Comparison of the effects of bilateral orbital prefrontal cortex lesions and amygdala lesions on emotional responses in rhesus monkeys
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The present study examines the effects of bilateral orbital prefrontal cortex (PFo) lesions on monkeys' emotional responses in two different contexts: in the presence of a rubber snake and in the presence of a human intruder. For comparison, we also assessed the responses of rhesus monkeys with selective amygdala lesions on these same tasks. Monkeys with PFo lesions, like those with amygdala lesions, displayed blunted emotional responses to the fake snake. Unlike monkeys with amygdala lesions, however, monkeys with PFo lesions displayed more mild aggression than controls in the presence of a human intruder. The findings support the idea that the PFo helps integrate sensory signals in the service of choosing among competing responses. In addition, they point to a divergence of the roles of the PFo and amygdala in responding to a social stimulus, the human intruder.
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The orbital and ventromedial PFC is essential for the regulation of emotion, such as the inhibition of aggressive impulses.
“while the orbital and ventromedial PFC is essential for the regulation of emotion, such as the inhibition of aggressive impulses (Best et al., 2002; Izquierdo et al., 2005; Price et al., 1996)”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Izquierdo et al., 2005
In “Responses to a human intruder” (page unavailable), monkeys with orbital prefrontal cortex lesions showed more mild aggression during a threatening stare, which the authors interpret as suggesting a role in modulating aggression. The paper does not establish that the orbital and ventromedial PFC are essential for inhibiting aggressive impulses generally; it studies orbital lesions in rhesus monkeys and describes the aggression difference as modest. (LLM, conf=0.86)
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- Authors
- Izquierdo, A., Suda, R. K., & Murray, E. A.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-09-14
- Volume
- 25
- Issue
- 37
- Pages
- 8534-8542
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725674
- OpenAlex
- W2097004047
- Cited by
- 186
- References
- 43
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 11
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- orbitofrontal cortex, amygdala, emotional responses, rhesus monkeys, aggression, fear, threat detection, lesion studies, sensory integration, competing responses
- MeSH terms
- Amygdala, Animals, Animal Feed, Emotions, Functional Laterality, Macaca mulatta, Reaction Time, Reward, Visual Cortex, Prefrontal Cortex
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