52].”
BackgroundBardeen, J. R., Kumpula, M. J., & Orcutt, H. K. (2013) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2013.01.003 · Cited by 209 · see citing works
Schnurr, P. P., Chard, K. M., Ruzek, J. I., Chow, B. K., Resick, P. A., Foa, E. B., Marx, B. P., Friedman, M. J., Bovin, M. J., Caudle, K., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.36921 · Cited by 195 · see citing works
First-line Psychotherapies for Military-Related PTSD
Steenkamp, M. M., Litz, B. T., & Marmar, C. R. (2020) · JAMA · doi:10.1001/jama.2019.20825 · Cited by 194 · cited 1× · see citing works
“Trauma-focused psychotherapy is considered a first line treatment for PTSD [5, 6].”
BackgroundMust Psilocybin Always “Assist Psychotherapy”?
Goodwin, G. M., Malievskaia, E., Fonzo, G. A., & Nemeroff, C. B. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20221043 · Cited by 191 · see citing works
Spinazzola, J., van der Kolk, B., & Ford, J. D. (2018) · Journal of Traumatic Stress · doi:10.1002/jts.22320 · Cited by 187 · cited 1× · see citing works
“All of these have been shown to correlate with poor treatment outcome [17, 18].”
BackgroundZeller, M., Yuval, K., Nitzan-Assayag, Y., & Bernstein, A. (2015) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-014-9937-y · Cited by 185 · see citing works
Attentional biases in PTSD: more evidence for interference
Pineles, S. L., Shipherd, J. C., Mostoufi, S. M., Abramovitz, S. M., & Yovel, I. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.08.001 · Cited by 179 · cited 1× · see citing works
“Difficulty with emotion regulation interfere with being able to disengage from trauma-related stimuli, which increases the probability of drop out due to an inability to manage distress arising during treatment [21].”
BackgroundPekár, S., & Brabec, M. (2018) · Ethology · doi:10.1111/eth.12713 · Cited by 178 · see citing works
A Randomized Controlled Study of Neurofeedback for Chronic PTSD
van der Kolk, B. A., Hodgdon, H., Gapen, M., Musicaro, R. M., Suvak, M. K., Hamlin, E., & Spinazzola, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166752 · Cited by 174 · see citing works
Wolfson, P. E., Andries, J., Feduccia, A. A., Jerome, L., Wang, J. B., Williams, E., Carlin, S. C., Sola, E., Hamilton, S., Yazar-Klosinski, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-75706-1 · Cited by 169 · see citing works
PTSD, emotion dysregulation, and dissociative symptoms in a highly traumatized sample
Powers, A. D., Cross, D., Fani, N., & Bradley, B. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.12.011 · Cited by 168 · see citing works
Diedrich, A., Hofmann, S. G., Cuijpers, P., & Berking, M. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.04.003 · Cited by 164 · cited 1× · see citing works
“Self-compassion has been shown to boost the efficacy of cognitive reappraisals [74]: Being caring and kind to oneself, rather than critical, even under stress, can mitigate the negative effects of trauma exposure by increasing resilience and by decreasing avoidance-oriented coping [75, 76].”
BackgroundBriere, J., & Rickards, S. (2007) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0b013e31803044e2 · Cited by 163 · cited 2× · see citing works
“…trust and self-worth, being unable to notice internal states (alexithymia), lack of a coherent sense of self, inability to modulate or tolerate distress, difficulties negotiating interpersonal conflicts and negative self-appraisals, such as shame, self-blame and low self-compassion [15, 16].”
BackgroundMethodMDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions
Hysek, C. M., Domes, G., & Liechti, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2645-9 · Cited by 144 · cited 1× · see citing works
“…have been shown to improve treatment results for a variety of psychological interventions [33, 34], which invites an exploration of the potential for MDMA in the treatment of PTSD. MDMA may differentially alter emotion recognition, depending on the emotional valence of the stimuli [35].”
