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Guidance Document on Good In Vitro Method Practices (GIVIMP)
Abstract
The Organisation for Economic Co-operation and Development (OECD) is an intergovernmental organisation in which representatives of 36 industrialised countries in North and South America, Europe and the Asia and Pacific region, as well as the European Commission, meet to co-ordinate and harmonise policies, discuss issues of mutual concern, and work together to respond to international problems.Most of the OECD's work is carried out by more than 200 specialised committees and working groups composed of member country delegates.Observers from several countries with special status at the OECD, and from interested international organisations, attend many of the OECD's workshops and other meetings.Committees and working groups are served by the OECD Secretariat, located in Paris, France, which is organised into directorates and divisions.The Environment, Health and Safety Division publishes free-of-charge documents in twelve different series: Testing and Assessment; Good Laboratory Practice and Compliance Monitoring; Pesticides;
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“The current testing paradigm for DNT mainly relies on results on results from in vivo guideline studies (OECD TG 426 (OECD 2007), OECD TG 443 with DNT cohort (OECD 2018a)).”
From Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology (2025) · cites this paper as OECD 2018a
In the citing paper
“The document provides guidance for development and implementation of cellular methods generating data for regulatory safety assessment.”
From Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology (2025) · cites this paper as OECD 2018b
In the citing paper
“Even if imaging technologies are not specifically covered, other important aspects related to in vitro methods (e.g., facilities, test systems, reference/control items, SOPs) are explained.”
From Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology (2025) · cites this paper as OECD 2018b
In the citing paper
“A significant step forward was the publication of the Guidance Document on Good In Vitro Method Practices (GIVIMP) by OECD in 2018 (OECD 2018b).”
From Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology (2025) · cites this paper as OECD 2018b
In the citing paper
“In addition, serum is a complex mixture of different factors, which introduces undefined constituents within the culture medium. Many of these components have not yet been identified, and in several cases, their effects on cell/tissue cultures are still unknown [18, 20].”
From A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation (2022) · cites this paper as [18]
In the citing paper
“Notably, all animal‐derived materials and reagents are obtained from different animal groups and result in batch‐to‐batch variation, which may lead to reliability and integrity concerns for generated in vitro data [18, 19].”
From A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation (2022) · cites this paper as [18]
In the citing paper
“Regulatory frameworks already provide clear guidance in his direction: the OECD Good Ín Vitro Method Practices (GIVIMP) guidelines recommend minimizing or eliminating undefined components such as FBS (OECD, 2018), while the Centre for the Validation of Alternative Methods Scientific Advisory Committee (ESAC) recommends avoiding FBS use unless scientifically justified (van der Valk et al., 2018).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as OECD, 2018
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Metadata
- Authors
- OECD
- Corresponding author
- OECD
- Venue
- OECD Series on Testing and Assessment
- Publisher
- OECD Publishing
- Published
- 2018-12-10
- ISSN
- 2077-7876 (ISSN-L)
- OpenAlex
- W4251582862
- Cited by
- 161
- References
- 199
- Citations by year
- 2026: 29 · 2025: 29 · 2024: 24 · 2023: 12 · 2022: 18 · 2021: 20 · 2020: 11 · 2019: 12 · 2018: 1
- FWCI
- 10.38
- Type
- book
- Language
- en
- Open access
- closed
- Locations
- OECD series on testing and assessment (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Keywords
- in vitro toxicity testing, test reproducibility, test reliability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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