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Vagus Nerve and Underlying Impact on the Gut Microbiota-Brain Axis in Behavior and Neurodegenerative Diseases
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The gut microbiota is the most abundant and diverse microbiota in the human body and the vagus nerve is the most widely distributed and complex nerve in the body, both of them are essential in maintaining homeostasis. The most important phenomenon is how they coordinate to regulate functions, which has attracted the great attention of scientists. The academic literature on the correlation with a host of intestinal diseases and even systemic diseases has revealed the bidirectional communication between the gut microbiota and the brain, which can be carried out via multiple patterns. In the review, firstly, we have a general overview of the gut microbiota and the gut microbiota-brain axis. Secondly, according to the distribution characteristics of the vagus nerve, we analyzed and summarized its function in the intestinal tract. At the same time, we have summarized the underlying mechanism of some behavior changes such as depressive and anxiety-like behaviors and related neurodegenerative diseases caused by the vagus nerve and intestinal microecological environment disorders, and then we also analyzed inconsistency of the experimental evidence in order to propose novel strategies for the clinical practice.
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“Furthermore, microbial metabolites stimulate the vagus nerve, thereby exerting an important impact on brain function in SZ [14].”
From Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials (2025) · cites this paper as [14]
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Calderón‐Garcidueñas, L., Reynoso-Robles, R., Pérez-Guillé, B., Mukherjee, P. S., & González-Maciel, A. (2017) · Environmental Research · doi:10.1016/j.envres.2017.08.008 · Cited by 51
Ultrasound Detection of Vagus Nerve Atrophy in Bulbar Amyotrophic Lateral Sclerosis
Holzapfel, K., & Naumann, M. K. (2020) · Journal of Neuroimaging · doi:10.1111/jon.12761 · Cited by 30
Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS
Bataveljić, D., Milosevic, M. M., Radenović, L., & Anđjus, P. R. (2014) · BioMed Research International · doi:10.1155/2014/907545 · Cited by 28
Roles for gut vagal sensory signals in determining energy availability and energy expenditure
Schwartz, G. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.004 · Cited by 26
Yogi-Morren, D., Galioto, R., Strandjord, S. E., Kennedy, L., Manroa, P., Kirwan, J. P., Kashyap, S. R., & Gunstad, J. (2014) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2014/656341 · Cited by 25
Dementia and vagotomy in Taiwan: a population-based cohort study
Lin, S.-Y., Lin, C., Wang, I., Lin, C., Lin, C., Hsu, W., & Kao, C. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019582 · Cited by 24
Glucose signaling in the brain and periphery to memory
Hossain, M. S., Oomura, Y., Fujino, T., & Akashi, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.018 · Cited by 24
Hill, A. E., Wade‐Martins, R., & Burnet, P. W. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.708587 · Cited by 19
Vagus nerve ultrasound in a patient with amyotrophic lateral sclerosis
Tawfik, E. A. (2016) · Muscle & Nerve · doi:10.1002/mus.25126 · Cited by 17
Cruz, M. T., Dezfuli, G., Murphy, E. C., Vicini, S., Sahibzada, N., & Gillis, R. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00967 · Cited by 12
Flagged first, then by citations
Research works printed but not linked: 2
- Rinaman, 1989, J Neurosci, 9, 1985, 10.1523/JNEUROSCI.09-06-01985 · DOI
- Cechetto, 1987, Fed Proc, 46, 17
Cited by
Sorted by citations
Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options
Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 174
Boundaries and integration between microbiota, the nervous system, and immunity
Macpherson, A. J., Pachnis, V., & Prinz, M. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.011 · Cited by 118
Yang, J., Liang, J., Hu, N., He, N., Liu, B., Liu, G., & Qin, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70091 · Cited by 109
Moțățăianu, A., Şerban, G. M., & Andone, S. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015094 · Cited by 94
Dziedzic, A., Maciak, K., Bliźniewska-Kowalska, K. M., Gałecka, M., Kobierecka, W., & Saluk, J. (2024) · Nutrients · doi:10.3390/nu16071054 · Cited by 94
Metadata
- Authors
- Han, Y., Wang, B., Gao, H., He, C., Hua, R., Liang, C., Zhang, S., Wang, Y., Xin, S., & Xu, J.
- Affiliations
- Capital Medical University (CN)
- Peking University People's Hospital (CN)
- Beijing Tongren Hospital (CN)
- Corresponding author
- Xu, Jingdong
- Venue
- Journal of Inflammation Research
- Publisher
- Informa UK Limited
- Published
- 2022-11
- Volume
- Volume 15
- Pages
- 6213-6230
- ISSN
- 1178-7031 (ISSN-L)
- PMC
- PMC9656367
- OpenAlex
- W4308542736
- Cited by
- 265
- References
- 100
- Citations by year
- 2026: 100 · 2025: 83 · 2024: 57 · 2023: 25
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Inflammation Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- National Natural Science Foundation of China (81673671, 82174056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- vagus nerve, gut microbiota, gut-brain axis, neurodegenerative diseases, depression-like behavior, anxiety-like behavior, two-way communication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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