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Weight Gain Is Associated with Reduced Striatal Response to Palatable Food
Open accessAbstract
Consistent with the theory that individuals with hypofunctioning reward circuitry overeat to compensate for a reward deficit, obese versus lean humans have fewer striatal D2 receptors and show less striatal response to palatable food intake. Low striatal response to food intake predicts future weight gain in those at genetic risk for reduced signaling of dopamine-based reward circuitry. Yet animal studies indicate that intake of palatable food results in downregulation of D2 receptors, reduced D2 sensitivity, and decreased reward sensitivity, implying that overeating may contribute to reduced striatal responsivity. Thus, we tested whether overeating leads to reduced striatal responsivity to palatable food intake in humans using repeated-measures functional magnetic resonance imaging. Results indicated that women who gained weight over a 6 month period showed a reduction in striatal response to palatable food consumption relative to weight-stable women. Collectively, results suggest that low sensitivity of reward circuitry increases risk for overeating and that this overeating may further attenuate responsivity of reward circuitry in a feedforward process.
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“In humans, weight gain over a six-month period is predicted by a reduction in striatal response to palatable food consumption over this same time period.182”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [182]
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Cites
Analysis of fMRI Time-Series Revisited—Again
Worsley, K. J., & Friston, K. J. (1995) · NeuroImage · doi:10.1006/nimg.1995.1023 · Cited by 2,198
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · cited 2×
“The dorsal striatum responds to ingestion of chocolate in lean humans and is sensitive to its devaluation by feeding beyond satiety (Small et al., 2001).”
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076
Widespread reward-system activation in obese women in response to pictures of high-calorie foods
Stoeckel, L. E., Weller, R. E., Cook, E. W., Twieg, D. B., Knowlton, R. C., & Cox, J. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.031 · Cited by 857
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by Taq IA A1 Allele
Stice, E., Spoor, S., Bohon, C., & Small, D. M. (2008) · Science · doi:10.1126/science.1161550 · Cited by 786
Self-citationStice, E., Spoor, S., Bohon, C., Veldhuizen, M. G., & Small, D. M. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013600 · Cited by 779
Self-citationRothemund, Y., Preuschhof, C., Bohner, G., Bauknecht, H.-C., Klingebiel, R., Flor, H., & Klapp, B. F. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.008 · Cited by 679 · cited 1×
“, 2008a,b), yet show greater striatal activation in response to pictures of food (Rothemund et al., 2007; Stoeckel et al., 2008; Stice et al., 2010), suggesting a dissociation between consummatory food reward and the incentive salience of food cues.”
Noble, E. P. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810310066012 · Cited by 655
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Thanos, P. K., Logan, J., Alexoff, D., Ding, Y.-S., Wong, C., Ma, Y., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.002 · Cited by 573
Use of the body mass index (BMI) as a measure of overweight in children and adolescents
Dietz, W. H., & Robinson, T. N. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70426-3 · Cited by 541
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496
Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain
Colantuoni, C., Schwenker, J., McCarthy, J., Rada, P., Ladenheim, B., Cadet, J.-L., Schwartz, G. J., Moran, T. H., & Hoebel, B. G. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00035 · Cited by 471
Development and Validation of the Food‐Craving Inventory
White, M. A., Whisenhunt, B. L., Williamson, D. A., Greenway, F. L., & Netemeyer, R. G. (2002) · Obesity Research · doi:10.1038/oby.2002.17 · Cited by 471
The D 2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome
Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608900711 · Cited by 443
Self-citationDissonance and healthy weight eating disorder prevention programs: A randomized efficacy trial.
