The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Microstructural Organization of the Cingulum Tract and the Level of Default Mode Functional Connectivity
Open accessAbstract
The default mode network is a functionally connected network of brain regions that show highly synchronized intrinsic neuronal activation during rest. However, less is known about the structural connections of this network, which could play an important role in the observed functional connectivity patterns. In this study, we examined the microstructural organization of the cingulum tract in relation to the level of resting-state default mode functional synchronization. Resting-state functional magnetic resonance imaging and diffusion tensor imaging data of 45 healthy subjects were acquired on a 3 tesla scanner. Both structural and functional connectivity of the default mode network were examined. In all subjects, the cingulum tract was identified from the total collection of reconstructed tracts to interconnect the precuneus/posterior cingulate cortex and medial frontal cortex, key regions of the default mode network. A significant positive correlation was found between the average fractional anisotropy value of the cingulum tract and the level of functional connectivity between the precuneus/posterior cingulate cortex and medial frontal cortex. Our results suggest a direct relationship between the structural and functional connectivity measures of the default mode network and contribute to the understanding of default mode network connectivity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“e.g., cingulum FA correlates with default-mode functional connectivity (van den Heuvel et al., 2008).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as van den Heuvel et al., 2008
In the citing paper
“higher FA has been associated with better functional connectivity between anatomically distant gray matter regions using resting-state fMRI (functional MRI) 35,47,48”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684
Andersson, J. L. R., Skare, S., & Ashburner, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00336-7 · Cited by 3,469
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 1×
“The T1 image was normalized to match the Montreal Neurological Institute 305 T1 template brain (Collins et al., 1994).”
MethodInvestigations into resting-state connectivity using independent component analysis
Beckmann, C. F., DeLuca, M., Devlin, J. T., & Smith, S. M. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1634 · Cited by 3,398
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371
Self-referential processing in our brain—A meta-analysis of imaging studies on the self
Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., & Panksepp, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.002 · Cited by 2,792
Wandering minds: the default network and stimulus-independent thought
Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007) · Science · doi:10.1126/science.1131295 · Cited by 2,792
Achard, S., Salvador, R., Whitcher, B., Suckling, J., & Bullmore, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3874-05.2006 · Cited by 2,393
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175
A default mode of brain function: a brief history of an evolving idea
Raichle, M. E., & Snyder, A. Z. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.041 · Cited by 2,173
Fiber Tract–based Atlas of Human White Matter Anatomy
Wakana, S., Jiang, H., Nagae‐Poetscher, L. M., van Zijl, P. C. M., & Mori, S. (2004) · Radiology · doi:10.1148/radiol.2301021640 · Cited by 2,023
Fiber tracking: principles and strategies – a technical review
Mori, S., & van Zijl, P. C. M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.781 · Cited by 2,019
Voluntary orienting is dissociated from target detection in human posterior parietal cortex
Corbetta, M., Kincade, J. M., Ollinger, J. M., McAvoy, M. P., & Shulman, G. L. (2000) · Nature Neuroscience · doi:10.1038/73009 · Cited by 1,816
Disruption of Large-Scale Brain Systems in Advanced Aging
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., & Buckner, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.038 · Cited by 1,592
Fiber tract-based atlas of human white matter anatomy
Wakana, S. (2006) · Medical Entomology and Zoology · Cited by 1,531
Cortical midline structures and the self
Northoff, G., & Bermpohl, F. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.01.004 · Cited by 1,446
Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data.
Cordes, D., Haughton, V. M., Arfanakis, K., Carew, J. D., Turski, P. A., Moritz, C. H., Quigley, M., & Meyerand, M. E. (2001) · PubMed Central · Cited by 1,402
Neurophysiological Architecture of Functional Magnetic Resonance Images of Human Brain
Salvador, R. M., John Suckling, A., Coleman, M. R., Pickard, J. D., Menon, D. K., & Bullmore, E. T. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi016 · Cited by 1,334
fMRI resting state networks define distinct modes of long-distance interactions in the human brain
De Luca, M., Beckmann, C. F., De Stefano, N., Matthews, P. M., & Smith, S. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.035 · Cited by 1,241
Reduced resting-state brain activity in the “default network” in normal aging
Damoiseaux, J. S., Beckmann, C. F., Arigita, E. J. S., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Rombouts, S. A. R. B. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm207 · Cited by 1,187 · cited 5×
“The level of overall default mode functional connectivity was significantly non-zero over the group of 45 subjects (Greicius et al., 2003; Beckmann et al., 2005; Salvador et al., 2005; De Luca et al., 2006; Damoiseaux et al., 2008; van den Heuvel et al., 2008).”
