Sex differences in the control of social investigation and anxiety by vasopressin cells of the paraventricular nucleus of the hypothalamus
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The neuropeptide arginine-vasopressin (AVP) has long been implicated in the regulation of social behavior and communication in diverse taxa, but the source of AVP release relevant for behavior has not been precisely determined. Potential sources include hypothalamic cell populations such as the paraventricular (PVN), supraoptic, and suprachiasmatic nuclei, as well as extrahypothalamic cell groups in the extended amygdala. To address if AVP-expressing cells in the PVN are important for mouse social communication, we deleted PVN AVP-expressing cells using viral-mediated delivery of Cre-dependent caspase-9 cell death construct into the PVN of AVP-Cre-positive mice (expressing Cre-recombinase under the control of the AVP promoter) or AVP-Cre-negative littermate controls, and assessed their levels of social investigation, social communication, anxiety, sex behavior, and aggressive behavior. We found that these lesions increased social investigation in females, but not in males. However, in males but not in females, these lesions increased non-social anxiety-related behaviors in the elevated-plus maze. These results therefore point at differential involvement of PVN AVP-expressing cells in the context of social and emotional behavior in the two sexes, which may contribute to sex differences in social communication and anxiety disorders.
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Vasopressin modulates social investigation.
“Vasopressin modulates social communication, social investigation, territorial behavior, and aggression, predominantly in males.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [52]
Some reports show greater vasopressin mRNA density in the supraoptic nucleus of male rats and greater oxytocin production in female mice, but other studies show similar amounts of oxytocin and vasopressin in both sexes in the paraventricular/supraoptic nuclei of various rodent species, nonhuman primates, and humans.
“Some reports have shown that AVP messenger RNA (mRNA) density measurements in the SON of rats are greater in males (50), while, in mice, OXT production is greater in females (51); however, other studies have shown a similar amount of OXT and AVP in both sexes in the PVN/SON of various rodent species, nonhuman primates, and humans (49,52).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [52]
Paraventricular vasopressin cell ablation increased female social investigation, but does not alter investigation in males.
“PVN AVP cell ablation increased female social investigation, but does not alter investigation in males (52,90,91).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [52]
There may be differential involvement of paraventricular and bed nucleus of the stria terminalis vasopressin cells in the control of social/emotional behavior in each sex.
“Nevertheless, there may be differential involvement of PVN and BNST AVP cells in the control of social/emotional behavior in each sex (52).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [52]
Ablation of vasopressin cells in the paraventricular and supraoptic nuclei did not affect social recognition.
“However, it is unlikely that just PVN projections contribute to AVP effects on social recognition as ablation of AVP cells in PVN and SON did not affect social recognition (52,107).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [52]
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Cited by
Sorted by citations
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Self-citationVasopressin regulates daily rhythms and circadian clock circuits in a manner influenced by sex
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Rigney, N., Zbib, A., de Vries, G. J., & Petrulis, A. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13083 · Cited by 29 · see citing works
Arakawa, H., & Higuchi, Y. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104597 · Cited by 8 · see citing works
- Authors
- Rigney, N., Whylings, J., de Vries, G. J., & Petrulis, A.
- Affiliations
- Georgia State University (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2020-06-15
- Volume
- 111
- Issue
- 6
- Pages
- 521-535
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- PMC
- PMC7736187
- OpenAlex
- W3035674118
- Cited by
- 42
- References
- 101
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 2
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH121603, R21MH111104)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, paraventricular nucleus, sex differences, social investigation, social communication, anxiety, social behavior, elevated plus maze, aggression, anxiety disorders
- MeSH terms
- Aggression, Animals, Anxiety, Arginine Vasopressin, Behavior, Animal, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Paraventricular Hypothalamic Nucleus, Sexual Behavior, Animal, Sex Characteristics, Social Behavior, Maze Learning, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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