Cited by 537Treatment of Major DepressionNerve injury and regenerationTryptophan and brain disorders

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders

Duman, Ronald S.·2004·NeuroMolecular Medicine

Abstract

Basic research in rodents has demonstrated that exposure to stress decreases levels of brain-derived neurotrophic factor (BDNF) in brain regions associated with depression. In contrast, antidepressant treatment produces the opposite effect and blocks the effects of stress on BDNF. BDNF upregulation and possibly other neurotrophic/growth factors could reverse or block the atrophy and cell loss that has been observed in rodent stress models and in depressed patients. The morphological alterations observed in depressed patients could result from decreased size or number of glia and/or neurons and may include regulation of adult neurogenesis. This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects.

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Crossref · 10.1385/nmm:5:1:011

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90 of 90 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Duman, R. S.
Affiliations
Yale University (US)
Corresponding author
Duman, Ronald S.
Venue
NeuroMolecular Medicine
Published
2004
Volume
5
Issue
1
Pages
011-026
ISSN
1535-1084 (ISSN-L)
OpenAlex
W2000273941
Cited by
537
References
90
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 18 · 2021: 25 · 2020: 13 · 2019: 14 · 2018: 18 · 2017: 25 · 2016: 30 · 2015: 27 · 2014: 22 · 2013: 29 · 2012: 37
FWCI
25.96
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroMolecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Institute of Mental Health (2-PO1-MH25642, MH-45481, P01MH025642)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
neurotrophic factors, brain-derived neurotrophic factor, depression, mood disorders, antidepressant action, stress, adult neurogenesis, neuronal atrophy, signaling pathways, neuroplasticity
MeSH terms
Animals, Antidepressive Agents, Humans, Nerve Degeneration, Nerve Growth Factors, Neuronal Plasticity, Stress, Physiological, Signal Transduction, Mood Disorders

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