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UMAP: Uniform Manifold Approximation and Projection
Open accessAbstract
Uniform Manifold Approximation and Projection (UMAP) is a dimension reduction technique that can be used for visualisation similarly to t-SNE, but also for general non-linear dimension reduction. UMAP has a rigorous mathematical foundation, but is simple to use, with a scikit-learn compatible API. UMAP is among the fastest manifold learning implementations available -significantly faster than most t-SNE implementations.
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“Other methods, such as t-distributed stochastic neighbor embedding (t-SNE) (68) or uniform manifold approximation and projection (UMAP) (69), aim to preserve apparent pairwise distances approximately in a reduced two-dimensional space so that it can be readily visualized.”
From Machine Learning for the Discovery, Design, and Engineering of Materials. (2022) · cites this paper as [69]
In the citing paper
“Uniform Manifold Approximation and Projection (UMAP) [58] is a successor of t-SNE, superior in run time performance, scalability regarding larger datasets, and perseverance of data structure.”
From Explainable AI in medical imaging: An overview for clinical practitioners – Beyond saliency-based XAI approaches (2023) · cites this paper as [58]
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“Lack of maturity”
From Explainable AI in medical imaging: An overview for clinical practitioners – Beyond saliency-based XAI approaches (2023) · cites this paper as [58]
In the citing paper
“Improved time performance, Better perseverance of data structure”
From Explainable AI in medical imaging: An overview for clinical practitioners – Beyond saliency-based XAI approaches (2023) · cites this paper as [58]
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UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction
McInnes, L., Healy, J., & Melville, J. (2018) · arXiv · doi:10.48550/arxiv.1802.03426 · Cited by 7,101
Self-citationMcInnes,%20Leland%20and%20Healy,%20John%20and%20Saul,%20Nathaniel%20and%20Grossberger,%20Lukas, UMAP, 2018, https://github.com/lmcinnes/umap, 2018-07-22
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Bradford, G., Lopez, J., Ruža, J., Stolberg, M. A., Osterude, R., Johnson, J. A., Gómez‐Bombarelli, R., & Shao‐Horn, Y. (2023) · ACS Central Science · doi:10.1021/acscentsci.2c01123 · Cited by 158
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Saarenpää, S., Shalev, O., Ashkenazy, H., Carlos, V., Lundberg, D. S., Weigel, D., & Giacomello, S. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01979-2 · Cited by 171
“We therefore investigated the effects of microbial hotspots on the host transcriptome by reducing the host expression patterns into five cell clusters using uniform manifold approximation and projection (UMAP 33 ; Fig.”
InfluentialAPT datasets and attack modeling for automated detection methods: A review
Stojanović, B., Hofer-Schmitz, K., & Kleb, U. (2020) · Computers & Security · doi:10.1016/j.cose.2020.101734 · Cited by 147
A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature
Xiang, M., Grosso, R. A., Takeda, A., Pan, J., Bekkhus, T., Brulois, K., Đermadi, D., Nordling, S., Vanlandewijck, M., Jalkanen, S., et al. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00052 · Cited by 143
A mixture-of-experts deep generative model for integrated analysis of single-cell multiomics data
Minoura, K., Abe, K., Nam, H., Nishikawa, H., & Shimamura, T. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100071 · Cited by 145
Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity
Quddos, F., Hubshman, Z., Tegge, A. N., Sane, D., Marti, E., Kablinger, A. S., Gatchalian, K. M., Kelly, A. L., DiFeliceantonio, A. G., & Bickel, W. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-48267-2 · Cited by 167
Dolezal, J. M., Srisuwananukorn, A., Karpeyev, D., Ramesh, S., Kochanny, S., Cody, B., Mansfield, A. S., Rakshit, S., Bansal, R., Bois, M. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34025-x · Cited by 147
Spitzer, H., Ripart, M., Whitaker, K. J., D’Arco, F., Mankad, K., Chen, A. A., Napolitano, A., Palma, L. D., BENEDICTIS, A. D., Foldes, S. T., et al. (2022) · Brain · doi:10.1093/brain/awac224 · Cited by 145
Liu, C.-C., Wang, N., Chen, Y., Inoue, Y., Shue, F., Ren, Y., Wang, M., Qiao, W., Ikezu, T. C., Li, Z., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01640-9 · Cited by 146
Epigenetic regulator function through mouse gastrulation
Grosswendt, S., Kretzmer, H., Smith, Z. D., Kumar, A. S., Hetzel, S., Wittler, L., Klages, S., Timmermann, B., Mukherji, S., & Meissner, A. (2020) · Nature · doi:10.1038/s41586-020-2552-x · Cited by 138
NanoCLUST: a species-level analysis of 16S rRNA nanopore sequencing data
Rodríguez‐Pérez, H., Ciuffreda, L., & Flores, C. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa900 · Cited by 143
Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells
Hwang, Y. S., Suzuki, S., Seita, Y., Ito, J., Sakata, Y., Aso, H., Sato, K., Hermann, B. P., & Sasaki, K. (2020) · Nature Communications · doi:10.1038/s41467-020-19350-3 · Cited by 149
Model-based deep embedding for constrained clustering analysis of single cell RNA-seq data
Tian, T., Zhang, J., Lin, X., Wei, Z., & Hakonarson, H. H. (2021) · Nature Communications · doi:10.1038/s41467-021-22008-3 · Cited by 150
Gaborieau, B., Vaysset, H., Tesson, F., Charachon, I., Dib, N., Bernier, J., Dequidt, T., Georjon, H., Clermont, O., Hersen, P., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01832-5 · Cited by 141
“The obtained pairwise distance matrix was then used to (1) perform exploratory data analysis using dimensionality reduction with the UMAP algorithm 79 and (2) partition the distance matrix between diverse sources of variation using PERMANOVA 39 .”
