Pathological gambling is linked to reduced activation of the mesolimbic reward system
Abstract
By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.
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A brain imaging study showed that patients with both substance and behavioral disorders demonstrated the same involvement of dopaminergic and mesolimbic pathways from the ventral tegmental area to the NAcc.
“A brain imaging study also showed that patients with both substance and behavioral disorders demonstrated the same involvement of dopaminergic and mesolimbic pathways from the ventral tegmental area to the NAcc.²³”
From Cybersex addiction: An overview of the development and treatment of a newly emerging disorder (2020) · cites this paper as [23]
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Self-citation
- Authors
- Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C.
- Affiliations
- Universität Hamburg (DE)
- Corresponding author
- Büchel, Christian
- Venue
- Nature Neuroscience
- Published
- 2005-01-09
- Volume
- 8
- Issue
- 2
- Pages
- 147-148
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1991448902
- Semantic Scholar
- 269d7b547795b9876a5cf1eef441c7b241d7e46d
- Cited by
- 734
- References
- 15
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 64 · 2019: 30 · 2018: 27 · 2017: 28 · 2016: 26 · 2015: 30 · 2014: 72 · 2013: 63 · 2012: 59
- FWCI
- 33.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- gambling addiction, mesolimbic reward system, ventral striatum, ventromedial prefrontal cortex, reward sensitivity, gambling severity, guessing games, functional MRI
- MeSH terms
- Adult, Brain Mapping, Gambling, Humans, Functional Laterality, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Psychiatric Status Rating Scales, Regression Analysis, Reward, Risk-Taking, Case-Control Studies, Behavior, Addictive, Prefrontal Cortex
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