p38 MAPK Signaling in Osteoblast Differentiation

Calcium's Role in Mechanotransduction during Muscle Development

Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2013) · Neurosignals · doi:10.1159/000334144 · Cited by 3,389

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Keys, J. R., Land vatter, S. W., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,288

Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274

The selectivity of protein kinase inhibitors: a further update

Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., Mclauchlan, H., Klevernic, I., Arthur, J. S. C., Alessi, D. R., & Cohen, P. (2007) · Biochemical Journal · doi:10.1042/bj20070797 · Cited by 2,520

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,241

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

(1995) · FEBS Letters · doi:10.1016/0014-5793(95)00357-f · Cited by 2,086

Mechanisms and functions of p38 MAPK signalling

Cuadrado, A., & Nebreda, A. R. (2010) · Biochemical Journal · doi:10.1042/bj20100323 · Cited by 1,676

Building strong bones: molecular regulation of the osteoblast lineage

Long, F. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,141

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

Wang, X., & Ron, D. (1996) · Science · doi:10.1126/science.272.5266.1347 · Cited by 883

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

Rousseau, S., Houle, F., Landry, J., & Huot, J. (1997) · Oncogene · doi:10.1038/sj.onc.1201380 · Cited by 845

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 820

Role of Stress Granules and RNA-Binding Proteins in Neurodegeneration: A Mini-Review

Vanderweyde, T., Youmans, K., Liu-Yesucevitz, L., & Wolozin, B. (2013) · Gerontology · doi:10.1159/000354170 · Cited by 805

Buried alive: How osteoblasts become osteocytes

Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795

Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase

Jaiswal, R. K., Jaiswal, N., Bruder, S. P., Mbalaviele, G., Marshak, D. R., & Pittenger, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9645 · Cited by 771

Development of the Endochondral Skeleton

Long, F., & Ornitz, D. M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008334 · Cited by 663

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

Arimoto, K., Fukuda, H., Imajoh-Ohmi, S., Saito, H., & Takekawa, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1791 · Cited by 603

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

Yamashita, M., Fatyol, K., Jin, C., Wang, X., Liu, Z., & Zhang, Y. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.002 · Cited by 559

Bone development

Berendsen, A. D., & Olsen, B. R. (2015) · Bone · doi:10.1016/j.bone.2015.04.035 · Cited by 559

Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal

Fuentealba, L. C., Eivers, E., Ikeda, A., Hurtado, C., Kuroda, H., Pera, E. M., & De Robertis, E. M. (2007) · Cell · doi:10.1016/j.cell.2007.09.027 · Cited by 554

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Sorrentino, A., Thakur, N., Grimsby, S., Marcusson, A., von Bulow, V., Schuster, N., Zhang, S., Heldin, C.-H., & Landström, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1780 · Cited by 553

MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1

Xiao, G., Jiang, D., Thomas, P., Benson, M. D., Guan, K., Karsenty, G., & Franceschi, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4453 · Cited by 552

The contribution of bone to whole-organism physiology

Karsenty, G., & Ferron, M. (2012) · Nature · doi:10.1038/nature10763 · Cited by 537

Mechanosensation and transduction in osteocytes

Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528

Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

An, J., Yang, H., Zhang, Q., Liu, C., Zhao, J., Zhang, L., & Chen, B. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.01.024 · Cited by 526

Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development

Ge, C., Xiao, G., Jiang, D., & Franceschi, R. T. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610046 · Cited by 507

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

Badger, A. M., Bradbeer, J. N., Votta, B., Lee, J. C., Adams, J. L., & Griswold, D. E. (1996) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21307-6 · Cited by 499

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

Livingstone, C., Patel, G., & Jones, N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07167.x · Cited by 494

Mechanism of p38 MAP kinase activation in vivo

Brancho, D., Tanaka, N., Jaeschke, A., Ventura, J.-J., Kelkar, N., Tanaka, Y., Kyuuma, M., Takeshita, T., Flavell, R. A., & Davis, R. J. (2003) · Genes & Development · doi:10.1101/gad.1107303 · Cited by 490

p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps

Wu, Z., Woodring, P. J., Bhakta, K. S., Tamura, K., Wen, F., Feramisco, J. R., Karin, M., Wang, J. Y. J., & Puri, P. L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.3951-3964.2000 · Cited by 474

p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation

Zetser, A., Gredinger, E., & Bengal, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5193 · Cited by 461

Bone Morphogenetic Proteins, Extracellular Matrix, and Mitogen-Activated Protein Kinase Signaling Pathways Are Required for Osteoblast-Specific Gene Expression and Differentiation in MC3T3-E1 Cells

Xiao, G., Gopalakrishnan, R., Jiang, D., Reith, E., Benson, M. D., & Franceschi, R. T. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.101 · Cited by 456

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways

Qi, X., Li, T.-G., Hao, J., Hu, J., Wang, J., Simmons, H., Miura, S., Mishina, Y., & Zhao, G.-Q. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401367101 · Cited by 440

Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts

Dallas, S. L., Rosser, J. L., Mundy, G. R., & Bonewald, L. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111663200 · Cited by 414

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

Greenblatt, M. B., Shim, J.-H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J. M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42285 · Cited by 414

p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci

Simone, C., Forcales, S. V., Hill, D. A., Imbalzano, A. N., Latella, L., & Puri, P. L. (2004) · Nature Genetics · doi:10.1038/ng1378 · Cited by 398

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

Yamaguchi, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.179 · Cited by 394

Fibroblast Growth Factor 2 Induction of the Osteocalcin Gene Requires MAPK Activity and Phosphorylation of the Osteoblast Transcription Factor, Cbfa1/Runx2

Xiao, G., Jiang, D., Gopalakrishnan, R., & Franceschi, R. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206057200 · Cited by 379

