The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults
Abstract
OBJECTIVE: Impaired brain insulin action has been linked to obesity, type 2 diabetes, and neurodegenerative diseases. To date, the central nervous effects of insulin in obese humans still remain ill defined, and no study thus far has evaluated the specific brain areas affected by insulin resistance. RESEARCH DESIGN AND METHODS: In 25 healthy lean and 23 overweight/obese participants, we performed magnetic resonance imaging to measure cerebral blood flow (CBF) before and 15 and 30 min after application of intranasal insulin or placebo. Additionally, participants explicitly rated pictures of high-caloric savory and sweet food 60 min after the spray for wanting and liking. RESULTS: In response to insulin compared with placebo, we found a significant CBF decrease in the hypothalamus in both lean and overweight/obese participants. The magnitude of this response correlated with visceral adipose tissue independent of other fat compartments. Furthermore, we observed a differential response in the lean compared with the overweight/obese group in the prefrontal cortex, resulting in an insulin-induced CBF reduction in lean participants only. This prefrontal cortex response significantly correlated with peripheral insulin sensitivity and eating behavior measures such as disinhibition and food craving. Behaviorally, we were able to observe a significant reduction for the wanting of sweet foods after insulin application in lean men only. CONCLUSIONS: Brain insulin action was selectively impaired in the prefrontal cortex in overweight and obese adults and in the hypothalamus in participants with high visceral adipose tissue, potentially promoting an altered homeostatic set point and reduced inhibitory control contributing to overeating behavior.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, in our previous placebo-controlled assessments6,8,39 (see Supplementary Material 2 for more details), the placebo nasal spray did not impact hypothalamic blood flow.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [8]
In the citing paper
“we evaluated hypothalamic CBF response before and 30 min after placebo administration based on previous publications8,39.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [8]
In the citing paper
“On the basis of our previous findings3,8, we assessed the insulin-induced response of hypothalamic cerebral blood flow (CBF) as a readout for hypothalamic insulin action.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [8]
In the citing paper
“CBF was extracted from the hypothalamus as our region of interest, based on recent findings3,8.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [8]
In the citing paper
“For the fMRI study, the sample size was chosen based on previous studies using fMRI in combination with intranasal insulin versus placebo showing moderate-to-high within-group (dz = 0.7) and high between-group differences (dz = 0.9) in hypothalamus insulin action8,48.”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [8]
In the citing paper
“No significant change in hypothalamic blood flow was observed in 110 healthy participants (P > 0.05).”
From Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase (2023) · cites this paper as [8]
Citations
Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873
Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications
Stefan, N., Häring, H.-U., Hu, F. B., & Schulze, M. B. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70062-7 · Cited by 857
Self-citationNeurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
van der Laan, L. N., de Ridder, D. T. D., Viergever, M. A., & Smeets, P. A. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.055 · Cited by 602
Cooper, Z., & Fairburn, C. G. (1987) · PsycTESTS Dataset · doi:10.1037/t03975-000 · Cited by 494
Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx
Wang, Z., Aguirre, G. K., Rao, H., Wang, J., Fernández‐Seara, M. A., Childress, A. R., & Detre, J. A. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2007.07.003 · Cited by 479
Research works printed but not linked: 2
- Löwe, 2002, PHQ-D. Gesundheitsfragebogen für Patienten
- Pudel, 1989, Fragebogen zum Eßverhalten (FEV). Handanweisung
Cited by
Sorted by citations
Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans
Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 654
Self-citationUpadhyay, J., Farr, O. M., Perakakis, N., Ghaly, W., & Mantzoros, C. S. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.004 · Cited by 425
The determinants of food choice
Leng, G., Adan, R. A. H., Belot, M., Brunstrom, J. M., de Graaf, K., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J., Preissl, H., et al. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s002966511600286x · Cited by 465
Self-citationThe determinants of food choice
Leng, G., Adan, R. A. H., Belot, M. V. K., Brunstrom, J. M., de Graaf, K. C., Dickson, S. L., Hare, T. A., Maier, S. U., Menzies, J. R. W., Preissl, H. T., et al. (2017) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-146390 · Cited by 255
