Cited by 217Hormonal and reproductive studiesAdrenal Hormones and DisordersMenopause: Health Impacts and Treatments

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THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study

Corona, Giovanni, Giagulli, Vito A, Maseroli, Elisa, Vignozzi, Linda, Aversa, Antonio, Zitzmann, Michael, Saad, Farid, Mannucci, Edoardo, Maggi, Mario·2016·European Journal of Endocrinology

DOI 10.1530/eje-15-0262

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Abstract

Objective: The role of testosterone (T) in regulating body composition is conflicting. Thus, our goal is to meta-analyse the effects of T supplementation (TS) on body composition and metabolic outcomes. Methods: All randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered. Results: Overall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control groups respectively. TS was associated with any significant modification in body weight, waist circumference and BMI. Conversely, TS was associated with a significant reduction in fat and with an increase in lean mass as well as with a reduction of fasting glycaemia and insulin resistance. The effect on fasting glycaemia was even higher in younger individuals and in those with metabolic diseases. When only RCTs enrolling hypogonadal (total T <12 mol/l) subjects were considered, a reduction of total cholesterol as well as triglyceride (TGs) levels were also detected. Conversely, an improvement in HDL cholesterol levels as well as in both systolic and diastolic blood pressure was not observed. Conclusion: Our data suggest that TS is able to improve body composition and glycometabolic profile particularly in younger subjects and in those with metabolic disturbances. Specifically designed studies are urgently needed to confirm this point.

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Psychological interventions for overweight or obesity
Shaw, K. A., O'Rourke, P., Del Mar, C., & Kenardy, J. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003818.pub2 · Cited by 442
Retracted
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Comparative quantification of health risks : global and regional burden of disease attributable to selected major risk factors
Ezzati, M., López, A. D., Rodgers, A., & Murray, C. J. L. (2004) · Cited by 3,319
Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study
Yusuf, S., Hawken, S., Ôunpuu, S., Bautista, L., Franzosi, M. G., Commerford, P., Lang, C. C., Rumboldt, Z., Onen, C. L., Lisheng, L., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67663-5 · Cited by 2,903
Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
Astrup, A., Rössner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., Madsen, J., Rasmussen, M. F., & Lean, M. E. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61375-1 · Cited by 1,163
Testosterone dose-response relationships in healthy young men
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Bhasin, D., Berman, N., Chen, X., Yarasheski, K. E., Magliano, L., Dzekov, C., et al. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1172 · Cited by 967
Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial
Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920
Long-term Drug Treatment for Obesity: A Systematic and Clinical Review
Yanovski, S. Z., & Yanovski, J. A. (2014) · JAMA · doi:10.1001/jama.2013.281361 · Cited by 876
Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance Randomized Study
on behalf of the NN8022-1923 Investigators, Wadden, T. A., Hollander, P., Klein, S., Niswender, K., Woo, V, Hale, P. M., & Aronne, L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.120 · Cited by 842
Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.
Katznelson, L., Finkelstein, J. S., Schoenfeld, D. A., Rosenthal, D. I., Anderson, E. J., & Klibanski, A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954042 · Cited by 791
Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
Finkelstein, J. S., Lee, H., Burnett-Bowie, S.-A. M., Pallais, J. C., Yu, E. W., Borges, L. F., Jones, B. F., Barry, C. V., Wulczyn, K. E., Thomas, B. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1206168 · Cited by 782
Meta-Analysis: Pharmacologic Treatment of Obesity
Li, Z., Maglione, M., Tu, W., Mojica, W., Arterburn, D., Shugarman, L. R., Hilton, L., Suttorp, M., Solomon, V., Shekelle, P. G., et al. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-7-200504050-00012 · Cited by 774
Effects of testosterone supplementation in the aging male
Tenover, J. S. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.4.1092 · Cited by 768
Adverse Events Associated With Testosterone Replacement in Middle-Aged and Older Men: A Meta-Analysis of Randomized, Placebo-Controlled Trials
Calof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728
Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Fernández-Balsells, M. M., Murad, M. H., Lane, M., Lampropulos, J. F., Albuquerque, F., Mullan, R. J., Agrwal, N., Elamin, M. B., Gallegos-Orozco, J. F., Wang, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2575 · Cited by 713
Effects of testosterone supplementation in the aging male.