The Regulation of Differentiation in Mesenchymal Stem Cells

Augello, A., & De Bari, C. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.173 · Cited by 370

Adiponectin Stimulates RANKL and Inhibits OPG Expression in Human Osteoblasts Through the MAPK Signaling Pathway

Luo, X.-H., Guo, L.-J., Xie, H., Yuan, L.-Q., Wu, X.-P., Zhou, H.-D., & Liao, E.-Y. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060707 · Cited by 369

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

Bezooijen, R. L. V., Dijke, P. T., Papapoulos, S. E., & G.M. Löwik, C. W. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.02.005 · Cited by 367

BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

Huang, H., Song, T.-J., Li, X., Hu, L., He, Q., Liu, M., Lane, M. D., & Tang, Q.-Q. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906266106 · Cited by 366

Specific Inhibitors of p38 Mitogen-activated Protein Kinase Block 3T3-L1 Adipogenesis

Engelman, J. A., Lisanti, M. P., & Scherer, P. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.48.32111 · Cited by 360

Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway

Luo, X.-H., Guo, L.-J., Yuan, L.-Q., Xie, H., Zhou, H.-D., Wu, X.-P., & Liao, E.-Y. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.05.021 · Cited by 352

Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis

Cuenda, A., & Cohen, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.4341 · Cited by 329

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

Guicheux, J., Lemonnier, J., Ghayor, C., Suzuki, A., Palmer, G., & Caverzasio, J. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.11.2060 · Cited by 324

BMP-2 and Insulin-like Growth Factor-I Mediate Osterix (Osx) Expression in Human Mesenchymal Stem Cells via the MAPK and Protein Kinase D Signaling Pathways

Celil, A. B., & Campbell, P. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503845200 · Cited by 324

Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells

Gallea, S., Lallemand, F., Atfi, A., Rawadi, G., Ramez, V, Spinella-Jaegle, S., Kawai, S., Faucheu, C., Huet, L., Baron, R., et al. (2001) · Bone · doi:10.1016/s8756-3282(01)00415-x · Cited by 303

Scaffold proteins of MAP-kinase modules

Dhanasekaran, D. N., Kashef, K., Lee, C. M., Xu, H., & Reddy, E. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210411 · Cited by 288

MyoD Targets Chromatin Remodeling Complexes to the Myogenin Locus Prior to Forming a Stable DNA-Bound Complex

de la Serna, I. L., Ohkawa, Y., Berkes, C. A., Bergstrom, D. A., Dacwag, C. S., Tapscott, S. J., & Imbalzano, A. N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.3997-4009.2005 · Cited by 287

Regulation of skeletal muscle gene expression by p38 MAP kinases

Lluís, F., Perdiguero, E., Nebreda, A. R., & Muñoz-Cánoves, P. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.11.002 · Cited by 279

The p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell

Jones, N. C., Tyner, K. J., Nibarger, L., Stanley, H. M., Cornelison, D. D. W., Fedorov, Y. V., & Olwin, B. B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408066 · Cited by 271

Coordination of Satellite Cell Activation and Self-Renewal by Par-Complex-Dependent Asymmetric Activation of p38α/β MAPK

Troy, A., Cadwallader, A. B., Fedorov, Y., Tyner, K., Tanaka, K. K., & Olwin, B. B. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.025 · Cited by 268 · cited 1×

Osteocyte: the unrecognized side of bone tissue

Rochefort, G. Y., Pallu, S., & Benhamou, C. L. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1194-5 · Cited by 268

Angiogenesis and intramembranous osteogenesis

Percival, C. J., & Richtsmeier, J. T. (2013) · Developmental Dynamics · doi:10.1002/dvdy.23992 · Cited by 266

Identification of differentially expressed genes between osteoblasts and osteocytes

Paic, F., Igwe, J. C., Nori, R., Kronenberg, M. S., Franceschetti, T., Harrington, P., Kuo, L., Shin, D.-G., Rowe, D. W., Harris, S. E., et al. (2009) · Bone · doi:10.1016/j.bone.2009.06.010 · Cited by 263

Mitogen-Activated Protein Kinase Pathways in Osteoblasts

Greenblatt, M. B., Shim, J.-H., & Glimcher, L. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122347 · Cited by 253

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

Honda, K., Sawada, H., Kihara, T., Urushitani, M., Nakamizo, T., Akaike, A., & Shimohama, S. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000501)60:3<321::aid-jnr6>3.0.co;2-t · Cited by 245

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells

Puri, P. L., Wu, Z., Zhang, P., Wood, L. D., Bhakta, K. S., Han, J., Feramisco, J. R., Karin, M., & Wang, J. Y. J. (2000) · Genes & Development · doi:10.1101/gad.14.5.574 · Cited by 244

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

Sumara, G., Formentini, I., Collins, S., Sumara, I., Windak, R., Bodenmiller, B., Ramracheya, R., Caille, D., Jiang, H., Platt, K. A., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.018 · Cited by 244

Generation and Characterization of p38β (MAPK11) Gene-Targeted Mice

Beardmore, V. A., Hinton, H. J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J. M., Armit, L. J., Clacher, C., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10454-10464.2005 · Cited by 236

Osteocyte control of osteoclastogenesis

O'Brien, C. A., Nakashima, T., & Takayanagi, H. (2013) · Bone · doi:10.1016/j.bone.2012.08.121 · Cited by 235

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

Matsushita, T., Chan, Y. Y., Kawanami, A., Balmes, G., Landreth, G. E., & Murakami, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01549-08 · Cited by 232

Identification and Functional Characterization of ERK/MAPK Phosphorylation Sites in the Runx2 Transcription Factor

Ge, C., Xiao, G., Jiang, D., Yang, Q., Hatch, N. E., Roca, H., & Franceschi, R. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040980 · Cited by 232

