Site of origin of and sex differences in the vasopressin innervation of the mouse ( Mus musculus ) brain

Rood, Benjamin D.; Stott, Ryan T.; You, Samantha; Smith, Caroline J.W.; Woodbury, Maya E.; De Vries, Geert J.

doi:10.1002/cne.23288

Cited by 120Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

Site of origin of and sex differences in the vasopressin innervation of the mouse ( Mus musculus ) brain

Rood, Benjamin D., Stott, Ryan T., You, Samantha, Smith, Caroline J.W., Woodbury, Maya E., De Vries, Geert J.·2013·Journal of Comparative Neurology

DOI 10.1002/cne.23288

Open this paper in CoChat — free account

Abstract

Defining how arginine vasopressin (AVP) acts centrally to regulate homeostasis and behavior is problematic, as AVP is made in multiple nuclei in the hypothalamus (i.e., paraventricular [PVN], supraoptic [SON], and suprachiasmatic [SCN]) and extended amygdala (i.e., bed nucleus of the stria terminalis [BNST] and medial amygdala [MeA]), and these groups of neurons have extensive projections throughout the brain. To understand the function of AVP, it is essential to know the site of origin of various projections. In mice, we used gonadectomy to eliminate gonadal steroid hormone-dependent expression of AVP in the BNST and MeA and electrolytic lesions to eliminate the SCN, effectively eliminating those AVP-immunoreactive projections; we also quantified AVP-immunoreactive fiber density in gonadectomized and sham-operated male and female mice to examine sex differences in AVP innervation. Our results suggest that the BNST/MeA AVP system innervates regions containing major modulatory neurotransmitters (e.g., serotonin and dopamine) and thus may be involved in regulating behavioral state. Furthermore, this system may be biased toward the regulation of male behavior, given the numerous regions in which males have a denser AVP-immunoreactive innervation than females. AVP from the SCN is found in regions important for the regulation of hormone output and behavior. Innervation from the PVN and SON is found in brain regions that likely work in concert with the well-known peripheral AVP actions of controlling homeostasis and stress response; female-biased sex differences in this system may be related to the heightened stress response observed in females.

Integrity signals

Registry

Crossref · 10.1002/cne.23288

Cites

103 of 103 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

AVP-ir fibers, and to a lesser extent OT-ir fibers and their receptors, have been observed in several forebrain constituents of the SBNN in rodents.
“AVP-ir fibers, and, to a lesser extent, OT-ir fibers and their receptors have been observed in several forebrain constituents of the “social behavior neural network” (SBNN) in rodents”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Rood et al., 2013
Male rodents have 2 to 3 times as many vasopressin cells as females in the bed nucleus of the stria terminalis/medial amygdala and pronounced sex-different projections to areas involved in social behavior such as the ventral pallidum, lateral septum, lateral habenula, dorsal raphe, periaqueductal gray, and other forebrain areas.
“For example, male rodents have 2 to 3 times as many AVP cells as females in the BNST/MeA and pronounced sex-different projections to areas involved in social behavior such as the ventral pallidum, lateral septum (LS), lateral habenula, dorsal raphe (DR), periaqueductal gray, as well as other forebrain areas (33, 60)”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [60]
The bed nucleus of the stria terminalis and medial amygdala contribute to the most pronounced sex difference in vasopressin innervation in the brain.
“Indeed, the BNST and MeA contribute to the most pronounced sex difference in AVP innervation in the brain (33,60).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [60]
Although the number of paraventricular vasopressin neurons does not appear to differ by sex, central projections from these neurons are generally denser in female than in male mice.
“Although the number of PVN AVP neurons do not appear to differ by sex, central projections from these neurons are generally denser in female than in male mice (60).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [60]
The female bias in the effects of similar manipulations of paraventricular vasopressin cells may be related to females having denser paraventricular vasopressin projections compared to males.
“The female bias in the effects of similar manipulations of PVN AVP cells may be related to females having denser PVN AVP projections compared to males (60).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [60]

