Mid- and Late-Life Diabetes in Relation to the Risk of Dementia
Open accessAbstract
OBJECTIVE: We aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease, and vascular dementia in twins and to explore whether genetic and early-life environmental factors could contribute to this association. RESEARCH DESIGN AND METHODS: This study included 13,693 twin individuals aged > or =65 years. Dementia was diagnosed according to DSM-IV (Diagnostic Manual of Mental Disorders, 4th ed.) criteria. Information on diabetes was collected from the inpatient registry and self- or informant-reported history of diabetes. Data were analyzed following two strategies: 1) unmatched case-control analysis for all participants using generalized estimating equation (GEE) models and 2) cotwin matched case-control analysis for dementia-discordant twin pairs using conditional logistic regression. RESULTS: Of all participants, 467 were diagnosed with dementia, including 292 with Alzheimer's disease and 105 with vascular dementia, and an additional 170 were diagnosed with questionable dementia. Diabetes was present in 1,396 subjects. In GEE models, diabetes was associated with adjusted odds ratios (ORs) (95% CI) of 1.89 (1.51-2.38) for dementia, 1.69 (1.16-2.36) for Alzheimer's disease, and 2.17 (1.36-3.47) for vascular dementia. Compared with late-life diabetes (onset age > or =65 years), the risk effect of mid-life diabetes (onset age <65 years) on dementia was stronger. Conditional logistic analysis of 210 dementia-discordant twin pairs led to ORs of 2.41 (1.05-5.51) and 0.68 (0.30-1.53) for dementia related to mid- and late-life diabetes, respectively. CONCLUSIONS: Diabetes increases the risk of Alzheimer disease and vascular dementia. The risk is stronger when diabetes occurs at mid-life than in late life. Genetic and early-life environmental factors might contribute to the late-life diabetes-dementia association but could not account for the mid-life diabetes-dementia association.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Only one previous study has discussed the relationship specifically between late-life diabetes and dementia.
“As far as we know, only one previous study has discussed the relationship specifically between late-life diabetes and dementia (24).”
From Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis (2014) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
Hearing loss and cognitive decline in older adults
Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017 · see citing works
Risk of dementia in diabetes mellitus: a systematic review
Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., & Scheltens, P. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70284-2 · Cited by 2,187 · see citing works
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175 · see citing works
The Developmental Origins of Adult Disease
Barker, D. J. P. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719428 · Cited by 1,854 · see citing works
Role of Genes and Environments for Explaining Alzheimer Disease
Gatz, M., Reynolds, C. A., Fratiglioni, L., Johansson, B., Mortimer, J. A., Berg, S., Fiske, A., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.168 · Cited by 1,798 · see citing works
Self-citationDiabetes mellitus and risk of Alzheimer disease and decline in cognitive function
Arvanitakis, Z., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.661 · Cited by 1,258 · see citing works
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies
Peila, R., Rodriguez, B. L., & Launer, L. J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1256 · Cited by 1,207 · see citing works
Advances in Male Contraception
Page, S. T., Amory, J. K., & Bremner, W. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0041 · Cited by 1,134 · see citing works
Increased Risk of Type 2 Diabetes in Alzheimer Disease
Janson, J., Laedtke, T., Parisi, J. E., O’Brien, P., Petersen, R. C., & Butler, P. C. (2004) · Diabetes · doi:10.2337/diabetes.53.2.474 · Cited by 950 · see citing works
Aggregation of vascular risk factors and risk of incident Alzheimer disease
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790 · see citing works
Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