MARS: discovering novel cell types across heterogeneous single-cell experiments
Brbić, M., Žitnik, M., Wang, S., Pisco, A. O., Altman, R. B., Darmanis, S., & Leskovec, J. (2020) · Nature Methods · doi:10.1038/s41592-020-00979-3 · Cited by 144
Global computational alignment of tumor and cell line transcriptional profiles
Warren, A. C., Chen, Y., Jones, A., Shibue, T., Hahn, W. C., Boehm, J. S., Vázquez, F., Tsherniak, A., & McFarland, J. M. (2021) · Nature Communications · doi:10.1038/s41467-020-20294-x · Cited by 147
Jessa, S., Mohammadnia, A., Harutyunyan, A. S., Hulswit, M., Varadharajan, S., Lakkis, H., Kabir, N., Bashardanesh, Z., Hébert, S., Faury, D., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01205-w · Cited by 150
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
Gayoso, A., Weiler, P., Lotfollahi, M., Klein, D., Hong, J., Streets, A., Theis, F. J., & Yosef, N. (2023) · Nature Methods · doi:10.1038/s41592-023-01994-w · Cited by 143
Identification of a regeneration-organizing cell in the Xenopus tail
Aztekin, C., Hiscock, T. W., Marioni, J. C., Gurdon, J. B., Simons, B. D., & Jullien, J. (2019) · Science · doi:10.1126/science.aav9996 · Cited by 142
Wang, T., Johnson, T. S., Shao, W., Lu, Z., Helm, B. R., Zhang, J., & Huang, K. (2019) · Genome biology · doi:10.1186/s13059-019-1764-6 · Cited by 143
Integration of molecular profiles in a longitudinal wellness profiling cohort
Tebani, A., Gummesson, A., Zhong, W., Schuppe‐Koistinen, I., Lakshmikanth, T., Olsson, L. M., Boulund, F., Neiman, M., Stenlund, H. C., Hellström, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18148-7 · Cited by 156
Huang, H., Wang, Y., Rudin, C. D., & Browne, E. P. (2022) · Communications Biology · doi:10.1038/s42003-022-03628-x · Cited by 160
Li, K., DeCost, B., Choudhary, K. K., Greenwood, M., & Hattrick-Simpers, J. R. (2023) · npj Computational Materials · doi:10.1038/s41524-023-01012-9 · Cited by 167
“Here we use Uniform Manifold Approximation and Projection (UMAP), a stochastic and non-linear dimensionality reduction algorithm that preserves the data’s local and global structure [58].”
BackgroundMethodMapping cells through time and space with moscot
Klein, D., Palla, G., Lange, M., Klein, M., Piran, Z., Gander, M., Meng-Papaxanthos, L., Sterr, M., Saber, L., Jing, C., et al. (2025) · Nature · doi:10.1038/s41586-024-08453-2 · Cited by 235
“TOME requires a 3D UMAP embedding.”
InfluentialAnalysis of the Human Protein Atlas Image Classification competition
Ouyang, W., Winsnes, C. F., Hjelmare, M., Cesnik, A. J., Åkesson, L., Xu, H., Sullivan, D. P., Dai, S., Lan, J., Jinmo, P., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0658-6 · Cited by 131
Whole-body integration of gene expression and single-cell morphology
Vergara, H. M., Pape, C., Meechan, K., Zinchenko, V., Genoud, C., Wanner, A. A., Mutemi, K. N., Titze, B., Templin, R., Bertucci, P. Y., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.017 · Cited by 146
EpiScanpy: integrated single-cell epigenomic analysis
Danese, A., Richter, M. L., Chaichoompu, K., Fischer, D. S., Theis, F. J., & Colomé‐Tatché, M. (2021) · Nature Communications · doi:10.1038/s41467-021-25131-3 · Cited by 138
Jäger, B., Schupp, J. C., Plappert, L., Terwolbeck, O., Artysh, N., Kayser, G., Engelhard, P., Adams, T. S., Zweigerdt, R., Kempf, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33193-0 · Cited by 144
Metadata
- Authors
- McInnes, L., Healy, J., Saul, N., & Großberger, L.
- Affiliations
- Washington State University (US)
- Max Planck Society (DE)
- Venue
- Journal of Open Source Software
- Publisher
- The Open Journal
- Published
- 2018-09-02
- Volume
- 3
- Issue
- 29
- Pages
- 861
- ISSN
- 2475-9066 (ISSN-L)
- OpenAlex
- W2889326414
- Cited by
- 9,826
- References
- 2
- Citations by year
- 2026: 1775 · 2025: 1933 · 2024: 1675 · 2023: 1392 · 2022: 1193 · 2021: 1058 · 2020: 587 · 2019: 186 · 2018: 24
- FWCI
- 232.44
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- The Journal of Open Source Software (publishedVersion, cc-by)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Face and Expression Recognition
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Topological and Geometric Data Analysis
- Physical Sciences › Computer Science › Artificial Intelligence › Stochastic Gradient Optimization Techniques
- Keywords
- UMAP, dimensionality reduction, manifold learning, nonlinear dimensionality reduction, data visualization, scikit-learn
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