Self-citationImpaired insulin action in the human brain: causes and metabolic consequences
Heni, M., Kullmann, S., Preissl, H., Fritsche, A., & Häring, H.-U. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.173 · Cited by 245
Self-citationCentral nervous pathways of insulin action in the control of metabolism and food intake
Kullmann, S., Kleinridders, A., Small, D. M., Fritsche, A., Häring, H.-U., Preissl, H., & Heni, M. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30113-3 · Cited by 233
Self-citationBrain insulin signalling in metabolic homeostasis and disease
Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205
Central nervous system regulation of eating: Insights from human brain imaging
Farr, O. M., Li, C. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.002 · Cited by 201
Kleinloog, J. P. D., Mensink, R. P., Ivanov, D., Adam, J. J., Uludaǧ, K., & Joris, P. J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00333 · Cited by 191
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176
Mansur, R. B., Ahmed, J., Cha, D. S., Woldeyohannes, H. O., Subramaniapillai, M., Lovshin, J. A., Lee, J. G., Lee, J.-H., Brietzke, E. M., Reininghaus, E. Z., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.056 · Cited by 166
Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions
Li, G., Hu, Y., Zhang, W., Wang, J., Ji, W., Manza, P., Volkow, N. D., Zhang, Y., & Wang, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02025-y · Cited by 149
Brain insulin sensitivity is linked to adiposity and body fat distribution
Kullmann, S., Valenta, V., Wagner, R., Tschritter, O., Machann, J., Häring, H.-U., Preissl, H., Fritsche, A., & Heni, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15686-y · Cited by 134
Self-citationKelly, T., Unwin, D., & Finucane, F. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072557 · Cited by 141
Heni, M., Wagner, R., Kullmann, S., Gancheva, S., Roden, M., Peter, A., Stefan, N., Preissl, H., Häring, H.-U., & Fritsche, A. (2017) · Diabetes · doi:10.2337/db16-1380 · Cited by 115
Self-citationCentral insulin modulates food valuation via mesolimbic pathways
Tiedemann, L. J., Schmid, S. M., Hettel, J., Giesen, K., Francke, P., Büchel, C., & Brassen, S. (2017) · Nature Communications · doi:10.1038/ncomms16052 · Cited by 113
Safety of intranasal human insulin: A review
Schmid, V., Kullmann, S., Gfrörer, W., Hund, V., Hallschmid, M., Lipp, H., Häring, H., Preissl, H., Fritsche, A., & Heni, M. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13279 · Cited by 110
Self-citationKullmann, S., Hummel, J., Wagner, R. J., Dannecker, C., Vosseler, A., Fritsche, L., Veit, R., Kantartzis, K., Machann, J., Birkenfeld, A. L., et al. (2021) · Diabetes Care · doi:10.2337/dc21-1136 · Cited by 112
Self-citationMolecular Mechanisms of Hypothalamic Insulin Resistance
Ono, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061317 · Cited by 112
Brain energy metabolism: A roadmap for future research
Rae, C. D., Baur, J. A., Borges, K., Dienel, G. A., Díaz‐García, C. M., Douglass, S. R., Drew, K. L., Duarte, J. M. N., Durán, J., Kann, O., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16032 · Cited by 113
Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection
Pozo, M., & Claret, M. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.001 · Cited by 97
Non-Invasive Strategies for Nose-to-Brain Drug Delivery.
Ja, T., Quispe, R. C., Khan, F. A., & Новак (2020) · PubMed · Cited by 114
Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H., Fritsche, A., & Preissl, H. T. (2017) · Scientific Reports · doi:10.1038/s41598-017-01907-w · Cited by 93
Self-citationExercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
Kullmann, S., Goj, T., Veit, R., Fritsche, L., Wagner, L., Schneeweiß, P., Hoene, M., Hoffmann, C., Machann, J., Niess, A. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161498 · Cited by 97
Self-citationShpakov, A. O., Derkach, K. V., & Berstein, L. M. (2015) · Future Science OA · doi:10.4155/fso.15.23 · Cited by 93
Circadian desynchrony and glucose metabolism
Speksnijder, E. M., Bisschop, P. H. L. T., Siegelaar, S. E., Stenvers, D. J., & Kalsbeek, A. (2024) · Journal of Pineal Research · doi:10.1111/jpi.12956 · Cited by 100
Gruber, J., Hanßen, R., Qubad, M., Bouzouina, A., Schack, V., Sochor, H., Schiweck, C., Aichholzer, M., Matura, S., Slattery, D. A., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105179 · Cited by 96
Impaired peripheral glucose homeostasis and Alzheimer's disease
Wijesekara, N., Gonçalves, R. A., Felice, F. G. D., & Fraser, P. E. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.027 · Cited by 84
Woo, Y., Seo, H.-J., McIntyre, R., & Bahk, W.-M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010080 · Cited by 79
Bae, C. S., & Song, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112493 · Cited by 82
Imaging of intranasal drug delivery to the brain.