BackgroundPsychological therapies for children and adolescents exposed to trauma
Gillies, D., Maiocchi, L., Bhandari, A. P., Taylor, F., Gray, C., & O'Brien, L. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012371 · Cited by 143 · cited 1× · see citing works
“…subgroup levels (TAS-20, SCS, or IASC factor), baseline CAPS-5 dissociative subtype, and CAPS-5 change scores 4 Variance: η 2 = semi-partial eta squared Baseline TAS-20 1 child maltreatment are associated with poorer responses to psychotherapy in individuals diagnosed with PTSD [50, 54].”
BackgroundPsychobiological Effects of Sexual Abuse
PUTNAM, F. W., & Trickett, P. K. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48276.x · Cited by 137 · see citing works
Russotti, J. M., Warmingham, J. M., Duprey, E. B., Handley, E. D., Manly, J. T., Rogosch, F. A., & Cicchetti, D. (2021) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2021.105215 · Cited by 136 · cited 1× · see citing works
“Abuse at the hands of one’s early caregivers has been shown to put individuals at risk for deficits in emotional coping skills /altered self-capacities, major obstacles to successful completion of currently available evidence-based treatments [50, 55].”
BackgroundThe role of early emotional neglect in alexithymia
Aust, S., Härtwig, E. A., Heuser, I., & Bajbouj, M. (2013) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/a0027314 · Cited by 134 · see citing works
Schmid, M., Petermann, F., & Fegert, J. M. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-3 · Cited by 124 · see citing works
The Inventory of Altered Self-Capacities (IASC)
Briere, J., & Runtz, M. (2002) · Assessment · doi:10.1177/1073191102009003002 · Cited by 121 · cited 1× · see citing works
“The IASC consists of 11 factors and sub-factors: Items for sub-factors are summed to calculate factor raw scores that range from 9 to 45 [42].”
BackgroundLinks between specific posttrauma appraisals and three forms of trauma-related distress.
DePrince, A. P., Chu, A. T., & Pineda, A. S. (2011) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/a0021576 · Cited by 116 · cited 1× · see citing works
“Multiple studies have shown that reduced self-capacities interfere with successful completion of psychotherapy for PTSD [19, 20].”
BackgroundHiraoka, R., Meyer, E. C., Kimbrel, N. A., DeBeer, B. B., Gulliver, S. B., & Morissette, S. B. (2015) · Journal of Traumatic Stress · doi:10.1002/jts.21995 · Cited by 111 · cited 1× · see citing works
“Self-compassion has been shown to boost the efficacy of cognitive reappraisals [74]: Being caring and kind to oneself, rather than critical, even under stress, can mitigate the negative effects of trauma exposure by increasing resilience and by decreasing avoidance-oriented coping [75, 76].”
BackgroundA Systematic Review of Cognitive Predictors of Treatment Outcome in Major Depression
Groves, S. J., Douglas, K. M., & Porter, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00382 · Cited by 111 · see citing works
Carhart-Harris, R. L., Wall, M. B., Erritzoe, D., Kaelen, M., Ferguson, B., De Meer, I., Tanner, M., Bloomfield, M., Williams, T. M., Bolstridge, M., et al. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001405 · Cited by 108 · cited 1× · see citing works
“In non-PTSD studies MDMA has been shown to promote a general sense of interpersonal “connectedness” [49] “openness” [50, 51], and to enhance positive appraisal of favorable memories, while reducing negative evaluations of painful memories [51].”
BackgroundJátiva, R., & Cerezo, M. Á. (2014) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2014.04.005 · Cited by 107 · cited 2× · see citing works
“Finally, self-compassion is a core component of overall mental health and well-being [27], often lacking in trauma survivors with PTSD who frequently experience self-loathing and self-blame [28, 29].”
BackgroundTrauma-related reactivity and regulation of emotion: Associations with posttraumatic stress symptoms
Badour, C. L., & Feldner, M. T. (2012) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2012.07.007 · Cited by 97 · cited 1× · see citing works
“…ER difficulties comprise a transdiagnostic risk factor for mental health problems in general, including the development and/or maintenance of symptoms of PTSD [71], by interfering with being able to disengage from trauma-related stimuli and inhibiting maladaptive emotion regulation strategies [72].”