The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796 · see citing works
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379 · see citing works
Sex and depression in the National Comorbidity Survey, I: lifetime prevalence, chronicity and recurrence
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · cited 1× · see citing works
“Thus the female-dominant sex differences in AVP innervation may be especially relevant given that females appear to be particularly vulnerable to stress-related disorders (Kessler et al., 1993, 1995; Young and Altemus, 2004).”
Background
Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039 · see citing works
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Azmitia, E. C., & Segal, M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901790311 · Cited by 1,908 · see citing works
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150 · see citing works
HANDBOOK OF EXPERIMENTAL PHARMACOLOGY
Reichlin, S. (1969) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196911000-00008 · Cited by 1,139 · see citing works
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029 · see citing works
Paraventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms
Swanson, L. W., & Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000123111 · Cited by 1,001 · see citing works
The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness
Van der Werf, Y. D., Witter, M. P., & Groenewegen, H. J. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00181-9 · Cited by 994 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891 · see citing works
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830 · see citing works
Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
Abrahamson, E. E., & Moore, R. Y. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02890-6 · Cited by 788 · see citing works
Psychomotor stimulant addiction: a neural systems perspective
Everitt, B. J., & Wolf, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03312.2002 · Cited by 700 · see citing works
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576 · see citing works
The hypothalamic integrator for circadian rhythms
Saper, C. B., Lü, J., Chou, T. C., & Gooley, J. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.12.009 · Cited by 528 · see citing works
The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum
de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524 · see citing works
Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus
Lolait, S. J., O'Carroll, A.-M., McBride, O. W., Konig, M., Morel, A., & Brownstein, M. J. (1992) · Nature · doi:10.1038/357336a0 · Cited by 524 · cited 1× · see citing works
“…(Yates et al., 1971), and the pathway ending in the posterior pituitary is crucial for peripheral AVP release, which affects distal target organs such as the liver, kidney, heart, and blood vessels (Lolait et al., 1992; Morel et al., 1992; Ostrowski et al., 1992, 1993, 1994; Saito et al., 1995).”
Background
The vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522 · see citing works
A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits
De Vries, G. J., Rissman, E. F., Simerly, R. B., Yang, L.-Y., Scordalakes, E. M., Auger, C. J., Swain, A., Lovell-Badge, R., Burgoyne, P. S., & Arnold, A. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09005.2002 · Cited by 509 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretory system of the rat
Vandesande, F., & Dierickx, K. (1975) · Cell and Tissue Research · doi:10.1007/bf00218970 · Cited by 496 · see citing works
Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters
Ferris, C. F., Melloni Jr, R. H., Koppel, G., Perry, K. W., Fuller, R. W., & Delville, Y. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04331.1997 · Cited by 495 · see citing works
Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488 · see citing works
Molecular cloning and expression of a rat Via arginine vasopressin receptor
Morel, A., O'Carroll, A.-M., Brownstein, M. J., & Lolaft, S. J. (1992) · Nature · doi:10.1038/356523a0 · Cited by 477 · see citing works
Nucleus Tractus Solitarius—Gateway to Neural Circulatory Control
Andresen, M. C., & Kunze, D. L. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.000521 · Cited by 470 · see citing works
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis
Pow, D. V., & Morris, J. F. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90091-2 · Cited by 446 · see citing works
Habenula: crossroad between the basal ganglia and the limbic system
Hikosaka, O., Sesack, S. R., Lecourtier, L., & Shepard, P. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-08.2008 · Cited by 432 · see citing works
Is social attachment an addictive disorder?
Insel, T. R. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00148-3 · Cited by 430 · see citing works
Modulation of social memory in male rats by neurohypophyseal peptides
Dantzer, R., Bluthe, R. M., Koob, G. F., & Le Moal, M. (1987) · Psychopharmacology · doi:10.1007/bf00518192 · Cited by 423 · see citing works
Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat
Christoph, G., Leonzio, R., & Wilcox, K. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00613.1986 · Cited by 418 · see citing works
Untitled work
Young (1999) · doi:10.1038/23650 · Cited by 389 · see citing works
Role of septal vasopressin innervation in paternal behavior in prairie voles (Microtus ochrogaster).
Wang, Z., Ferris, C. F., & De Vries, G. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.400 · Cited by 381 · see citing works
A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K., & Wang, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03483.2003 · Cited by 351 · see citing works
Sexual differentiation of central vasopressin and vasotocin systems in vertebrates: different mechanisms, similar endpoints
De Vries, G. J., & Panzica, G. C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.050 · Cited by 346 · see citing works
The Concepts of the Ventral Striatopallidal System and Extended Amygdala
de Olmos, J. S., & Heimer, L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09258.x · Cited by 343 · see citing works
Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
Lim, M. M., & Young, L. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.008 · Cited by 322 · see citing works
Ontogeny of the vasopressinergic neurons of the suprachiasmatic nucleus and their extrahypothalamic projections in the rat brain–presence of a sex difference in the lateral septum
De Vries, G. J., Buds, R. M., & Swaab, D. F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90989-6 · Cited by 319 · see citing works
Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens
Bakker, J., De Mees, C., Douhard, Q., Balthazart, J., Gabant, P., Szpirer, J., & Szpirer, C. (2006) · Nature Neuroscience · doi:10.1038/nn1624 · Cited by 305 · see citing works
Vasopressin cells in the medial amygdala of the rat project to the lateral septum and ventral hippocampus
Caffé, A. R., van Leeuwen, F. W., & Luiten, P. G. M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902610206 · Cited by 286 · see citing works
Cellular localization of vasopressin V1a receptor messenger ribonucleic acid in adult male rat brain, pineal, and brain vasculature.
Ostrowski, N. L., Lolait, S. J., & Young, W. S. (1994) · Endocrinology · doi:10.1210/endo.135.4.7925112 · Cited by 284 · see citing works
A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition
Lecourtier, L., & Kelly, P. H. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.004 · Cited by 283 · see citing works
A Diurnal Rhythm of Stimulatory Input to the Hypothalamo–Pituitary–Adrenal System as Revealed by Timed Intrahypothalamic Administration of the Vasopressin V1Antagonist
Kalsbeek, A., van Heerikhuize, J. J., Wortel, J., & Buijs, R. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05555.1996 · Cited by 274 · see citing works
Vasopressin injected into the hypothalamus triggers a stereotypic behavior in golden hamsters
Ferris, C. F., Albers, H. E., Wesolowski, S. M., Goldman, B. D., & Luman, S. E. (1984) · Science · doi:10.1126/science.6538700 · Cited by 255 · see citing works
Sex Chromosome Complement and Gonadal Sex Influence Aggressive and Parental Behaviors in Mice
Gatewood, J. D., Wills, A., Shetty, S. R. J., Xu, J., Arnold, A. P., Burgoyne, P. S., & Rissman, E. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3743-05.2006 · Cited by 247 · see citing works
Potentiation by Vasopressin of Corticotropin Release Induced by Corticotropin-Releasing Factor1
Yates, F. E., Russell, S. M., Dallman, M. F., Hedge, G. A., McCann, S. M., & DHARIWAL, A. P. S. (1971) · Endocrinology · doi:10.1210/endo-88-1-3 · Cited by 245 · see citing works
Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus
Yang, L.-M., Hu, B., Xia, Y.-H., Zhang, B.-L., & Zhao, H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.022 · Cited by 236 · see citing works
Distribution of V1a and V2 vasopressin receptor messenger ribonucleic acids in rat liver, kidney, pituitary and brain
Ostrowski, N. L., Lolait, S. J., Bradley, D. J., O’Carroll, A., Brownstein, M. J., & Young, W. S. (1992) · Endocrinology · doi:10.1210/endo.131.1.1535312 · Cited by 236 · see citing works
Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain
De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224 · see citing works
Vasopressin fiber pathways in the rat brain following suprachiasmatic nucleus lesioning
Hoorneman, E. M. D., & Buijs, R. M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90246-3 · Cited by 211 · see citing works
Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., 三島, 健., Iwasaki, K., & Fujiwara, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.009 · Cited by 193 · see citing works
Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats
De Vries, G., Wang, Z., Bullock, N., & Numan, S. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01789.1994 · Cited by 193 · see citing works
Vasopressin and the Output of the Hypothalamic Biological Clock
Kalsbeek, A., Fliers, E., Hofman, M. A., Swaab, D. F., & Buijs, R. M. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01956.x · Cited by 192 · see citing works
Chapter 1.1 Anatomy and function of extrahypothalamic vasopressin systems in the brain
Vries, G. J. D., & MILLER, M. A. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61558-7 · Cited by 183 · see citing works
Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion
Jørgensen, H., Riis, M., Knigge, U., Kjær, A., & Warberg, J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00978.x · Cited by 182 · see citing works
Transgenic Expression of Enhanced Green Fluorescent Protein Enables Direct Visualization for Physiological Studies of Vasopressin Neurons and Isolated Nerve Terminals of the Rat
Ueta, Y., Fujihara, H., Serino, R., Dayanithi, G., Ozawa, H., Matsuda, K., Kawata, M., Yamada, J., Ueno, S., Fukuda, A., et al. (2004) · Endocrinology · doi:10.1210/en.2004-0830 · Cited by 160 · see citing works
Vasopressin induces a luteinizing hormone surge in ovariectomized, estradiol-treated rats with lesions of the suprachiasmatic nucleus