Veronesi, M. C., Alhamami, M., Miedema, S. B., Yun, Y., Ruiz-Cardozo, M. A., & Vannier, M. W. (2020) · PubMed · Cited by 88
Dose-Dependent Effects of Intranasal Insulin on Resting-State Brain Activity
Kullmann, S., Veit, R., Peter, A., Pohmann, R., Scheffler, K., Häring, H.-U., Fritsche, A., Preissl, H., & Heni, M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01976 · Cited by 78
Self-citationInsulin action in the brain: Roles in energy and glucose homeostasis
Dodd, G. T., & Tiganis, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12513 · Cited by 77
Insulin Resistance in Peripheral Tissues and the Brain: A Tale of Two Sites
Rhea, E. M., Banks, W. A., & Raber, J. (2022) · Biomedicines · doi:10.3390/biomedicines10071582 · Cited by 76
Borrajo, M. L., & Alonso, M. J. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01086-2 · Cited by 76
State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease
Rhea, E. M., Leclerc, M., Yassine, H. N., Capuano, A. W., Tong, H., Petyuk, V. A., Macauley, S. L., Fioramonti, X., Carmichael, O., Calon, F., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0814 · Cited by 70
Wingrove, J., Swedrowska, M., Scherließ, R., Parry, M., Ramjeeawon, M., Taylor, D., Gauthier, G., Brown, L., Amiel, S., Zelaya, F., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.03.032 · Cited by 67
Deciphering Brain Insulin Receptor and Insulin‐Like Growth Factor 1 Receptor Signalling
Kleinridders, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12433 · Cited by 67
Sleep Deprivation Selectively Upregulates an Amygdala–Hypothalamic Circuit Involved in Food Reward
Rihm, J. S., Menz, M. M., Schultz, H., Bruder, L. R., Schilbach, L., Schmid, S. M., & Peters, J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0250-18.2018 · Cited by 69
The insulin resistant brain: impact on whole-body metabolism and body fat distribution
Heni, M. (2024) · Diabetologia · doi:10.1007/s00125-024-06104-9 · Cited by 76
Self-citationLuo, Y., Wang, Q., & Zhang, Y. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.011 · Cited by 64
The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond
Lee, P. L., Jung, S. M., & Guertin, D. A. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.01.004 · Cited by 66
Recent advances in understanding body weight homeostasis in humans
Müller, M. J., Geisler, C., Heymsfield, S. B., & Bosy‐Westphal, A. (2018) · F1000Research · doi:10.12688/f1000research.14151.1 · Cited by 61
The regulation of food intake by insulin in the central nervous system
Mitchell, C. S., & Begg, D. P. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12952 · Cited by 62
Shpakov, A. O., Zorina, I. I., & Derkach, K. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043278 · Cited by 59
Akintola, A. A., van Opstal, A. M., Westendorp, R. G. J., Postmus, I., van der Grond, J., & van Heemst, D. (2017) · Aging · doi:10.18632/aging.101192 · Cited by 56
Modulation of midbrain neurocircuitry by intranasal insulin
Edwin Thanarajah, S., Iglesias, S., Kuzmanovic, B., Rigoux, L., Stephan, K. E., Brüning, J. C., & Tittgemeyer, M. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.03.050 · Cited by 55
Central Insulin Modulates Dopamine Signaling in the Human Striatum
Kullmann, S., Blum, D., Jaghutriz, B. A., Gassenmaier, C., Bender, B., Häring, H., Reischl, G., Preissl, H. T., la Fougère, C., Fritsche, A., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab410 · Cited by 61
Self-citationNovel phenotypes of prediabetes?