Leibson, C. L., Rocca, W. A., Hanson, V. A., Cha, R., Kokmen, E., O'Brien, P. C., & Palumbo, P. J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009106 · Cited by 700 · see citing works
The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
Lichtenstein, P., Fairé, U. D., Floderus, B., Svartengren, M., Svedberg, P., & Pedersen, N. L. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01032.x · Cited by 696 · see citing works
Self-citationHyperinsulinemia and risk of Alzheimer disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683 · see citing works
Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort
Luchsinger, J. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.635 · Cited by 682 · see citing works
The developmental origins of adult disease (Barker) hypothesis
de Boo, H. A., & Harding, J. E. (2006) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2006.00506.x · Cited by 631 · see citing works
Trends in cardiovascular complications of diabetes
Fox, C. S. (2004) · JAMA · doi:10.1001/jama.292.20.2495 · Cited by 626 · see citing works
Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis
Haataja, L., Gurlo, T., Huang, C. J., & Butler, P. C. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0037 · Cited by 612 · see citing works
Type 2 diabetes mellitus, cognitive impairment and dementia
Stewart, R., & Liolitsa, D. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00027.x · Cited by 562 · see citing works
Qiu, W. Q., & Folstein, M. F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.004 · Cited by 538 · see citing works
Diabetes mellitus and risk of dementia in the Kungsholmen project
Xu, W., Qiu, C., Wåhlin, Å., Winblad, B. G., & Fratiglioni, L. (2004) · Neurology · doi:10.1212/01.wnl.0000140291.86406.d1 · Cited by 409 · see citing works
Self-citationKloppenborg, R. P., van den Berg, E., Kappelle, L. J., & Biessels, G. J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.049 · Cited by 368 · see citing works
Brain Imaging in Patients With Diabetes
van Harten, B., de Leeuw, F., Weinstein, H. C., Scheltens, P., & Biessels, G. J. (2006) · Diabetes Care · doi:10.2337/dc06-1637 · Cited by 349 · see citing works
A life-course approach to the aetiology of late-onset dementias
Whalley, L. J., Dick, F. D., & McNeill, G. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70286-6 · Cited by 346 · see citing works
Gregg, E. W., Cadwell, B. L., Cheng, Y. J., Cowie, C. C., Williams, D. E., Geiss, L. S., Engelgau, M. M., & Vinicor, F. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2806 · Cited by 331 · see citing works
MacKnight, C., Rockwood, K., Awalt, E., & McDowell, I. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000064928 · Cited by 313 · see citing works
Diabetes Mellitus and Risk of Developing Alzheimer Disease
Akomolafe, A., Beiser, A., Meigs, J. B., Au, R., Green, R. C., Farrer, L. A., Wolf, P. A., & Seshadri, S. S. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1551 · Cited by 281 · see citing works
Diabetes mellitus in midlife and the risk of dementia three decades later
Beeri, M. S., Goldbourt, U., Silverman, J. M., Noy, S., Schmeidler, J., Ravona‐Springer, R., Sverdlick, A., & Davidson, M. (2004) · Neurology · doi:10.1212/01.wnl.0000144278.79488.dd · Cited by 263 · see citing works
Early-Life Risk Factors for Alzheimer Disease
Borenstein, A. R., Copenhaver, C. I., & Mortimer, J. A. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000201854.62116.d7 · Cited by 259 · see citing works
Genetic Factors in Type 2 Diabetes: The End of the Beginning?
O’Rahilly, S., Barroso, I., & Wareham, N. J. (2005) · Science · doi:10.1126/science.1104346 · Cited by 252 · see citing works
The Effect of Borderline Diabetes on the Risk of Dementia and Alzheimer’s Disease
Xu, W., Qiu, C., Winblad, B. G., & Fratiglioni, L. (2006) · Diabetes · doi:10.2337/db06-0879 · Cited by 218 · see citing works
Self-citationType 2 diabetes and risk of cognitive impairment and dementia
Whitmer, R. A. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0058-7 · Cited by 195 · see citing works
Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
Gatz, M., Fratiglioni, L., Johansson, B. E. A., Berg, S., Mortimer, J. A., Reynolds, C. A., Fiske, A., & Pedersen, N. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.004 · Cited by 177 · see citing works