Palm, I. F., van der Beek, E. M., Wiegant, V. M., Buijs, R. M., & Kalsbeek, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00106-2 · Cited by 159 · see citing works
Lateral parabrachial nucleus and serotonergic mechanisms in the control of salt appetite in rats
Menani, J. V., Thunhorst, R. L., & Johnson, A. K. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.1.r162 · Cited by 157 · see citing works
Evidence for Suprachiasmatic Vasopressin Neurones Innervating Kisspeptin Neurones in the Rostral Periventricular Area of the Mouse Brain: Regulation by Oestrogen
Vida, B., Deli, L., Hrabovszky, E., Kalamatianos, T., Caraty, A., Coen, C. W., Liposits, Z., & Kalló, I. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02045.x · Cited by 156 · see citing works
Expression of vasopressin V1a and V2 receptor messenger ribonucleic acid in the liver and kidney of embryonic, developing, and adult rats
Ostrowski, N. L., Young, W. S., Knepper, M. A., & Lolait, S. J. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404628 · Cited by 152 · see citing works
Serotonin blocks vasopressin-facilitated offensive aggression: Interactions within the ventrolateral hypothalamus of golden hamsters
Delville, Y. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02166-3 · Cited by 149 · see citing works
Neurobiological Mechanisms of Aggression and Stress Coping: A Comparative Study in Mouse and Rat Selection Lines
Veenema, A. H., & Neumann, I. D. (2007) · Brain Behavior and Evolution · doi:10.1159/000105491 · Cited by 149 · see citing works
Social recognition does not involve vasopressinergic neurotransmission in female rats
Bluthe´, R.-M., & Dantzer, R. (1990) · Brain Research · doi:10.1016/0006-8993(90)91613-l · Cited by 147 · see citing works
The neurophysin-containing innervation of the forebrain of the mouse
Castel, M., & Morris, J. F. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90078-4 · Cited by 143 · see citing works
The influence of androgens on the development of a sex difference in the vasopressinergic innervation of the rat lateral septum
Vries, G. J. D., Best, W., & Sluiter, A. A. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90019-6 · Cited by 141 · see citing works
Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei
Li, J., Burton, K. J., Zhang, C., Hu, S.-B., & Zhou, Q. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90463.2008 · Cited by 135 · see citing works
Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord
Hallbeck, M., Larhammar, D., & Blomqvist, A. G. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1137 · Cited by 135 · see citing works
Vasopressin innervation of the mouse ( <i>Mus musculus</i> ) brain and spinal cord
Rood, B. D., & De Vries, G. J. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22635 · Cited by 134 · see citing works
Medial amygdala and aggressive behavior: Interaction between testosterone and vasopressin
Koolhaas, J. M., Brink, T. H. C. V. D., Roozendaal, B., & Boorsma, F. (1990) · Aggressive Behavior · doi:10.1002/1098-2337(1990)16:3/4 · Cited by 134 · see citing works
Sex differences in hormonal responses of vasopressin pathways in the rat brain
De Vries, G. J., & Al‐Shamma, H. A. (1990) · Journal of Neurobiology · doi:10.1002/neu.480210503 · Cited by 129 · see citing works
Sex differences in vasopressin neurons in the bed nucleus of the stria terminalis by in situ hybridization
MILLER, M. A., Vician, L. J., Clifton, D. K., & Dorsa, D. M. (1989) · Peptides · doi:10.1016/0196-9781(89)90152-6 · Cited by 126 · see citing works
Neurochemical regulation of pair bonding in male prairie voles
Wang, Z., & Aragona, B. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.024 · Cited by 125 · see citing works
Molecular Cloning and Characterization of Rat V1B Vasopressin Receptor: Evidence for Its Expression in Extrapituitary Tissues
Saito, M., Sugimoto, T., Tahara, A., & Kawashima, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2033 · Cited by 124 · see citing works
Puberty, Ovarian Steroids, and Stress
Young, E. A., & Altemus, M. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1308.013 · Cited by 123 · see citing works
Sexual differentiation of vasopressin projections of the bed nucleus of the stria terminals and medial amygdaloid nucleus in rats.
Wang, Z., Bullock, N. A., & De Vries, G. J. (1993) · Endocrinology · doi:10.1210/endo.132.6.8504734 · Cited by 123 · see citing works
Decline of vasopressin immunoreactivity and mRNA levels in the bed nucleus of the stria terminalis following castration
Miller, M., DeVries, G., al-Shamma, H., & Dorsa, D. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-08-02881.1992 · Cited by 122 · see citing works
Cellular localization of vasopressin V1a receptor messenger ribonucleic acid in adult male rat brain, pineal, and brain vasculature
Ostrowski, N. L., Lolait, S. J., & Young, W. S. (1994) · Endocrinology · doi:10.1210/en.135.4.1511 · Cited by 119 · see citing works
Organizational effects of testosterone, estradiol, and dihydrotestosterone on vasopressin mRNA expression in the bed nucleus of the stria terminalis
Han, T. M., & De Vries, G. J. (2003) · Journal of Neurobiology · doi:10.1002/neu.10157 · Cited by 116 · see citing works
Serotonin and neuropeptides in affiliative behaviors
Insel, T. R., & Winslow, J. T. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00094-8 · Cited by 105 · see citing works
Opposite actions of hypothalamic vasopressin on circadian corticosterone rhythm in nocturnal versus diurnal species
Kalsbeek, A., Verhagen, L. A. W., Schalij, I., Foppen, E., Saboureau, M., Bothorel, B., Buijs, R. M., & Pévet, P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06057.x · Cited by 100 · see citing works
Multiple telencephalic and extratelencephalic embryonic domains contribute neurons to the medial extended amygdala
Bupesh, M., Legáz, I., Abellán, A., & Medina, L. M. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22581 · Cited by 89 · see citing works
Sex differences in corticotropin-releasing factor signaling and trafficking
Bangasser, D. A., Curtis, A. L., Reyes, B. A. S., Bethea, T. T., Parastatidis, I., Ischiropoulos, H., Bockstaele, E. J. V., & Valentino, R. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.89 · Cited by 83 · see citing works
Involvement of lateral habenula-dorsal raphe neurons in the differential regulation of striatal and nigral serotonergic transmission cats
Reisine, T., Soubrié, P., Artaud, F., & Glowinski, J. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-08-01062.1982 · Cited by 80 · see citing works
Androgen and Estrogen Effects on Vasopressin Messenger RNA Expression in the Medial Amygdaloid Nucleus in Male and Female Rats
Wang, Z., & De Vries, G. J. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00722.x · Cited by 77 · see citing works
Vasopressin cell groups exhibit strongly divergent responses to copulation and male-male interactions in mice
Ho, J. M., Murray, J. H., Demas, G. E., & Goodson, J. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.021 · Cited by 76 · see citing works
Exaggerated Response of Arginine Vasopressin‐Enhanced Green Fluorescent Protein Fusion Gene to Salt Loading without Disturbance of Body Fluid Homeostasis in Rats
Fujio, T., Fujihara, H., Shibata, M., Yamada, S., Onaka, T., Tanaka, K., Morita, H., Dayanithi, G., Kawata, M., Murphy, D., et al. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01476.x · Cited by 59 · see citing works
Sex and strain variability in the rat hypothalamo-pituitary-adrenal (HPA) axis function
Chisari, A. N., Carino, M. H., Perone, M. J., Gaillard, R. C., & Spinedi, E. (1995) · Journal of Endocrinological Investigation · doi:10.1007/bf03349692 · Cited by 59 · see citing works
Vasopressin involvement in antipyresis, social communication, and social recognition: a synthesis.
Dantzer, R., & Bluthé, R.-M. (1992) · PubMed · Cited by 55 · see citing works
Gonadal steroids influence neurophysin II distribution in the forebrain of normal and mutant mice
Mayes, C. R., Watts, A. G., McQueen, J., Fink, G., & Charlton, H. M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90054-1 · Cited by 54 · see citing works
Does the release of vasopressin within the supraoptic nucleus of the rat brain depend upon changes in osmolality and Ca2+/K+?
Ludwig, M., & Landgraf, R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90685-3 · Cited by 46 · see citing works
Serotonin and vasopressin interact in the hypothalamus to control communicative behavior
Albers, E. H., Karom, M. C., & Smith, D. (2002) · Neuroreport · doi:10.1097/00001756-200205240-00006 · Cited by 44 · see citing works
Gonadal Steroid Modulation of Vasopressin Pathwaysa
Vries, G. J. D., Crenshaw, B. J., & AL‐SHAMMA, H. A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34369.x · Cited by 38 · see citing works
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat
Yang, J., Yang, Y., Xu, H., Chen, J.-M., Liu, W., & Lin, B.-C. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.01.006 · Cited by 38 · see citing works
Vasopressin augments depolarization-induced release and synthesis of serotonin in hippocampal slices
Auerbach, S. B., & Lipton, P. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-04-00477.1982 · Cited by 36 · see citing works
Differential ventral septal vasopressin release is associated with sexual dimorphism in PGE2 fever
Chen, X., Landgraf, R., & Pittman, Q. J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.5.r1664 · Cited by 31 · see citing works
Ontogeny of bidirectional connections between the medial nucleus of the amygdala and the principal bed nucleus of the stria terminalis in the rat
Cooke, B. M., & Simerly, R. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20612 · Cited by 31 · see citing works
Absence of progestin receptors alters distribution of vasopressin fibers but not sexual differentiation of vasopressin system in mice
Rood, B. D., Murray, E. K., Laroche, J., Yang, M. K., Blaustein, J. D., & De Vries, G. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.087 · Cited by 30 · see citing works
Flank-marking behavior and the neural distribution of vasopressin innervation in golden hamsters with suprachiasmatic lesions.
Delville, Y., Vries, G. J. D., Schwartz, W. J., & Ferris, C. F. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1486 · Cited by 24 · see citing works
Flank-marking behavior and the neural distribution of vasopressin innervation in golden hamsters with suprachiasmatic lesions.
Delville, Y., Vries, G. J. D., Schwartz, W. J., et al. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1486 · Cited by 20 · see citing works
The distribution of vasopressin- or oxytocin-neurons projecting to the posterior pituitary as revealed by a combination of retrograde transport of horseradish peroxidase and immunohistochemistry.
Taniguchi, Y., Yoshida, M., Ishikawa, K., Suzuki, M., & Kurosumi, K. (1988) · Archivum histologicum japonicum · doi:10.1679/aohc.51.83 · Cited by 17 · see citing works
Vasopressin: more than just an output of the circadian pacemaker? Focus on “Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei”
Bittman, E. L. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90991.2008 · Cited by 15 · see citing works