Häring, H. (2016) · Diabetologia · doi:10.1007/s00125-016-4015-3 · Cited by 54
Self-citationVanWagner, L. B., Terry, J. G., Chow, L. S., Alman, A. C., Kang, H., Ingram, K. H., Shay, C. M., Lewis, C. E., Bryan, R. N., Launer, L. J., et al. (2017) · Obesity · doi:10.1002/oby.21767 · Cited by 50
Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase
Hummel, J., Benkendorff, C., Fritsche, L., Prystupa, K., Vosseler, A., Gancheva, S., Trenkamp, S., Birkenfeld, A. L., Preissl, H., Roden, M., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00869-w · Cited by 48
Self-citationSteward, T., Miranda‐Olivos, R., Soriano‐Mas, C., & Fernández‐Aranda, F. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09515-x · Cited by 48
Investigating obesity‐associated brain inflammation using quantitative water content mapping
Kullmann, S., Abbas, Z., Machann, J., Shah, N. J., Scheffler, K., Birkenfeld, A. L., Häring, H., Fritsche, A., Heni, M., & Preissl, H. T. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12907 · Cited by 46
Self-citationThe Upper Nasal Space: Option for Systemic Drug Delivery, Mucosal Vaccines and “Nose-to-Brain”
Shrewsbury, S. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061720 · Cited by 48
Olver, T. D., Grunewald, Z. I., Jurrissen, T. J., MacPherson, R. E. K., LeBlanc, P. J., Schnurbusch, T., Czajkowski, A. M., Laughlin, M. H., Rector, R. S., Bender, S. B., et al. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00213.2017 · Cited by 45
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity
Schriever, S. C., Kabra, D. G., Pfuhlmann, K., Baumann, P., Baumgart, E. V., Nagler, J., Seebacher, F., Harrison, L. P., Irmler, M., Kullmann, S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136363 · Cited by 38
Self-citationNijssen, K. M. R., Mensink, R. P., & Joris, P. J. (2022) · Neuroendocrinology · doi:10.1159/000526717 · Cited by 43
Drummen, M., Dorenbos, E., Vreugdenhil, A. C. E., Raben, A., Westerterp‐Plantenga, M. S., & Adam, T. C. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy252 · Cited by 37
Insulin Action in the Hypothalamus Increases Second-Phase Insulin Secretion in Humans
Heni, M., Wagner, R., Willmann, C., Jaghutriz, B. A., Vosseler, A., Kübler, C., Hund, V., Scheffler, K., Peter, A., Häring, H.-U., et al. (2020) · Neuroendocrinology · doi:10.1159/000504551 · Cited by 36
Self-citationIntranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35
Schneider, E. M., Spetter, M. S., Martin, E., Sapey, E., Yip, K. P., Manolopoulos, K. N., Tahrani, A. A., Thomas, J. M., Lee, M. D., Hallschmid, M., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01115-1 · Cited by 38
Ahmad, R. M. A. H., Ababneh, N. A., & Al-Domi, H. A. (2022) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2022.102468 · Cited by 34
Anderson, K. L., Frazier, H. N., Maimaiti, S., Bakshi, V., Majeed, Z. R., Brewer, L. D., Porter, N. M., Lin, A., & Thibault, O. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw065 · Cited by 34
Chruvattil, R., Banerjee, S., Nath, S., Machhi, J., Kharkwal, G. B., Yadav, M. R., & Gupta, S. S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0251-2 · Cited by 33
Wagner, L., Veit, R., Fritsche, L., Häring, H., Fritsche, A., Birkenfeld, A. L., Heni, M., Preissl, H. T., & Kullmann, S. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01167-3 · Cited by 33
Self-citationHypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans
Kullmann, S., Fritsche, A., Wagner, R. J., Schwab, S., Häring, H., Preissl, H. T., & Heni, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.036 · Cited by 31
Self-citationHuang, X., Wang, Y., & Xiang, Y. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104263 · Cited by 32
A short-term, high-caloric diet has prolonged effects on brain insulin action in men
Kullmann, S., Wagner, L., Hauffe, R., Kühnel, A., Sandforth, L., Veit, R., Dannecker, C., Machann, J., Fritsche, A., Stefan, N., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01226-9 · Cited by 32
Self-citationNovel calcium-related targets of insulin in hippocampal neurons