BackgroundKrieger, T., Reber, F., von Glutz, B., Urech, A., Moser, C. T., Schulz, A., & Berger, T. (2018) · Behavior Therapy · doi:10.1016/j.beth.2018.08.003 · Cited by 90 · cited 1× · see citing works
“Self-compassion has been shown to boost the efficacy of cognitive reappraisals [74]: Being caring and kind to oneself, rather than critical, even under stress, can mitigate the negative effects of trauma exposure by increasing resilience and by decreasing avoidance-oriented coping [75, 76].”
BackgroundMDMA decreases the effects of simulated social rejection
Frye, C. G., Wardle, M. C., Norman, G. J., & de Wit, H. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.030 · Cited by 85 · cited 1× · see citing works
“MDMA’s effects on emotion regulation have been studied in healthy volunteers [31, 32].”
BackgroundEmotion Regulation Deficits as Mediators between Trauma Exposure and Borderline Symptoms
Gaher, R. M., Hofman, N. L., Simons, J. S., & Hunsaker, R. (2013) · Cognitive Therapy and Research · doi:10.1007/s10608-012-9515-y · Cited by 84 · see citing works
Potential Psychiatric Uses for MDMA
Yazar‐Klosinski, B., & Mithoefer, M. C. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.565 · Cited by 80 · cited 1× · see citing works
“…SCS, or IASC factor) and baseline CAPS-5 dissociative subtype 3 Variance: η 2 = semi-partial eta squared focused on careful attention to set and setting; over fifty years of clinical experience suggest that set and setting are critical in achieving positive outcomes in psychedelic therapies [79].”
BackgroundSchroeders, U., Kubera, F., & Gnambs, T. (2022) · Assessment · doi:10.1177/10731911211033894 · Cited by 76 · see citing works
Arntz, A., Stupar-Rutenfrans, S., Bloo, J., van Dyck, R., & Spinhoven, P. (2015) · Behaviour Research and Therapy · doi:10.1016/j.brat.2015.09.002 · Cited by 73 · cited 1× · see citing works
“Being able to emotionally process traumatic experiences is an important element of successful treatment [56, 57].”
BackgroundA systematic review of randomized trials of mind-body interventions for PTSD
Niles, B. L., Mori, D. L., Polizzi, C., Pless Kaiser, A., Weinstein, E. S., Gershkovich, M., & Wang, C. (2018) · Journal of Clinical Psychology · doi:10.1002/jclp.22634 · Cited by 72 · cited 1× · see citing works
“The Inventory of Altered Self Capacities (IASC), is a standardized self-reported measure of an individual’s psychological functioning and has been frequently utilized in treatment outcome studies of PTSD [15, 40, 41].”
MethodWangelin, B. C., & Tuerk, P. W. (2015) · Depression and Anxiety · doi:10.1002/da.22449 · Cited by 70 · cited 2× · see citing works
“Being able to tolerate physiological arousal to trauma-related stimuli predicts improvement in exposure treatment, supporting a gradual diminution in the distress experienced in response to trauma recall (habituation) within-and between-sessions [65].”
BackgroundWeiss, N. H., Nelson, R. J., Contractor, A. A., & Sullivan, T. P. (2019) · Anxiety Stress & Coping · doi:10.1080/10615806.2019.1618842 · Cited by 67 · see citing works
Transdiagnostic pathways from early social stress to psychopathology: a 20‐year prospective study
Conway, C. C., Raposa, E. B., Hammen, C., & Brennan, P. A. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12862 · Cited by 60 · see citing works
Decoupling between physiological, self-reported, and expressed emotional responses in alexithymia
Eastabrook, J. M., Lanteigne, D. M., & Hollenstein, T. (2013) · Personality and Individual Differences · doi:10.1016/j.paid.2013.08.001 · Cited by 59 · see citing works
Kefeli, M. C., Goldsmith, R. E., Yıldırım, A., & Boysan, M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.026 · Cited by 58 · see citing works
Gilmore, A. K., López, C. M., Muzzy, W. A., Brown, W. J., Grubaugh, A. L., Oesterle, D. W., & Acierno, R. E. (2020) · Women s Health Issues · doi:10.1016/j.whi.2020.07.004 · Cited by 42 · cited 1× · see citing works
“Problems with emotion regulation (ER) influence both the development and the maintenance of PTSD symptoms after exposure to potentially traumatizing experiences [8, 62, 63], and predict both functional impairment and symptom complexity [50].”