Tenover, J. S. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400877 · Cited by 702
Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis
Isidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695
Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men
Wang, C., Cunningham, G., Dobs, A., Iranmanesh, A., Matsumoto, A. M., Snyder, P. J., Weber, T., Berman, N., Hull, L., & Swerdloff, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032006 · Cited by 656
Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, and Quality of Life in Intermediate-Frail and Frail Elderly Men: A Randomized, Double-Blind, Placebo-Controlled Study
Srinivas-Shankar, U., Roberts, S. A., Connolly, M. J., O'Connell, M. D. L., Adams, J. E., Oldham, J. A., & Wu, F. C. W. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1251 · Cited by 629
Testosterone Replacement Increases Fat-Free Mass and Muscle Size in Hypogonadal Men
Bhasin, S., Storer, T. W., Berman, N., Yarasheski, K. E., Clevenger, B., Phillips, J., Lee, W. P., Bunnell, T. J., & Casaburi, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.2.3733 · Cited by 596
DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566
Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T
Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1933 · Cited by 566
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553
Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
Jones, T. H., Arver, S., Behre, H. M., Buvat, J., Meuleman, E., Moncada, I., Morales, A. M., Volterrani, M., Yellowlees, A., Howell, J. D., et al. (2011) · Diabetes Care · doi:10.2337/dc10-1233 · Cited by 548
Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2647 · Cited by 531
Effect of Testosterone Supplementation on Functional Mobility, Cognition, and Other Parameters in Older Men: A Randomized Controlled Trial
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
Effects of Testosterone Replacement Therapy in Old Hypogonadal Males: A Preliminary Study
Morley, J. E., Perry, H. M., Kaiser, F. E., Kraenzle, D., Jensen, J., Houston, K., Mattammal, M. B., & Perry, H. M. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb02049.x · Cited by 462
Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels
Kenny, A. M., Prestwood, K. M., Gruman, C. A., Marcello, K. M., & Raisz, L. G. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.5.m266 · Cited by 456
Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial
Blackman, M. R. (2002) · JAMA · doi:10.1001/jama.288.18.2282 · Cited by 455
Effect of Long-Acting Testosterone Treatment on Functional Exercise Capacity, Skeletal Muscle Performance, Insulin Resistance, and Baroreflex Sensitivity in Elderly Patients With Chronic Heart Failure
Caminiti, G., Volterrani, M., Iellamo, F., Marazzi, G., Massaro, R., Miceli, M., Mammi, C., Piepoli, M., Fini, M., & Rosano, G. M. C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.078 · Cited by 444
Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men--a clinical research center study.
Brodsky, I. G., Balagopal, P., & Nair, K. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.10.8855787 · Cited by 444
Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis
Corona, G., Rastrelli, G., Monami, M., Saad, F., Luconi, M., Lucchese, M., Facchiano, E., Sforza, A., Forti, G., Mannucci, E., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0955 · Cited by 414
Self-citation
AA2500 Testosterone Gel Normalizes Androgen Levels in Aging Males with Improvements in Body Composition and Sexual Function
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 409
Testosterone and Metabolic Syndrome: A Meta-Analysis Study
Corona, G., Monami, M., Rastrelli, G., Aversa, A., Tishova, Y., Saad, F., Lenzi, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01991.x · Cited by 400
Self-citation
Effects of Testosterone and Resistance Training in Men with Chronic Obstructive Pulmonary Disease
Casaburi, R. H., Bhasin, S., Cosentino, L. M., Pórszász, J., Somfay, A., Lewis, M. I., Fournier, M., & Storer, T. W. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200305-617oc · Cited by 388
Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
Boyanov, M. A., Boneva, Z., & Christov, V. G. (2003) · The Aging Male · doi:10.1080/tam.6.1.1.7 · Cited by 381
Testosterone Therapy in Glucocorticoid-Treated Men
Reid, I. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440100065008 · Cited by 370
Type 2 diabetes mellitus and testosterone: a meta-analysis study: Type 2 diabetes and testosterone
Corona, G., Monami, M., Rastrelli, G., Aversa, A., Sforza, A., Lenzi, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01117.x · Cited by 370
Self-citation
Transdermal Testosterone Gel Improves Sexual Function, Mood, Muscle Strength, and Body Composition Parameters in Hypogonadal Men
Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359