Maimaiti, S., Frazier, H. N., Anderson, K. L., Ghoweri, A. O., Brewer, L. D., Porter, N. M., & Thibault, O. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.019 · Cited by 31
Legend of Weight Loss: A Crosstalk Between the Bariatric Surgery and the Brain
Lin, Z., & Qu, S. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04474-8 · Cited by 28
Ritze, Y., Kern, W., Ebner, E.-M., Jahn, S., Benedict, C., & Hallschmid, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00663 · Cited by 28
Wingrove, J. O., O’Daly, O., Forbes, B., Swedrowska, M., Amiel, S. A., & Zelaya, F. O. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14213 · Cited by 28
Intranasal Insulin: a Treatment Strategy for Addiction
Kashyap, B., Hanson, L. R., & Frey, W. H. (2020) · Neurotherapeutics · doi:10.1007/s13311-019-00822-4 · Cited by 27
Yagin, N. L., Aliasgari, F., Alizadeh, M., Aliasgharzadeh, S., & Mahdavi, R. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.09.001 · Cited by 27
Heni, M., Kullmann, S., Gallwitz, B., Häring, H., Preissl, H. T., & Fritsche, A. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.007 · Cited by 29
Self-citationSmall, D. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00134 · Cited by 30
Chakravartti, S. P., Jann, K., Veit, R., Liu, H., Yunker, A. G., ANGELO, B. C., Monterosso, J. R., Xiang, A. H., Kullmann, S., & Page, K. A. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01227-8 · Cited by 26
Self-citationHippocampal insulin resistance and altered food decision-making as players on obesity risk
Mucellini, A. B., da Fonseca, N. K. D. O., Manfro, G. G., & Silveira, P. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.011 · Cited by 26
Drummen, M., Dorenbos, E., Vreugdenhil, A. C. E., Stratton, G., Raben, A., Westerterp‐Plantenga, M. S., & Adam, T. C. (2018) · Nutrients · doi:10.3390/nu10111771 · Cited by 27
Aliasghari, F., Yagin, N. L., & Mahdavi, R. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.11.013 · Cited by 26
Expanding the understanding of insulin resistance in brain and periphery
Chen, W., Kullmann, S., & Rhea, E. M. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.04.010 · Cited by 23
Self-citationMolecular imaging of diabetes and diabetic complications: Beyond pancreatic β-cell targeting
Yang, J., Zhang, L. J., Wang, F., Hong, T., & Liu, Z. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.11.007 · Cited by 25
Brain insulin responsiveness is linked to age and peripheral insulin sensitivity
Wagner, L., Veit, R., Kübler, C., Fritsche, A., Häring, H., Birkenfeld, A. L., Heni, M., Preissl, H., & Kullmann, S. (2023) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15094 · Cited by 22
Self-citationChildhood Metabolic Biomarkers Are Associated with Performance on Cognitive Tasks in Young Children
Shapiro, A. L. B., Wilkening, G. N., Aalborg, J., Ringham, B. M., Glueck, D. H., Tregellas, J. R., & Dabelea, D. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.03.043 · Cited by 24
Camps, G., Veit, R., Mars, M., de Graaf, C., & Smeets, P. A. M. (2018) · Appetite · doi:10.1016/j.appet.2018.04.023 · Cited by 19
Self-citationAn insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus
Eckstrand, K., Mummareddy, N., Kang, H., Cowan, R. L., Zhou, M., Zald, D. H., Silver, H. J., Niswender, K. D., & Avison, M. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189113 · Cited by 20
The effect of hunger state on hypothalamic functional connectivity in response to food cues
Kullmann, S., Veit, R., Crabtree, D. R., Buosi, W., Androutsos, O., Johnstone, A. M., Μanios, Y., Preissl, H. T., & Smeets, P. A. M. (2022) · Human Brain Mapping · doi:10.1002/hbm.26059 · Cited by 16
Self-citationNijssen, K. M. R., Mensink, R. P., Plat, J., Ivanov, D., Preissl, H. T., & Joris, P. J. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.12.010 · Cited by 19
Self-citationFrank, S., von Schnurbein, J., Veit, R., Heni, M., Machann, J., Heinze, J. M., Kullmann, S., Manzoor, J., Mahmood, S., Häring, H., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1867 · Cited by 17
