The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Amygdala and Orbitofrontal Cortex Lesions Differentially Influence Choices during Object Reversal Learning
Open accessAbstract
In nonhuman primates, interaction between the orbitofrontal cortex (OFC) and the amygdala (AMG) has been seen as critical for learning and subsequently changing associations between stimuli and reinforcement. However, it is still unclear what the precise role of the OFC is in altering these stimulus–reward associations, and recent research has questioned whether the AMG makes an essential contribution at all. To gain a better understanding of the role of these two structures in flexibly associating stimuli with reinforcement, we reanalyzed a set of previously published data from groups of monkeys with either OFC or AMG lesions that had been tested on an object reversal learning task. Based on trial-by-trial analyses of rewarded and unrewarded choices, we report two new findings. First, monkeys with OFC lesions were, compared with both control and AMG groups, unable to use correctly performed trials to optimally guide subsequent choices. Second, monkeys with AMG lesions showed the opposite pattern of behavior. This group benefited more than controls from correctly performed trials that followed an error. Finally, as has been reported by others, after a change in reward contingencies, monkeys with OFC lesions also showed a slightly greater tendency to choose the previously rewarded object. These findings demonstrate that the OFC and AMG make different contributions to object reversal learning not highlighted previously.
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In the citing paper
“In addition, lesions of the orbital cortex produce a deficit in the ability to use reward as a guide to behavior (Rudebeck and Murray, 2008)”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Rudebeck and Murray, 2008
Experimental — accuracy not yet measuredIn the citing paper
“This analysis shows that PFo lesions cause an inefficiency in using positive feedback (blue asterisks in Fig. 4B).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“A more detailed, trial-by-trial analysis indicates that both PFo and amygdala lesions influence the use of positive feedback. As Figure 4B shows, however, they do so in opposite directions.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“These findings indicate that PFo lesions cause a deficit in using positive feedback, but not in the use of negative feedback (91, but cf. 94).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“In contrast to the deficits seen after PFo lesions, selective bilateral amygdala lesions cause an improvement in using positive feedback to make future choices (red asterisk in Fig. 4B).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“Even when two, three, or four correct (and rewarded) responses intervene between an error and an upcoming choice, monkeys with PFo lesions make many more errors than do intact control monkeys.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“After performing one correct (rewarded) trial following an error (the EC+1 trial type), monkeys with amygdala lesions out-perform intact monkeys in their future choices.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“Bilateral lesions of PFo (Figure 4A, blue), however, significantly slow reversal learning (91, 92), a finding that has been replicated many times (93).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“Like the monkeys studied by Rudebeck and Murray (91), the PFo lesion group studied by Buckley et al. was inefficient in using positive feedback after rule changes, suggesting that PFo plays an important role in the valuation of rule representations as well as object representations.”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“The red curve in Figure 4A illustrates that selective bilateral amygdala lesions have no effect on learning these object-reward reversals (75, 91).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
In the citing paper
“This updating needs to occur in order to make good choices in the serial object-reversal task (91) and when making object choices that optimize the probability of reward (90).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [91]
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Citations
Cites
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527
Optimal decision making and the anterior cingulate cortex
Kennerley, S. W., Walton, M. E., Behrens, T. E. J., Buckley, M. J., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1724 · Cited by 948
Limbic lesions and the problem of stimulus--reinforcement associations.
Jones, B., & Mishkin, M. (1972) · Experimental Neurology · doi:10.1016/0014-4886(72)90030-1 · Cited by 864
A cytoarchitectural study of the prefrontal area of the macaque monkey
Walker, A. E. (1940) · The Journal of Comparative Neurology · doi:10.1002/cne.900730106 · Cited by 803
Iversen, S., & Mishkin, M. (1970) · Experimental Brain Research · doi:10.1007/bf00237911 · Cited by 767
The amygdala, reward and emotion
Murray, E. A. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.08.013 · Cited by 679
Self-citationIzquierdo, A., Suda, R. K., & Murray, E. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1921-04.2004 · Cited by 588
Self-citationBaxter, M. G., Parker, A., Lindner, C. C. C., Izquierdo, A. D., & Murray, E. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04311.2000 · Cited by 582
Self-citationChudasama, Y., & Robbins, T. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08771.2003 · Cited by 543
Schoenbaum, G., Setlow, B., Saddoris, M. P., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00474-4 · Cited by 484
Málková, L., Gaffan, D., & Murray, E. A. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-06011.1997 · Cited by 295
Self-citationSyndrome produced by lesions of the amygdala in monkeys (Macaca mulatta).
