The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders
Abstract
Basic research in rodents has demonstrated that exposure to stress decreases levels of brain-derived neurotrophic factor (BDNF) in brain regions associated with depression. In contrast, antidepressant treatment produces the opposite effect and blocks the effects of stress on BDNF. BDNF upregulation and possibly other neurotrophic/growth factors could reverse or block the atrophy and cell loss that has been observed in rodent stress models and in depressed patients. The morphological alterations observed in depressed patients could result from decreased size or number of glia and/or neurons and may include regulation of adult neurogenesis. This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These results lend substantial support to the neuroplasticity hypothesis of depression (sometimes referred to as the neurotrophin hypothesis) (11, 23–36).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [24]
In the citing paper
“Antidepressants increase adult hippocampal neurogenesis in animal models, but the underlying molecular mechanisms are unknown.”
From Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor (2011) · cites this paper as [1]
In the citing paper
“Several studies have shown that antidepressants increase hippocampal neurogenesis in both animals and humans,1, 2, 3, 4, 5”
From Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor (2011) · cites this paper as [1]
In the citing paper
“The effects of antidepressants on hippocampal neurogenesis have been demonstrated for different, chemically unrelated classes of antidepressants,1”
From Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor (2011) · cites this paper as [1]
Citations
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Self-citationda Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Self-citationFunctional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Self-citationNibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Self-citation
Cited by
Sorted by citations
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Self-citationRoss, S., Bossis, A., Guss, J., Agin-Liebes, G., Malone, T., Cohen, B., Mennenga, S. E., Belser, A., Kalliontzi, K., Babb, J., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116675512 · Cited by 1,698
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942
Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541
Overview of the Genetics of Major Depressive Disorder
Lohoff, F. W. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0150-6 · Cited by 498
Verhagen, M., van der Meij, A., van Deurzen, P. A. M., Janzing, J. G. E., Arias-Vásquez, A., Buitelaar, J. K., & Franke, B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.109 · Cited by 470
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438
Self-citationCytokines in bipolar disorder vs. healthy control subjects: A systematic review and meta-analysis
Munkholm, K., Braüner, J. V., Kessing, L. V., & Vinberg, M. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.018 · Cited by 402
Bernard, R., Kerman, I. A., Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., & Watson, S. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.44 · Cited by 372
Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
Hoshaw, B. A., Malberg, J. E., & Lucki, I. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.007 · Cited by 348
Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324
Agomelatine, a new antidepressant, induces regional changes in hippocampal neurogenesis
Banasr, M., Soumier, A., Hery, M., Mocaër, E., & Daszuta, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.025 · Cited by 318
Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304
Self-citationDepression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298
Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?
Li, X., & Jope, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.105 · Cited by 294
REDD1 is essential for stress-induced synaptic loss and depressive behavior
Ota, K. T., Liu, R.-J., Voleti, B., Maldonado-Aviles, J. G., Duric, V., Iwata, M., Dutheil, S., Duman, C., Boikess, S., Lewis, D. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3513 · Cited by 267
Self-citationSani, G., Serra, G., Kotzalidis, G. D., Romano, S., Tamorri, S. M., Manfredi, G., Caloro, M., Telesforo, C. L., Caltagirone, S. S., Panaccione, I., et al. (2012) · CNS Drugs · doi:10.2165/11634390-000000000-00000 · Cited by 273
Classical psychedelics for the treatment of depression and anxiety: A systematic review
Muttoni, S., Ardissino, M., & John, C. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.076 · Cited by 256
Cytokines in bipolar disorder: A systematic review and meta-analysis
Munkholm, K., Vinberg, M., & Vedel Kessing, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.010 · Cited by 256
Stress, depression and Parkinson's disease
Hemmerle, A. M., Herman, J. P., & Seroogy, K. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.035 · Cited by 225
Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
Nugent, A. C., Milham, M. P., Bain, E. E., Mah, L., Cannon, D. M., Marrett, S., Zarate, C. A., Pine, D. S., Price, J. L., & Drevets, W. C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.029 · Cited by 206
Vadnie, C. A., & McClung, C. A. (2017) · Neural Plasticity · doi:10.1155/2017/1504507 · Cited by 199
Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301276 · Cited by 189
Self-citationThe role of zinc in neurodegenerative inflammatory pathways in depression
Szewczyk, B., Kubera, M., & Nowak, G. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.02.010 · Cited by 176
Psychedelics and Other Psychoplastogens for Treating Mental Illness.
Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166
Machado-Vieira, R., Yuan, P., Brutsche, N., DiazGranados, N., Luckenbaugh, D., Manji, H. K., & Zarate, C. A. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04659 · Cited by 155
Krystal, J. H., Abdallah, C. G., Averill, L. A., Kelmendi, B., Harpaz-Rotem, I., Sanacora, G., Southwick, S. M., & Duman, R. S. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0829-z · Cited by 145
Self-citationGreene, J., Banasr, M., Lee, B., Warner-Schmidt, J., & Duman, R. S. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.68 · Cited by 143
Self-citationCampos, A. C., Ferreira, F. R., & Guimarães, F. S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.012 · Cited by 139
Epigenetic control of neurobehavioural plasticity: the role of neurotrophins
Branchi, I., Francia, N., & Alleva, E. (2004) · Behavioural Pharmacology · doi:10.1097/00008877-200409000-00006 · Cited by 133
The Fibroblast Growth Factor System and Mood Disorders
Turner, C. A., Akil, H., Watson, S. J., & Evans, S. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.026 · Cited by 131
Sakharkar, A. J., Vetreno, R. P., Zhang, H., Kokare, D. M., Crews, F. T., & Pandey, S. C. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1196-y · Cited by 122
Duman, C. H., Schlesinger, L., Terwilliger, R., Russell, D. S., Newton, S. S., & Duman, R. S. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.016 · Cited by 123
Self-citationPiccinni, A., Del Debbio, A., Medda, P., Bianchi, C., Roncaglia, I., Veltri, A., Zanello, S., Massimetti, E., Origlia, N., & Domenici, L. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.01.002 · Cited by 120
Mitschelen, M., Yan, H., Farley, J. A., Warrington, J. P., Han, S., Hereñú, C. B., Csiszar, A., Ungvari, Z., Bailey-Downs, L. C., Bass, C. E., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.032 · Cited by 103
Duclot, F., & Kabbaj, M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107086 · Cited by 103
Serotonin 2C receptor antagonists induce fast-onset antidepressant effects
Opal, M. D., Klenotich, S. C., Morais, M., Bessa, J., Winkle, J., Doukas, D., Kay, L. J., Sousa, N., & Dulawa, S. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.144 · Cited by 103
Malberg, J. E., Platt, B., Rizzo, S. J. S., Ring, R. H., Lucki, I., Schechter, L. E., & Rosenzweig-Lipson, S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301358 · Cited by 101
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95
Ota, K. T., & Duman, R. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.022 · Cited by 94
Self-citationDetka, J., & Głombik, K. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00274-8 · Cited by 79
Richards, E. M., Mathews, D. C., Luckenbaugh, D. A., Ionescu, D. F., Machado-Vieira, R., Niciu, M. J., Duncan, W. C., Nolan, N. M., Franco-Chaves, J. A., Hudzik, T., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4195-4 · Cited by 76
Khundakar, A., Morris, C., Oakley, A., McMeekin, W., & Thomas, A. J. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.052688 · Cited by 71
Possible contribution of IGF-1 to depressive disorder
Szczęsny, E., Ślusarczyk, J., Głombik, K., Budziszewska, B., Kubera, M., Lasoń, W., & Basta-Kaim, A. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71523-8 · Cited by 68
Cognitive debt and Alzheimer’s disease
Marchant, N. L., & Howard, R. J. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141515 · Cited by 68
Mao, R., Zhang, C., Chen, J., Zhao, G., Zhou, R., Wang, F., Xu, J., Yang, T., Su, Y., Huang, J., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.115 · Cited by 68
Raber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62
Li, Z., Zhang, Y., Wang, Z., Chen, J., Fan, J., Guan, Y., Zhang, C., Yuan, C., Hong, W., Wang, Y., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.10.003 · Cited by 63
Greenwood, B. N., Strong, P. V., Foley, T. E., Thompson, R. S., & Fleshner, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.007 · Cited by 61
Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission
Hoshaw, B. A., Hill, T. I., Crowley, J. J., Malberg, J. E., Khawaja, X., Rosenzweig-Lipson, S., Schechter, L. E., & Lucki, I. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.07.023 · Cited by 60
Morais, M., Patrício, P., Mateus-Pinheiro, A., Alves, N. D., Machado-Santos, A. R., Correia, J. S., Pereira, J., Pinto, L., Sousa, N., & Bessa, J. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.120 · Cited by 56
Dolotov, O. V., Karpenko, E. A., Inozemtseva, L. S., Seredenina, T. S., Levitskaya, N. G., Rozyczka, J., Dubynina, E. V., Novosadova, E. V., Andreeva, L. A., Alfeeva, L. Y., et al. (2006) · Brain Research · doi:10.1016/j.brainres.2006.07.108 · Cited by 57
Bot, M., Milaneschi, Y., Penninx, B. W. J. H., & Drent, M. L. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.028 · Cited by 50
Understanding the effects of chronic benzodiazepine use in depression: a focus on neuropharmacology
Lim, B., Sproule, B. A., Zahra, Z., Sunderji, N., Kennedy, S. H., & Rizvi, S. J. (2020) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000316 · Cited by 50
Dagyte, G., Luiten, P. G., De Jager, T., Gabriel, C., Mocaër, E., Den Boer, J. A., & Van der Zee, E. A. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22697 · Cited by 32
Eremin, K. O., Kudrin, V. S., Saransaari, P., Oja, S. S., Grivennikov, I. A., Myasoedov, N. F., & Rayevsky, K. S. (2005) · Neurochemical Research · doi:10.1007/s11064-005-8826-8 · Cited by 29
Acetyl-L-carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders?
Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. Z., & McIntyre, R. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.6.827 · Cited by 23
VEGF regulates antidepressant effects of lamotrigine
Sun, R., Li, N., & Li, T. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.09.010 · Cited by 22
Metadata
- Authors
- Duman, R. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Duman, Ronald S.
- ORCID
- Duman, Ronald S.
- Venue
- NeuroMolecular Medicine
- Published
- 2004
- Volume
- 5
- Issue
- 1
- Pages
- 011-026
- ISSN
- 1535-1084 (ISSN-L)
- OpenAlex
- W2000273941
- Cited by
- 537
- References
- 90
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 18 · 2021: 25 · 2020: 13 · 2019: 14 · 2018: 18 · 2017: 25 · 2016: 30 · 2015: 27 · 2014: 22 · 2013: 29 · 2012: 37
- FWCI
- 25.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroMolecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Mental Health (2-PO1-MH25642, MH-45481, P01MH025642)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- neurotrophic factors, brain-derived neurotrophic factor, depression, mood disorders, antidepressant action, stress, adult neurogenesis, neuronal atrophy, signaling pathways, neuroplasticity
- MeSH terms
- Animals, Antidepressive Agents, Humans, Nerve Degeneration, Nerve Growth Factors, Neuronal Plasticity, Stress, Physiological, Signal Transduction, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review