Fifty‐ two—Week Treatment With Diet and Exercise Plus Transdermal Testosterone Reverses the Metabolic Syndrome and Improves Glycemic Control in Men With Newly Diagnosed Type 2 Diabetes and Subnormal Plasma Testosterone
Heufelder, A. E., Saad, F., Bunck, M. C., & Gooren, L. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.007005 · Cited by 349
Self-citation
Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double‐blinded placebo‐controlled Moscow study
Kalinchenko, S. Y., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J., Giltay, E. J., & Saad, F. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03845.x · Cited by 348
Self-citation
Androgen Treatment of Abdominally Obese Men
Mårin, P., Holmtäng, S., Gustafsson, C., Jönsson, ‡., Kvist, ‡., Elander, A., Eldh, J., Sjöström, L., Holm, G., & Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00618.x · Cited by 345
Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343
Self-citation
Oral Testosterone Supplementation Increases Muscle and Decreases Fat Mass in Healthy Elderly Males With Low-Normal Gonadal Status
Wittert, G., Chapman, I. M., Haren, M. T., Mackintosh, S. F., Coates, P. S., & Morley, J. E. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.7.m618 · Cited by 342
Testosterone and Cardiovascular Risk in Men: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Haddad, R. M., Kennedy, C. C., Caples, S. M., Tracz, M. J., Boloña, E. R., Sideras, K., Úraga, M. V., Erwin, P. J., & Montori, V. M. (2007) · Mayo Clinic Proceedings · doi:10.4065/82.1.29 · Cited by 329
Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS)
Tajar, A., Huhtaniemi, I. T., O'Neill, T. W., Finn, J. D., Pye, S. R., Lee, D. M., Bartfai, G., Boonen, S., Casanueva, F. F. F., Forti, G., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2513 · Cited by 318
Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men
Allan, C. A., Strauss, B. J. G., Burger, H. G., Forbes, E. A., & McLachlan, R. I. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1291 · Cited by 298
The impact of extended care on the long-term maintenance of weight loss: a systematic review and meta-analysis
Ross Middleton, K. M., Patidar, S. M., & Perri, M. G. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00972.x · Cited by 276
The Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men
Liu, P. Y., Yee, B., Wishart, S. M., Jimenez, M., Jung, D. G., Grunstein, R. R., & Handelsman, D. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030236 · Cited by 275
Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study
Kalinchenko, S. Y., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J., Giltay, E. J., & Saad, F. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04105.x · Cited by 267
Self-citation
Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 24-month, randomized, double-blind, placebo-controlled study
Aversa, A., Bruzziches, R., Francomano, D., Rosano, G., Isidori, A. M., Lenzi, A., & Spera, G. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01931.x · Cited by 265
Self-citation
Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study
Wang, C., Eyre, D. R., Clark, R. V., Kleinberg, D. L., Newman, C. B., Iranmanesh, A., Veldhuis, J. D., Dudley, R. E., Berman, N., Davidson, T., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.10.3654 · Cited by 259
Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty
Kenny, R. A., Kleppinger, A., Annis, K., Rathier, M., Browner, B., Judge, J. O., & McGee, D. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02865.x · Cited by 250
Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis
Whitsel, E. A., Boyko, E. J., Matsumoto, A. M., Anawalt, B. D., & Siscovick, D. S. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00833-6 · Cited by 240
Randomized Placebo-Controlled Trial of Androgen Effects on Muscle and Bone in Men Requiring Long-Term Systemic Glucocorticoid Treatment
Crawford, B. A. L., Liu, P. Y., Kean, M. T., Bleasel, J. F., & Handelsman, D. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021827 · Cited by 238
Effect of testosterone on abdominal adipose tissue in men.
Rebuffé-Scrive, M., Mårin, P., & Björntorp, P. A. (1991) · PubMed · Cited by 223
Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues.
Mårin, P., Krotkiewski, M., & Björntorp, P. A. (1992) · PubMed · Cited by 192
Long‐term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long‐term registry study
Traish, A. M., Haider, A., Doros, G. D., & Saad, F. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12319 · Cited by 188
Self-citation
Single and Combined Effects of Growth Hormone and Testosterone Administration on Measures of Body Composition, Physical Performance, Mood, Sexual Function, Bone Turnover, and Muscle Gene Expression in Healthy Older Men
Brill, K. T., WELTMAN, A. L., Gentili, A., Patrie, J. T., Fryburg, D. A., Hanks, J. B., Urban, R. J., & Veldhuis, J. D. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020098 · Cited by 186