BackgroundCognitive Behavioral Therapy for PTSD: The Role of Complex PTSD on Treatment Outcome
Lonergan, M. H. (2014) · Journal of Aggression Maltreatment & Trauma · doi:10.1080/10926771.2014.904467 · Cited by 40 · see citing works
Fitzgerald, J. M., Gorka, S. M., Kujawa, A., DiGangi, J. A., Proescher, E., Greenstein, J. E., Aase, D. M., Schroth, C., Afshar, K., Kennedy, A. E., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.005 · Cited by 37 · see citing works
Tedesco, S., Gajaram, G., Chida, S., Ahmad, A., Pentak, M., Kelada, M., Lewis, L., Krishnan, D., Tran, C., Soetan, O. T., et al. (2021) · Cureus · doi:10.7759/cureus.15070 · Cited by 33 · cited 1× · see citing works
“MDMA’s effects on emotion regulation have been studied in healthy volunteers [31, 32].”
BackgroundReyno, S. M., Simmons, M., & Kinley, J. (2020) · Research in Psychotherapy Psychopathology Process and Outcome · doi:10.4081/ripppo.2020.439 · Cited by 30 · cited 1× · see citing works
“Alexithymia, deficits in being able to identify and describe emotions, is associated with posttraumatic pathology [22–24], and with a lack of habituation to emotionally distressing stimuli [25].”
BackgroundChing, T. H. W., Williams, M. T., Wang, J. B., Jerome, L., Yazar‐Klosinski, B., Emerson, A., & Doblin, R. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221104052 · Cited by 29 · cited 1× · see citing works
“Some of this disparity can be attributed to a lower percentage of non-White participants seeking treatment [80], which warrants systematic changes to reduce cultural barriers to increase engagement in clinical research [81].”
BackgroundPost, L. M., Youngstrom, E. A., Connell, A. M., Zoellner, L. A., & Feeny, N. C. (2021) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2021.102367 · Cited by 28 · see citing works
Raudales, A. M., Weiss, N. H., Schmidt, N. B., & Short, N. A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.028 · Cited by 24 · see citing works
Bardeen, J. R., Daniel, T. A., Gordon, R. D., Hinnant, J. B., & Weathers, F. W. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103709 · Cited by 24 · see citing works
Ford, J. D., Spinazzola, J., & van der Kolk, B. A. (2021) · European Journal of Psychotraumatology · doi:10.1080/20008198.2021.1929028 · Cited by 21 · cited 1× · see citing works
“All of these have been shown to correlate with poor treatment outcome [17, 18].”
BackgroundTracy, A., Jopling, E., & LeMoult, J. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103965 · Cited by 17 · cited 1× · see citing works
“…levels of emotion-regulation and self-compassion have been shown to improve treatment results for a variety of psychological interventions [33, 34], which invites an exploration of the potential for MDMA in the treatment of PTSD. MDMA may differentially alter emotion recognition, depending on…”
BackgroundEmotion response disconcordance among trauma-exposed adults: the impact of alexithymia
Putica, A., O'Donnell, M. L., Felmingham, K. L., & Dam, N. T. V. (2022) · Psychological Medicine · doi:10.1017/s0033291722002586 · Cited by 14 · cited 1× · see citing works
“Identifying feelings, describing them and recognizing their triggers are thought to allow an individual to reflect on the situation and to respond appropriately to the context, rather than acting solely on their emotional arousal [58].”
BackgroundPsychotherapy-supported MDMA treatment for PTSD
Krystal, J. H., Kelmendi, B., & Petrakis, I. L. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100378 · Cited by 11 · cited 1× · see citing works
“There has been a resurgence of interest in the therapeutic potential of psychedelic substances such as tryptamines (e.g., psilocybin), ketamine, and phenethylamines (e.g., 3,4-methylene-dioxymethamphetamine (MDMA)) [1, 2].”
BackgroundMcDonald, W. M., & van Rooij, S. J. H. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19080895 · Cited by 7 · cited 1× · see citing works
“At least one-quarter of patients drop out of trauma-focused psychotherapy, and up to one-half are left with significant lingering symptoms [7–9].”