The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

Bermudez, O., Pagès, G., & Gimond, C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00347.2009 · Cited by 230

p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

Sabio, G., Arthur, J. S. C., Kuma, Y., Peggie, M., Carr, J., Murray‐Tait, V., Centeno, F., Goedert, M., Morrice, N. A., & Cuenda, A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600578 · Cited by 228

Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling

Ming, L., Chen, K., & Xian, C. J. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24158 · Cited by 218

BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38

Ulsamer, A., Ortuño, M. J., Ruiz, S., Susperregui, A. R. G., Osses, N., Rosa, J. L., & Ventura, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m704724200 · Cited by 214

The Prodomain of BMP-7 Targets the BMP-7 Complex to the Extracellular Matrix

Gregory, K. E., Ono, R. N., Charbonneau, N. L., Kuo, C.-L., Keene, D. R., Bächinger, H. P., & Sakai, L. Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504270200 · Cited by 207

Transcriptional Regulation of Osteoblasts

FRANCESCHI, R. T., GE, C., XIAO, G., ROCA, H., & JIANG, D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.081 · Cited by 206

Specific Activation of the p38 Mitogen-activated Protein Kinase Signaling Pathway and Induction of Neurite Outgrowth in PC12 Cells by Bone Morphogenetic Protein-2

Iwasaki, S., Iguchi, M., Watanabe, K., Hoshino, R., Kohno, M., & Tsujimoto, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26503 · Cited by 203

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts

Kamiya, N., Kobayashi, T., Mochida, Y., Yu, P. B., Yamauchi, M., Kronenberg, H. M., & Mishina, Y. (2010) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090806 · Cited by 198

E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle‐specific gene transcription

Lluís, F., Ballestar, E., Suelves, M., Esteller, M., & Muñoz‐Cánoves, P. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600528 · Cited by 197

A BMP-Inducible Gene, Dlx5, Regulates Osteoblast Differentiation and Mesoderm Induction

Miyama, K., Yamada, G., Yamamoto, T. S., Takagi, C., Miyado, K., Sakai, M., Ueno, N., & Shibuya, H. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9197 · Cited by 196

Regulation of the Bone-Specific Osteocalcin Gene by p300 Requires Runx2/Cbfa1 and the Vitamin D3 Receptor but Not p300 Intrinsic Histone Acetyltransferase Activity

Sierra, J., Villagra, A., Paredes, R., Cruzat, F., Gutierrez, S., Javed, A., Arriagada, G., Olate, J., Imschenetzky, M., van Wijnen, A. J., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3339-3351.2003 · Cited by 196

Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages

Aouadi, M., Laurent, K., Prot, M., Le Marchand-Brustel, Y., Binétruy, B., & Bost, F. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0963 · Cited by 193

p38 mitogen-activated protein kinase regulates canonical Wnt–β-catenin signaling by inactivation of GSK3β

Bikkavilli, R. K., Feigin, M. E., & Malbon, C. C. (2008) · Journal of Cell Science · doi:10.1242/jcs.032854 · Cited by 191

Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation

Suzuki, A., Guicheux, J., Palmer, G., Miura, Y., Oiso, Y., Bonjour, J.-P., & Caverzasio, J. (2002) · Bone · doi:10.1016/s8756-3282(01)00660-3 · Cited by 187

Differential Roles of Smad1 and p38 Kinase in Regulation of Peroxisome Proliferator-activating Receptor γ during Bone Morphogenetic Protein 2-induced Adipogenesis

Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T., & Yoneda, T. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0356 · Cited by 187

Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation

Huang, R.-L., Yuan, Y., Tu, J., Zou, G.-M., & Li, Q. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.101 · Cited by 182

Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases

Yang, T. T. C., Xiong, Q., Enslen, H., Davis, R. J., & Chow, C.-W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3892-3904.2002 · Cited by 174

Distinct Anabolic Response of Osteoblast to Low-Intensity Pulsed Ultrasound

Naruse, K., Miyauchi, A., Itoman, M., & Mikuni-Takagaki, Y. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.2.360 · Cited by 173

Nuclear Localization of p38 MAPK in Response to DNA Damage

Wood, C. D., Thornton, T. M., Sabio, G., Davis, R. A., & Rincon, M. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.428 · Cited by 169

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

Asada, N., Katayama, Y., Sato, M., Minagawa, K., Wakahashi, K., Kawano, H., Kawano, Y., Sada, A., Ikeda, K., Matsui, T., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.05.001 · Cited by 166

The role of osteoclast differentiation and function in skeletal homeostasis

Ikeda, K., & Takeshita, S. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv112 · Cited by 164

Focus on the p38 MAPK signaling pathway in bone development and maintenance

Thouverey, C., & Caverzasio, J. (2015) · BoneKEy Reports · doi:10.1038/bonekey.2015.80 · Cited by 162

Role of the JIP4 Scaffold Protein in the Regulation of Mitogen-Activated Protein Kinase Signaling Pathways

Kelkar, N., Standen, C. L., & Davis, R. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2733-2743.2005 · Cited by 157

Differential activation of p38MAPK isoforms by MKK6 and MKK3

Rémy, G., Risco, A. M., Iñesta-Vaquera, F., González‐Terán, B., Sabio, G., Davis, R. J., & Cuenda, A. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.020 · Cited by 155

Interactions between extracellular signal-regulated kinase 1/2 and P38 Map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity

Ge, C., Yang, Q., Zhao, G., Yu, H. H., Kirkwood, K. L., & Franceschi, R. T. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.561 · Cited by 154

Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways

Ryu, C. H., Park, S. A., Kim, S. M., Lim, J. Y., Jeong, C. H., Jun, J. A., Oh, J. H., Park, S. H., Oh, W., & Jeun, S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.043 · Cited by 153

Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling

Yu, B., Zhao, X., Yang, C., Crane, J. L., Xian, L., Lu, W. W., Wan, M., & Cao, X. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1663 · Cited by 149