Self-citationHassing, L. B., Johansson, B. E. A., Nilsson, S. E., Berg, S., Pedersen, N. L., Gatz, M., & McClearn, G. E. (2002) · International Psychogeriatrics · doi:10.1017/s104161020200844x · Cited by 175 · see citing works
Self-citationMolecular connexions between dementia and diabetes
Cole, A. R., Astell, A. J., Green, C., & Sutherland, C. D. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.004 · Cited by 161 · see citing works
Fasting insulin and incident dementia in an elderly population of Japanese-American men
Peila, R., Rodriguez, B. L., White, L. R., & Launer, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000129989.28404.9b · Cited by 152 · see citing works
Predictors of cognitive impairment and dementia in older people with diabetes
Bruce, D. G., Davis, W. A., Casey, G. P., STARKSTEIN, S. E., Clarnette, R., Foster, J. K., Almeida, O. P., & Davis, T. M. E. (2007) · Diabetologia · doi:10.1007/s00125-007-0894-7 · Cited by 148 · see citing works
Education and the Risk of Alzheimer's Disease: Findings From the Study of Dementia in Swedish Twins
Gatz, M., Svedberg, P., Pedersen, N. L., Mortimer, J. A., Berg, S., & Johansson, B. E. A. (2001) · The Journals of Gerontology Series B · doi:10.1093/geronb/56.5.p292 · Cited by 142 · see citing works
Self-citationHow heritable is Alzheimer's disease late in life? Findings from Swedish twins
Pedersen, N. L., Gatz, M., Berg, S., & Johansson, B. E. A. (2003) · Annals of Neurology · doi:10.1002/ana.10999 · Cited by 131 · see citing works
Self-citationDevelopmental and vascular risk factors for Alzheimer's disease
Borenstein, A. R., Wu, Y., Mortimer, J. A., Schellenberg, G. D., McCormick, W. C., Bowen, J. D., McCurry, S. M., & Larson, E. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.010 · Cited by 125 · see citing works
An Empirical Test of Telephone Screening to Identify Potential Dementia Cases
Gatz, M., Reynolds, C. A., Nikolic, J., Lowe, B. F., Karel, M. J., & Pedersen, N. L. (1995) · International Psychogeriatrics · doi:10.1017/s1041610295002171 · Cited by 114 · see citing works
Self-citationLow birthweight and Type 2 diabetes: A study on 11 162 Swedish twins
Iliadou, A. N. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh117 · Cited by 93 · see citing works
The Epidemiology of Adiposity and Dementia
Whitmer, R. A. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362065 · Cited by 92 · see citing works
Gatz, M., John, R. S., Reynolds, C. A., Johansson, B. E. A., Mortimer, J. A., & Pedersen, N. L. (2002) · International Psychogeriatrics · doi:10.1017/s1041610202008475 · Cited by 88 · see citing works
Self-citationDiabetes and brain aging: Epidemiologic evidence
Launer, L. J. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0069-1 · Cited by 85 · see citing works
Poulsen, P., & Vaag, A. A. (2006) · Diabetes · doi:10.2337/db05-1462 · Cited by 68 · see citing works
Assessing Age of Dementia Onset
Fiske, A., Gatz, M., Aadn??y, B., & Pedersen, N. L. (2005) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000174947.76968.74 · Cited by 40 · see citing works
Self-citationDiabetes and Coronary Heart Disease in Filipino-American Women
Langenberg, C., Araneta, M. R. G., Bergstrom, J., Marmot, M. G., & Barrett-Connor, E. L. (2007) · Diabetes Care · doi:10.2337/dc06-1403 · Cited by 39 · see citing works
Reliability of Information Collected by Proxy in Family Studies of Alzheimer’s Disease
Demissie, S., Green, R. C., Mucci, L. A., Tziavas, S., Martelli, K., Bang, K., Coons, L., Bourque, S., Buchillon, D., Johnson, K., et al. (2001) · Neuroepidemiology · doi:10.1159/000054768 · Cited by 32 · see citing works
Intra-uterine origins of type 2 diabetes
Jones, R. H., & Ozanne, S. E. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701318484 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [27]American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC, American Psychiatric Association, 1994
Cited by
Sorted by citations
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597 · see citing works
Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention
Qiu, C., Kivipelto, M., & von Strauss, E. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/cqiu · Cited by 1,261 · see citing works
Self-citationBiessels, G. J., Strachan, M. W. J., Visseren, F. L. J., Kappelle, L. J., & Whitmer, R. A. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70088-3 · Cited by 555 · see citing works
