Cited by 734Gambling Behavior and TreatmentsNeural and Behavioral Psychology StudiesObsessive-Compulsive Spectrum Disorders

Pathological gambling is linked to reduced activation of the mesolimbic reward system

Reuter, Jan, Raedler, Thomas, Rose, Michael, Hand, Iver, Gläscher, Jan, Büchel, Christian·2005·Nature Neuroscience

Abstract

By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.

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Crossref · 10.1038/nn1378

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  • A brain imaging study showed that patients with both substance and behavioral disorders demonstrated the same involvement of dopaminergic and mesolimbic pathways from the ventral tegmental area to the NAcc.

    “A brain imaging study also showed that patients with both substance and behavioral disorders demonstrated the same involvement of dopaminergic and mesolimbic pathways from the ventral tegmental area to the NAcc.²³”

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Research works printed but not linked: 1

  1. Blum, K., Cull, J.C., Braverman, E.R. & Comings, D.E. Am. Sci. 84, 132–145 (1996).

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Authors
Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C.
Affiliations
Universität Hamburg (DE)
Corresponding author
Büchel, Christian
Venue
Nature Neuroscience
Published
2005-01-09
Volume
8
Issue
2
Pages
147-148
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1991448902
Cited by
734
References
15
Citations by year
2026: 8 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 16 · 2020: 64 · 2019: 30 · 2018: 27 · 2017: 28 · 2016: 26 · 2015: 30 · 2014: 72 · 2013: 63 · 2012: 59
FWCI
33.94
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
gambling addiction, mesolimbic reward system, ventral striatum, ventromedial prefrontal cortex, reward sensitivity, gambling severity, guessing games, functional MRI
MeSH terms
Adult, Brain Mapping, Gambling, Humans, Functional Laterality, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Psychiatric Status Rating Scales, Regression Analysis, Reward, Risk-Taking, Case-Control Studies, Behavior, Addictive, Prefrontal Cortex

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