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Cited by 51Extracellular vesicles in diseaseBarrier Structure and Function StudiesMesenchymal stem cell research

Mesenchymal stem cell derived extracellular vesicles for repairing the neurovascular unit after ischemic stroke

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Davis, Courtney, Savitz, Sean I., Satani, Nikunj·2021·Cells
DOI 10.3390/cells10040767PMC PMC8065444
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Abstract

Ischemic stroke is a debilitating disease and one of the leading causes of long-term disability. During the early phase after ischemic stroke, the blood-brain barrier (BBB) exhibits increased permeability and disruption, leading to an influx of immune cells and inflammatory molecules that exacerbate the damage to the brain tissue. Mesenchymal stem cells have been investigated as a promising therapy to improve the recovery after ischemic stroke. The therapeutic effects imparted by MSCs are mostly paracrine. Recently, the role of extracellular vesicles released by these MSCs have been studied as possible carriers of information to the brain. This review focuses on the potential of MSC derived EVs to repair the components of the neurovascular unit (NVU) controlling the BBB, in order to promote overall recovery from stroke. Here, we review the techniques for increasing the effectiveness of MSC-based therapeutics, such as improved homing capabilities, bioengineering protein expression, modified culture conditions, and customizing the contents of EVs. Combining multiple techniques targeting NVU repair may provide the basis for improved future stroke treatment paradigms.

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  • MSCs have emerged as a promising platform for neurovascular repair due to their perivascular origin and paracrine capacity to modulate endothelial, metabolic, and neuronal function.

    “Simultaneously, MSCs have emerged as a promising platform for neurovascular repair due to their perivascular origin and paracrine capacity to modulate endothelial, metabolic, and neuronal function (Davis et al., 2021).”

    From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Davis et al., 2021

    The Introduction and Section 4 describe MSCs as a promising potential stroke therapy whose effects are believed to arise largely from paracrine signaling. Sections 6.1 and 6.5 discuss effects of MSC-derived vesicles on endothelial cells and neurons. The copy does not establish a perivascular origin for MSCs or show that they modulate metabolic function; Section 6.3 notes similarities between MSCs and pericytes, not a shared origin. Page numbers are unavailable in our copy. (LLM, conf=0.85)

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200 of 218 shown

Cited by

Sorted by citations

Authors
Davis, C., Savitz, S. I., & Satani, N.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
Satani, Nikunj
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2021-03-31
Volume
10
Issue
4
Pages
767
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells10040767
PMC
PMC8065444
OpenAlex
W3139989032
Cited by
51
References
11
Citations by year
2026: 11 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 6
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
mesenchymal stem cells, extracellular vesicles, ischemic stroke, neurovascular unit, blood-brain barrier permeability, paracrine signaling, stroke recovery, stem cell homing, neuroinflammation
MeSH terms
Extracellular Vesicles, Ischemic Stroke, Animals, Blood-Brain Barrier, Brain, Humans, Nerve Regeneration, Mesenchymal Stem Cells

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