Cited by 654Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Obici, Silvana, Feng, Zhaohui, Morgan, Kimyata, Stein, Daniel, Karkanias, George, Rossetti, Luciano·2002·Diabetes

DOI 10.2337/diabetes.51.2.271

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Abstract

The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K+ channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation.

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Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Environmental Contributions to the Obesity Epidemic
Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,258
Signals That Regulate Food Intake and Energy Homeostasis
Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,177
Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors
Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
Rossetti, L., Smith, D. J., Shulman, G. I., Papachristou, D. N., & DeFronzo, R. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112981 · Cited by 824
Self-citation
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823
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A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736
Obesity in the new millennium
Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 709
Malonyl-CoA, fuel sensing, and insulin resistance
Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 649

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Obici S, Feng Z, Rossetti L: Hypothalamic insulin action is required for the inhibitory effects of systemic insulin on hepatic glucose fluxes (Abstract). Proceedings of the Keystone Symposium. Obesity and the Regulation of Energy Homeostasis. Taos, NM, 24 February 2001 to 1 March 2001

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Amdi, C., Giblin, L., Hennessy, A. A., Ryan, T., Stanton, C., Stickland, N. C., & Lawlor, P. G. (2013) · Journal of Nutritional Science · doi:10.1017/jns.2012.20 · Cited by 62
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Nogueiras, R., López, M., & Diéguez, C. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00669.x · Cited by 67
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Migrenne, S., Magnan, C., & Cruciani‐Guglielmacci, C. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.01.006 · Cited by 64
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Watt, M. J., Hoy, A. J., Muoio, D. M., & Coleman, R. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00418.2011 · Cited by 59
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Authors: Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L.
Affiliations: Albert Einstein College of Medicine (US)
ORCID: Feng, Zhaohui
Karkanias, George
Rossetti, Luciano
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-02-01
Volume: 51
Issue: 2
Pages: 271-275
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.2.271
OpenAlex: W2148366635
Cited by: 654
References: 27
Citations by year: 2026: 7 · 2025: 9 · 2024: 12 · 2023: 19 · 2022: 14 · 2021: 19 · 2020: 22 · 2019: 19 · 2018: 20 · 2017: 34 · 2016: 28 · 2015: 41 · 2014: 36 · 2013: 36 · 2012: 30
FWCI: 8.75
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK20541, DK-45024)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: oleic acid, long-chain fatty acids, glucose production, dietary intake, anorectic effect, hypothalamus, neuropeptide Y, octanoic acid, short-chain fatty acids, ATP-sensitive potassium channels, nutrient sensing, intracerebroventricular administration
MeSH terms: Adenosine Triphosphate, Animals, Eating, Glucose, Hypothalamus, Injections, Intraventricular, Insulin, Male, Neuropeptide Y, Sulfonylurea Compounds, Potassium Channels, Rats, Sprague-Dawley, Oleic Acid, Third Ventricle, Potassium Channel Blockers, Rats

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Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

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