Flagged first, then by citations

Sorted by citations

Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“…of rodent species (summarized in De Vries & Panzica, 2006), including mice (De Vries et al., 2002; Bakker et al., 2006; Gatewood et al., 2006; Rood et al., 2013), voles (Wang, 1995; Wang et al., 1996; Lonstein & De Vries, 1999), gerbils (Crenshaw et al., 1992), European hamsters (but…”
Background
The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions
Sheng, J. A., Bales, N. J., Myers, S. A., Bautista, A. I., Roueinfar, M., Hale, T. M., & Handa, R. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601939 · Cited by 418 · see citing works
Sex Differences in the HPA Axis
Goel, N., Workman, J. L., Lee, T. T., Innala, L., & Viau, V. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130054 · Cited by 448 · see citing works
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348 · see citing works
Targeted activation of the hippocampal CA2 area strongly enhances social memory
Smith, A. S., Williams Avram, S. K., Cymerblit-Sabba, A., Song, J., & Young, W. S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.189 · Cited by 236 · see citing works
“1) 22 .”
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
“…vasopressin system (vasopressinproducing cells in the bed nucleus of the stria terminalis and the medial amygdala) is established early postnatally and is sexually dimorphic with much greater vasopressin production in males (De Vries et al, 1981; Szot and Dorsa, 1993; Rood et al, 2013).”
Background
What's in a name? Considerations of homologies and nomenclature for vertebrate social behavior networks
Goodson, J. L., & Kingsbury, M. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.05.006 · Cited by 156 · see citing works
“In mammals, most of the direct VP–OT innervation of the brain appears to come from the PVN, particularly in the case of OT (much of the VP arises from extrahypothalamic sites), although the supraoptic nucleus likely makes a contribution, as well (De Vries and Buijs, 1983; Rood et al., 2013 ).”
Social functions of individual vasopressin–oxytocin cell groups in vertebrates: What do we really know?
Kelly, A. M., & Goodson, J. L. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.04.005 · Cited by 141 · see citing works
“(2013) show that lesions of the SCN produce significant reductions in the VP-ir innervation of forebrain regions that are important for such processes, including the BSTm, POA, dorsomedial hypothalamus, and numerous areas of the medial hypothalamus (Rood et al., 2013).”
BackgroundInfluential
Hypothalamic oxytocin and vasopressin neurons exert sex-specific effects on pair bonding, gregariousness, and aggression in finches
Kelly, A. M., & Goodson, J. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322554111 · Cited by 106 · see citing works
“Previous findings show that knockdown of VP production in the BSTm reduces gregariousness in males but not in females, and thus gregariousness is related to nonapeptide production in a sexually differentiated pattern across the cell groups of the PVN and BSTm.”
BackgroundInfluential
Separate effects of sex hormones and sex chromosomes on brain structure and function revealed by high-resolution magnetic resonance imaging and spatial navigation assessment of the Four Core Genotype mouse model
Corre, C., Friedel, M., Vousden, D. A., Metcalf, A., Spring, S., Qiu, L. R., Lerch, J. P., & Palmert, M. R. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0952-0 · Cited by 98 · see citing works
“2014) or looked at vasopressin innervation (Rood et al. 2013); we hope that our whole-brain coverage will generate novel hypotheses and follow-up studies to further investigate the regions identified here as being influenced by steroids or sex chromosomes.”
Background
Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring
Sussman, D., Germann, J., & Henkelman, R. M. (2014) · Brain and Behavior · doi:10.1002/brb3.300 · Cited by 96 · see citing works
“The effects of gender on rodent neurobehavior have been previously reported (van Haaren et al. 1990; Lopez-Aumatell et al. 2008; Breu et al. 2012; Kazutaka et al. 2012; Rood et al. 2012); however, the underlying mechanisms remain unknown.”
Afferent projections to the different medial amygdala subdivisions: a retrograde tracing study in the mouse
Cádiz‐Moretti, B., Otero‐García, M., Martínez‐Garciá, F., & Lanuza, E. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0954-y · Cited by 88 · see citing works
“On the other hand, the MeA is interconnected mainly with the BSTMPI, where sexual dimorphism is less apparent, but affects at least a population of vasopressinergic cells (Rood et al. 2013; Otero-Garcia et al. 2014).”
Background
Sex Differences in the HPA Axis
Goel, N., Workman, J. L., Lee, T. T., Innala, L., & Viau, V. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00575.x · Cited by 82 · see citing works
“Reports on sex differences in basal AVP expression convey mixed results, including no sex differences in mRNA or immunoreactivity, greater mRNA in females, and lower immunoreactivity in female rodents (73, 85, 317, 381).”
Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice
Otero‐García, M., Agustín‐Pavón, C., Lanuza, E., & Martínez‐Garciá, F. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1111-y · Cited by 76 · see citing works
Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network
DiBenedictis, B. T., Nussbaum, E. R., Cheung, H. K., & Veenema, A. H. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24216 · Cited by 74 · see citing works
“, 1992; Szot & Dorsa, 1993) as well as in several other species, including mice and prairie voles (Bamshad, Novak, & De Vries, 1993; Rood et al., 2013).”
BackgroundMethodInfluential
Sexually dimorphic vasopressin cells modulate social investigation and communication in sex-specific ways
Rigney, N., Whylings, J., Mieda, M., de Vries, G. J., & Petrulis, A. (2019) · eNeuro · doi:10.1523/eneuro.0415-18.2019 · Cited by 63 · see citing works
“…1998), it may simply mean that, as with aggressive behavior, AVP cells in the BNST are not critically involved in anxiety-like behaviors, and that AVP derived from other sources, such as the PVN or the amygdala (Rood et al., 2013), also drive AVP’s anxiogenic action in the septum and elsewhere.”
BackgroundInfluential
Social preference and maternal defeat-induced social avoidance in virgin female rats: Sex differences in involvement of brain oxytocin and vasopressin
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 63 · see citing works
Sex differences in daily timekeeping and circadian clock circuits
Joye, D. A. M., & Evans, J. A. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.026 · Cited by 61 · see citing works
Modulation of social behavior by distinct vasopressin sources
Rigney, N., Vries, G. J. D., & Petrulis, A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1127792 · Cited by 61 · see citing works
“Brain regions that lose AVP innervation following gonadectomy (46) or BNST lesions (47, 64): (LS), lateral septum; (VP), ventral pallidum; (HBD)horizontal diagonal band; (MPOA) medial preoptic area; (LPO) lateral preoptic area; (LHb) lateral habenula; (EA) extended amygdala; (MeA) medial amygdala; (LH) lateral hypotha…”
BackgroundInfluential
Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: implications for cross-system signaling
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
“…et al., 1981; Caffe et al., 1987) as well as of other rodent species with higher AVP-ir fiber density in adult males versus adult females in mice (Rood et al., 2013), gerbils (Crenshaw et al., 1992), European hamsters (Buijs et al., 1986) and prairie, pine, meadow and montane voles (Table 2;…”
Background
Stress, sex, and addiction
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 60 · see citing works
“states (Rood et al., 2013) that are triggered by drugs of abuse and stressful conditions.”
Background
Sex Differences in Steroid Receptor Coexpression and Circadian-Timed Activation of Kisspeptin and RFRP-3 Neurons May Contribute to the Sexually Dimorphic Basis of the LH Surge
Poling, M. C., Luo, E., & Kauffman, A. S. (2017) · Endocrinology · doi:10.1210/en.2017-00405 · Cited by 49 · see citing works