Gender and incidence of dementia in the Framingham Heart Study from mid‐adult life
Chêne, G., Beiser, A., Au, R., Preis, S. R., Wolf, P. A., Dufouil, C., & Seshadri, S. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.10.005 · Cited by 499 · see citing works
Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C., La Rue, A., Hermann, B. P., Koscik, R. L., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0613 · Cited by 418 · see citing works
Defining the relationship between hypertension, cognitive decline, and dementia: a review
Walker, K. A., Power, M. C., & Gottesman, R. F. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0724-3 · Cited by 394 · see citing works
An updated meta-analysis of cohort studies: Diabetes and risk of Alzheimer’s disease
Zhang, J., Chen, C., Hua, S., Liao, H., Wang, M., Xiong, Y., & Cao, F. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.10.024 · Cited by 376 · see citing works
Association between age at diabetes onset and subsequent risk of dementia
Barbiellini Amidei, C., Fayosse, A., Dumurgier, J., Machado-Fragua, M. D., Tabak, A. G., van Sloten, T., Kivimäki, M., Dugravot, A., Sabia, S., & Singh-Manoux, A. (2021) · JAMA · doi:10.1001/jama.2021.4001 · Cited by 355 · see citing works
Models and Mechanisms of Vascular Dementia
Venkat, P., Chopp, M., & Chen, J.-L. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.05.006 · Cited by 323 · see citing works
Fish, docosahexaenoic acid and Alzheimer’s disease
Cunnane, S. C., Plourde, M., Pifferi, F., Bégin, M. E., Féart, C., & Barberger‐Gateau, P. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.04.001 · Cited by 316 · see citing works
Diabetes, glucose control, and 9-year cognitive decline among older adults without dementia
Yaffe, K., Falvey, C., Hamilton, N., Schwartz, A. V., Simonsick, E. M., Satterfield, S., Cauley, J. A., Rosano, C., Launer, L. J., Strotmeyer, E. S., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.1117 · Cited by 313 · see citing works
Vascular Cognitive Impairment (VCI)
Rundek, T., Tolea, M. I., Ariko, T., Fagerli, E. A., & Camargo, C. J. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01170-y · Cited by 325 · see citing works
Early Adult to Midlife Cardiovascular Risk Factors and Cognitive Function
Yaffe, K., Vittinghoff, E., Pletcher, M. J., Hoang, T. D., Launer, L. J., Whitmer, R. A., Coker, L. H., & Sidney, S. (2014) · Circulation · doi:10.1161/circulationaha.113.004798 · Cited by 308 · see citing works
Takiishi, T., Gysemans, C. A., Bouillon, R., & Mathieu, C. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.02.013 · Cited by 274 · see citing works
Fiest, K. M., Roberts, J. I., Maxwell, C. J., Hogan, D. B., Smith, E. E., Frolkis, A. D., Cohen, A., Kirk, A., Pearson, D. M., Pringsheim, T. M., et al. (2016) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2016.36 · Cited by 270 · see citing works
Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
Xu, W., Caracciolo, B., Wang, H.-X., Winblad, B., Bäckman, L., Qiu, C., & Fratiglioni, L. (2010) · Diabetes · doi:10.2337/db10-0539 · Cited by 260 · see citing works
Self-citationZloković, B. V., Gottesman, R. F., Bernstein, K. E., Seshadri, S. S., McKee, A. C., Snyder, H. M., Greenberg, S. M., Yaffe, K. S., Schaffer, C. B., Yuan, C., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12157 · Cited by 241 · see citing works
Insulin, cognition, and dementia
Cholerton, B., Baker, L. D., & Craft, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.08.008 · Cited by 229 · see citing works
Rajeev, V., Chai, Y. L., Poh, L., Selvaraji, S., Fann, D. Y., Jo, D., Silva, T. M. D., Drummond, G. R., Sobey, C. G., Arumugam, T. V., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01590-1 · Cited by 237 · see citing works
Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Jiang, T., Yu, J., Tian, Y., & Tan, L. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990155 · Cited by 224 · see citing works
Is Alzheimer’s disease a systemic disease?
Morris, J. K., Honea, R. A., Vidoni, E. D., Swerdlow, R. H., & Burns, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.012 · Cited by 219 · see citing works