Adiponectin Stimulates Osteoblast Differentiation Through Induction of COX2 in Mesenchymal Progenitor Cells

Lee, H. W., Kim, S., Kim, A., Lee, E. J., Choi, J., & Kim, J. B. (2009) · Stem Cells · doi:10.1002/stem.144 · Cited by 140

Mitogen-activated Protein Kinase (MAPK)-regulated Interactions between Osterix and Runx2 Are Critical for the Transcriptional Osteogenic Program

Artigas, N., Martín, C. U., Rodríguez-Carballo, E., Rosa, J. L., & Ventura, F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.576793 · Cited by 140

TNF-α Mediates p38 MAP Kinase Activation and Negatively Regulates Bone Formation at the Injured Growth Plate in Rats

Zhou, F. H., Foster, B. K., Zhou, X., Cowin, A. J., & Xian, C. J. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060410 · Cited by 137

Effect of Intermittent Shear Stress on Mechanotransductive Signaling and Osteoblastic Differentiation of Bone Marrow Stromal Cells

Kreke, M. R., Sharp, L. A., Lee, Y. W., & Goldstein, A. S. (2008) · Tissue Engineering Part A · doi:10.1089/tea.2007.0068 · Cited by 133

Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling

Chen, J., Lazarenko, O. P., Wu, X., Kang, J., Blackburn, M. L., Shankar, K., Badger, T. M., & Ronis, M. J. J. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.137 · Cited by 133

Berberine Promotes Osteoblast Differentiation by Runx2 Activation With p38 MAPK

Lee, H. W., Suh, J. H., Kim, H.-N., Kim, A., Park, S. Y., Shin, C. S., Choi, J., & Kim, J. B. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080325 · Cited by 130

The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells Through Integrin α 5 β 1 , p38 MAPK, and Matrix Metalloproteinases

Odagiri, H., Kadomatsu, T., Endo, M., Masuda, T., Morioka, M. S., Fukuhara, S., Miyamoto, T. K., Kobayashi, E., Miyata, K., Aoi, J., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004612 · Cited by 130

Andrographolide suppresses RANKL ‐induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo

Zhai, Z., Li, H. W., Liu, G. W., Qu, X., Tian, B., Yan, W., Lin, Z., Tang, T., Qin, A., & Dai, K. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12463 · Cited by 127

BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity

Gamell, C., Osses, N., Bartrons, R., Rückle, T., Camps, M., Rosa, J. L., & Ventura, F. (2008) · Journal of Cell Science · doi:10.1242/jcs.031286 · Cited by 125

Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP‐2

Viñals, F., López‐Rovira, T., Rosa, J. L., & Ventura, F. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03236-7 · Cited by 125

Constitutively Active Mitogen-activated Protein Kinase Kinase 6 (MKK6) or Salicylate Induces Spontaneous 3T3-L1 Adipogenesis

Engelman, J. A., Berg, A. H., Lewis, R. Y., Lin, A., Lisanti, M. P., & Scherer, P. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35630 · Cited by 124

p38 Regulates Expression of Osteoblast-specific Genes by Phosphorylation of Osterix

Ortuño, M. J., Ruiz-Gaspà, S., Rodríguez-Carballo, E., Susperregui, A. R. G., Bartrons, R., Rosa, J. L., & Ventura, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123612 · Cited by 123

Transforming Growth Factor-β1 Regulation of Collagenase-3 Expression in Osteoblastic Cells by Cross-talk between the Smad and MAPK Signaling Pathways and Their Components, Smad2 and Runx2

Selvamurugan, N., Kwok, S., Alliston, T. N., Reiß, M., & Partridge, N. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314048200 · Cited by 119

A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways

Zuzarte‐Luís, V., Montero, J. A., Rodríguez‐León, J., Merino, R., Rodríguez-Rey, J. C., & Hurlé, J. M. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.04.015 · Cited by 118

Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6

Červenka, I., Wolf, J., Mašek, J., Krejci, P., Wilcox, W. R., Kozubík, A., Schulte, G., Gutkind, J. S., & Bryja, V. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00550-10 · Cited by 117

Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts

Nöth, U. A., Tuli, R., Seghatoleslami, R., Howard, M., Shah, A., Hall, D. J., Hickok, N. J., & Tuan, R. S. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00386-0 · Cited by 116

Novel Effect of Biphasic Electric Current on In Vitro Osteogenesis and Cytokine Production in Human Mesenchymal Stromal Cells

Kim, I. S., Song, J. K., Song, Y. M., Cho, T. H., Lee, T. H., Lim, S. S., Kim, S. J., & Hwang, S. J. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0554 · Cited by 115

IL-1 and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase.

Kumar, S., Votta, B. J., Rieman, D. J., Badger, A. M., Gowen, M., & Lee, J. C. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1082 · Cited by 107

Epidermal Growth Factor Receptor (EGFR) Signaling Promotes Proliferation and Survival in Osteoprogenitors by Increasing Early Growth Response 2 (EGR2) Expression

Chandra, A., Lan, S., Zhu, J., Siclari, V. A., & Qin, L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.447250 · Cited by 107

Cyclin D1 as a Target for the Proliferative Effects of PTH and PTHrP in Early Osteoblastic Cells

Datta, N. S., Pettway, G. J., Chen, C., Koh, A. J., & McCauley, L. K. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070328 · Cited by 107

Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts

Tang, C., Yang, R., Chien, M.-Y., Chen, C.-C., & Fu, W. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.10.013 · Cited by 107

Migration of bone marrow‐derived mesenchymal stem cells induced by tumor necrosis factor‐α and its possible role in wound healing

Fu, X., Han, B., Cai, S., Lei, Y., Sun, T., & Sheng, Z.-Y. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2009.00454.x · Cited by 107

