Legend of Weight Loss: A Crosstalk Between the Bariatric Surgery and the Brain

Lin, Ziwei; Qu, Shen

doi:10.1007/s11695-020-04474-8

Cited by 28Bariatric Surgery and OutcomesRegulation of Appetite and ObesityEating Disorders and Behaviors

Legend of Weight Loss: A Crosstalk Between the Bariatric Surgery and the Brain

Lin, Ziwei, Qu, Shen·2020·Obesity Surgery

DOI 10.1007/s11695-020-04474-8

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Abstract

In recent years, plenty of researches have reported in obese individuals with abnormal brain processes implicated in homeostatic regulation, reward, emotion, memory, attention, and executive function in eating behaviors. Thus, treating obesity cannot remain "brainless." Behavioral and psychological interventions activate the food reward, attention, and motivation system, leading to minimal weight loss and high relapse rates. Pharmacotherapy is an effective weight loss method and regulate brain activity but with concerns about its brain function safety problems. Obesity surgery, the most effective therapy currently available for obesity, shows pronounced effects on brain activity, such as deactivation of reward and attention system, and activation of inhibition control toward food cues. In this review, we present an overview of alterations in the brain after the three common weight loss methods.

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Impairment in brain systems that activate reward, emotion, impulsivity, motivation for food, decreased inhibitory control and memory functioning have all been implicated as possible pathways in the development of obesity.
“Impairment in brain systems that activate reward, emotion, impulsivity, motivation for food, decreased inhibitory control and memory functioning have all been implicated as possible pathways in the development of obesity (11).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [11]
Bariatric surgery affects regions in the brain associated with motivation, reward, attention, and inhibition in response to food exposure.
“Bariatric surgery is now known to affect regions in the brain associated with motivation, reward, attention, and inhibition in response to food exposure (11).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [11]
Bariatric surgery has been proposed as a treatment to improve executive functioning for patients living with obesity.
“Bariatric surgery has been proposed as a treatment to improve executive functioning for patients living with obesity (11) (68).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [11]

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Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery
Ames, G. E., Koball, A. M., & Clark, M. M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.934680 · Cited by 28 · see citing works

Authors: Lin, Z., & Qu, S.
Affiliations: Tongji University (CN)
Corresponding author: Qu, Shen
ORCID: Lin, Ziwei
Qu, Shen
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 2020-02-24
Volume: 30
Issue: 5
Pages: 1988-2002
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1007/s11695-020-04474-8
OpenAlex: W3006794579
Cited by: 28
References: 122
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 12 · 2020: 3
FWCI: 1.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Obesity Surgery (publishedVersion)
PubMed (publishedVersion)
Funders: Key Technologies Research and Development Program (2018YFC1314100)
National Natural Science Foundation of China (81970677, 81500687)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: bariatric surgery, obesity
MeSH terms: Brain, Feeding Behavior, Humans, Obesity, Obesity, Morbid, Weight Loss, Bariatric Surgery

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Legend of Weight Loss: A Crosstalk Between the Bariatric Surgery and the Brain

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