BackgroundInfluentialSchmahmann, J. D., Pandya, D. N., Wang, R., Dai, G., D'Arceuil, H. E., de Crespigny, A. J., & Wedeen, V. J. (2007) · Brain · doi:10.1093/brain/awl359 · Cited by 1,067
Disrupted small-world networks in schizophrenia
Liu, Y., Liang, M., Zhou, Y., Yong He, A., Hao, Y., Song, M., Yu, C., Liu, H., Liu, Z., & Jiang, T. (2008) · Brain · doi:10.1093/brain/awn018 · Cited by 1,038
Jones, D. K. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20033 · Cited by 794
Rombouts, S. A. R. B., Barkhof, F., Goekoop, R., Stam, C. J., & Scheltens, P. (2005) · Human Brain Mapping · doi:10.1002/hbm.20160 · Cited by 734
Wise, R. G., Ide, K., Poulin, M. J., & Tracey, I. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.025 · Cited by 664
RESTORE: Robust estimation of tensors by outlier rejection
Chang, L., Jones, D. K., & Pierpaoli, C. M. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20426 · Cited by 611
Bluhm, R. L., Miller, J., Lanius, R. A., Osuch, E. A., Boksman, K., Neufeld, R. W. J., Théberge, J., Schaefer, B., & Williamson, P. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm052 · Cited by 578
Stam, C. J. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.063 · Cited by 550
Unrest at rest: Default activity and spontaneous network correlations
Buckner, R. L., & Vincent, J. L. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.010 · Cited by 523
Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
Zhang, Y., Schuff, N. W., Jahng, G., Bayne, W., Mori, S., Schad, L. R., Mueller, S. G., Du, A., Kramer, J. H., Yaffe, K. S., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000250326.77323.01 · Cited by 513
An investigation of functional and anatomical connectivity using magnetic resonance imaging
Koch, M. A., Norris, D. G., & Hund-Georgiadis, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.1052 · Cited by 509
Small-world networks and disturbed functional connectivity in schizophrenia
Micheloyannis, S., Pachou, E., Stam, C. J., Breakspear, M. J., Bitsios, P., Vourkas, M., Erimaki, S., & Zervakis, M. E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.06.028 · Cited by 435
Normalized Cut Group Clustering of Resting-State fMRI Data
van den Heuvel, M. P., Mandl, R. C. W., & Pol, H. E. H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002001 · Cited by 418
Self-citationSun, F. T., Miller, L. M., & D’Esposito, M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.056 · Cited by 406
Liang, M., Zhou, Y., Jiang, T., Liu, Z., Tian, L., Liu, H., & Hao, Y. (2006) · Neuroreport · doi:10.1097/01.wnr.0000198434.06518.b8 · Cited by 402
Lawes, I. N. C., Barrick, T. R., Murugam, V., Spierings, N. M. K., Evans, D. R., Song, M., & Clark, C. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.041 · Cited by 379
Schizophrenia and the disconnection hypothesis
Friston, K. J. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb05985.x · Cited by 330
Johnston, J. M., Vaishnavi, S. N., Smyth, M. D., Zhang, D., He, B. J., Zempel, J. M., Shimony, J. S., Snyder, A. Z., & Raichle, M. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0573-08.2008 · Cited by 296
Relevance to self: A brief review and framework of neural systems underlying appraisal
Schmitz, T. W., & Johnson, S. C. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.12.003 · Cited by 282
A Model-Based Method for Retrospective Correction of Geometric Distortions in Diffusion-Weighted EPI
Andersson, J., & Skare, S. T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1039 · Cited by 273
Kim, J. H., Loy, D. N., Liang, H., Trinkaus, K. M., Schmidt, R. E., & Song, S. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21316 · Cited by 173
Toosy, A., Ciccarelli, O., Parker, G. J. M., Wheeler‐Kingshott, C. A. M. G., Miller, D. H., & Thompson, A. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.022 · Cited by 172
Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study
Sun, Z., Wang, F., Cui, L., Breeze, J. L., Du, X., Wang, X., Cong, Z., Zhang, H., Li, B., Hong, N., et al. (2003) · Neuroreport · doi:10.1097/00001756-200310060-00015 · Cited by 171
Are Anticorrelated Networks in the Brain Relevant to Schizophrenia?