Tuligenga, R. H., Dugravot, A., Tabák, Á. G., Elbaz, A., Brunner, E. J., Mika Kivimaki, B., & Singh‐Manoux, A. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70192-x · Cited by 213 · see citing works
Rawlings, A. M., Sharrett, A. R., Albert, M., Coresh, J., Windham, B. G., Power, M. C., Knopman, D. S., Walker, K. A., Burgard, S. L., Mosley, T. H., et al. (2019) · Diabetes Care · doi:10.2337/dc19-0120 · Cited by 210 · see citing works
Cognitive decline, dietary factors and gut–brain interactions
Caracciolo, B., Xu, W., Collins, S. M., & Fratiglioni, L. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.11.011 · Cited by 205 · see citing works
Self-citationDementia prevention: current epidemiological evidence and future perspective
Mangialasche, F., Kivipelto, M., Solomon, A., & Fratiglioni, L. (2012) · Alzheimer s Research & Therapy · doi:10.1186/alzrt104 · Cited by 204 · see citing works
Self-citationThe prevalence and incidence of dementia: a systematic review and meta-analysis
Fiest, K. M., Jetté, N., Roberts, J. I., Maxwell, C. J., Smith, E. E., Black, S. E., Blaikie, L., Cohen, A., Day, L., Holroyd-Leduc, J., et al. (2016) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2016.18 · Cited by 188 · see citing works
Simó, R., Ciudin, A., Simó‐Servat, O., & Hernández, C. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-0970-5 · Cited by 172 · see citing works
Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis
Cheng, C., Lin, C.-H., Tsai, Y.-W., Tsai, C.-J., Chou, P.-H., & Lan, T.-H. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu073 · Cited by 167 · see citing works
Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia
Hughes, T. F., & Ganguli, M. (2009) · Current Psychiatry Reviews · doi:10.2174/157340009788167347 · Cited by 152 · see citing works
Meng, X.-F., Yu, J.-T., Wang, H.-F., Tan, M.-S., Wang, C., Tan, C.-C., & Tan, L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140954 · Cited by 150 · see citing works
Relationship between cognitive function and regulation of cerebral blood flow
Ogoh, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0525-0 · Cited by 150 · see citing works
Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry
Dove, A. E., Guo, J., Marseglia, A., Fastbom, J., Vetrano, D. L., Fratiglioni, L., Pedersen, N. L., & Xu, W. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac744 · Cited by 145 · see citing works
Self-citationKorczyn, A. D., Vakhapova, V., & Grinberg, L. T. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.03.027 · Cited by 144 · see citing works
Low cerebral blood flow is associated with lower memory function in metabolic syndrome
Birdsill, A. C., Carlsson, C. M., Willette, A. A., Okonkwo, O. C., Johnson, S. C., Xu, G., Oh, J. M., Gallagher, C. L., Koscik, R. L., Jonaitis, E. M., et al. (2013) · Obesity · doi:10.1002/oby.20170 · Cited by 139 · see citing works
Epidemiological of and risk factors for Alzheimer's disease: A review
Povová, J., Ambrož, P., Bar, M., Pavuková, V., Šerý, O., Tomášková, H., & Janout, V. (2012) · Biomedical Papers · doi:10.5507/bp.2012.055 · Cited by 136 · see citing works
Cognitive Decline in Early and Premature Menopause
Sochocka, M., Karska, J., Pszczołowska, M., Ochnik, M., Fułek, M., Fułek, K., Kurpas, D., Chojdak-Łukasiewicz, J., Rosner‐Tenerowicz, A., & Leszek, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076566 · Cited by 138 · see citing works
Smolina, K., Wotton, C. J., & Goldacre, M. J. (2015) · Diabetologia · doi:10.1007/s00125-015-3515-x · Cited by 133 · see citing works
Zilkens, R., Bruce, D. G., Duke, J. M., Spilsbury, K., & Semmens, J. B. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140812115004 · Cited by 125 · see citing works
Greendale, G. A., Derby, C. A., & Maki, P. M. (2011) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2011.05.007 · Cited by 114 · see citing works
Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells
Guo, D.-H., Yamamoto, M., Hernandez, C. M., Khodadadi, H., Baban, B., & Stranahan, A. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci126078 · Cited by 112 · see citing works
Type 2 diabetes mellitus, dyslipidemia, and Alzheimer’s disease
Carlsson, C. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100012 · Cited by 109 · see citing works
Review: Therapy for Alzheimer's disease: how effective are current treatments?