Regulation of Alkaline Phosphatase Activity by p38 MAP Kinase in Response to Activation of Gi Protein-Coupled Receptors by Epinephrine in Osteoblast-Like Cells1

Suzuki, A., Palmer, G., Bonjour, J., & Caverzasio, J. (1999) · Endocrinology · doi:10.1210/endo.140.7.6857 · Cited by 106

Fibroblast Growth Factor Receptor Signaling Activates the Human Interstitial Collagenase Promoter via the Bipartite Ets-AP1 Element

Newberry, E. P., Willis, D., Latifi, T. N., Boudreaux, J. M., & Towler, D. A. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.8.9958 · Cited by 105

Activation of p42/44 and p38 Mitogen-Activated Protein Kinases by Extracellular Calcium-Sensing Receptor Agonists Induces Mitogenic Responses in the Mouse Osteoblastic MC3T3-E1 Cell Line

Yamaguchi, T., Chattopadhyay, N., Kifor, O., Sanders, J. L., & Brown, E. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3955 · Cited by 105

Differential Activation of p38 Mitogen-activated Protein Kinase Isoforms Depending on Signal Strength

Alonso, G., Ambrosino, C., Jones, M., & Nebreda, Á. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007835200 · Cited by 104

BMP signals regulate Dlx5 during early avian skull development

Holleville, N., Quilhac, A., Bontoux, M., & Monsoro-Burq, A. H. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00059-9 · Cited by 99

Essential Role of Wnt3a-Mediated Activation of Mitogen-Activated Protein Kinase p38 for the Stimulation of Alkaline Phosphatase Activity and Matrix Mineralization in C3H10T1/2 Mesenchymal Cells

Caverzasio, J., & Manen, D. (2007) · Endocrinology · doi:10.1210/en.2007-0520 · Cited by 98

Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation

Lin, K.-L., Chou, C., Hsieh, S., Hwa, S., Lee, M.-T., & Wang, F.-F. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.159 · Cited by 96

Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions

Ortuño, M. J., Susperregui, A. R. G., Artigas, N., Rosa, J. L., & Ventura, F. (2012) · Bone · doi:10.1016/j.bone.2012.11.007 · Cited by 95

The Effects of Flavonoids on Bone

Welch, A. A., & Hardcastle, A. C. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0212-5 · Cited by 95

Thiazolidinediones Induce Osteocyte Apoptosis by a G Protein-coupled Receptor 40-dependent Mechanism

Mieczkowska, A., Baslé, M. F., Chappard, D., & Mabilleau, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324814 · Cited by 91

MAPK and SRC-Kinases Control EGR-1 and NF-κB Inductions by Changes in Mechanical Environment in Osteoblasts

Granet, C., Boutahar, N., Vico, L., Alexandre, C., & Lafage‐Proust, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5023 · Cited by 91

The Role of ATF-2 Family Transcription Factors in Adipocyte Differentiation: Antiobesity Effects of p38 Inhibitors

Maekawa, T., Jin, W., & Ishii, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00685-09 · Cited by 91

Development of Arterial Calcification in Adiponectin-Deficient Mice: Adiponectin Regulates Arterial Calcification

Luo, X., Zhao, L.-L., Yuan, L., Wang, M., Xie, H., & Liao, E.-Y. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090227 · Cited by 90

Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

Zhang, Y., Mei, Z., Wu, J., & Wang, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801703200 · Cited by 90

Asperosaponin VI, A Saponin Component from Dipsacus asper Wall, induces Osteoblast Differentiation through Bone Morphogenetic Protein‐2/p38 and Extracellular Signal‐regulated Kinase 1/2 Pathway

Niu, Y., Li, Y., Huang, H., Kong, X., Zhang, R., Liu, L., Sun, Y., Wang, T., & Mei, Q. (2011) · Phytotherapy Research · doi:10.1002/ptr.3414 · Cited by 87

Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-Activated Protein Kinase Pathways in Osteoblasts

Yen, M. L., Su, J. L., Chien, C. L., Tseng, K., Yang, C., Chen, W. F., Chang, C. C., & Kuo, M. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.010082 · Cited by 87

Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways

Kawaki, H., Kubota, S., Suzuki, A., Suzuki, M., Kohsaka, K., Hoshi, K., Fujii, T., Lazar, N., Ohgawara, T., Maeda, T., et al. (2011) · Bone · doi:10.1016/j.bone.2011.06.033 · Cited by 86

Integrin-Mediated Expression of Bone Formation-Related Genes in Osteoblast-Like Cells in Response to Fluid Shear Stress: Roles of Extracellular Matrix, Shc, and Mitogen-Activated Protein Kinase

Lee, D.-Y., Yeh, C.-R., Chang, S., Lee, P.-L., Chien, S., Cheng, C., & Chiu, J. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080302 · Cited by 86

p38MAP Kinase activity is required for human primary adipocyte differentiation

Aouadi, M., Jager, J., Laurent, K., Gonzalez, T., Cormont, M., Binétruy, B., MARCHAND‐BRUSTEL, Y. L., Tanti, J., & Bost, F. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.064 · Cited by 84

A Selective p38α Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis

Medicherla, S., Jing, Y., Mangadu, R., Jiang, Y., Zhao, J. J., Almirez, R. G., Kerr, I., Stebbins, E. G., O’Young, G., Kapoun, A. M., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.098020 · Cited by 83

Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways

Zhang, X., Zhou, C., Zha, X., Xu, Z., Li, L., Liu, Y., Xu, L., Cui, L., Xu, D., & Zhu, B. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2452-9 · Cited by 80

Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts

Debiais, F., Lemonnier, J., Haÿ, E., Delannoy, P., Caverzasio, J., & Marie, P. J. (2001) · Journal of Cellular Biochemistry · Cited by 79

Specific Contribution of Estrogen Receptors on Mitogen-Activated Protein Kinase Pathways and Vascular Cell Activation

