Cited by 537Treatment of Major DepressionNerve injury and regenerationTryptophan and brain disorders

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Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders

Duman, Ronald S.·2004·NeuroMolecular Medicine

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Abstract

Basic research in rodents has demonstrated that exposure to stress decreases levels of brain-derived neurotrophic factor (BDNF) in brain regions associated with depression. In contrast, antidepressant treatment produces the opposite effect and blocks the effects of stress on BDNF. BDNF upregulation and possibly other neurotrophic/growth factors could reverse or block the atrophy and cell loss that has been observed in rodent stress models and in depressed patients. The morphological alterations observed in depressed patients could result from decreased size or number of glia and/or neurons and may include regulation of adult neurogenesis. This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects.

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Authors: Duman, R. S.
Affiliations: Yale University (US)
Corresponding author: Duman, Ronald S.
ORCID: Duman, Ronald S.
Venue: NeuroMolecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2004
Volume: 5
Issue: 1
Pages: 011-026
ISSN: 1535-1084 (ISSN-L)
DOI: 10.1385/nmm:5:1:011
OpenAlex: W2000273941
Cited by: 537
References: 90
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 18 · 2021: 25 · 2020: 13 · 2019: 14 · 2018: 18 · 2017: 25 · 2016: 30 · 2015: 27 · 2014: 22 · 2013: 29 · 2012: 37
FWCI: 25.96
Type: journal article
Language: en
Open access: closed
Locations: NeuroMolecular Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service
National Institute of Mental Health (2-PO1-MH25642, MH-45481, P01MH025642)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: neurotrophic factors, brain-derived neurotrophic factor, depression, mood disorders, antidepressant action, stress, adult neurogenesis, neuronal atrophy, signaling pathways, neuroplasticity
MeSH terms: Animals, Antidepressive Agents, Humans, Nerve Degeneration, Nerve Growth Factors, Neuronal Plasticity, Stress, Physiological, Signal Transduction, Mood Disorders

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Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders

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