Background
Flagged first, then by citations
Research works printed but not linked: 1
- [38]Beck AT, Steer RA, Brown GK. Manual for the beck depression inventory-II. San Antonio, TX: Psychological Corporation. 1996; 1: 82.
Cited by
Sorted by citations
Yao, Y., Guo, D., Lu, T., Liu, F.-L., Huang, S., Diao, M.-Q., Li, S., Zhang, X.-J., Kosten, T. R., Shi, J., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115886 · Cited by 149 · see citing works
Højlund, M., Kafalı, H. Y., Kırmızı, B., Fusar‐Poli, P., Correll, C. U., Cortese, S., Sabé, M., Fiedorowicz, J. G., Saraf, G., Zein, J., et al. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.09.011 · Cited by 20 · see citing works
Introducing the legacies and trajectories of trauma to the archival field
Sexton, A. (2024) · Archival Science · doi:10.1007/s10502-024-09471-9 · Cited by 16 · see citing works
“…interest in exploring new treatments is in fact extensive and includes looking at how brain–computer interaction devices that alter neural signals (neurofeedback) may help traumatised individuals (van der Kolk et al. 2016) as well as MDMA-assisted therapy techniques (van der Kolk et al. 2024).”
Blinding Integrity in Psychedelic Randomized Clinical Trials
Orsini, D. K., Wong, S., Luch, S. D. D., Chan, B., Vasudeva, S., Lovell, G. F. M., Le, G. H., Jones, B. D. M., Chisamore, N., Mollica, A., et al. (2026) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2026.0255 · Cited by 18 · see citing works
Agin-Liebes, G., Zeifman, R. J., & Mitchell, J. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2485513 · Cited by 12 · see citing works
“Moreover, a recent secondary analysis of a phase 3 trial investigating MDMA-AT for PTSD reported a significant increase in self-compassion (using a single-factor total score) between baseline and 18 weeks after baseline, relative to the Placebo + Therapy (PT) group (van der Kolk et al., 2024).”
Healy, C. J., Frazier, A., Kirsch, S., Sanford, A., Garcia‐Romeu, A., Todman, M., Varon, J. P., & D'Andrea, W. M. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111361 · Cited by 9 · see citing works
EMBARK Psychedelic Therapy for Depression
Brennan, B., & Belser, A. (2024) · doi:10.1093/9780197762622.001.0001 · Cited by 8 · see citing works
MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study
Kvam, T.-M., Goksøyr, I. W., Rog, J., van de Vooren, I.-T. J., Stewart, L. H., Autran, I., Berthold‐Losleben, M., Mørch-Johnsen, L. E., Holst, R., Clausen, I., et al. (2025) · The British Journal of Psychiatry · doi:10.1192/bjp.2025.10320 · Cited by 7 · see citing works
Albert, A. E., & Back, A. L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1529427 · Cited by 6 · see citing works
MDMA-Assisted Group Therapy for PTSD: Development of a Novel Protocol
Stauffer, C. S., Bouleh, P., & Anderson, B. T. (2025) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2025.03.001 · Cited by 6 · see citing works
Bozzatello, P., Novelli, R., Schisano, R., Brasso, C., Rocca, P., & Bellino, S. (2025) · Pharmaceuticals · doi:10.3390/ph18050665 · Cited by 7 · see citing works
“We found two recent studies on this drug: an RCT and its subsequent exploratory data analysis [107,108].”
Yehuda, R., Lehrner, A. L., Sperka, M., Zaretsky, T. G., Pratchett, L. C., Haznedar, M. M., & Lepow, L. (2026) · Psychedelics · doi:10.1016/j.psyche.2026.100008 · Cited by 4 · see citing works
Obi, T., & Ressler, K. J. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02371-9 · Cited by 5 · see citing works
Kvam, T.-M., Goksøyr, I. W., Rog, J., van de Vooren, I.-T. J., Stewart, L. H., Autran, I., Berthold‐Losleben, M., Mørch-Johnsen, L. E., Holst, R., Røssberg, J. I., et al. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.11.030 · Cited by 4 · see citing works
Exploring the potential of psychedelic-assisted psychotherapy for moral injury: A scoping review
Kurkova, V., Winkler, O., Greenshaw, A. J., Jetly, R., Swainson, J., Lodewyk, K., Saghafi, P., Dennett, L., & Burback, L. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111333 · Cited by 2 · see citing works
Fares‐Otero, N. E., Furukawa, Y., Sijbrandij, M., Leucht, S., Vieta, E., Cuijpers, P. J., Harrer, M., & Seedat, S. (2026) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2026.112802 · Cited by 2 · see citing works
Is there a place for psychedelics in sports practice?