Geraldes, P., Sirois, M. G., & Tanguay, J. (2003) · Circulation Research · doi:10.1161/01.res.0000088640.18462.42 · Cited by 78

Emodin Regulates Bone Remodeling by Inhibiting Osteoclastogenesis and Stimulating Osteoblast Formation

Kim, J., Cheon, Y., Kwak, S. C., Baek, J. M., Yoon, K., Lee, M. S., & Oh, J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2183 · Cited by 77

Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways

Wanachewin, O., Boonmaleerat, K., Pothacharoen, P., Reutrakul, V., & Kongtawelert, P. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-71 · Cited by 77

The Kinetic Mechanism of the Dual Phosphorylation of the ATF2 Transcription Factor by p38 Mitogen-activated Protein (MAP) Kinase α

Waas, W. F., Lo, H., & Dalby, K. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008787200 · Cited by 76

NRAGE Mediates p38 Activation and Neural Progenitor Apoptosis via the Bone Morphogenetic Protein Signaling Cascade

Kendall, S. E., Battelli, C., Irwin, S., Mitchell, J., Glackin, C. A., & Verdi, J. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7711-7724.2005 · Cited by 76

Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2

Tsubaki, M., Satou, T., Itoh, T., Imano, M., Yanae, M., Kato, C., Takagoshi, R., Komai, M., & Nishida, S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.002 · Cited by 75

p38δ Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice

Schindler, E. M., Hindes, A. E., Gribben, E. L., Burns, C. J., Yin, Y., Lin, M., Owen, R. J., Longmore, G. D., Kissling, G. E., Arthur, J. S. C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4455 · Cited by 75

c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104

Huang, Y.-F., Lin, J., Lin, C., Su, Y., & Hung, S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1548 · Cited by 74

Differential regulation of platelet‐derived growth factor stimulated migration and proliferation in osteoblastic cells

Mehrotra, M., Krane, S. M., Walters, K., & Pilbeam, C. C. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20138 · Cited by 73

Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways

Rodríguez-Carballo, E., Ulsamer, A., Susperregui, A. R. G., Manzanares‐Céspedes, M. C., Sánchez-García, E., Bartrons, R., Rosa, J. L., & Ventura, F. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.260 · Cited by 72

p38 MAPK Regulates IL‐1β Induced IL‐6 Expression Through mRNA Stability in Osteoblasts

Patil, C. S., Zhu, X., Rossa, C., Kim, Y., & Kirkwood, K. L. (2004) · Immunological Investigations · doi:10.1081/imm-120034231 · Cited by 71

EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures

Minamizaki, T., Yoshiko, Y., Kozai, K., Aubin, J. E., & Maeda, N. (2009) · Bone · doi:10.1016/j.bone.2009.02.010 · Cited by 69

Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells

Rey, A., Manen, D., Rizzoli, R., Ferrari, S., & Caverzasio, J. (2007) · Bone · doi:10.1016/j.bone.2007.02.031 · Cited by 68

Bone morphogenetic protein 2-induced human dental pulp cell differentiation involves p38 mitogen-activated protein kinase-activated canonical WNT pathway

Yang, J., Ye, L., Hui, T.-Q., Yang, D.-M., Huang, D.-M., Zhou, X.-D., Mao, J. J., & Wang, C.-L. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2015.7 · Cited by 68

Effects of phytoestrogens and other plant-derived compounds on mesenchymal stem cells, bone maintenance and regeneration

Schilling, T., Ebert, R., Raaijmakers, N., Schütze, N., & Jakob, F. J. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.12.006 · Cited by 66

The p38α MAPK positively regulates osteoblast function and postnatal bone acquisition

Thouverey, C., & Caverzasio, J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0983-8 · Cited by 64

Calcium-mediated Stress Kinase Activation by DMP1 Promotes Osteoblast Differentiation

Eapen, A. S., Sundivakkam, P. C., Song, Y., Ravindran, S., Ramachandran, A., Tiruppathi, C., & George, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145607 · Cited by 64

RhoA-Mediated Signaling in Mechanotransduction of Osteoblasts

Hamamura, K., Swarnkar, G., Tanjung, N., Cho, E., Li, J., Na, S., & Yokota, H. (2012) · Connective Tissue Research · doi:10.3109/03008207.2012.671398 · Cited by 64

Activation of FGF Receptors is a new Mechanism by which Strontium Ranelate Induces Osteoblastic Cell Growth

Caverzasio, J., & Thouverey, C. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000327950 · Cited by 63

MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice

Zou, W., Greenblatt, M. B., Shim, J., Kant, S., Zhai, B., Lotinun, S., Brady, N. J., Hu, D. Z., Gygi, S. P., Baron, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59041 · Cited by 63

Genetic analysis of specific and redundant roles for p38α and p38β MAPKs during mouse development

Barrantes, I. D. B., Coya, J. M., Maina, F., Arthur, J. S. C., & Nebreda, Á. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015013108 · Cited by 62

MEKK4 Stimulation of p38 and JNK Activity Is Negatively Regulated by GSK3β

Abell, A. N., Granger, D. A., & Johnson, G. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705783200 · Cited by 61

Genistein induces oestrogen receptor-α gene expression in osteoblasts through the activation of mitogen-activated protein kinases/NF-κB/activator protein-1 and promotes cell mineralisation

Liao, M.-H., Tai, Y., Cherng, Y., Liu, S., Chang, Y.-A., Lin, P.-I., & Chen, R. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002043 · Cited by 61

p38α MAPK Regulates Adult Muscle Stem Cell Fate by Restricting Progenitor Proliferation During Postnatal Growth and Repair

Brien, P., Pugazhendhi, D., Woodhouse, S., Oxley, D., & Pell, J. M. (2013) · Stem Cells · doi:10.1002/stem.1399 · Cited by 58