Lanctôt, K. L., Rajaram, R. D., & Herrmann, N. (2009) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285609102724 · Cited by 105 · see citing works
Models and mechanisms for hippocampal dysfunction in obesity and diabetes
Stranahan, A. M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.045 · Cited by 101 · see citing works
Military Risk Factors for Cognitive Decline, Dementia and Alzheimer’s Disease
Veitch, D. P., Friedl, K. E., & Weiner, M. W. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990142 · Cited by 102 · see citing works
Cardiac Disorders as Risk Factors for Alzheimer's Disease
Alves, T. C. T. F., Ferreira, L. K., Wajngarten, M., & Busatto, G. F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091561 · Cited by 102 · see citing works
Brain functional alterations in Type 2 Diabetes – A systematic review of fMRI studies
Macpherson, H., Formica, M., Harris, E., & Daly, R. M. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.001 · Cited by 101 · see citing works
Wagner, M., Helmer, C., Tzourio, C., Berr, C., Proust‐Lima, C., & Samieri, C. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2004 · Cited by 86 · see citing works
Headache as a risk factor for dementia: A prospective population-based study
Hagen, K., Stordal, E., Linde, M., Steiner, T. J., Zwart, J., & Stovner, L. J. (2013) · Cephalalgia · doi:10.1177/0333102413513181 · Cited by 85 · see citing works
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease
Platt, T. L., Beckett, T. L., Köhler, K., Niedowicz, D. M., & Murphy, M. P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.011 · Cited by 86 · see citing works
Earlier Age of Dementia Onset and Shorter Survival Times in Dementia Patients With Diabetes
Zilkens, R., Davis, W. A., Spilsbury, K., Semmens, J. B., & Bruce, D. G. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws387 · Cited by 84 · see citing works
INSULIN RESISTANCE AND GRAY MATTER VOLUME IN NEURODEGENERATIVE DISEASE
Morris, J. K., Vidoni, E., Perea, R., Rada, R. C., Johnson, D. K., Lyons, K., Pahwa, R., Burns, J. M., & Honea, R. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.006 · Cited by 81 · see citing works
Type 2 Diabetes and 10-Year Risk of Dementia and Cognitive Impairment Among Older Mexican Americans
Mayeda, E. R., Haan, M. N., Kanaya, A. M., Yaffe, K. S., & Neuhaus, J. M. (2013) · Diabetes Care · doi:10.2337/dc12-2158 · Cited by 79 · see citing works
Preventing Alzheimer's Disease by Targeting Vascular Risk Factors: Hope and Gap
Qiu, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120922 · Cited by 78 · see citing works
Self-citationMidlife predictors of Alzheimer's disease
Bendlin, B. B., Carlsson, C. M., Gleason, C. E., Johnson, S. C., Sodhi, A., Gallagher, C. L., Puglielli, L., Engelman, C. D., Ries, M. L., Xu, G., et al. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.12.014 · Cited by 79 · see citing works
Insulin: An Emerging Treatment for Alzheimer’s Disease Dementia?
Morris, J. K., & Burns, J. M. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0297-0 · Cited by 72 · see citing works
Couttas, T. A., Kain, N., Tran, C., Chatterton, Z., Kwok, J. B., & Don, A. S. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171054 · Cited by 70 · see citing works
Charles, E. F., Lambert, C. G., & Kerner, B. (2016) · International Journal of Bipolar Disorders · doi:10.1186/s40345-016-0054-4 · Cited by 65 · see citing works
Kim, Y. J., Kim, S. M., Jeong, D. H., Lee, S., Ahn, M., & Ryu, O. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00620-5 · Cited by 67 · see citing works
Kwok, T. C. Y., Lee, J., Ronald, C. W., Wong, S. Y. S., Kung, K., Lam, A. T., Ho, C. S., Lee, V. W. Y., Harrison, J., & LAM, L. C. W. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.10.018 · Cited by 68 · see citing works
Aging, Diabetes, Obesity, and Cognitive Decline: A Population‐Based Study
Ganguli, M., Beer, J. C., Zmuda, J. M., Ryan, C. M., Sullivan, K., Chang, C. H., & Rao, R. H. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16321 · Cited by 66 · see citing works
Reassessment of Pioglitazone for Alzheimer’s Disease
Saunders, A. M., Burns, D. K., & Gottschalk, W. K. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.666958 · Cited by 67 · see citing works
Diabetes Is Associated with Increased Rate of Cognitive Decline in Questionably Demented Elderly
Ravona‐Springer, R., Luo, X., Schmeidler, J., Wysocki, M., Lesser, G. T., Rapp, M. A., Dahlman, K. L., Grossman, H. T., Haroutunian, V. H., & Beeri, M. S. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000265552 · Cited by 65 · see citing works
Goldwaser, E. L., Acharya, N. K., Sarkar, A., Godsey, G. A., & Nagele, R. G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160284 · Cited by 65 · see citing works
Fereshtehnejad, S., Vosoughi, K., Heydarpour, P., Sepanlou, S. G., Farzadfar, F., Tehrani‐Banihashemi, A., Malekzadeh, R., Sahraian, M. A., Vollset, S. E., Naghavi, M., et al. (2019) · European Journal of Neurology · doi:10.1111/ene.13972 · Cited by 62 · see citing works
Age-related brain pathology in Octodon degu: Blood vessel, white matter and Alzheimer-like pathology
van Groen, T., Kadish, I., Popović, N., Popović, M., Caballero‐Bleda, M., Baño‐Otálora, B., Vivanco, P., Rol, M. A., & Madrid, J. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.008 · Cited by 64 · see citing works
Takiishi, T., Gysemans, C. A., Bouillon, R., & Mathieu, C. (2012) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2012.03.015 · Cited by 63 · see citing works
Diabetes duration and the risk of dementia: a cohort study based on German health claims data
Reinke, C., Buchmann, N., Fink, A., Tegeler, C., Demuth, I., & Doblhammer, G. (2021) · Age and Ageing · doi:10.1093/ageing/afab231 · Cited by 60 · see citing works
Rethinking Alzheimer's Disease Therapy: Are Mitochondria the Key?