Stice, E. M., Shaw, H. E., Burton, E. M., & Wade, E. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.2.263 · Cited by 390
Self-citationHenson, R. N., Price, C. J., Rugg, M. D., Turner, R., & Friston, K. J. (2002) · NeuroImage · doi:10.1006/nimg.2001.0940 · Cited by 356
Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354
Stice, E. M., Yokum, S., Bohon, C., Marti, N., & Smolen, A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.081 · Cited by 333
Self-citationDavis, C. A., Levitan, R. D., Reid, C., Carter, J. C., Kaplan, A. S., Patte, K. A., King, N., Curtis, C., & Kennedy, J. L. (2009) · Obesity · doi:10.1038/oby.2009.52 · Cited by 314
Ritchie, T. L., & Noble, E. P. (2003) · Neurochemical Research · doi:10.1023/a:1021648128758 · Cited by 294
Reinforcing Value of Food in Obese and Non-obese Women
SAELENS, B. E., & EPSTEIN, L. H. (1996) · Appetite · doi:10.1006/appe.1996.0032 · Cited by 288
The role of dopamine in motivation for food in humans: implications for obesity
Wang, G.-J., Volkow, N. D., & Fowler, J. S. (2002) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.6.5.601 · Cited by 285
Alterations of Central Dopamine Receptors Before and After Gastric Bypass Surgery
Steele, K. E., Prokopowicz, G. P., Schweitzer, M. A., Magunsuon, T. H., Lidor, A. O., Kuwabawa, H., Kumar, A., Brasic, J., & Wong, D. F. (2010) · Obesity Surgery · doi:10.1007/s11695-009-0015-4 · Cited by 213
D2 dopamine receptor polymorphism and brain regional glucose metabolism
Noble, E. P., Gottschalk, L. A., Fallon, J. H., Ritchie, T. L., & Wu, J. C. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970418)74:2 · Cited by 165
Kelley, A. E., Will, M. J., Steininger, T. L., Zhang, M., & Haber, S. N. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02991.x · Cited by 149
Repeated sucrose access influences dopamine D2 receptor density in the striatum
Bello, N. T., Lucas, L. R., & Hajnal, A. (2002) · Neuroreport · doi:10.1097/00001756-200208270-00017 · Cited by 144
Cortical Activation Induced by Intraoral Stimulation with Water in Humans
Zald, D. H., & Pardo, J. V. (2000) · Chemical Senses · doi:10.1093/chemse/25.3.267 · Cited by 126
Fetissov, S. O., Meguid, M. M., Sato, T., & Zhang, L.-H. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00092.2002 · Cited by 119
Neural substrates for the processing of cognitive and affective aspects of taste in the brain
Yamamoto, T. (2006) · Archivum histologicum japonicum · doi:10.1679/aohc.69.243 · Cited by 102
Tupala, E., Hall, H., Bergström, K., Mantere, T., Räsänen, P. K., Särkioja, T., & Tiihonen, J. (2003) · Human Brain Mapping · doi:10.1002/hbm.10129 · Cited by 46
Striatal dopamine transmission in healthy humans during a passive monetary reward task
Hakyemez, H., Dagher, A., Smith, S. D., & Zald, D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.034 · Cited by 42
Orosco, M., Rouch, C., & Nicolaı̈dis, S. (1996) · Appetite · doi:10.1006/appe.1996.0001 · Cited by 17
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Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748
Neural correlates of food addiction
Gearhardt, A. N. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.32 · Cited by 707
Interoception, contemplative practice, and health
Farb, N., Daubenmier, J., Price, C. J., Gard, T., Kerr, C., Dunn, B. D., Klein, A. C., Paulus, M. P., & Mehling, W. E. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00763 · Cited by 650
Mindfulness-Based Eating Awareness Training (MB-EAT) for Binge Eating: A Randomized Clinical Trial
Kristeller, J., Wolever, R. Q., & Sheets, V. (2014) · Mindfulness · doi:10.1007/s12671-012-0179-1 · Cited by 469
Metadata
- Authors
- Stice, E., Yokum, S., Blum, K., & Bohon, C.
- Affiliations
- The University of Texas at Austin (US)
- University of Florida (US)
- University of California, Los Angeles (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-09-29
- Volume
- 30
- Issue
- 39
- Pages
- 13105-13109
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2967483
- OpenAlex
- W1967830372
- Cited by
- 401
- References
- 35
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 9 · 2023: 13 · 2022: 17 · 2021: 25 · 2020: 22 · 2019: 22 · 2018: 30 · 2017: 33 · 2016: 27 · 2015: 37 · 2014: 35 · 2013: 31 · 2012: 39
- FWCI
- 13.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R1MH64560A, R01MH064560)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK080760, R01DK080760)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- weight gain, striatum, dopamine D2 receptor, reward systems, palatable food, overeating, obesity, dopamine sensitivity, food reward, women
- MeSH terms
- Appetite Regulation, Appetitive Behavior, Brain Mapping, Corpus Striatum, Female, Humans, Hyperphagia, Magnetic Resonance Imaging, Neural Inhibition, Neuropsychological Tests, Obesity, Prospective Studies, Reward, Weight Gain, Young Adult
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