Sex differences in vasopressin 1a receptor regulation of social communication within the lateral habenula and dorsal raphe of mice
Rigney, N., Beaumont, R., & Petrulis, A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104715 · Cited by 47 · see citing works
“Here, we pharmacologically blocked V1aR in LHb or DR, areas known to have sex-different (male-biased) AVP expression (Rood et al. 2013) and broad involvement in social behavior (Luo et al.”
BackgroundMethodInfluential
Are neuropeptides relevant for the mechanism of action of SSRIs?
Gołyszny, M. J., & Obuchowicz, E. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.02.002 · Cited by 47 · see citing works
Sex differences in the control of social investigation and anxiety by vasopressin cells of the paraventricular nucleus of the hypothalamus
Rigney, N., Whylings, J., de Vries, G. J., & Petrulis, A. (2021) · Neuroendocrinology · doi:10.1159/000509421 · Cited by 42 · see citing works
Neuroendocrine underpinning of social recognition in males and females
Aspesi, D., & Choleris, E. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13070 · Cited by 41 · see citing works
Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice
Tong, W. H., Abdulai-Saiku, S., & Vyas, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00033 · Cited by 41 · see citing works
Functional significance of a phylogenetically widespread sexual dimorphism in vasotocin/vasopressin production
Kelly, A. M., & Goodson, J. L. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.09.006 · Cited by 38 · see citing works
Extending the socio-sexual brain: arginine-vasopressin immunoreactive circuits in the telencephalon of mice
Otero-Garcia, M., Martín-Sánchez, A., Fortes-Marco, L., Martínez-Ricós, J., Agustín-Pavón, C., Lanuza, E., & Martínez-García, F. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0553-3 · Cited by 38 · see citing works
Sexually dimorphic role of BNST vasopressin cells in sickness and social behavior in male and female mice
Whylings, J., Rigney, N., Peters, N. V., de Vries, G. J., & Petrulis, A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.015 · Cited by 37 · see citing works
“Additionally, the SCN sends AVP projections to nuclei that regulate behaviors changed by LPS injection, such as the PVN, BNST, and medial preoptic area (Rood et al., 2013), and is therefore well positioned to play a role in sickness behavior.”
Background
Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain
Madrigal, M. P., & Jurado, S. (2021) · Communications Biology · doi:10.1038/s42003-021-02110-4 · Cited by 38 · see citing works
Vasopressin regulates daily rhythms and circadian clock circuits in a manner influenced by sex
Rohr, K. E., Telega, A., Savaglio, A., & Evans, J. A. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104888 · Cited by 35 · see citing works
Vasopressin indirectly excites dorsal raphe serotonin neurons through activation of the vasopressin1A receptor
Rood, B. D., & Beck, S. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.012 · Cited by 35 · see citing works
“, 2012), whereas innervation to the lateral septum and DR comes primarily from the extended amygdala (De Vries and Buijs, 1983; Rood et al., 2012).”
BackgroundInfluential
Long-Term Effects of Early Adolescent Methamphetamine Exposure on Depression-Like Behavior and the Hypothalamic Vasopressin System in Mice
Joca, L. K., Zuloaga, D. G., Raber, J., & Siegel, J. A. (2014) · Developmental Neuroscience · doi:10.1159/000360001 · Cited by 36 · see citing works
Vasopressin and alcohol: a multifaceted relationship
Harper, K. M., Knapp, D. J., Criswell, H. E., & Breese, G. R. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5099-x · Cited by 34 · see citing works
“In many species, including humans, males have more VP-immunoreactive fibers, more VP-immunoreactive neurons, VP neurons of larger size, and altered V1a receptor-binding densities (De Vries and Panzica 2006; DiBenedictis et al. 2017; Dumais and Veenema 2016; Ishunina and Swaab 1999; Rood et al. 2013; Smith et al. 2017;…”
Influential
What can animal research tell us about the link between androgens and social competition in humans?
Fuxjager, M. J., Trainor, B. C., & Marler, C. A. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.014 · Cited by 32 · see citing works
“Testosterone is also known to promote vasopressin (AVP) synthesis (Wang and De Vries, 1993; Rood et al., 2013).”
Background
Central and peripheral roles of vasopressin in the circadian defense of body hydration
Gizowski, C., Trudel, E., & Bourque, C. W. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.11.001 · Cited by 31 · see citing works
Knockdown of sexually differentiated vasopressin expression in the bed nucleus of the stria terminalis reduces social and sexual behaviour in male, but not female, mice
Rigney, N., Zbib, A., de Vries, G. J., & Petrulis, A. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13083 · Cited by 29 · see citing works
Structure and function of the medial amygdala
(2020) · Handbook of Behavioral Neuroscience · doi:10.1016/b978-0-12-815134-1.00002-7 · Cited by 29 · see citing works
Neonatal Inhibition of DNA Methylation Disrupts Testosterone-Dependent Masculinization of Neurochemical Phenotype
Cisternas, C. D., Cortes, L. R., Golynker, I., Castillo‐Ruiz, A., & Forger, N. G. (2019) · Endocrinology · doi:10.1210/endocr/bqz022 · Cited by 28 · see citing works
Long‐term consequences of peri‐adolescent social isolation on social preference, anxiety‐like behaviour, and vasopressin neural circuitry of male and female rats
Kinley, B. L., Kyne, R. F., Lawton‐Stone, T. S., Walker, D. M., & Paul, M. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15520 · Cited by 27 · see citing works
“Greater VP fibre density in females has been reported for other circadian outputs, including the periventricular, retrochiasmatic, and dorsomedial nuclei of the hypothalamus (Rood et al., 2013).”
BackgroundMethodInfluential
A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner
Rigney, N., Campos‐Lira, E., Kirchner, M. K., Wei, W., Belkasim, S., Beaumont, R., Singh, S. P., Suarez, S. G., Hartswick, D., Stern, J. E., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319641121 · Cited by 23 · see citing works
“…mentioned above, the output of these cells in mice show important sex differences as well (30) and track the differences in density of vasopressin fibers in brain areas, such as the LS, that receive steroid - sensitive AVP innervation in rats and mice (higher in males than in females) (21, 53).”
Medial Amygdala Arginine Vasopressin Neurons Regulate Innate Aversion to Cat Odors in Male Mice
Tong, W. H., Abdulai-Saiku, S., & Vyas, A. (2020) · Neuroendocrinology · doi:10.1159/000508862 · Cited by 25 · see citing works
Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice
Cox, K. H., Quinnies, K. M., Eschendroeder, A., Didrick, P., Eugster, E. A., & Rissman, E. F. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.010 · Cited by 25 · see citing works
Temporal Expression Patterns of Genes Related to Sex Steroid Action in Sexually Dimorphic Nuclei During Puberty
Kanaya, M., Morishita, M., & Tsukahara, S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00213 · Cited by 23 · see citing works
“Males have a greater number of vasopressin neurons in the BNSTp, which are involved in anxiety, aggressive behavior, and stress responses (14), and which project to the lateral septum (15–17).”
Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals
Ogawa, S., & Parhar, I. S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.818782 · Cited by 24 · see citing works
Putting it in Context: Linking Auditory Processing with Social Behavior Circuits in the Vertebrate Brain
Petersen, C. L., & Hurley, L. M. (2017) · Integrative and Comparative Biology · doi:10.1093/icb/icx055 · Cited by 23 · see citing works
“Castration not only eliminates AVP-ir neurons in BNST, but also reduces AVP-ir fibers within DRN of male mice, suggesting that BNST is a major source of AVP to DRN (Rood et al. 2013) [but see (Pollak Dorocic et al.”
BackgroundInfluential
In vivo processing and release into the circulation of GFP fusion protein in arginine vasopressin enhanced GFP transgenic rats: response to osmotic stimulation
