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Postsynaptic Density-95 Mimics and Occludes Hippocampal Long-Term Potentiation and Enhances Long-Term Depression
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Previous studies have shown that overexpression of the protein PSD-95 (postsynaptic density-95) selectively enhances AMPA receptor-mediated synaptic responses in hippocampal pyramidal cells. To determine whether this effect is related to synaptic plasticity at these synapses, we examined whether PSD-95 expression mimics long-term potentiation (LTP), and also whether it influences LTP and long-term depression (LTD) in hippocampal slice cultures. Using simultaneous recording from transfected or infected cells and control pyramidal cells, we found that PSD-95, similar to LTP, increases the amplitude and frequency of miniature EPSCs. It also converts silent synapses to functional synapses, as does LTP. In addition, LTP is completely occluded in cells expressing PSD-95, whereas LTD is greatly enhanced. These results suggest that common mechanisms are involved in controlling synaptic AMPA receptors by PSD-95 and synaptic plasticity.
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“since overexpression of PSD-95 on its own potentiates AMPAR EPSCs and occludes LTP (131, 297, 298) and the S73D mutant causes a similar potentiation.”
From Synaptic memory and CaMKII (2023) · cites this paper as [297]
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“The quantity of surface receptors controls synaptic strength [57-59]; therefore, reduction of both synaptic transmission and plasticity in the Shank3 heterozygotes would support a mechanism involving altered AMPA receptor trafficking.”
From Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication (2010) · cites this paper as [59]
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Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303
Self-citationEvidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233
Self-citationMigaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111
Self-citationDirect interactions between PSD-95 and stargazin control synaptic AMPA receptor number
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 775
Self-citationPostsynaptic signaling and plasticity mechanisms
Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731
Synaptic Strength Regulated by Palmitate Cycling on PSD-95
El-Husseini, A., Schnell, E., Dakoji, S., Sweeney, N. T., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., & Bredt, D. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00683-9 · Cited by 569
Self-citation
Research works printed but not linked: 1
- 2002, Soc Neurosci Abstr, 28, 713.2
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Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,630
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Self-citationHomeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
Yoshii, A., & Constantine‐Paton, M. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20765 · Cited by 744
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590
Bozdagi, O., Sakurai, T., Papapetrou, D., Wang, X., Dickstein, D. L., Takahashi, N., Kajiwara, Y., Yang, M., Katz, A. M., Scattoni, M. L., et al. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-15 · Cited by 584
Ehrlich, I., & Malinow, R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4733-03.2004 · Cited by 567
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567
Identification of PSD-95 Palmitoylating Enzymes
Fukata, M., Fukata, Y., Adesnik, H., Nicoll, R. A., & Bredt, D. S. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.005 · Cited by 532
Self-citationStargazin modulates AMPA receptor gating and trafficking by distinct domains
Tomita, S., Adesnik, H., Sekiguchi, M., Zhang, W., Wada, K., Howe, J. R., Nicoll, R. A., & Bredt, D. S. (2005) · Nature · doi:10.1038/nature03624 · Cited by 486
Self-citationPSD-95 is required for activity-driven synapse stabilization.
Ehrlich, I., Klein, M., Rumpel, S., & Malinow, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609307104 · Cited by 470
Spine Dynamics: Are They All the Same?
Berry, K., & Nedivi, E. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.008 · Cited by 497
MEMBRANE-ASSOCIATED GUANYLATE KINASES REGULATE ADHESION AND PLASTICITY AT CELL JUNCTIONS
Funke, L., Dakoji, S., & Bredt, D. S. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133339 · Cited by 482
Self-citationOh, M. C., Derkach, V. A., Guire, E. S., & Soderling, T. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509677200 · Cited by 456
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425
Self-citationElias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413
Self-citationCaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin
Opazo, P., Labrecque, S., Tigaret, C. M., Frouin, A., Wiseman, P. W., Koninck, P. D., & Choquet, D. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.007 · Cited by 434
Synapse-specific regulation of AMPA receptor function by PSD-95.
Béïque, J.-C., Lin, D.-T., Kang, M.-G., Aizawa, H., Takamiya, K., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608492103 · Cited by 398
Astroglial networks scale synaptic activity and plasticity
Pannasch, U., Vargová, L., Reingruber, J., Ezan, P., Holcman, D., Giaume, C., Syková, E., & Rouach, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016650108 · Cited by 383
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 390
A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin
Prange, O., Wong, T. P., Gerrow, K., Wang, Y. T., & El-Husseini, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405939101 · Cited by 381
Glutamate receptor dynamics in dendritic microdomains.
