Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex
Abstract
Both oxytocin and oxytocin receptors are implicated in neuropsychiatric disorders, particularly autism which involves a severe deficit in social cognition. Consistently, oxytocin enhances social cognition in humans and animals. The infralimbic medial prefrontal cortex (IL-mPFC) is believed to play an important role in the regulation of social cognition which might involve top-down control of subcortical structures including the amygdala. However, little is known about whether and how oxytocin modulates synaptic function in the IL-mPFC. The effect of oxytocin on excitatory neurotransmission in the IL-mPFC was studied by examining both the evoked and spontaneous excitatory neurotransmission in the IL-mPFC layer V pyramidal neurons before and after perfusion with oxytocin. To investigate the effect of oxytocin on synaptic plasticity, low-frequency stimulation-induced long-lasting depression was studied in oxytocin-treated brain slices. Oxytocin produced a significant suppression of glutamatergic neurotransmission in the IL-mPFC layer V pyramidal neurons which was mediated by a reduction in glutamate release. Activation of the cannabinoid CB1 receptors was involved in this pre-synaptic effect. Treatment of brain slices with oxytocin for 1 h converted long-lasting depression into long-lasting potentiation of glutamatergic neurotransmission. This oxytocin-mediated plasticity was NMDA receptor-dependent and was mediated by the synaptic insertion of calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors. The aforementioned suppression of basal glutamatergic neurotransmission and facilitation of activity-dependent synaptic plasticity in the IL-mPFC might be critical for the effect of oxytocin on social cognition.
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The mPFC contains OT-sensitive neurons.
“Among the brain regions in which activities are sensitive to ingroup pain, the mPFC contains OT-sensitive neurons (Ninan, 2011).”
From A neurobiological association of revenge propensity during intergroup conflict (2020) · cites this paper as Ninan, 2011
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“…gene expression (Jurek and Neumann, 2018; Uvnas-Moberg, 2024) and synaptic plasticity in the amygdala (Gur et al., 2014), hippocampus (Lin and Hsu, 2018), and prefrontal cortex (Ninan, 2011) to support long-term adaptations in emotional responses and social behaviors (Marlin and Froemke, 2017).”
- Authors
- Ninan, I.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Ninan, Ipe
- ORCID
- Ninan, Ipe
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2011-09-20
- Volume
- 119
- Issue
- 2
- Pages
- 324-331
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1879824241
- Cited by
- 110
- References
- 69
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 12 · 2016: 3 · 2015: 7 · 2014: 11 · 2013: 11 · 2012: 4
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, medial prefrontal cortex, infralimbic cortex, glutamatergic neurotransmission, synaptic plasticity, layer 5 pyramidal neurons, glutamate release, CB1 receptor, NMDA receptor, calcium-permeable AMPA receptors, social cognition, autism spectrum disorder, oxytocin receptor
- MeSH terms
- Animals, Dose-Response Relationship, Drug, Female, Male, Mice, Inbred C57BL, Synaptic Transmission, Neuronal Plasticity, Oxytocin, Synapses, Prefrontal Cortex, Pyramidal Cells, Receptors, Oxytocin, Receptors, AMPA, Neurotransmitter Agents, Glutamic Acid, Excitatory Postsynaptic Potentials, Receptor, Cannabinoid, CB1, Mice, Electrophysiological Phenomena, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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