Aggleton, J., & Passingham, R. (1981) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077848 · Cited by 236
Rapid Associative Encoding in Basolateral Amygdala Depends on Connections with Orbitofrontal Cortex
Saddoris, M. P., Gallagher, M., & Schoenbaum, G. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.018 · Cited by 213
Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex
Hampton, A. N., Adolphs, R., Tyszka, J. M., & O'Doherty, J. P. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.022 · Cited by 213
Izquierdo, A., Suda, R. K., & Murray, E. A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1232-05.2005 · Cited by 186
Self-citationMurray, E. A., Baxter, M. G., & Gaffan, D. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1291 · Cited by 182
Self-citationMurray, E. A., Baxter, M. G., & Gaffan, D. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1291 · Cited by 174
Self-citationIzquierdo, A., & Murray, E. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00968.2003 · Cited by 167
Self-citationPears, A., Parkinson, J. A., Hopewell, L. J., Everitt, B. J., & Roberts, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11189.2003 · Cited by 136
GABAA-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
Wellman, L. L., Gale, K., & Malkova, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2257-04.2005 · Cited by 126
Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning
Izquierdo, A., & Murray, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3616-06.2007 · Cited by 121
Self-citationBussey, T. J., Wise, S. P., & Murray, E. A. (2002) · Behavioral Neuroscience · doi:10.1037/0735-7044.116.4.703 · Cited by 111
Self-citationThe Role of the Primate Amygdala in Conditioned Reinforcement
Parkinson, J. A., Crofts, H. S., McGuigan, M., Tomic, D. L., Everitt, B. J., & Roberts, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07770.2001 · Cited by 100
Izquierdo, A., & Murray, E. A. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04434.x · Cited by 97
Self-citationHippocampus: memory, habit and voluntary movement
Gaffan, D. (1985) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1985.0012 · Cited by 81
Discrimination behavior after amygdalectomy in monkeys: Learning set and discrimination reversals.
Schwartzbaum, J. S., & Poulos, D. A. (1965) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0022551 · Cited by 79
Murray, E. A., & Wise, S. P. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1261 · Cited by 75
Self-citationMurray, E. A., & Wise, S. P. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1261 · Cited by 74
Self-citationFrontal-Temporal Disconnection Abolishes Object Discrimination Learning Set in Macaque Monkeys
Browning, P. G. F., Easton, A., & Gaffan, D. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk039 · Cited by 64
Research works printed but not linked: 1
- Mishkin M (1964) in The frontal granular cortex and behavior, Perseveration of central sets after frontal lesions in monkeys, eds Warren JM Akert K (McGraw-Hill, New York), pp 219–241.
Cited by
Sorted by citations
The brain basis of emotion: a meta-analytic review
Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11000446 · Cited by 2,320
“…1994; 1996) decision making (e.g., Bechara et al. 1996; 2000; Koenigs et al. 2007) and reversal learning, in which the reward values associated with choice options are reversed and animals must learn the current reward value (Chudasama & Robbins 2003; Hornak et al. 2004; Rudebeck & Murray 2008).”
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606
The neural basis of reversal learning: An updated perspective
Izquierdo, A., Brigman, J. L., Radke, A. K., Rudebeck, P. H., & Holmes, A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.021 · Cited by 670
Self-citationWhat the orbitofrontal cortex does not do
Stalnaker, T. A., Cooch, N. K., & Schoenbaum, G. (2015) · Nature Neuroscience · doi:10.1038/nn.3982 · Cited by 531
Metadata
- Authors
- Rudebeck, P. H., & Murray, E. A.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-08-13
- Volume
- 28
- Issue
- 33
- Pages
- 8338-8343
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2556079
- OpenAlex
- W2046214338
- Cited by
- 148
- References
- 27
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 10 · 2017: 4 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 10
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Soochow University
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- amygdala, orbitofrontal cortex, lesion studies, non-human primates, stimulus-reward associations, error-based learning, reward contingency, choice behavior, neural basis of learning
- MeSH terms
- Amygdala, Animals, Choice Behavior, Frontal Lobe, Macaca mulatta, Male, Photic Stimulation, Reversal Learning, Prefrontal Cortex
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