Sex differences in lean and adipose tissue distribution by magnetic resonance imaging: anthropometric relationships
Ross, R., Shaw, K., Rissanen, J., Martel, Y., de Guise, J. A., & Avruch, L. I. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.6.1277 · Cited by 184
Testosterone Replacement Therapy with Long‒Acting Testosterone Undecanoate Improves Sexual Function and Quality‒of‒Life Parameters vs. Placebo in a Population of Men with Type 2 Diabetes
Hackett, G., Cole, N., Bhartia, M., Kennedy, D., Raju, J., & Wilkinson, P. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12146 · Cited by 182
A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function
McNicholas, T. A., Dean, J. D., Mulder, H., Carnegie, C., & Jones, N. A. (2003) · BJU International · doi:10.1046/j.1464-410x.2003.04016.x · Cited by 178
Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis of TRT outcomes
Corona, G., Rastrelli, G., & Maggi, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.002 · Cited by 177
Self-citation
Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial
Gianatti, E., Dupuis, P., Hoermann, R., Strauss, B. J., Wentworth, J. M., Zajac, J. D., & Grossmann, M. (2014) · Diabetes Care · doi:10.2337/dc13-2845 · Cited by 168
Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men
Zgliczynski, S., Ossowski, M., Slowinska-Srzednicka, J., Brzezinska, A., Zgliczynski, W., Soszynski, P., Chotkowska, E., Srzednicki, M., & Sadowski, Z. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05673-4 · Cited by 167
Long-Term Testosterone Treatment in Elderly Men with Hypogonadism and Erectile Dysfunction Reduces Obesity Parameters and Improves Metabolic Syndrome and Health-Related Quality of Life
Yassin, D., Doros, G. D., Hammerer, P. G., & Yassin, A. A. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12523 · Cited by 165
The Effects of Growth Hormone and/or Testosterone in Healthy Elderly Men: A Randomized Controlled Trial
Giannoulis, M. G., Sonksen, P. H., Umpleby, M., Breen, L., Pentecost, C., Whyte, M., McMillan, C. V., Bradley, C., & Martin, F. C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0957 · Cited by 164
Long‐term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss
Saad, F., Haider, A., Doros, G. D., & Traish, A. M. (2013) · Obesity · doi:10.1002/oby.20407 · Cited by 161
Self-citation
Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip
Svartberg, J., Agledahl, I., Figenschau, Y., Sildnes, T., Waterloo, K., & Jorde, R. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.19 · Cited by 160
Differential Anabolic Effects of Testosterone and Amino Acid Feeding in Older Men
Ferrando, A. A., Sheffield‐Moore, M., Paddon‐Jones, D., Wolfe, R. R., & Urban, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021041 · Cited by 155
Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men
Mathur, A., Malkin, C. J., Saeed, B., Muthusamy, R., Jones, T. H., & Channer, K. S. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0092 · Cited by 148
Testosterone as potential effective therapy in treatment of obesity in men with testosterone deficiency: a review
Saad, F., Aversa, A., M. Isidori, A., & J. Gooren, L. (2012) · Current Diabetes Reviews · doi:10.2174/157339912799424573 · Cited by 148
Self-citation
Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
Hoyos, C. M., Yee, B. J., Phillips, C. L., Machan, E. A., Grunstein, R. R., & Liu, P. Y. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0525 · Cited by 145
Effects of Testosterone and Progressive Resistance Exercise in Healthy, Highly Functioning Older Men With Low-Normal Testosterone Levels
Hildreth, K. L., Barry, D. W., Moreau, K. L., Vande Griend, J., Meacham, R. B., Nakamura, T., Wolfe, P., Kohrt, W. M., Ruscin, J. M., Kittelson, J., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3695 · Cited by 140
Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta‐analysis of randomized controlled clinical trials
Grossmann, M., Hoermann, R., Wittert, G., & Yeap, B. B. (2015) · Clinical Endocrinology · doi:10.1111/cen.12664 · Cited by 139
Androgen Therapy Improves Insulin Sensitivity and Decreases Leptin Level in Healthy Adult Men With Low Plasma Total Testosterone
Simon, D., Charles, M.-A., Lahlou, N., Nahoul, K., Oppert, J.-M., Gouault-Heilmann, M., Lemort, N., Thibult, N., Joubert, E., Balkau, B., et al. (2001) · Diabetes Care · doi:10.2337/diacare.24.12.2149 · Cited by 136
A Dose‐Response Study of Testosterone on Sexual Dysfunction and Features of the Metabolic Syndrome Using Testosterone Gel and Parenteral Testosterone Undecanoate
Saad, F., Gooren, L. J., Haider, A., & Yassin, A. (2008) · Journal of Andrology · doi:10.2164/jandrol.107.002774 · Cited by 132
Self-citation
Sequence of Changes in Body Composition Induced by Testosterone and Reversal of Changes After Drug Is Stopped
Forbes, G. B. (1992) · JAMA · doi:10.1001/jama.1992.03480030075040 · Cited by 126
Hypogonadism and metabolic syndrome.