Relaxin Augments BMP-2–Induced Osteoblast Differentiation and Bone Formation

Moon, J., Kim, S.-H., Oh, S., Jeong, Y., Kang, J., Park, J.-C., Son, H.-J., Bae, S. C., Park, B., Kim, M., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2197 · Cited by 57

Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway

Liu, L., Channavajhala, P. L., Rao, V. R., Moutsatsos, I. K., Wu, L., Zhang, Y., Lin, L.-L., & Qiu, Y. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.06.016 · Cited by 57

Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells

Mori-Abe, A., Tsutsumi, S., Takahashi, K., Toya, M., Yoshida, M., Du, B., Kawagoe, J., Nakahara, K., Takahashi, T., Ohmichi, M., et al. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780417 · Cited by 57

Effects of vascular endothelial cells on osteogenic differentiation of noncontact co‐cultured periodontal ligament stem cells under hypoxia

Wu, Y., Cao, H., Yang, Y., Zhou, Y., Gu, Y., Zhao, X., Zhang, Y., Zhao, Z., Zhang, L., & Yin, J. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2012.01503.x · Cited by 56

TNFα and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics

Dai, J. C., He, P., Chen, X., & Greenfield, E. M. (2005) · Bone · doi:10.1016/j.bone.2005.10.007 · Cited by 54

CD99 Drives Terminal Differentiation of Osteosarcoma Cells by Acting as a Spatial Regulator of ERK 1/2

Sciandra, M., Marino, M. T., Manara, M. C., Guerzoni, C., Grano, M., Oranger, A., Lucarelli, E., Lollini, P., Dozza, B., Pratelli, L., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2141 · Cited by 50

Combined MEK Inhibition and BMP2 Treatment Promotes Osteoblast Differentiation and Bone Healing in Nf1Osx−/− Mice

Ndong, J. D. L. C., Stevens, D. M., Vignaux, G., Uppuganti, S., Perrien, D. S., Yang, X., Nyman, J. S., Harth, E. M., & Elefteriou, F. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2316 · Cited by 49

Mark4 promotes adipogenesis and triggers apoptosis in 3T3‐L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways

Feng, M., Liang, T., Gan, L., Liu, Z., & Sun, C. (2014) · Biology of the Cell · doi:10.1111/boc.201400004 · Cited by 49

Molecular requirements for induction of CTGF expression by TGF-β1 in primary osteoblasts

Arnott, J. A., Zhang, X., Sanjay, A., Owen, T. A., Smock, S. L., Rehman, S., DeLong, W. G., Safadi, F. F., & Popoff, S. N. (2008) · Bone · doi:10.1016/j.bone.2008.01.006 · Cited by 49

Mitogen-Activated Protein Kinases Promote WNT/beta-CateninSignaling via Phosphorylation of LRP6

Červenka, I., Wolf, J. H., Mas̆ek, J., Krejčı́, P., Wilcox, W. R., Kozubı́k, A., Schulte, G., Gutkind, J., & Bryja, V. (2011) · Cited by 49

Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts

Kozawa, O., Tokuda, H., Matsuno, H., & Uematsu, T. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990901)74:3<479::aid-jcb15>3.0.co;2-9 · Cited by 48

Estrogen augments shear stress–induced signaling and gene expression in osteoblast-like cells via estrogen receptor–mediated expression of β1-integrin

Yeh, C.-R., Chiu, J., Lee, C.-I., Lee, P.-L., Shih, Y., Sun, J., Chien, S., & Cheng, C. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.091008 · Cited by 47

17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway

Li, Y., Yan, M., Wang, Z., Zheng, Y., Li, J., Ma, S., Liu, G., & Yu, J. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt515 · Cited by 47

CCN3 increases BMP‐4 expression and bone mineralization in osteoblasts

Tan, T., Huang, Y., Chang, J., Lin, J., Fong, Y., Kuo, C., Tsai, C., Chen, Y., Hsu, H., Cho, D., et al. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.22991 · Cited by 46

Involvement of MAP kinases in TGF-β-stimulated vascular endothelial growth factor synthesis in osteoblasts

Tokuda, H., Hatakeyama, D., Akamatsu, S., Tanabe, K., Yoshida, M., Shibata, T., & Kozawa, O. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00225-x · Cited by 46

Involvement of p38MAPK/NF-κB Signaling Pathways in Osteoblasts Differentiation in Response to Mechanical Stretch

Wang, L., Li, J., Zhang, X., Liu, L., Wan, Z., Li, R., & Guo, Y. (2012) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0548-x · Cited by 45

The p38/MK2/Hsp25 Pathway Is Required for BMP-2-Induced Cell Migration

Gamell, C., Susperregui, A. R. G., Bernard, O., Rosa, J. L., & Ventura, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016477 · Cited by 45

Effect of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells

Soda, A., Ikehara, T., Kinouchi, Y., & Yoshizaki, K. (2008) · The Journal of Medical Investigation · doi:10.2152/jmi.55.267 · Cited by 43

The flavonoid quercetin induces apoptosis and inhibits migration through a MAPK-dependent mechanism in osteoblasts

Nam, T. W., Yoo, C. I., Kim, H. T., Kwon, C. H., Park, J., & Kim, Y. K. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-008-0864-2 · Cited by 42

Electromagnetic Wave Irradiation Promotes Osteoblastic Cell Proliferation and Up-Regulates Growth Factors via Activation of the ERK1/2 and p38 MAPK Pathways

Yumoto, H., Hirao, K., Tominaga, T., Bando, N., Takahashi, K., & Matsuo, T. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369722 · Cited by 40

Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes

Zhu, J. J., Siclari, V. A., Liu, F., Spatz, J., Chandra, A., Pajevic, P. D., & Qin, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050099 · Cited by 40

Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death

Koyani, C. N., Kitz, K., Rossmann, C. R., Bernhart, E. M., Huber, E., Trummer, C., Windischhofer, W., Sattler, W., & Malle, E. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.01.011 · Cited by 40

Crosstalk between tyrosine kinase receptors, GSK3 and BMP2 signaling during osteoblastic differentiation of human mesenchymal stem cells

Biver, E., Thouverey, C., Magne, D., & Caverzasio, J. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.018 · Cited by 39

Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways.

