Default mode alterations in posttraumatic stress disorder related to early-life trauma: a developmental perspective
Open accessAbstract
Recently, altered default mode network (DMN) connectivity in individuals with posttraumatic stress disorder (PTSD) has been related to prolonged childhood maltreatment.[1][1] An emerging body of literature also describes the developmental differentiation of the DMN in healthy children.[2][2]–[6][3
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Recent studies have reported alterations in subcortical and default network connectivity in individuals with PTSD.
“Recent studies have begun to investigate resting-state connectivity in individuals with PTSD and have reported alterations in subcortical31 and default network connectivity.32–35”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [34]
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Flagged first, then by citations
Research works printed but not linked: 2
- De Bellis MD, Keshavan MS, Clark DB, et al. Developmental trauma- tology. Part II: brain development. Biol Psychiatry 1999;45:1271-84.
- Daniels J, McFarlane AC, Bluhm RL, et al. Switching between ex- ecutive and default mode networks in posttraumatic stress disor- der: alterations in functional connectivity. J Psychiatry Neurosci 2010;35:258-66.
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- Authors
- Daniels, J.
- Affiliations
- Western University (CA)
- Corresponding author
- Daniels, Judith
- ORCID
- Daniels, Judith
- Venue
- Journal of Psychiatry & Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2011-01-01
- Volume
- 36
- Issue
- 1
- Pages
- 56-59
- ISSN
- 1180-4882 (ISSN-L)
- PMC
- PMC3004976
- OpenAlex
- W2025401386
- Cited by
- 93
- References
- 65
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 12 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 1 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, default mode network, early trauma, child abuse, developmental neuroplasticity, neuronal connectivity, children
- MeSH terms
- Adult, Brain, Child, Child Abuse, Child, Preschool, Humans, Neural Pathways, Stress Disorders, Post-Traumatic
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