(2011) · PubMed · doi:10.3275/7806 · Cited by 125
Self-citation
IPASS: a study on the tolerability and effectiveness of injectable testosterone undecanoate for the treatment of male hypogonadism in a worldwide sample of 1,438 men
Zitzmann, M., Mattern, A., Hanisch, J., Gooren, L., Jones, H., & Maggi, M. (2013) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02853.x · Cited by 122
Self-citation
Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception
Young, N., Baker, H. W. G., Liu, G., & Seeman, E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.4.8408450 · Cited by 122
Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate-- a clinical research center study
Salehian, B., Wang, C., Alexander, G. M., Davidson, T., McDonald, V., Berman, N., Dudley, R. E., Ziel, F. H., & Swerdloff, R. S. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530600 · Cited by 114
Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Wang, K., Cai, X., Tian, Y., Wu, T., Cao, C., & Li, H. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122346 · Cited by 113
Erectile dysfunction and central obesity: an Italian perspective
Maggi, M., Corona, G., Rastrelli, G., Filippi, S., Vignozzi, L., & Mannucci, E. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.126386 · Cited by 112
Self-citation
Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial
Svartberg, J. B., Aasebø, U., Hjalmarsen, A., Sundsfjord, J., & Jorde, R. (2004) · Respiratory Medicine · doi:10.1016/j.rmed.2004.02.015 · Cited by 111
Effects of Five-Year Treatment with Testosterone Undecanoate on Metabolic and Hormonal Parameters in Ageing Men with Metabolic Syndrome
Francomano, D., Lenzi, A., & Aversa, A. (2014) · International Journal of Endocrinology · doi:10.1155/2014/527470 · Cited by 110
Self-citation
How to recognize late-onset hypogonadism in men with sexual dysfunction
Corona, G., Rastrelli, G., Vignozzi, L., Mannucci, E., & Maggi, M. (2012) · Asian Journal of Andrology · doi:10.1038/aja.2011.138 · Cited by 108
Self-citation
Randomized clinical trial of testosterone replacement therapy in hypogonadal men
Conway, A. J., Boylan, L. M., Howe, C. A., Ross, G. P., & Handelsman, D. J. (1988) · International Journal of Andrology · doi:10.1111/j.1365-2605.1988.tb00999.x · Cited by 103
Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes
Haider, A., Yassin, A. A., Doros, G. D., & Saad, F. (2014) · International Journal of Endocrinology · doi:10.1155/2014/683515 · Cited by 101
Self-citation
Difficulties in measuring the effect of testosterone replacement therapy on muscle function in older men
Clague, J. E., Wu, F. C. W., & Horan, M. A. (1999) · International Journal of Andrology · doi:10.1046/j.1365-2605.1999.00177.x · Cited by 100
Muscular strength, body composition and health responses to the use of testosterone enanthate: a double blind study
Giorgi, A., Weatherby, R. P., & Murphy, P. (1999) · Journal of science and medicine in sport · doi:10.1016/s1440-2440(99)80007-3 · Cited by 98
Do the Effects of Testosterone on Muscle Strength, Physical Function, Body Composition, And Quality of Life Persist Six Months after Treatment in Intermediate-Frail and Frail Elderly Men?
O'Connell, M. D. L., Roberts, S. A., Srinivas-Shankar, U., Tajar, A., Connolly, M. J., Adams, J. E., Oldham, J. A., & Wu, F. C. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1167 · Cited by 98
Phosphodiesterase Type 5 (PDE5) Inhibitors in Erectile Dysfunction: The Proper Drug for the Proper Patient
Corona, G., Mondaini, N., Ungar, A., Razzoli, E., Rossi, A., & Fusco, F. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02473.x · Cited by 96
Self-citation
Testosterone substitution increases the activity of lipoprotein lipase and hepatic lipase in hypogonadal males
Sorva, R., Kuusi, T., Taskinen, M., Perheentupa, J., & Nikkilä, E. A. (1988) · Atherosclerosis · doi:10.1016/0021-9150(88)90014-7 · Cited by 96
Treatment for overweight and obesity in adult populations: a systematic review and meta-analysis
Peirson, L., Douketis, J. D., Ciliska, D. K., Fitzpatrick‐Lewis, D., Ali, M. U., & Raina, P. S. (2014) · CMAJ Open · doi:10.9778/cmajo.20140012 · Cited by 96
Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss
Yassin, A. A., & Doros, G. D. (2013) · Clinical Obesity · doi:10.1111/cob.12022 · Cited by 94
Testosterone therapy decreases subcutaneous fat and adiponectin in aging men
Frederiksen, L., Højlund, K., Hougaard, D. M., Mosbech, T. H., Larsen, R., Flyvbjerg, A., Frystyk, J., Brixen, K., & Andersen, M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0565 · Cited by 93
Efficacy and safety of two different testosterone undecanoate formulations in hypogonadal men with metabolic syndrome
Aversa, A., Bruzziches, R., Francomano, D., Spera, G., & Lenzi, A. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03350341 · Cited by 92
Self-citation
Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements
Maneschi, E., Morelli, A., Filippi, S., Cellai, I., Comeglio, P., Mazzanti, B., Mello, T., Calcagno, A., Sarchielli, E., Vignozzi, L., et al. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0333 · Cited by 89
Self-citation
An Exploratory Study of the Effects of 12 Month Administration of the Novel Long-Acting Testosterone Undecanoate on Measures of Sexual Function and the Metabolic Syndrome
Saad, F., Gooren, L., Haider, A., & Yassin, A. (2007) · Archives of Andrology · doi:10.1080/01485010701730880 · Cited by 87
Self-citation
The Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure
Malkin, C. J., Jones, T. H., & Channer, K. S. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.04.006 · Cited by 84
Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: An experimental study in the rabbit
Vignozzi, L., Filippi, S., Comeglio, P., Cellai, I., Sarchielli, E., Morelli, A., Rastrelli, G., Maneschi, E., Galli, A., Vannelli, G. B., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.014 · Cited by 81
Self-citation
Andrological characterization of the patient with diabetes mellitus.