Zhou, C., Liu, W., He, W., Wang, H., Chen, Q.-Q., & Song, H.-P. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.01.010 · Cited by 38

Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells

Miyahara, T., Katoh, T., Watanabe, M., Mikami, Y., Uchida, S., Hosoe, M., Sakuma, T., Nemoto, N., Takayama, K., & Komurasaki, T. (2004) · Toxicology · doi:10.1016/j.tox.2004.03.014 · Cited by 37

β-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFκB gene expression network in osteoblasts

Bianchi, E. N., & Ferrari, S. (2009) · Bone · doi:10.1016/j.bone.2009.06.020 · Cited by 36

Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation

Ferguson, B. S., Nam, H., Stephens, J. M., & Morrison, R. F. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25248 · Cited by 36

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts

Fukuno, N., Matsui, H., Kanda, Y., Suzuki, O., Matsumoto, K., Sasaki, K., Kobayashi, T., & Tamura, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.127 · Cited by 35

Differentiation of Osteoprogenitor Cells Is Induced by High-Frequency Pulsed Electromagnetic Fields

Teven, C. M., Greives, M. R., Natale, R. B., Su, Y., Luo, Q., He, B., Shenaq, D. S., He, T., & Reid, R. R. (2012) · Journal of Craniofacial Surgery · doi:10.1097/scs.0b013e31824cd6de · Cited by 35

Estradiol induces osteoprotegerin expression by human dental pulp cells

Manokawinchoke, J., Ritprajak, P., Osathanon, T., & Pavasant, P. (2014) · Odontology · doi:10.1007/s10266-014-0178-x · Cited by 33

Further Insights in the Mechanisms of Interleukin-1β Stimulation of Osteoprotegerin in Osteoblast-Like Cells

Lambert, C., Oury, C., Dejardin, E., Chariot, A., Piette, J. G., Malaise, M., Merville, M., & Franchimont, N. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070508 · Cited by 33

The p38α MAPK Function in Osteoprecursors Is Required for Bone Formation and Bone Homeostasis in Adult Mice

Rodríguez-Carballo, E., Gámez, B., Sedó-Cabezón, L., Sánchez‐Feutrie, M., Antonio Zorzano, A., Manzanares‐Céspedes, M. C., Rosa, J. L., & Ventura, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102032 · Cited by 33

Dual-Specificity Phosphatase 10 Controls Brown Adipocyte Differentiation by Modulating the Phosphorylation of P38 Mitogen-Activated Protein Kinase

Choi, H., Kim, W. K., Kim, E. Y., Han, B., Min, J., Chi, S., Park, S. G., Bae, K., & Lee, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072340 · Cited by 33

Role of NF-κB in hematopoietic niche function of osteoblasts after radiation injury

Xiao, M., Inal, C. E., Parekh, V. I., Li, X. H., & Whitnall, M. H. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.09.001 · Cited by 32

Gambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways

Ma, J., Ma, Y., Liu, X., Chen, S., Liu, C., Qin, A., & Fan, S. (2015) · Biochemical Journal · doi:10.1042/bj20150151 · Cited by 32

A p38 Mitogen-Activated Protein Kinase-Regulated Myocyte Enhancer Factor 2–β-Catenin Interaction Enhances Canonical Wnt Signaling

Ehyai, S., Dionyssiou, M. G., Gordon, J. W., Williams, D., Siu, K. W. M., & McDermott, J. C. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00832-15 · Cited by 32

15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species

Kitz, K., Windischhofer, W., Leis, H., Huber, E., Kollroser, M., & Malle, E. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.039 · Cited by 31

BMP-2 Induction of Dlx3 Expression Is Mediated by p38/Smad5 Signaling Pathway in Osteoblastic MC3T3-E1 Cells

Yang, G., Yuan, G., Li, X., Liu, P., Chen, Z., & Fan, M. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24525 · Cited by 29

Cross-talk between the estrogen receptor-, protein kinase A-, and mitogen-activated protein kinase-mediated signaling pathways in the regulation of lactotroph proliferation in primary culture

Yamakawa, K., & Arita, J. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2003.11.003 · Cited by 29

Diversity and versatility of p38 kinase signalling in health and disease

Canovas, B., & Nebreda, A. R. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00322-w · Cited by 657

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

Zengini, E., Hatzikotoulas, K., Tachmazidou, I., Steinberg, J., Hartwig, F. P., Southam, L., Hackinger, S., Boer, C. G., Styrkarsdottir, U., Gilly, A., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0079-y · Cited by 319

Human mesenchymal stem cell derived exosomes enhance cell‐free bone regeneration by altering their miRNAs profiles

Zhai, M., Zhu, Y., Yang, M., & Mao, C. (2020) · Advanced Science · doi:10.1002/advs.202001334 · Cited by 277

Activating; ‐catenin/Pax6 axis negatively regulates osteoclastogenesis by selectively inhibiting phosphorylation of p38/MAPK

Jie, Z., Shen, S., Zhao, X., Xu, W., Zhang, X., Huang, B., Tang, P., Qin, A., Fan, S., & Xie, Z. (2019) · The FASEB Journal · doi:10.1096/fj.201801977r · Cited by 22

Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating

Miyake, R., Shimabukuro, M., Terauchi, M., Marukawa, E., & Kawashita, M. (2025) · Advanced Biology · doi:10.1002/adbi.202500401 · Cited by 5