Self-citationBlasi, C. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2419-2 · Cited by 16
An interoceptive model of energy allostasis linking metabolic and mental health
Mehrhof, S. Z., Fleming, H. A., & Nord, C. L. (2025) · Science Advances · doi:10.1126/sciadv.ady4356 · Cited by 22
Food reinforcement architecture: A framework for impulsive and compulsive overeating and food abuse
Burger, K. S. (2023) · Obesity · doi:10.1002/oby.23792 · Cited by 15
Cognitive profile in burning mouth syndrome versus mild cognitive impairment: A comparative study
Femminella, G. D., Canfora, F., Musella, G., Tella, G. S. D., Ugga, L., Pecoraro, G., Leuci, S., Coppola, N., Lucia, N. D., Maldonato, N. M., et al. (2024) · Oral Diseases · doi:10.1111/odi.15087 · Cited by 16
Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder
Mansur, R. B., Rizzo, L. B., Santos, C. M., Asevedo, E. D. M., da Cunha, G. R., Noto, M. N., Pedrini, M., Zeni‐Graiff, M., Cordeiro, Q., McIntyre, R. S., et al. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12535 · Cited by 15
Ectopic fat accumulation in human astrocytes impairs insulin action
Heni, M., Eckstein, S. S., Schittenhelm, J., Böhm, A., Hogrefe, N., Irmler, M., Beckers, J., de Angelis, M. H., Häring, H., Fritsche, A., et al. (2020) · Royal Society Open Science · doi:10.1098/rsos.200701 · Cited by 14
Self-citationGalmiche, M. C., Lucas, N., Déchelotte, P., Deroissart, C., Solliec, M.-A. L., Rondeaux, J., Azhar, S., Grigioni, S., Colange, G., Delay, J., et al. (2020) · Nutrients · doi:10.3390/nu12020522 · Cited by 13
Inter-Organ Crosstalk in Neurodegenerative Disease
Carata, E., Destino, M., Tenuzzo, B. A., & Panzarini, E. (2025) · Life · doi:10.3390/life15101499 · Cited by 14
Kleinloog, J. P. D., Mensink, R. P., Smeets, E. T. H. C., Ivanov, D., & Joris, P. J. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103115 · Cited by 11
Obesity May Connect Insulin Resistance to Decreased Neuronal Viability in Human Diabetic Brain
Lee, S. L., Joo, Y., Kim, R. Y., Hwang, J., Lim, S. M., Yoon, S. J., & Kim, J. (2020) · Obesity · doi:10.1002/oby.22869 · Cited by 11
Malkki-Keinänen, K., Lankinen, M. A., Karhunen, L. J., & Schwab, U. (2022) · Nutrition and Health · doi:10.1177/02601060221112178 · Cited by 13
Metadata
- Authors
- Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H.-U., Fritsche, A., & Preissl, H.
- Affiliations
- German Center for Diabetes Research (DE)
- Max Planck Institute for Biological Cybernetics (DE)
- Corresponding author
- Kullmann, Stephanie
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2015-03-20
- Volume
- 38
- Issue
- 6
- Pages
- 1044-1050
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2053859901
- Cited by
- 175
- References
- 38
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 12 · 2023: 17 · 2022: 16 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 16 · 2017: 21 · 2016: 16 · 2015: 5
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- Site cant be reached (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- German Federal Ministry of Education and Research (01GIL22F)
- Helmholtz Alliance ICEMED
- European Union Seventh Framework Programme (FP7/2007-2013)
- German Diabetes Foundation (DDS 309/01/12)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- brain insulin resistance, intranasal insulin, cerebral blood flow, hypothalamus, prefrontal cortex, visceral adipose tissue, obesity, overweight, food cravings, desire to eat, disinhibition, dietary habits, homeostatic set point, inhibitory control, cognitive control
- MeSH terms
- Administration, Intranasal, Adult, Brain, Brain Mapping, Cerebrovascular Circulation, Cognition, Diabetes Mellitus, Type 2, Feeding Behavior, Female, Homeostasis, Humans, Hunger, Hypoglycemic Agents, Hypothalamus, Inhibition, Psychological, Insulin, Insulin Resistance, Magnetic Resonance Imaging, Male, Obesity, Body Mass Index, Prefrontal Cortex, Intra-Abdominal Fat, Overweight, Craving
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