Vignera, S. L., Calogero, A. E., Condorelli, R. A., Lanzafame, F., Giammusso, B., & Vicari, E. S. D. (2009) · PubMed · Cited by 79
Effects of testosterone undecanoate replacement and withdrawal on cardio-metabolic, hormonal and body composition outcomes in severely obese hypogonadal men: a pilot study
Francomano, D., Bruzziches, R., Bárbaro, G., Lenzi, A., & Aversa, A. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0066-9 · Cited by 76
Self-citation
Beneficial Effects of Testosterone Undecanoate on the Lipoprotein Profiles in Healthy Elderly Men. A Placebo Controlled Study.
UYANIK, B. S., ARI, Z., GÜMÜS, B., YIGITOGLU, M. R., & ARSLAN, T. (1997) · Japanese Heart Journal · doi:10.1536/ihj.38.73 · Cited by 75
Effect of Testosterone on Insulin Sensitivity in Men with Idiopathic Hypogonadotropic Hypogonadism
Naharcı, M. İ., Pinar, M., Bolu, E., & Olgun, A. (2007) · Endocrine Practice · doi:10.4158/ep.13.6.629 · Cited by 74
Treatment of Hypogonadism with Testosterone in Patients with Type 2 Diabetes Mellitus
Gopal, R. A., Bothra, N., Acharya, S. V., Ganesh, H. K., Bandgar, T., Menon, P. S., & Shah, N. S. (2010) · Endocrine Practice · doi:10.4158/ep09355.or · Cited by 72
Influence of various modes of androgen substitution on serum lipids and lipoproteins in hypogonadal men
Jockenhövel, F., Bullmann, C., Schubert, M., Vogel, E., Reinhardt, W., REINWEIN, D., Müller‐Wieland, D., & Krone, W. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90056-2 · Cited by 72
Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis
Kong, A. H., & Edmonds, P. M. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00441-3 · Cited by 71
Hypogonadal obese men with and without diabetes mellitus type 2 lose weight and show improvement in cardiovascular risk factors when treated with testosterone: An observational study
Haider, A., Saad, F., Doros, G. D., & Gooren, L. J. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.10.005 · Cited by 70
Self-citation
Effects of gonadotropin and testosterone treatments on Lipoprotein(a), high density lipoprotein particles, and other lipoprotein levels in male hypogonadism.
Özata, M., Yıldırımkaya, M., Bulur, M., Yılmaz, K. N., Bolu, E., Corakci, A., & Gündoğan, M. A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784099 · Cited by 67
Effect of Testosterone Replacement on Whole Body Glucose Utilisation and Other Cardiovascular Risk Factors in Males with Idiopathic Hypogonadotrophic Hypogonadism
Tripathy, D., Shah, P., Lakshmy, R., & Reddy, K. (1998) · Hormone and Metabolic Research · doi:10.1055/s-2007-978950 · Cited by 66
Effects of testosterone replacement on HDL subfractions and apolipoprotein A-I containing lipoproteins
Tan, Shiu, Pang, & Kung (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00372.x · Cited by 65
Endogenous testosterone level and testosterone supplementation therapy in chronic obstructive pulmonary disease (COPD): a systematic review and meta-analysis
Atlantis, E. E., Fahey, P. P., Cochrane, B., Wittert, G., & Smith, S. M. S. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003127 · Cited by 64
Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men
Katznelson, L. J., Robinson, M. W., Coyle, C. L., Lee, H., & Farrell, C. E. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02291 · Cited by 62
Oral testosterone undecanoate (Andriol®) supplement therapy improves the quality of life for men with testosterone deficiency
Park, N. C., Yan, B. Q., Chung, J. M., & Lee, K. (2003) · The Aging Male · doi:10.1080/713604766 · Cited by 61
Effects of testosterone replacement on HDL subfractions and apolipoprotein A-I containing lipoproteins
Tan, K. C. B., Shiu, S. W. M., Pang, R. W. C., & Kung, A. W. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.3721211.x · Cited by 60
Bariatric surgery: a best practice article
Neff, K., & le Roux, C. W. (2012) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2012-200798 · Cited by 59
