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Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex
Open accessAbstract
Glucose is the primary energetic substrate of the brain, and measurements of its metabolism are the basis of major functional cerebral imaging methods. Contrary to the general view that neurons are fueled solely by glucose in proportion to their energetic needs, recent in vitro and ex vivo analyses suggest that glucose preferentially feeds astrocytes. However, the cellular fate of glucose in the intact brain has not yet been directly observed. We have used a real-time method for measuring glucose uptake in astrocytes and neurons in vivo in male rats by imaging the trafficking of the nonmetabolizable glucose analog 6-deoxy-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-aminoglucose (6-NBDG) using two-photon microscopy. During resting conditions we found that astrocytes and neurons both take up 6-NBDG at the same rate in the barrel cortex of the rat. However, during intense neuronal activity triggered by whisker stimulation, astrocytes rapidly accelerated their uptake, whereas neuronal uptake remained almost unchanged. After the stimulation period, astrocytes returned to their preactivation rates of uptake paralleling the neuronal rate of uptake. These observations suggest that glucose is taken up primarily by astrocytes, supporting the view that functional imaging experiments based on glucose analogs extraction may predominantly reflect the metabolic activity of the astrocytic network.
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“The first study (Chuquet et al., 2010) used the fluorescent glucose analogue 6-NBDG; because it cannot be phosphorylated by hexokinase (given that the 6 position was already occupied by the fluorophore), this analogue’s accumulation may not correspond with the actual rate of glucose utilization, and it has been shown in some cases to correlate negatively with glucose utilization (DiNuzzo et al., 2”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
In the citing paper
“Two recent in vivo studies monitored glucose analogue accumulation in somatosensory cortex during whisker stimulation; they used two different glucose analogues and obtained opposite results.”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
In the citing paper
“The first study (Chuquet et al., 2010) used the fluorescent glucose analogue 6-NBDG; because it cannot be phosphorylated by hexokinase (given that the 6 position was already occupied by the fluorophore), this analogue’s accumulation may not correspond with the actual rate of glucose utilization, and it has been shown in some cases to correlate negatively with glucose utilization (DiNuzzo et al., 2”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
In the citing paper
“Baseline accumulation of the analogue into astrocytes and neurons was similar; upon whisker stimulation in anesthetized rats, uptake into both cell types tended to increase, though only significantly for astrocytes (Chuquet et al., 2010).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
In the citing paper
“Baseline accumulation of the analogue into astrocytes and neurons was similar; upon whisker stimulation in anesthetized rats, uptake into both cell types tended to increase, though only significantly for astrocytes (Chuquet et al., 2010).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Chuquet et al., 2010
In the citing paper
“In vivo measurements to learn which cell type shows greater stimulated uptake of glucose analogs have given conflicting results (Chuquet et al., 2010; Lundgaard et al., 2015)”
From Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake (2017) · cites this paper as Chuquet et al., 2010
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Metadata
- Authors
- Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-11-10
- Volume
- 30
- Issue
- 45
- Pages
- 15298-15303
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2997269
- OpenAlex
- W2009966509
- Cited by
- 217
- References
- 42
- Citations by year
- 2026: 1 · 2025: 14 · 2024: 13 · 2023: 18 · 2022: 12 · 2021: 15 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 23 · 2016: 13 · 2015: 19 · 2014: 11 · 2013: 14 · 2012: 14
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC009947)
- National Institute of Neurological Disorders and Stroke (R01NS034994)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, neurons, glucose uptake, somatosensory cortex, barrel cortex, whisker stimulation, neuronal activation, two-photon microscopy, brain energy metabolism, functional neuroimaging
- MeSH terms
- Analysis of Variance, Animals, Astrocytes, Biological Transport, Glucose, Male, Neurons, Somatosensory Cortex, Vibrissae, Rats, Sprague-Dawley, Microscopy, Fluorescence, Multiphoton, Rats
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