Ankarcrona, M., Mangialasche, F., & Winblad, B. G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100327 · Cited by 59 · see citing works
Tolppanen, A.-M., Lavikainen, P., Solomon, A., Kivipelto, M., Uusitupa, M. I. J., Soininen, H. S., & Hartikainen, S. A. (2013) · Diabetes Care · doi:10.2337/dc12-1287 · Cited by 55 · see citing works
Takalo, M., Haapasalo, A., Martiskainen, H., Kurkinen, K. M. A., Koivisto, H., Miettinen, P., Khandelwal, V. K. M., Kemppainen, S., Kamińska, D., Mäkinen, P. M., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.02.003 · Cited by 54 · see citing works
Blood Glucose, Diet-Based Glycemic Load and Cognitive Aging Among Dementia-Free Older Adults
Seetharaman, S., Andel, R., McEvoy, C. L., Aslan, A. K. D., Finkel, D., & Pedersen, N. L. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu135 · Cited by 54 · see citing works
Self-citationEpidemiological Approaches to Understanding the Link Between Type 2 Diabetes and Dementia
Sutherland, G. T., Lim, J., Srikanth, V. K., & Bruce, D. G. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161194 · Cited by 55 · see citing works
Agüera-Ortiz, L., Frank-García, A., Gil, P., & Moreno, A. (2010) · International Psychogeriatrics · doi:10.1017/s104161021000150x · Cited by 52 · see citing works
Arbonés-Mainar, J. M., Johnson, L. A., Torres-Pérez, E., Whitlock, A. E. G., Pérez‐Díaz, S., Raber, J., & Maeda, N. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.93 · Cited by 50 · see citing works
Crosby‐Nwaobi, R., Sivaprasad, S., & Forbes, A. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.11.010 · Cited by 52 · see citing works
Sacuiu, S. F. (2016) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802973-2.00008-2 · Cited by 51 · see citing works
Bruce, D. G., Davis, W. A., STARKSTEIN, S. E., & Davis, T. M. E. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132654 · Cited by 49 · see citing works
Linking Glycemic Control and Executive Function in Rural Older Adults with Diabetes Mellitus
Nguyen, H., Grzywacz, J. G., Arcury, T. A., Chapman, C., Kirk, J. K., Ip, E. H., Bell, R. A., & Quandt, S. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02857.x · Cited by 49 · see citing works
Meng, L., Li, X., Shen, L., & Ji, H. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.02.002 · Cited by 49 · see citing works
Asslih, S., Damri, O., & Agam, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116138 · Cited by 48 · see citing works
Karczewski, P., Hempel, P., Kunze, R., & Bimmler, M. (2012) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2012.02684.x · Cited by 48 · see citing works
The Aging Mind: Vascular Health in Normal Cognitive Aging
Warsch, J. R. L., & Wright, C. B. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02983.x · Cited by 47 · see citing works
Eaton, N. R., Krueger, R. F., South, S. C., Gruenewald, T. L., Seeman, T. E., & Roberts, B. W. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls090 · Cited by 46 · see citing works
Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank
Chen, H., Cao, Y., Ma, Y., Xu, W., Zong, G., & Yuan, C. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-022-00952-8 · Cited by 45 · see citing works
Self-citationKerola, T. V., Kettunen, R., & Nieminen, T. V. M. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.018 · Cited by 46 · see citing works
Cardiovascular Risk Factors, Cerebrovascular Disease Burden, and Healthy Brain Aging
Flicker, L. A. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.12.005 · Cited by 44 · see citing works
Influence of Diabetes Duration and Glycemic Control on Dementia: A Cohort Study
Li, F., Yang, H., Zhou, R., Zheng, J., Chen, G., Wu, X., Zou, M., Wang, J.-Y., Fu, Q. J., & Wu, X. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab221 · Cited by 45 · see citing works
Impact of Nutrition on Cerebral Circulation and Cognition in the Metabolic Syndrome
Mellendijk, L., Wiesmann, M., & Kiliaan, A. J. (2015) · Nutrients · doi:10.3390/nu7115477 · Cited by 43 · see citing works