Satoh, K., Oti, T., Katoh, A., Ueta, Y., Morris, J. F., Sakamoto, T., & Sakamoto, H. (2015) · FEBS Journal · doi:10.1111/febs.13291 · Cited by 21 · see citing works
Developmental Methamphetamine Exposure Results in Short- and Long-Term Alterations in Hypothalamic-Pituitary-Adrenal-Axis-Associated Proteins
Zuloaga, D. G., Siegel, J. A., Acevedo, S. F., Agam, M. R., & Raber, J. (2013) · Developmental Neuroscience · doi:10.1159/000351278 · Cited by 20 · see citing works
Two ancient neuropeptides, PACAP and AVP, modulate motivated behavior at synapses in the extrahypothalamic brain: a study in contrast
Zhang, L., & Eiden, L. E. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2958-z · Cited by 21 · see citing works
Involvement of ventral pallidal vasopressin in the sex-specific regulation of sociosexual motivation in rats
DiBenedictis, B. T., Cheung, H. K., Nussbaum, E. R., & Veenema, A. H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104462 · Cited by 20 · see citing works
“…have been previously reported in the lateral septum (LS) and lateral habenular nucleus in many rodent species including rats, mice, and prairie voles (De Vries et al., 1981; Miller et al., 1992; Szot & Dorsa, 1993; Bamshad, Novak, & De Vries, 1993; Rood et al., 2013; DiBenedictis et al., 2017).”
Background
Androgen receptor deficiency alters the arginine-vasopressin sexually dimorphic system in Tfm rats
Allieri, F., Spigolon, G., Melcangi, R. C., Collado, P., Guillamón, A., Gotti, S., & Panzica, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.036 · Cited by 20 · see citing works
“…contain more AVP-immunoreactive (AVP-ir) cells in male than in female and projections from these nuclei to the lateral septum (LS) are denser in male than in female; in addition, several other brain regions show sexually dimorphic AVP innervation (De Vries et al., 1984b, Rood et al., 2013).”
Chemogenetic manipulation of the bed nucleus of the stria terminalis counteracts social behavioral deficits induced by early life stress in C57BL/6J mice
Emmons, R., Sadok, T., Rovero, N. G., Belnap, M. A., Henderson, H. J. M., Quan, A., Toro, N. J. D., & Halladay, L. R. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24644 · Cited by 19 · see citing works
“Neuropeptides CRF, OT, and AVP that contribute to anxiety-like and social behaviors, and are altered by ELS, are known to differ between sexes (Duque-Wilckens et al., 2018; Miller, Vician, Clifton, & Dorsa, 1989; Rigney et al., 2019; Rood et al., 2013; Uchida et al., 2019).”
Background
Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way
Ponti, G., Rodriguez-Gomez, A., Farinetti, A., Marraudino, M., Filice, F., Foglio, B., Sciacca, G., Panzica, G. C., & Gotti, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.01.024 · Cited by 21 · see citing works
“As expected, we observed a significant dimorphism in the BST and LS with a higher density of immunoreactive material in males than in females (De Vries and Panzica, 2006, Rood et al., 2013).”
DNA Methylation and Demethylation Underlie the Sex Difference in Estrogen Receptor Alpha in the Arcuate Nucleus
Cortes, L. R., Cisternas, C. D., Cabahug, I. N. K. V., Mason, D., Ramlall, E. K., Castillo‐Ruiz, A., & Forger, N. G. (2021) · Neuroendocrinology · doi:10.1159/000519671 · Cited by 19 · see citing works
Dissociation of Puberty and Adolescent Social Development in a Seasonally Breeding Species
Paul, M. J., Probst, C. K., Brown, L. M., & Vries, G. J. D. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.030 · Cited by 18 · see citing works
Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications
Godino, A., & Renard, G. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12611 · Cited by 17 · see citing works
Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Protective Mechanisms in Preeclampsia
Vignato, J. A., Gumusoglu, S. B., Davis, H., Scroggins, S. M., Hamilton, W. S., Brandt, D. S., Pierce, G. L., Knosp, B. M., Santillan, D. A., & Santillan, M. K. O. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-01065-z · Cited by 16 · see citing works
“Furthermore, these dorsal raphe serotonin neurons directly downregulate AVP neuron activity in the supraoptic nucleus [24, 26, 56].”
Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake
Whylings, J., Rigney, N., Vries, G. J. D., & Petrulis, A. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.104997 · Cited by 15 · see citing works
Sex differences in afferents and efferents of vasopressin neurons of the bed nucleus of the stria terminalis and medial amygdala in mice
Rigney, N., Vries, G. J. D., & Petrulis, A. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105407 · Cited by 13 · see citing works
Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal
Francesconi, W., Olivera-Pasilio, V., Berton, F., Olson, S. L., Chudoba, R., Monroy, L. M., Krabichler, Q., Grinevich, V., & Dabrowska, J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115768 · Cited by 14 · see citing works
“AVP is produced in hypothalamic neurons—including the paraventricular nucleus (PVN), supraoptic nucleus (SON), and suprachiasmatic nucleus (SCN) 2,21 and the extended amygdala—including the MeA and posterior BNST. 22 Since AVP and OT largely exist in separate neurons within the hypothalamus, 23…”
Subtle sex differences in vasopressin mRNA expression in the embryonic mouse brain
Aulino, E. A., & Caldwell, H. K. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12835 · Cited by 14 · see citing works
Neurosteroids; potential underpinning roles in maintaining homeostasis
Rahmani, B., Ghasemi, R., Dargahi, L., Ahmadiani, A., & Haeri, A. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.09.030 · Cited by 14 · see citing works
Social Interactions Increase Activation of Vasopressin-Responsive Neurons in the Dorsal Raphe
Patel, T. N., Caiola, H., Mallari, O. G., Blandino, K. L., Goldenthal, A. R., Dymecki, S. M., & Rood, B. D. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.032 · Cited by 12 · see citing works
Faded neural projection from the posterior bed nucleus of the stria terminalis to the lateral habenula contributes to social signaling deficit in male BTBR mice as a mouse model of autism
Higuchi, Y., Tachigori, S.-I., & Arakawa, H. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.106004 · Cited by 12 · see citing works
“dant in male B6 mice (Rood, De Vries, 2011; Rood et al., 2013), suggesting that a blunted AVP projection from the pBnST to LHb in BTBR males is associated with unresponsive scent marking behavior expressed in BTBR males.”
Background
Involvement of TRPC5 channels, inwardly rectifying K+channels, PLCβ and PIP2in vasopressin‐mediated excitation of medial central amygdala neurons
Boyle, C. A., Hu, B., Quaintance, K. L., & Lei, S. (2021) · The Journal of Physiology · doi:10.1113/jp281260 · Cited by 13 · see citing works
“Vasopressin-producing cells have also been detected in the medial amygdala and the bed nucleus of the stria terminalis, an extended structure of the amygdala (Buijs & Swaab, 1979; Szot & Dorsa, 1993; Rood et al. 2013).”
Background
Arginine vasopressin in the medial amygdala causes greater post-stress recruitment of hypothalamic vasopressin neurons
Tong, W. H., Abdulai-Saiku, S., & Vyas, A. (2021) · Molecular Brain · doi:10.1186/s13041-021-00850-2 · Cited by 12 · see citing works
“Among these, the medial amygdala (MeA) is especially interesting because it contains a sexually dimorphic population of extra-hypothalamic AVP neurons [2].”
Background
Sex Differences in the Structure and Function of the Vasopressin System in the Ventral Pallidum are Associated with the Sex-Specific Regulation of Social Play Behavior in Juvenile Rats
Lee, J., Reppucci, C. J., Bowden, S. M., Huez, E. D. M., Bredewold, R., & Veenema, A. H. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105563 · Cited by 10 · see citing works
Sexual Differentiation of Brain and Behavior
Forger, N. G., Vries, G. J. D., & Breedlove, S. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00047-8 · Cited by 12 · see citing works
Relaxin increases sympathetic nerve activity and activates spinally projecting neurons in the paraventricular nucleus of nonpregnant, but not pregnant, rats
Coldren, K. M., Brown, R. J., Hasser, E. M., & Heesch, C. M. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00186.2015 · Cited by 11 · see citing works
