Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

Identification of stem cells in small intestine and colon by marker gene Lgr5

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Wnt signalling in stem cells and cancer

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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

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Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

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Defining the Epithelial Stem Cell Niche in Skin

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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

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Generation of a functional mammary gland from a single stem cell

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

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Mutation selection and the natural history of cancer

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Purification and unique properties of mammary epithelial stem cells

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Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche

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β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

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Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

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Capturing and profiling adult hair follicle stem cells

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Bmi1 is expressed in vivo in intestinal stem cells

Sangiorgi, E., & Capecchi, M. R. (2008) · Nature Genetics · doi:10.1038/ng.165 · Cited by 1,194

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,066

Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., & Barrandon, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00208-2 · Cited by 1,046

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Pinto, D., Gregorieff, A., Begthel, H., & Clevers, H. (2003) · Genes & Development · doi:10.1101/gad.267103 · Cited by 1,026

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966

A single type of progenitor cell maintains normal epidermis

Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H. (2007) · Nature · doi:10.1038/nature05574 · Cited by 853

Epidermal Stem Cells of the Skin

Blanpain, C., & Fuchs, E. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 849

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

Kuhnert, F., Davis, C. R., Wang, H.-T., Chu, P., Lee, M., Yuan, J., Nusse, R., & Kuo, C. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536800100 · Cited by 636

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

Merrill, B. J., Gat, U., DasGupta, R., & Fuchs, E. (2001) · Genes & Development · doi:10.1101/gad.891401 · Cited by 558

Epithelial Stem Cells: A Folliculocentric View

Cotsarelis, G. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700376 · Cited by 553

The hair cycle

Alonso, L., & Fuchs, E. (2006) · Journal of Cell Science · doi:10.1242/jcs.02793 · Cited by 539

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

Stoick-Cooper, C. L., Weidinger, G., Riehle, K. J., Hubbert, C., Major, M. B., Fausto, N., & Moon, R. T. (2007) · Development · doi:10.1242/dev.001123 · Cited by 532

The Intestinal Wnt/TCF Signature

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Contribution of olfactory neural stem cells to tissue maintenance and regeneration

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Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

POTTEN, C. S. (1977) · Nature · doi:10.1038/269518a0 · Cited by 441

Clonal analysis of mouse intestinal epithelial progenitors

Bjerknes, M., & Cheng, H. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70222-2 · Cited by 428

Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.06.048 · Cited by 426

Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

Braun, K. M., Niemann, C., Jensen, U. B., Sundberg, J. P., Silva-Vargas, V., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00703 · Cited by 425

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU

Kiel, M. J., He, S., Ashkenazi, R., Gentry, S. N., Teta, M., Kushner, J. A., Jackson, T. L., & Morrison, S. J. (2007) · Nature · doi:10.1038/nature06115 · Cited by 417

Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells

Lowry, W. E., Blanpain, C., Nowak, J. A., Guasch, G., Lewis, L., & Fuchs, E. (2005) · Genes & Development · doi:10.1101/gad.1324905 · Cited by 392

Gut instincts: thoughts on intestinal epithelial stem cells

Booth, C., & Potten, C. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10229 · Cited by 369

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin

Ghazizadeh, S., & Taichman, L. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1215 · Cited by 348

Tcf3 Governs Stem Cell Features and Represses Cell Fate Determination in Skin

Nguyen, H., Rendl, M., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.07.036 · Cited by 287

Characterization of Two LGR Genes Homologous to Gonadotropin and Thyrotropin Receptors with Extracellular Leucine-Rich Repeats and a G Protein-Coupled, Seven-Transmembrane Region

Hsu, S. Y. (1998) · Molecular Endocrinology · doi:10.1210/me.12.12.1830 · Cited by 281

CONTINUOUS LABELLING STUDIES ON MOUSE SKIN AND INTESTINE

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The stem‐cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse

Bjerknes, M., & Cheng, H. (1981) · American Journal of Anatomy · doi:10.1002/aja.1001600107 · Cited by 204

Overexpression of Orphan G–Protein-Coupled Receptor, Gpr49 , in Human Hepatocellular Carcinomas With β–Catenin Mutations

Yamamoto, Y., Sakamoto, M., Fujii, G., Tsuiji, H., Kenetaka, K., Asaka, M., & Hirohashi, S. (2003) · Hepatology · doi:10.1053/jhep.2003.50029 · Cited by 200

Neonatal Lethality of LGR5 Null Mice Is Associated with Ankyloglossia and Gastrointestinal Distension

Morita, H., Mazerbourg, S., Bouley, D. M., Luo, C.-W., Kawamura, K., Kuwabara, Y., Baribault, H., Tian, H., & Hsueh, A. J. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9736-9743.2004 · Cited by 187

Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors

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The hair cycle

Alonso, L. (2006) · Journal of Cell Science · doi:10.1242/jcs02793 · Cited by 111

TCF/LEFs and Wnt Signaling in the Nucleus

Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 760

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

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Mitotic and mitogenic Wnt signalling

Niehrs, C., & Acebron, S. P. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.124 · Cited by 305

Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer

Junttila, M. R., Mao, W., Wang, X., Wang, B.-E., Pham, T., Flygare, J., Yu, S.-F., Yee, S., Goldenberg, D., Fields, C., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac7433 · Cited by 182

Development and homeostasis of the sebaceous gland

Niemann, C., & Horsley, V. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.010 · Cited by 151