Portes, M. A. M., Werle, I., & Bertoglio, L. J. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2025.13 · Cited by 2 · see citing works
Herbert, M. S., Blanco, B. H., Perivoliotis, D., Luoma, J. B., Fernandes‐Osterhold, G., Bismark, A. W., & Woolley, J. D. (2025) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2025.01.001 · Cited by 2 · see citing works
Psychedelics - A Cure for Sexual Trauma or a Risk Factor in Recreational and Treatment Settings?
Struble, C. A. (2025) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-025-00372-x · Cited by 2 · see citing works
Peled‐Avron, L., Aday, J. S., Kalafateli, A. L., Hamilton, H., & Woolley, J. D. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1431389 · Cited by 2 · see citing works
Kronman, H. G., Locker, A., Assadi, A., & Guss, J. R. (2025) · Journal of Psychedelic Studies · doi:10.1556/2054.2025.00402 · Cited by 1 · see citing works
The stigma paradox: sympathetic and discriminatory responses toward trauma survivors in China
Chen, W., Cheung, M., Leung, P., Brewer, K. B., He, X., & Gearing, R. E. (2025) · Journal of Ethnic & Cultural Diversity in Social Work · doi:10.1080/15313204.2025.2524356 · Cited by 1 · see citing works
Psychological support in psychedelic-assisted therapy clinical trials: A systematic review
Brusky, B., M’Baïlara, K., Alla, F., & Barrault, M. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261424204 · Cited by 1 · see citing works
“…mediate outcomes, including oceanic boundlessness and ego dissolution; emotional regulation; psychological flexibility; rumination and thought suppression; and experiential avoidance (Barba et al., 2022; Roseman et al., 2018; Sloshower et al., 2024; Van Der Kolk et al., 2024; Zeifman et al., 2023).”
Lehrner, A. L., Sperka, M., Lepow, L., Pratchett, L. C., Zaretsky, T. G., Haznedar, M. M., & Yehuda, R. (2026) · Psychedelic Medicine · doi:10.1177/28314425261429233 · Cited by 1 · see citing works
Introduction to the EMBARK Approach
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0003
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0006
Bringing It Home and Carrying It Forward
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0009
Considerations Prior to Meeting With a Participant
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0005
INTRODUCTION: A New Approach for the Whole Person
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0001
Choosing Suggested Integration Goals
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.005.0004
Working Within the EMBARK Domains Cheat Sheet
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.005.0003
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0007
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.005.0002
An Overview of Psychedelic-Assisted Therapy
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0002
Personal Care for the Therapist
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.005.0001
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0008
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.002.0004
EMBARK Mechanisms of Change in the Treatment of Depression
Brennan, B., & Belser, A. (2024) · Oxford University Press eBooks · doi:10.1093/9780197762622.003.0004
Open MDMA: An Open Source Framework and Practical Guide for the Therapeutic use of MDMAPreprint
Groeneveld, M., & Harper, T. (2024) · doi:10.31234/osf.io/aps5g
Groeneveld, M., & Harper, T. (2025) · doi:10.31234/osf.io/aps5g_v3
ALTERNATIVAS FARMACOLÓGICAS PARA O TRATAMENTO DE TRANSTORNOS DE ANSIEDADE: UMA REVISÃO DA LITERATURA
Lopes, R. M. L., Galvão, J. G. F. M., Marques, A. E. F., & Pereira, L. R. D. A. B. (2025) · Revista interdisciplinar em saúde · doi:10.35621/23587490.v12.n1.p1507-1530
Zech, J. M., Richard, J., & Jones, G. M. (2025) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2025.2583967
“Tragic Person evolved: Transforming tragedy into hope through new, alternative treatments”
Zimmerman, D. (2025) · Psychoanalysis Self and Context · doi:10.1080/24720038.2025.2604803
“The prevailing research by Dore et al. (2019) and others (Feder et al., 2014; Van der Kolk et al., 2024; Wolfson et al., 2024), overwhelmingly supports the therapeutic potential for alternative medications in a clinical setting.”