Newpher, T. M., & Ehlers, M. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.030 · Cited by 356
Yoshii, A., & Constantine-Paton, M. (2007) · Nature Neuroscience · doi:10.1038/nn1903 · Cited by 345
ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346
Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo
Gray, N. W., Weimer, R. M., Bureau, I., & Svoboda, K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040370 · Cited by 350
Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs
Tomita, S., Stein, V., Stocker, T. J., Nicoll, R. A., & Bredt, D. S. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.009 · Cited by 343
Self-citationPostsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288
Self-citationKim, M. J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.007 · Cited by 278
Roselli, F., Tirard, M., Lu, J., Hutzler, P., Lamberti, P., Livrea, P., Morabito, M. A., & Almeida, O. F. X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-05.2005 · Cited by 284
Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260
Schlüter, O. M., Xu, W., & Malenka, R. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.016 · Cited by 262
Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal
van Zundert, B., Yoshii, A., & Constantine‐Paton, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.010 · Cited by 248
Nakagawa, T., Futai, K., Lashuel, H. A., Lo, I., Okamoto, K., Walz, T., Hayashi, Y., & Sheng, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.012 · Cited by 250
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234
Synaptic nanomodules underlie the organization and plasticity of spine synapses
Hruska, M., Henderson, N., Le Marchand, S. J., Jafri, H., & Dalva, M. B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0138-9 · Cited by 233
Identification of PSD-95 Depalmitoylating Enzymes
Yokoi, N., Fukata, Y., Sekiya, A., Murakami, T., Kobayashi, K., & Fukata, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0419-16.2016 · Cited by 229
GluR1 Links Structural and Functional Plasticity at Excitatory Synapses
Kopec, C. D., Réal, É., Kessels, H. W. H. G., & Malinow, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3503-07.2007 · Cited by 226
Elias, G. M., Elias, L. A. B., Apostolides, P. F., Kriegstein, A. R., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811025106 · Cited by 223
Self-citationExcitation control: balancing PSD-95 function at the synapse
Keith, D. J. (2008) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.004.2008 · Cited by 223
Kuriu, T., Inoue, A., Bito, H., Sobue, K., & Okabe, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0522-06.2006 · Cited by 219
The neuroligin and neurexin families: from structure to function at the synapse
Lisé, M.-F., & El-Husseini, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6061-3 · Cited by 205
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
Farı́as, G. G., Alfaro, I. E., Cerpa, W. F., Grabowski, C. P., Godoy, J. A., Bonansco, C., & Inestrosa, N. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808986200 · Cited by 205
Lee, C.-C., Huang, C., Wu, M.-Y., & Hsu, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414112200 · Cited by 197
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Xu, W., Schlüter, O. M., Steiner, P., Czervionke, B. L., Sabatini, B., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.027 · Cited by 193
A three-step model for the synaptic recruitment of AMPA receptors
Opazo, P., & Choquet, D. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.014 · Cited by 190
Nithianantharajah, J., Barkus, C., Murphy, M., & Hannan, A. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.006 · Cited by 187
Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function
Yi, J. J., & Ehlers, M. D. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.1.4 · Cited by 224
A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185
Docosahexaenoic acid: one molecule diverse functions
Hashimoto, M., Hossain, S., Mamun, A. A., Matsuzaki, K., & Arai, H. (2016) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2016.1207153 · Cited by 191
PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling
Nikonenko, I., Boda, B., Steen, S., Knott, G. W., Welker, E., & Müller, D. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805132 · Cited by 176
Carlisle, H. J., Fink, A. E., Grant, S. G. N., & O’Dell, T. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163469 · Cited by 172
PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity
Xu, W. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.03.001 · Cited by 171
Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
Cao, C., Rioult-Pedotti, M. S., Migani, P., Yu, C. J., Tiwari, R. K., Parang, K., Spaller, M. R., Goebel, D. J., & Marshall, J. J. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001478 · Cited by 174
Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission
Zeng, M., Díaz-Alonso, J., Ye, F., Chen, X., Xu, J., Ji, Z., Nicoll, R. A., & Zhang, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.001 · Cited by 171
Self-citationLong-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity
Minerbi, A., Kahana, R., Goldfeld, L., Kaufman, M., Marom, S., & Ziv, N. E. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000136 · Cited by 170
TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka, A., Yan, D., & Tomita, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.035 · Cited by 167
Synaptic adhesion molecules and PSD-95
Han, K., & Kim, E. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.011 · Cited by 169
S-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95
Ho, G. P. H., Selvakumar, B., Mukai, J., Hester, L. D., Wang, Y., Gogos, J. A., & Snyder, S. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.033 · Cited by 168
Wiegert, O., Joëls, M., & Krugers, H. (2006) · Learning & Memory · doi:10.1101/lm.87706 · Cited by 162
PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane
Arendt, K. L., Royo, M., Fernández‐Monreal, M., Knafo, S., Petrok, C. N., Martens, J. R., & Esteban, J. A. (2009) · Nature Neuroscience · doi:10.1038/nn.2462 · Cited by 168
Neurogranin enhances synaptic strength through its interaction with calmodulin
Zhong, L., Cherry, T., Bies, C. E., Florence, M. A., & Gerges, N. Z. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.236 · Cited by 158
Huang, C. S., Shi, S.-H., Ule, J., Ruggiu, M., Barker, L. A., Darnell, R. B., Jan, Y. N., & Jan, L. Y. (2005) · Cell · doi:10.1016/j.cell.2005.07.033 · Cited by 157
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153
PSD-95 protects synapses from β-amyloid
Dore, K., Carrico, Z., Alfonso, S., Marino, M., Koymans, K., Kessels, H. W., & Malinow, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109194 · Cited by 149
Gerges, N. Z., Backos, D. S., & Esteban, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404982200 · Cited by 147
Dahlhaus, R., Hines, R. M., Eadie, B. D., Kannangara, T. S., Hines, D. J., Brown, C. E., Christie, B. R., & El-Husseini, A. (2009) · Hippocampus · doi:10.1002/hipo.20630 · Cited by 150
VanGuilder, H. D., Farley, J. A., Han, Y., Kirk, C. A. V., Mitschelen, M. C., Sonntag, W. E., & Freeman, W. M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.03.012 · Cited by 144
Sturgill, J., Steiner, P., Czervionke, B. L., & Sabatini, B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1841-09.2009 · Cited by 131
A single episode of neonatal seizures permanently alters glutamatergic synapses
Cornejo, B. J., Mesches, M. H., Coultrap, S. J., Browning, M. D., & Benke, T. A. (2007) · Annals of Neurology · doi:10.1002/ana.21071 · Cited by 139
Compans, B., Camus, C., Kallergi, E., Sposini, S., Martineau, M., Butler, C., Kechkar, A., Klaassen, R. V., Retailleau, N., B, T. J. S. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23133-9 · Cited by 144
Nelson, C. D., Kim, M. J., Hsin, H., Chen, Y., & Sheng, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-13.2013 · Cited by 139
PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down
Sun, Q., & Turrigiano, G. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5616-10.2011 · Cited by 135
Daoud, F., Candelario‐Martínez, A., Billard, J., Avital, A., Khelfaoui, M., Rozenvald, Y., Guégan, M., Mornet, D., Jaillard, D., Nudel, U., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006574 · Cited by 135
Synaptic protein degradation by the ubiquitin proteasome system
Bingol, B., & Schuman, E. M. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.016 · Cited by 129
Corticosterone Alters AMPAR Mobility and Facilitates Bidirectional Synaptic Plasticity
Martin, S., Henley, J. M., Holman, D., Zhou, M., Wiegert, O., van Spronsen, M., Joëls, M., Hoogenraad, C. C., & Krugers, H. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004714 · Cited by 130
Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits
Milstein, A. D., & Nicoll, R. A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.04.004 · Cited by 135
Self-citationDoublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation
Shin, E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, J. G., & Okabe, S. (2013) · Nature Communications · doi:10.1038/ncomms2443 · Cited by 134
Progressive maturation of silent synapses governs the duration of a critical period
Huang, X., Stodieck, S. K., Goetze, B., Cui, L., Wong, M. H., Wenzel, C., Hosang, L., Dong, Y., Löwel, S., & Schlüter, O. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506488112 · Cited by 136
The role of SAP97 in synaptic glutamate receptor dynamics
Howard, M. A., Elias, G. M., Elias, L. A. B., Swat, W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914422107 · Cited by 129
Self-citationNicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126
“However, the results are dif fi cult to interpret, since overexpression of PSD-95 on its own potentiates AMPAR EPSCs and occludes LTP (131, 297, 298) and the S73D mutant causes a similar potentiation.”
BackgroundSelf-citationCaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory
Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E., & Tomita, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.002 · Cited by 121
Zhang, Y., Meredith, G. E., Mendoza‐Elias, N., Rademacher, D. J., Tseng, K. Y., & Steece‐Collier, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0288-13.2013 · Cited by 125
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Metadata
- Authors
- Stein, V., House, D. R. C., Bredt, D. S., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-07-02
- Volume
- 23
- Issue
- 13
- Pages
- 5503-5506
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6741246
- OpenAlex
- W2155715182
- Cited by
- 341
- References
- 15
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 13 · 2022: 10 · 2021: 10 · 2020: 18 · 2019: 16 · 2018: 11 · 2017: 15 · 2016: 15 · 2015: 14 · 2014: 15 · 2013: 18 · 2012: 11
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Bristol-Myers Squibb
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Center for Neuroscience Research
- National Cancer Institute (R01CA094143)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- PSD-95, postsynaptic density, long-term potentiation, long-term depression, synaptic plasticity, AMPA receptors, hippocampal pyramidal neurons, miniature EPSCs, silent synapses, synaptic transmission, hippocampal slice cultures
- MeSH terms
- Disks Large Homolog 4 Protein, Animals, Cells, Cultured, Hippocampus, Humans, Luminescent Proteins, Membrane Proteins, Nerve Tissue Proteins, Neuronal Plasticity, Recombinant Fusion Proteins, Synapses, Transfection, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Intracellular Signaling Peptides and Proteins, Green Fluorescent Proteins, Rats, In Vitro Techniques
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