“Guinea pig anti-AVP specificity was confirmed previously in mouse brain by preabsorption experiments using (Arg8)-AVP (47).”
Removal of vasopressin cells from the paraventricular nucleus of the hypothalamus enhances lipopolysaccharide‐induced sickness behaviour in mice
Whylings, J., Rigney, N., Vries, G. J. D., & Petrulis, A. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12915 · Cited by 10 · see citing works
The medial amygdala’s neural circuitry: Insights into social processing and sex differences
Ignacio, B., Baeza, J., Ruiz, B., Romero, J. P., Yáñez, P., Ramírez, C., Caprile, T., Farkas, C., & Recabal, A. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101190 · Cited by 9 · see citing works
“…a role in the fear response can generate extra-hypothalamic AVP (Ferris, 1995), being MeA-AVP expression sexually dimorphic (found more in males) (Rood, 2013; Wang et al., 1993), dependent on developmental steroids (Wang et al., 1993; Wang and De Vries, 1995), on age (found more in adults vs…”
Vasopressin as a Stress Hormone
Antoni, F. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00009-7 · Cited by 10 · see citing works
Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour
Martínez-Rodríguez, E., Martín‐Sánchez, A., Kul, E., Bose, A., Martínez-Martínez, F. J., Stork, O., Martínez‐Garciá, F., Lanuza, E., Santos, M., & Agustín‐Pavón, C. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02122-6 · Cited by 10 · see citing works
Sex-Dependent Effects of Chronic Social Defeat on Emotional and Social Behaviors, and Parameters of Oxytocin and Vasopressin Systems in Mandarin Voles (Microtus mandarinus)
Hou, W., Ma, H., Xun, Y., Zhang, X., Cai, W., Huang, S., He, Z., Tai, F., & Jia, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.625116 · Cited by 10 · see citing works
Disorders of puberty and neurodevelopment: A shared etiology?
Read, J. E., Vasile‐Tudorache, A., Newsome, A., Lorente, M. J., Agustín‐Pavón, C., & Howard, S. R. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15246 · Cited by 10 · see citing works
“94] Beuren”
Genotypic sex shapes maternal care in the African pygmy mouse, Mus minutoides
Heitzmann, L. D., Challe, M., Pérez, J., Castell, L., Galibert, E., Martin, A., Valjent, E., & Veyrunes, F. (2023) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2023.1224 · Cited by 9 · see citing works
“expressing neurons, a neuropeptide involved in crouching over the pups or maternal aggression among others, likely to result from an imbalance in X chromosome number between the sexes (Crenshaw et al., 1992; De Vries & Miller, 1998; De Vries et al., 2002; Gatewood et al., 2006; Bosch & Neumann, 2012; Cox et al., 2015;…”
Background
Viral rescue of magnocellular vasopressin cells in adolescent Brattleboro rats ameliorates diabetes insipidus, but not the hypoaroused phenotype
Schatz, K. C., Brown, L. M., Barrett, A., Roth, L. C., Grinevich, V., & Paul, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-44776-1 · Cited by 9 · see citing works
Oxytocin, but not arginine-vasopressin neurons project from the hypothalamus to amygdala in human: DiI-based tracing study in postmortem brain
Sivukhina, E. V., & Jirikowski, G. F. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101882 · Cited by 9 · see citing works
Exocrine scent marking: coordinative role of arginine vasopressin in the systemic regulation of social signaling behaviors
Arakawa, H., & Higuchi, Y. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104597 · Cited by 8 · see citing works
Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems
Török, B., Varga, J. M., & Zelena, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415467 · Cited by 6 · see citing works
“Indeed, the vasopressinergic output of the SCN innervates brain areas that are important for the regulation of hormone secretion and behavior [73].”
Background
The circadian clock in the mouse habenula is set by catecholamines
Salaberry, N. L., & Mendoza, J. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03557-x · Cited by 5 · see citing works
Sex-dependent and -independent regulation of thyrotropin-releasing hormone expression in the hypothalamic dorsomedial nucleus by negative energy balance, exercise, and chronic stress
Vargas, Y., de Oca, M. P.-M., Sánchez‐Jaramillo, E., Jaimes-Hoy, L., Sánchez-Islas, E., Uribe, R. M., Joseph‐Bravo, P., & Charli, J. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148083 · Cited by 5 · see citing works
Neuroendocrine hypothalamus as a homeostat of endogenous time
Chernysheva, M. P., & Ad, N. (2017) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s002209301701001x · Cited by 5 · see citing works
The Mouse Hypothalamus
Schröder, H., Moser, N., & Huggenberger, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-19898-5_9 · Cited by 5 · see citing works
Adolescent social isolation disrupts developmental tuning of neuropeptide circuits in the hypothalamus to amygdala regulating social and defensive behavior
Arakawa, H., Tokashiki, M., Higuchi, Y., & Konno, T. (2024) · Peptides · doi:10.1016/j.peptides.2024.171178 · Cited by 4 · see citing works
Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk
Gumusoglu, S. B., Kiel, M. D., Gugel, A., Schickling, B., Weaver, K. R., Lauffer, M. C., Sullivan, H. R., Coulter, K. J., Blaine, B., Kamal, M., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01749-3 · Cited by 4 · see citing works
Bed Nucleus of Stria Terminalis (BNST) circuits
Centanni, S. W., Brown, J. A., Williford, K. M., Flook, E. A., Luchsinger, J. R., & Winder, D. G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823453-2.00011-4 · Cited by 3 · see citing works
Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons
Kola, P. K., Oraegbuna, C. S., & Lei, S. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103951 · Cited by 2 · see citing works
Sex difference in the effects of ventral pallidum vasopressin 1a receptor partial knockdown on social behavior in mice
Friesen, C. N., Hartswick, D., Selke, A., Vries, G. J. D., & Petrulis, A. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105792 · Cited by 2 · see citing works
Long-term depression of excitatory transmission in the lateral septum
Chaichim, C., Cannings, M. J., Dumlao, G., & Power, J. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00657.2019 · Cited by 2 · see citing works
Identifying the Role of Vasopressin and Oxytocin in the Microbiota-Gut-Brain-Behavior Axis
Peters, N. V. (2022) · Digital Archive @ GSU · doi:10.57709/14972899 · Cited by 2 · see citing works
Sex–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse BrainPreprint
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.7554/elife.105355.3 · Cited by 2 · see citing works
Sex-dependent effects of adolescent chronic social defeat and social accompanying on emotional and social behaviors and the numbers of OT/Fos and AVP/Fos dual-labelled cells in brain regions of the mandarin vole (Microtus mandarinus)
Cui, Y. X., Guo, M. L., Ren, J. Q., Yang, J., Miao, Y. X., Wei, J., Zhang, Z. Y., He, F., Wang, B., & Wang, Z. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114997 · Cited by 1 · see citing works
PVN AVP neurons projecting to MeA modulate social recognition and anxiety-like behavior in female mice
Zhang, W., Huang, C., Liu, J., Lu, L., Bai, Y., Sun, Y., Zhang, L., Ren, L., Huang, K., Yan, S., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115984 · Cited by 1 · see citing works
An extended epiphenotype for an extended phenotype in Toxoplasma gondii infected feral house mice
Ngo, P., Lignereux, L., O'Handley, R. M., & Vyas, A. (2022) · Functional Ecology · doi:10.1111/1365-2435.14223 · Cited by 1 · see citing works
A vasopressin circuit that modulates sex-specific social interest and anxiety-like behavior in micePreprint
Rigney, N., Campos‐Lira, E., Kirchner, M. K., Wei, W., Belkasim, S., Beaumont, R., Singh, S. P., Vries, G. J. D., & Petrulis, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.06.564847 · Cited by 1 · see citing works
Cross-talk between the Oxytocin and Vasopressin Systems in the Brian: Roles in Social Behavior
Song, Z. (2022) · Digital Archive @ GSU · doi:10.57709/7996120
Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice
Cox, K. H., Quinnies, K. M., Eschendroeder, A., Didrick, P., Eugster, E. A., & Rissman, E. F. (2015) · PMC