Headache disorder and the risk of dementia: a systematic review and meta-analysis of cohort studies
Wang, J., Xu, W., Sun, S., Yu, S., & Fan, L. (2018) · The Journal of Headache and Pain · doi:10.1186/s10194-018-0925-4 · Cited by 42 · see citing works
Self-citationMorris, J. K., Vidoni, E. D., Mahnken, J. D., Montgomery, R. N., Johnson, D. K., Thyfault, J. P., & Burns, J. M. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.005 · Cited by 41 · see citing works
Guo, C., Zhang, S., Li, J., Ding, C., Yang, Z., Chai, R., Wang, X., & Wang, Z. (2016) · Scientific Reports · doi:10.1038/srep29396 · Cited by 41 · see citing works
Cooccurrence of vascular risk factors and late-life white-matter integrity changes
Maillard, P., Carmichael, O. T., Reed, B., Mungas, D., & DeCarli, C. S. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.007 · Cited by 41 · see citing works
Cognitive Impairment after Age 60: Clinical and Social Correlates in the “Faenza Project”
Atti, A. R., Forlani, C., De Ronchi, D., Palmer, K., Casadio, P., Dalmonte, E., & Fratiglioni, L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091618 · Cited by 40 · see citing works
Self-citationVitamin B—Can it prevent cognitive decline? A systematic review and meta-analysis
Behrens, A. S., Graessel, E., Pendergrass, A., & Donath, C. (2020) · Systematic Reviews · doi:10.1186/s13643-020-01378-7 · Cited by 40 · see citing works
Brain aging: lessons from community studies
Fratiglioni, L., Mangialasche, F., & Qiu, C. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00353.x · Cited by 39 · see citing works
Self-citationUnfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases
Milisav, I., Šuput, D., & Ribarič, S. (2015) · Molecules · doi:10.3390/molecules201219865 · Cited by 40 · see citing works
A Population Perspective on Prevention of Dementia
Eggink, E., van Charante, E. P. M., van Gool, W. A., & Richard, E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060834 · Cited by 38 · see citing works
Onset age of diabetes and incident dementia: A prospective cohort study
Wang, Y., Li, C., Liang, J., Gao, D., Pan, Y., Zhang, W., Zhang, Y., Zheng, F., & Xie, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.138 · Cited by 36 · see citing works
Brain Activation during Memory Encoding in Type 2 Diabetes Mellitus: A Discordant Twin Pair Study
WOOD, A. G., Chen, J., Moran, C., Phan, T. G., Beare, R. J., Cooper, K., Litras, S., & Srikanth, V. K. (2016) · Journal of Diabetes Research · doi:10.1155/2016/3978428 · Cited by 36 · see citing works
Mendelian Randomization in Cardiovascular Research
Bell, K., Loy, C. T., Cust, A. E., & Teixeira-Pinto, A. M. (2021) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.005623 · Cited by 34 · see citing works
- Authors
- Xu, W., Qiu, C., Gatz, M., Pedersen, N. L., Johansson, B., & Fratiglioni, L.
- Affiliations
- Karolinska Institutet (SE)
- University of Southern California (US)
- University of Gothenburg (SE)
- Corresponding author
- Xu, Weili
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2009-01-01
- Volume
- 58
- Issue
- 1
- Pages
- 71-77
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC2606895
- OpenAlex
- W2116839722
- Cited by
- 284
- References
- 52
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 10 · 2023: 18 · 2022: 11 · 2021: 23 · 2020: 19 · 2019: 25 · 2018: 12 · 2017: 14 · 2016: 16 · 2015: 14 · 2014: 29 · 2013: 19 · 2012: 18
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association (ZEN-02-3895)
- Vetenskapsrådet
- Swedish Brain Power
- National Institute on Aging (R01-AG08724, AG 08724, R01AG008724)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- dementia, Alzheimer's disease, vascular dementia, twins, genetic factors, dementia risk
- MeSH terms
- Aged, Alzheimer Disease, Dementia, Diabetes Mellitus, Type 2, Diseases in Twins, Female, Humans, Male, Risk Factors, Sweden, Logistic Models, Odds Ratio, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
