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Cited by 136

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Functional Compartmentalization of Endosomal Trafficking for the Synaptic Delivery of AMPA Receptors during Long-Term Potentiation

Brown, Tyler C., Correia, Susana S., Petrok, Cortney N., Esteban, José A.·2007·The Journal of Neuroscience
DOI 10.1523/jneurosci.4258-07.2007
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Abstract

Endosomal membrane trafficking in dendritic spines is important for proper synaptic function and plasticity. However, little is known about the molecular identity and functional compartmentalization of the membrane trafficking machinery operating at the postsynaptic terminal. Here we report that the transport of AMPA-type glutamate receptors into synapses occurs in two discrete steps, and we identify the specific endosomal functions that control this process during long-term potentiation. We found that Rab11-dependent endosomes translocate AMPA receptors from the dendritic shaft into spines. Subsequently, an additional endosomal trafficking step, controlled by Rab8, drives receptor insertion into the synaptic membrane. Separate from this receptor delivery route, we show that Rab4 mediates a constitutive endosomal recycling within the spine. This Rab4-dependent cycling is critical for maintaining spine size but does not influence receptor transport. Therefore, our data reveal a highly compartmentalized endosomal network within the spine and identify the molecular components and functional organization of the membrane organelles that mediate AMPA receptor synaptic delivery during plasticity.

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  • Delivery of new AMPARs during LTP into synapses requires two distinct steps: Rab11-driven endosomes mediate translocation of AMPARs into spines, and Rab8 mediates final insertion into synaptic membrane.

    “Previous studies have found that the delivery of new AMPARs during LTP into synapses requires two distinct steps.First, Rab11-driven endosomes mediate the translocation of AMPARs into spines and then Rab8 mediates the final insertion of AMPARs into the synaptic membrane (Brown et al., 2007).”

    From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Brown et al., 2007

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Research works printed but not linked: 41

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Metadata

Authors
Brown, T. C., Correia, S. S., Petrok, C. N., & Esteban, J. A.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2007-11-28
Volume
27
Issue
48
Pages
13311-13315
ISSN
  • 0270-6474
  • 1529-2401
DOI
10.1523/jneurosci.4258-07.2007
Cited by
136
References
4
Language
en
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)

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