A Randomized Pilot Study of Monthly Cycled Testosterone Replacement or Continuous Testosterone ReplacementVersusPlacebo in Older Men
Sheffield‐Moore, M., Dillon, E. L., Casperson, S. L., Gilkison, C. R., Paddon‐Jones, D., Durham, W. J., Grady, J. J., & Urban, R. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1262 · Cited by 54
Impact of testosterone treatment on postprandial triglyceride metabolism in elderly men with subnormal testosterone levels
Agledahl, I., Hansen, J., & Svartberg, J. B. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510801999068 · Cited by 51
Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study
Tan, W. S., Low, W. Y., Ng, C. J., Tan, W. K., Tong, S. F., Ho, C. C. K., Khoo, E. M., Lee, G., Lee, B. C., Lee, V., et al. (2013) · British Journal of Urology · doi:10.1111/bju.12037 · Cited by 51
Effects of oral testosterone undecanoate on growth, body composition, strength and energy expenditure of adolescent boys
Gregory, J. W., Greene, S. A., Thompson, J., Scrlmgeour, C. M., & Rennle, M. J. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02312.x · Cited by 48
Effects of oral testosterone undecanoate therapy on bone mineral density and body composition in 322 aging men with symptomatic testosterone deficiency: a 1-year, randomized, placebo-controlled, dose-ranging study
Bouloux, P. M., Legros, J., Elbers, J. M. H., Geurts, T. B. P., Kaspers, M. J. G. H., Meehan, A. G., MEULEMAN, E. J. H., & and for the Study 43203 Investigators (2013) · The Aging Male · doi:10.3109/13685538.2013.773420 · Cited by 46
The Efficacy and Safety of Testosterone Undecanoate (Nebido®) in Testosterone Deficiency Syndrome in Korean: A Multicenter Prospective Study
Moon, D. G., Park, M. G., Lee, S. W., Park, K., Park, J. K., Kim, S. W., Park, N. C., Ahn, T. Y., Paick, J. S., Seo, J. T., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01765.x · Cited by 46
A 6-month observational study of energy, sexual desire, and body proportions in hypogonadal men treated with a testosterone 1% gel
Pexman-Fieth, C., Behre, H. M., Morales, Á., Kan‐Dobrosky, N., & Miller, M. G. (2013) · The Aging Male · doi:10.3109/13685538.2013.858113 · Cited by 45
Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints
Permpongkosol, S., Tantirangsee, N., & Ratana-olarn, K. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01994.x · Cited by 44
Abdominal Adiposity Distribution in Diabetic/Prediabetic and Nondiabetic Populations: A Meta-Analysis
Lee, J., Beretvas, S. N., & FREELAND-GRAVES, J. H. (2014) · Journal of Obesity · doi:10.1155/2014/697264 · Cited by 40
Anabolic steroids for the treatment of weight loss in HIV-infected individuals
Johns, K., Beddall, M., & Corrin, R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005483 · Cited by 39
Effect of Testosterone Replacement Therapy on Bone Mineral Density in Patients with Klinefelter Syndrome
Jo, D. G., Lee, H. S., Joo, Y. M., & Seo, J. T. (2013) · Yonsei Medical Journal · doi:10.3349/ymj.2013.54.6.1331 · Cited by 39
Testosterone Replacement Alone for Testosterone Deficiency Syndrome Improves Moderate Lower Urinary Tract Symptoms: One Year Follow-Up
Ko, Y. H., Moon, D. G., & Moon, K. H. (2013) · The World Journal of Men s Health · doi:10.5534/wjmh.2013.31.1.47 · Cited by 37
Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation
Schroeder, E. T., He, J., Yarasheski, K. E., Binder, E. F., Castaneda-Sceppa, C., Bhasin, S., Dieli-Conwright, C. M., Kawakubo, M., Roubenoff, R., Azen, S. P., et al. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2077-y · Cited by 37
Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism
Minnemann, T., Schubert, M., Freude, S., Hübler, D., Gouni-Berthold, I., Schumann, C. Y., Christoph, A., Oettel, M., Ernst, M. E., Mellinger, U., et al. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346421 · Cited by 35
Is Obesity a Further Cardiovascular Risk Factor in Patients with Erectile Dysfunction?