PHARMACOLOGICAL TREATMENT OF PTSD WITH PSYCHEDELICS: A FUTURE OUTLOOK
Gorski, M., Januszkiewicz, A., Januszkiewicz, W., Machulski, W., Ciarkowska, M., Makulski, J. K., Franczyk, K., Swierk, K., Podkościelny, D., & Gierasimiuk, M. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4392
Mac, A. M., Kallakuri, S., Mascarin, A. T., LeVasseur, G. W., Haq, S., Moua, M. M., Vasiq, A. H., Lewis-Gates, M. E., Thompson-Huber, E. J., Baggott, M. J., et al. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07010-1
Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives
Rajkumar, R. P. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1786811
Somatic symptoms and sensory dysregulation are central to the clinical presentation of PTSD
van der Kolk, B. A., & McFARLANE, A. C. (2026) · World Psychiatry · doi:10.1002/wps.70039
Modlin, N. L., Elek, Z., Maggio, C., Agrawal, M., Lepow, L., Rucker, J., Stubley, J., & Guss, J. R. (2026) · Psychodynamic Psychiatry · doi:10.1521/pdps.2026.54.2.338
Smith, S., Mohammad, H., Lee, L.-H. N., Dennett, L., Smith, S., Burback, L., Winkler, O., Greenshaw, A., Jetly, R., Kennedy, S., et al. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07110-y
Kasiviswanathan, K., Nilaweera, D., Morando, M., Rao, S., Lee, J., Fettling, J., & Broadbear, J. H. (2026) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253251408626
“…evidence from this review suggests that there were significant reductions in abandonment concerns and emotional dysregulation post-MDMA-AP treatment (in 91% of all participants, n = 42/46), some participants in van der Kolk et al. 2024 experienced abandonment issues at the end of treatment.”
MDMA as an early post-trauma intervention in a translational animal model of PTSD
Baruch, O., Reiss, N., Todder, D., Zohar, J., & Cohen, H. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111853
Shinozuka, K., Dumanis, S. B., & Williams, N. (2026) · Springer eBooks · doi:10.1007/978-3-032-31497-0_6
Green, W., Raut, S. B., James, F. L. J., Benedek, D. M., Ursano, R. J., Capaldi, V. F., & Johnson, L. R. (2026) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000478
Current drug treatment of mental disorders
Bidan, N., Datkhayev, U., Serikbayeva, E., ZHAKIPBEKOV, K., Umurzakhova, G., Omirbayeva, A., & Shimirova, Z. (2026) · Pharmacia · doi:10.3897/pharmacia.73.e194894
“This research highlights the psychological benefits that psy-chedelic substances may offer in alleviating PTSD symptoms (Mitchell et al. 2023; van der Kolk et al. 2024).”
- Authors
- van der Kolk, B. A., Wang, J. B., Yehuda, R., Bedrosian, L., Coker, A. R., Harrison, C., Mithoefer, M., Yazar-Klosinki, B., Emerson, A., & Doblin, R.
- Affiliations
- James J. Peters VA Medical Center (US)
- University of California, San Francisco (US)
- Medical University of South Carolina (US)
- Multidisciplinary Association for Psychedelic Studies (US)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2024-01-10
- Volume
- 19
- Issue
- 1
- Pages
- e0295926
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC10781106
- OpenAlex
- W4390693439
- Cited by
- 55
- References
- 81
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 19
- FWCI
- 27.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/publicdomain/zero/1.0/ (vor)
- Locations
- PLoS ONE (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Multidisciplinary Association for Psychedlic Studies (MAPP1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- MDMA-assisted psychotherapy, post-traumatic stress disorder, self-experience, alexithymia, self-compassion, affect dysregulation, interpersonal conflict, transdiagnostic mechanisms, psychedelic therapy, treatment outcome predictors
- MeSH terms
- Coping Skills, Anxiety, Hallucinogens, Humans, Stress Disorders, Post-Traumatic, N-Methyl-3,4-methylenedioxyamphetamine
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