Williamson, P. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm043 · Cited by 125
Frontal connections and cognitive changes in normal aging rhesus monkeys: A DTI study.
Makris, N., Papadimitriou, G. M., van der Kouwe, A., Kennedy, D. N., Hodge, S. M., Dale, A. M., Benner, T., Wald, L. L., Wu, O., Tuch, D. S., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.005 · Cited by 115
Neggers, S. F. W., Hermans, E. J., & Ramsey, N. F. (2008) · NMR in Biomedicine · doi:10.1002/nbm.1235 · Cited by 114
Attentional networks and cingulum bundle in chronic schizophrenia☆
Nestor, P. G., Kubicki, M. R., Spencer, K., Niznikiewicz, M. A., McCarley, R. W., & Shenton, M. E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.10.005 · Cited by 112
Salvador, R. M., Martínez-Pérez, Á., Pomarol‐Clotet, E., Sarró, S., John Suckling, A., & Bullmore, E. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.001 · Cited by 89
Region-specific changes of cerebral white matter during normal aging: A diffusion-tensor analysis
Yoon, B., Shim, Y., Lee, K., Shon, Y., & Yang, D. (2007) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2007.07.004 · Cited by 75
Evaluation of bilateral cingulum with tractography in patients with Alzheimer’s disease
Xie, S., Xiao, J. X., Wang, Y. H., Wu, H. K., Gong, G. L., & Jiang, X. X. (2005) · NeuroReport · doi:10.1097/01.wnr.0000174061.41897.ee · Cited by 68
Myelination shapes functional activity in the developing brain
Fornari, E., Knyazeva, M. G., Meuli, R. A., & Maeder, P. P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.010 · Cited by 66
Does, M. D., & Gore, J. C. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200006)43:6 · Cited by 62
Diffusion Tensor Anisotropy in Adolescents and Adults
Schneiderman, J. S., Buchsbaum, M. S., Haznedar, M. M., Hazlett, E. A., Brickman, A. M., Shihabuddin, L., Brand, J. G., Torosjan, Y., Newmark, R. E., Tang, C. Y., et al. (2007) · Neuropsychobiology · doi:10.1159/000104277 · Cited by 51
Seo, Y., Shinar, H., Morita, Y., & Navon, G. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199909)42:3 · Cited by 19
Biswal (1997) · doi:10.1002/(sici)1099-1492(199706/08)10:4/5
Research works printed but not linked: 1
- van den Heuvel, 2007, Anatomical dependence of resting-state networks, Soc Neurosci Abstr, 33, 761
Cited by
Sorted by citations
Exploring the brain network: A review on resting-state fMRI functional connectivity
van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.03.008 · Cited by 3,326
Rich-club organization of the human connectome
van den Heuvel, M. P., & Sporns, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3539-11.2011 · Cited by 2,354
The human connectome: a complex network
Sporns, O. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05888.x · Cited by 1,440
Efficiency of Functional Brain Networks and Intellectual Performance
van den Heuvel, M. P., Stam, C. J., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-09.2009 · Cited by 1,078
van den Heuvel, M. P., Mandl, R. C. W., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Human Brain Mapping · doi:10.1002/hbm.20737 · Cited by 987
Self-citation
Metadata
- Authors
- van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff Pol, H.
- Affiliations
- Utrecht University (NL)
- ORCID
- Mandl, René
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-10-22
- Volume
- 28
- Issue
- 43
- Pages
- 10844-10851
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671361
- OpenAlex
- W1997491128
- Cited by
- 349
- References
- 63
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 15 · 2023: 14 · 2022: 13 · 2021: 20 · 2020: 16 · 2019: 12 · 2018: 25 · 2017: 33 · 2016: 21 · 2015: 22 · 2014: 29 · 2013: 27 · 2012: 24
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- default mode network, resting-state functional connectivity, structural connectivity, fractional anisotropy, precuneus, posterior cingulate cortex, medial frontal cortex, white matter tracts
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Neural Pathways, Oxygen, Rest
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