Corona, G., Monami, M., Boddi, V., Balzi, D., Melani, C., Federico, N., Balzi, D., Sforza, A., Rotella, C. M., Forti, G., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01839.x · Cited by 35
Self-citation
A four-year efficacy and safety study of the long-acting parenteral testosterone undecanoate
Minnemann, T., Schubert, M., Minnemann, T., Schubert, M., Hübler, D., Gouni‐Berthold, I., Freude, S., Schumann, C. Y., Oettel, M., Ernst, M. E., et al. (2007) · The Aging Male · doi:10.1080/13685530701437510 · Cited by 34
Testosterone undecanoate improves erectile dysfunction in hypogonadal men with the metabolic syndrome refractory to treatment with phosphodiesterase type 5 inhibitors alone
Garcia, J. A., Sanchez, P. E., Fraile, C., & Escovar, P. (2011) · Andrologia · doi:10.1111/j.1439-0272.2009.00991.x · Cited by 33
Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism
Tirabassi, G., Muti, N. D., Corona, G., Maggi, M., & Balercia, G. (2013) · International Journal of Endocrinology · doi:10.1155/2013/816740 · Cited by 31
Self-citation
Effects of gonadotropin and testosterone treatments on Lipoprotein(a), high density lipoprotein particles, and other lipoprotein levels in male hypogonadism
Ozata, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.9.3372 · Cited by 28
Effects of testosterone treatment on body composition in males with testosterone deficiency syndrome
Tolrà, J. R., Barreda, J. T., del Río, L., Gregorio, S. D., & Miranda, E. F. (2013) · The Aging Male · doi:10.3109/13685538.2013.839648 · Cited by 27
Erratum: Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men (Journal of Clinical Endocrinology and Metabolism 85 (2839-2853))
Wang, C., Swerdloff, R. S., Iranmanesh, A., Dobs, A. S., Snyder, P. J., Cunningham, G. R., Matsumoto, A. M., Weber, T. J., & Berman, N. (2000) · The Journal of Clinical Endocrinology & Metabolism · Cited by 26
Anabolic steroids for the treatment of weight loss in HIV-infected individuals
Johns, K., Beddall, M., & Corrin, R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002836.pub2 · Cited by 24
Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men
Glintborg, D., Christensen, L. L., Kvorning, T., Larsen, R., Brixen, K., HOUGAARD, D. M., Richelsen, B., Bruun, J. M., & Andersen, M. (2013) · Mediators of Inflammation · doi:10.1155/2013/539156 · Cited by 20
Testosterone replacement therapy improves insulin sensitivity and decreases high sensitivity C-reactive protein levels in hypogonadotropic hypogonadal young male patients.
Wu, X., Mao, J., Lu, S., Zhang, Q., & Shi, Y. (2009) · PubMed · Cited by 18
Short term testosterone replacement therapy improves libido and body composition
Júnior, E. S. D. A., Clapauch, R., & Buksman, S. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000800014 · Cited by 16
Increase in Hepatic Lipase Activity after Testosterone Substitution in Men with Hypogonadism of Pituitary Origin
Valdemarsson, S. V., Hedner, P., & Nilsson‐Ehle, P. (1987) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1987.tb03357.x · Cited by 15
Impact of a physician-supervised exercise-nutrition program with testosterone substitution in partial androgen-deficient middle-aged obese men
Schwarz Ernst, R., & Willix Jr Robert, D. (2012) · 老年心脏病学杂志：英文版 · doi:10.3724/sp.j.1263.2011.00201 · Cited by 12
Prevalence of late-onset hypogonadism in men with type 2 diabetes mellitus
Arafa, M. M., Zohdy, W., Aboulsoud, S. H., & Shamloul, R. M. (2011) · Andrologia · doi:10.1111/j.1439-0272.2011.01262.x · Cited by 11

Research works printed but not linked: 7

10.1210/jc.77.4.1028 · DOI
10.1210/jc.82.6.1661 · DOI
10.1210/jc.81.10.3469 · DOI · Paper page
10.1210/jc.81.12.4358 · DOI · Paper page
10.1210/jc.82.2.407 · DOI
Zitzmann, 2014, Long-term treatment with testosterone undecanoate injections leads to sustained weight loss and improvement of metabolic syndrome parameters in 381 hypogonadal men, Journal of Sexual Medicine, 11, 7
10.1210/jc.80.12.3567 · DOI

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Authors: Corona, G., Giagulli, V. A., Maseroli, E., Vignozzi, L., Aversa, A., Zitzmann, M., Saad, F., Mannucci, E., & Maggi, M.
Affiliations: Azienda USL di Bologna (IT)
University of Münster (DE)
Gulf Medical University (AE)
Azienda Ospedaliero-Universitaria Careggi (IT)
Corresponding author: Maggi, Mario
ORCID: Corona, Giovanni
Giagulli, Vito A
Maseroli, Elisa
Vignozzi, Linda
Zitzmann, Michael
Saad, Farid
Mannucci, Edoardo
Maggi, Mario
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2016-03
Volume: 174
Issue: 3
Pages: R99-R116
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje-15-0262
OpenAlex: W2263005700
Cited by: 217
References: 152
Citations by year: 2026: 10 · 2025: 14 · 2024: 14 · 2023: 14 · 2022: 24 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 28 · 2017: 31 · 2016: 18
FWCI: 3.86
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone supplementation, body composition, hypogonadism, lean body mass, fat mass, insulin resistance, cholesterol, triglycerides, blood pressure
MeSH terms: Adipose Tissue, Androgens, Blood Glucose, Body Composition, Humans, Hypogonadism, Insulin Resistance, Cholesterol, HDL, Male, Testosterone, Triglycerides, Treatment Outcome, Hormone Replacement Therapy

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THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study

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