Sex differences in hormonal responses of vasopressin pathways in the rat brain
De Vries, G. J., & Al‐Shamma, H. A. (1990) · Journal of Neurobiology · doi:10.1002/neu.480210503 · Cited by 129 · see citing works
Sex differences in afferents and efferents of vasopressin neurons of the bed nucleus of the stria terminalis and medial amygdala in mice
Rigney, N., Vries, G. J. D., & Petrulis, A. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105407 · Cited by 13 · see citing works
Gender–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse BrainPreprint
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355.1
A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner
Rigney, N., Campos‐Lira, E., Kirchner, M. K., Wei, W., Belkasim, S., Beaumont, R., Singh, S. P., Suarez, S. G., Hartswick, D., Stern, J. E., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319641121 · Cited by 23 · see citing works
Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.1101/2024.12.09.627541

Authors: Rood, B. D., Stott, R. T., You, S., Smith, C. J. W., Woodbury, M. E., & De Vries, G. J.
Affiliations: Children's Hospital of Philadelphia (US)
University of Massachusetts Amherst (US)
Smith College (US)
Corresponding author: Rood, Benjamin D.
ORCID: Smith, Caroline J.W.
Woodbury, Maya E.
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 2013-04-19
Volume: 521
Issue: 10
Pages: 2321-2358
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.23288
OpenAlex: W2060309994
Cited by: 120
References: 102
Citations by year: 2026: 7 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 16 · 2020: 11 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 13 · 2013: 7
FWCI: 13.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32mh020051-09)
National Institute of Mental Health (T32-MH020051)
National Institute of General Medical Sciences (T32GM008541)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: vasopressin, sex differences, hypothalamus, bed nucleus of the stria terminalis, medial amygdala, suprachiasmatic nucleus, paraventricular nucleus, supraoptic nucleus, gonadectomy, stress response, serotonin, dopamine, mouse brain
MeSH terms: Animals, Arginine Vasopressin, Brain, Castration, Cell Count, Dopamine, Electrolytes, Female, Male, Mice, Inbred C57BL, Neural Pathways, Neurons, Serotonin, Sex Characteristics, Suprachiasmatic Nucleus, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Site of origin of and sex differences in the vasopressin innervation of the mouse ( Mus musculus ) brain

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks