BIOPEP-UWM Database of Bioactive Peptides: Current Opportunities

Open Babel: An open chemical toolbox

O'Boyle, N. M., Banck, M. S., James, C. A. J., Morley, C., Vandermeersch, T., & Hutchison, G. R. (2011) · Journal of Cheminformatics · doi:10.1186/1758-2946-3-33 · Cited by 10,745

DrugBank 5.0: a major update to the DrugBank database for 2018

Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1037 · Cited by 8,404

SMILES, a chemical language and information system. 1. Introduction to methodology and encoding rules

Weininger, D. (1988) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci00057a005 · Cited by 7,436

INFOGEST static in vitro simulation of gastrointestinal food digestion

Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0119-1 · Cited by 5,199

HMDB 4.0: the human metabolome database for 2018

Wishart, D. S., Feunang, Y. D., Marcu, A., Guo, A. C., Liang, K., Vázquez-Fresno, R., Sajed, T., Johnson, D., Li, C., Karu, N., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1089 · Cited by 3,438

PubChem 2019 update: improved access to chemical data

Kim, S., Chen, J., Cheng, T., Gindulyte, A., He, J., He, S., Li, Q., Shoemaker, B. A., Thiessen, P. A., Yu, B., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1033 · Cited by 3,249

ZINC 15 – Ligand Discovery for Everyone

Sterling, T., & Irwin, J. J. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00559 · Cited by 3,224

APD3: the antimicrobial peptide database as a tool for research and education

Wang, G., Li, X., & Wang, Z. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1278 · Cited by 2,402

ChEMBL: towards direct deposition of bioassay data

Mendez, D., Gaulton, A., Bento, A. P., Chambers, J., De Veij, M., Félix, E., Magariños, M. P., Mosquera, J. F., Mutowo, P., Nowotka, M., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1075 · Cited by 2,372

New approach for understanding genome variations in KEGG

Kanehisa, M. I., Sato, Y., Furumichi, M., Morishima, K., & Tanabe, M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky962 · Cited by 1,845

Changes of antioxidative activities and peptidomic patterns of Auxenochlorella pyrenoidosa protein hydrolysates: Effects of enzymatic hydrolysis and decoloration processes

Zhang, W., Jia, N., Zhu, Z., Wang, Y., Wang, J., & Xue, C. (2021) · LWT · doi:10.1016/j.lwt.2021.112306 · Cited by 21

The Stability of Food Bioactive Peptides in Blood: An Overview

Gülseren, İ., & Sarıcaoğlu, B. (2021) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-021-10321-w · Cited by 21

Bioactive dipeptides enhance the tolerance of lager yeast to ethanol-oxidation cross-stress by regulating the multilevel defense system

Wu, C., Guo, J., Jian, H., Liu, L., Zhang, H., Yang, N., Xu, H., & Lei, H. (2023) · Food Microbiology · doi:10.1016/j.fm.2023.104288 · Cited by 21

Identification of Putative Cell‐entry‐inhibitory Peptides against SARS‐CoV‐2 from Edible Insects: An in silico Study

Wong, F., Ong, J., & Chai, T. (2020) · eFood · doi:10.2991/efood.k.200918.002 · Cited by 21

Microalga nannochloropsis gaditana as a sustainable source of bioactive peptides: a proteomic and in silico approach

Paterson, S., Alonso-Pintre, L., Morato-López, E., González de la Fuente, S., Gómez-Cortés, P., & Hernández-Ledesma, B. (2025) · Foods · doi:10.3390/foods14020252 · Cited by 20

Exploring bioactive compounds in chickpea and bean aquafaba: Insights from glycomics and peptidomics analyses

Huang, Y., Masarweh, C. F., Paviani, B., Mills, D. A., & Barile, D. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140635 · Cited by 20

Self-assembly potential of bioactive peptides from Norwegian sea cucumber Parastichopus tremulus for development of functional hydrogels

Mildenberger, J., Remm, M., & Atanassova, M. (2021) · LWT · doi:10.1016/j.lwt.2021.111678 · Cited by 20

The Bioactivity Prediction of Peptides from Tuna Skin Collagen Using Integrated Method Combining In Vitro and In Silico

Devita, L., Lioe, H. N., Nurilmala, M., & Suhartono, M. T. (2021) · Foods · doi:10.3390/foods10112739 · Cited by 20

Exploring the DPP-IV Inhibitory, Antioxidant and Antibacterial Potential of Ovine “Scotta” Hydrolysates

Cabizza, R., Fancello, F., Petretto, G. L., Addis, R., Pisanu, S., Pagnozzi, D., Piga, A., & Urgeghe, P. P. (2021) · Foods · doi:10.3390/foods10123137 · Cited by 20

Carboxyl-containing compounds in food: Category, functions, and analysis with chemical derivatization-based LC-MS

Zhang, L., Li, N., Chen, S., Bian, X., Farag, M. A., Ge, Y., Xiao, J., & Wu, J. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116818 · Cited by 20

An in silico approach to unveil peptides from Acheta domesticus with potential bioactivity against hypertension, diabetes, cardiac and pulmonary fibrosis

Teixeira, C. S. S., Villa, C., Sousa, S. F., Costa, J. S., Ferreira, I. M. P. L. V. O., & Mafra, I. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112847 · Cited by 20

New insights into the bioaccessibility and metabolic fates of short-chain bioactive peptides in goat milk using the INFOGEST static digestion model and an improved data acquisition strategy

Du, A., & Jia, W. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112948 · Cited by 20

Functional attributes of bioactive peptides of bovine milk origin and application of in silico approaches for peptide prediction and functional annotations

Dhar, H., Verma, S., Dogra, S., Katoch, S., Vij, R., Singh, G., & Sharma, M. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2212803 · Cited by 20

Novel α-Glucosidase Inhibitory Peptides Identified In Silico from Dry-Cured Pork Loins with Probiotics through Peptidomic and Molecular Docking Analysis

Kęska, P., Stadnik, J., Łupawka, A., & Michalska, A. (2023) · Nutrients · doi:10.3390/nu15163539 · Cited by 20

Identification of novel dipeptidyl peptidase-4 inhibitory peptides from pea proteins: A combined in silico and in vitro study

Zhang, M., Zhu, L., Zhang, H., Wang, X., Liu, T., Qi, X., & Wu, G. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103374 · Cited by 20

Bioactive peptides in dry-cured ham: A comprehensive review of preparation methods, metabolic stability, safety, health benefits, and regulatory frameworks

Hu, Y.-Y., Xiao, S., Zhou, G., Chen, X., Wang, B., & Wang, J. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114367 · Cited by 20

Introducing Bacillus natto and Propionibacterium shermanii into soymilk fermentation: A promising strategy for quality improvement and bioactive peptide production during in vitro digestion

Wu, X., Liu, H., Han, J., Zhou, Z., Chen, J., & Liu, X. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.139585 · Cited by 20

Properties of peptides released from salmon and carp via simulated human-like gastrointestinal digestion described applying quantitative parameters

Borawska, J., Darewicz, M., & Tarczyńska, A. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255969 · Cited by 20

Whey Protein Enzymatic Breakdown: Synthesis, Analysis, and Discovery of New Biologically Active Peptides in Papain-Derived Hydrolysates

Czelej, M., Garbacz, K., Czernecki, T., Rachwał, K., Wawrzykowski, J., & Waśko, A. D. (2025) · Molecules · doi:10.3390/molecules30071451 · Cited by 19

Preparation, unique structural characteristics and immunomodulatory effects of peptides from Antarctic krill (Euphausia superba)

Yang, T., Meng, Y., Li, S., Zhao, X. Y., & Hou, H. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116592 · Cited by 19

Possibilities and limitations of artificial intelligence in food‐derived peptides

Zhao, C., He, Z., & Ashaolu, T. J. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70099 · Cited by 19

In Silico Peptide Design: Methods, Resources, and Role of AI

Choudhury, P. R., Mishra, S. K., Yadav, S., Singh, S., & Mathur, P. (2025) · Journal of Peptide Science · doi:10.1002/psc.70063 · Cited by 20

Design of melanogenesis regulatory peptides derived from phycocyanin of the microalgae Spirulina platensis

Köse, A., & Öncel, S. Ş. (2022) · Peptides · doi:10.1016/j.peptides.2022.170783 · Cited by 19

Humanizing plant-derived snakins and their encrypted antimicrobial peptides

Ghanbarzadeh, Z., Hemmati, S., & Mohagheghzadeh, A. (2022) · Biochimie · doi:10.1016/j.biochi.2022.04.011 · Cited by 19

Reference genome of the nutrition-rich orphan crop chia (Salvia hispanica) and its implications for future breeding

Gupta, P., Geniza, M. J., Elser, J. L., Al-Bader, N., Baschieri, R., Phillips, J. L., Haq, E., Preece, J., Naithani, S., & Jaiswal, P. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1272966 · Cited by 19

Contemporary bioinformatics and cheminformatics support for food peptidomics

Mińkiewicz, P., Iwaniak, A., & Darewicz, M. (2024) · Current Opinion in Food Science · doi:10.1016/j.cofs.2024.101125 · Cited by 19

UmamiPreDL: Deep learning model for umami taste prediction of peptides using BERT and CNN

Indiran, A. P., Fatima, H., Chattopadhyay, S., Ramadoss, S., & Radhakrishnan, Y. (2024) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2024.108116 · Cited by 19

Isolation, purification and characterization of antioxidant peptides from Spirulina platensis extracts co-fermentation with Thermus thermophilus HB27 and Saccharomyces cerevisiae CH006

Wei, Y.-F., Wang, J., Luo, Y.-J., Zhao, X.-F., Zou, L.-H., Qiu, X., Nie, S., & Liu, H.-Y. (2024) · LWT · doi:10.1016/j.lwt.2024.116497 · Cited by 19

Characterisation of Seasonal Mytilus edulis By-Products and Generation of Bioactive Hydrolysates

Naik, A. S., Mora, L., & Hayes, M. (2020) · Applied Sciences · doi:10.3390/app10196892 · Cited by 19

Tombul hazelnut (Corylus avellana L.) peptides with DPP-IV inhibitory activity: In vitro and in silico studies

Çağlar, A. F., Göksu, A. G., Çakır, B., & Gülseren, İ. (2021) · Food Chemistry X · doi:10.1016/j.fochx.2021.100151 · Cited by 19

Antioxidant Potential of the Sweet Whey-Based Beverage Colada after the Digestive Process and Relationships with the Lipid and Protein Fractions

Casas, V. G., Seiquer, I., Pardo, Z., Haro, A., Recio, I., & Olías, R. (2022) · Antioxidants · doi:10.3390/antiox11091827 · Cited by 19

Supercritical fluid extraction prior pulsed electric fields to improve high-added-value compounds recovery from salmon side streams: Evaluation of protein, bioactive peptides and minerals

Liu, Y., Berrada, H., Castagnini, J. M., & Barba, F. J. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142283 · Cited by 18

Novel bioactive peptides from ginger rhizome: Integrating in silico and in vitro analysis with mechanistic insights through molecular docking

Purohit, K., Pathak, R., Hayes, E., & Sunna, A. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144432 · Cited by 18

Accurate prediction for adsorption rate of peptides with high ACE-inhibitory activity from sericin hydrolysate on thiophene hypercross-linked polymer using CoMSIA in 3D-QSAR model

Shao, S., Sun, H., Muhammad, Y., Huang, H., Wang, R., Nie, S., Huang, M., Zhao, Z., & Zhao, Z. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110144 · Cited by 18

Anticoagulant Dodecapeptide Suppresses Thrombosis In Vivo by Inhibiting the Thrombin Exosite-I Binding Site

Cheng, S., Wang, Y., Chen, H., Liu, H., Wang, L., Battino, M. A., Yao, X., Zhu, B., & Du, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03414 · Cited by 18

Effect of radio frequency, ultrasound, microwave‐assisted papain, and alcalase hydrolysis on the structure, antioxidant activity, and peptidomic profile of Rosa roxburghii Tratt. seed protein

Yin, H., Jiang, Y., Zhou, X., Zhong, Y. X., Wang, D., Deng, Y., & Xue, H. (2022) · Journal of Food Science · doi:10.1111/1750-3841.16266 · Cited by 18

Bioactive properties of peptide fractions from Brazilian soy protein hydrolysates: In silico evaluation and experimental evidence

Farias, T. C., de Abreu, J. P., Oliveira, J. P. D. S., Macedo, A. F., Rodríguez-Vega, A., Tonin, A. P. P., Cardoso, F. S. N., Meurer, E. C., & Koblitz, M. G. B. (2022) · Food Hydrocolloids for Health · doi:10.1016/j.fhfh.2022.100112 · Cited by 18

Screening potential hypertensive peptides using two consecutive bioassay-guided SPE fractionations and identification of an ACE inhibitory peptide, DHSTAVW (DW7), derived from pearl garlic protein hydrolysate

Sutopo, C. C. Y., Aznam, N., Arianingrum, R., & Hsu, J. (2023) · Peptides · doi:10.1016/j.peptides.2023.171046 · Cited by 18

Ion-exchange purification, nano-HPLC–MS/MS identification and molecular dynamics simulation of novel umami peptides from fermented grain wine (Huangjiu)

Chang, R., Zhou, Z., Dong, Y., Xu, Y., Ji, Z., Liu, S., Gong, M., & Mao, J. (2023) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2023.105822 · Cited by 18

Gastro‐Intestinal Digested Bovine Milk Osteopontin Modulates Gut Barrier Biomarkers In Vitro

Li, L., Chen, J., Zheng, Y., Lane, J. A., Hu, R., Zhu, J., Fu, X., Huang, Q., Liu, F., & Zhang, B. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200777 · Cited by 18

Fractionation and identification of bioactive peptides from red macroalgae protein hydrolysates: In silico analysis and in vitro bioactivities

Dhaouafi, J., Romdhani, M., Deracinois, B., Flahaut, C., Nedjar, N., & Balti, R. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103211 · Cited by 18

Functional chia (Salvia hispanica L.) co-product protein hydrolysate: An analysis of biochemical, antidiabetic, antioxidant potential and physicochemical properties

Briceño-Islas, G., Mojica, L., & Urías‐Silvas, J. E. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140406 · Cited by 18

Virtual-screening of xanthine oxidase inhibitory peptides: Inhibition mechanisms and prediction of activity using machine-learning

Chen, Q., Ge, Y., He, X., Li, S., Fang, Z., Cheng, L., & Chen, H. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140741 · Cited by 20

Peptides for Health Benefits 2019

Martínez‐Villaluenga, C., & Hernández‐Ledesma, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072543 · Cited by 18

Potential of Plant Proteins Digested In Silico by Gastrointestinal Enzymes as Nutritional Supplement for COVID-19 Patients

Luo, Z., Su, K., & Zhang, X. (2020) · Plant Foods for Human Nutrition · doi:10.1007/s11130-020-00850-y · Cited by 18

Biologia futura: medicinal plants-derived bioactive peptides in functional perspective—a review

Meena, S., Kanthaliya, B., Joshi, A., Khan, F., & Arora, J. (2020) · Biologia Futura · doi:10.1007/s42977-020-00042-4 · Cited by 18

High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products

Montone, C. M., Aita, S. E., Cavaliere, C., Cerrato, A., Laganà, A., Piovesana, S., & Capriotti, A. L. (2021) · Molecules · doi:10.3390/molecules26216472 · Cited by 18

Investigating the Short Peptidome Profile of Italian Dry-Cured Ham at Different Processing Times by High-Resolution Mass Spectrometry and Chemometrics

Cerrato, A., Aita, S. E., Capriotti, A. L., Cavaliere, C., Montone, A. M. I., Montone, C. M., & Laganà, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063193 · Cited by 18

TastepepAI: An artificial intelligence platform for taste peptide de novo design

Yue, J., Li, T., Ouyang, J., Xu, J., Tan, H., Chen, Z., Han, C., Li, H., Liang, S., Liu, Z., et al. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013602 · Cited by 17

Novel angiotensin I‐converting enzyme ( ACE ) inhibitory peptides from walnut protein isolate: Separation, identification and molecular docking study

Tang, H., Wang, C., Cao, S., & Wang, F. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14411 · Cited by 17

Novel Peptide Sequences with ACE-Inhibitory and Antioxidant Activities Derived from the Heads and Bones of Hybrid Groupers (Epinephelus lanceolatus × Epinephelus fuscoguttatus)

Chan, P.-T., Matanjun, P., Budiman, C., Shapawi, R., & Lee, J. (2022) · Foods · doi:10.3390/foods11243991 · Cited by 17

Novel Peptides in Fermented Milk with Specific Lactobacillus Strains Potential Antiobesity Effect: In Vitro and in Silico Analysis

Manzanarez-Quin, C. G., García‐Romo, J. S., Beltrán‐Barrientos, L. M., Torres‐Llanez, M. J., Mazorra-Manzano, M. A., Hernández‐Mendoza, A., González-Córdova, A. F., & Vallejo‐Córdoba, B. (2023) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.2c00347 · Cited by 17

A review on the types of amino acid at ultimate, penultimate and antepenultimate position in some dipeptidyl-peptidase IV inhibitory peptides based on molecular docking analysis

Rodhi, A. M., Yap, P., Olalere, O. A., & Gan, C. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2023.100244 · Cited by 17

Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors

Wong, F., & Chai, T. (2023) · Biology · doi:10.3390/biology12070917 · Cited by 17

iAnOxPep: A Machine Learning Model for the Identification of Anti-Oxidative Peptides Using Ensemble Learning

Hassan, M. T., Tayara, H., & Chong, K. T. (2024) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2024.3489614 · Cited by 17

Identification of C-phycocyanin-derived Peptides as Angiotensin Converting Enzyme and Dipeptidyl Peptidase IV Inhibitors via Molecular Docking and Molecular Dynamic Simulation

Pan, F., Zhou, N., Li, J., Du, X., Zhao, L., Wang, C., Zhang, M., & Ai, X. (2020) · ES Food & Agroforestry · doi:10.30919/esfaf1116 · Cited by 17

Sensopeptidomic Kinetic Approach Combined with Decision Trees and Random Forests to Study the Bitterness during Enzymatic Hydrolysis Kinetics of Micellar Caseins

Daher, D., Deracinois, B., Courcoux, P., Baniel, A., Chollet, S., Froidevaux, R., & Flahaut, C. (2021) · Foods · doi:10.3390/foods10061312 · Cited by 17

Identification of dipeptides by MALDI-ToF mass spectrometry in long-processing Spanish dry-cured ham

Heres, A., Saldaña, C., Toldrá, F., & Mora, L. (2021) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2021.100048 · Cited by 17

Computational Tools and Strategies to Develop Peptide-Based Inhibitors of Protein-Protein Interactions

Delaunay, M., & Ha‐Duong, T. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1855-4_11 · Cited by 17

Is Pulsed Electric Field (PEF) a Useful Tool for the Valorization of Solid and Liquid Sea Bass Side Streams?: Evaluation of Nutrients and Contaminants

Liu, Y., Berrada, H., Wang, M., Zhou, J., Kousoulaki, K., Barba, F. J., & Castagnini, J. M. (2024) · Food and Bioprocess Technology · doi:10.1007/s11947-024-03553-3 · Cited by 16

Screening of antioxidant peptides from soy protein isolate: In vitro activity validation and structure-activity relationships investigation through quantum chemical calculations

Chen, Z., Xia, Y., & Liang, G. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144616 · Cited by 16

Enzymatic Hydrolysis of Defatted Antheraea pernyi (Lepidoptera: Saturniidae) Pupa Protein by Combined Neutral Protease Yield Peptides With Antioxidant Activity

Ma, S., Li, X., Sun, Y., Mi, R., Li, Y., Wen, Z., Meng, N., Yi, L., Du, X., & Li, S. (2021) · Journal of Insect Science · doi:10.1093/jisesa/ieab013 · Cited by 17

Manufacture of Whey Protein Hydrolysates Using Plant Enzymes: Effect of Processing Conditions and Simulated Gastrointestinal Digestion on Angiotensin-I-Converting Enzyme (ACE) Inhibitory Activity

Peslerbes, M., Fellenberg, M. A., Jardin, J., Deglaire, A., & Ibáñez, R. A. (2022) · Foods · doi:10.3390/foods11162429 · Cited by 16

Identification of ACE I-Inhibitory Peptides Released by the Hydrolysis of Tub Gurnard (Chelidonichthys lucerna) Skin Proteins and the Impact of Their In Silico Gastrointestinal Digestion

Bougatef, H., de la Vega-Fernández, C., Sila, A., Bougatef, A., & Martínez‐Álvarez, Ó. (2023) · Marine Drugs · doi:10.3390/md21020131 · Cited by 16

Carboxyl-containing components delineation via feature-based molecular networking: A key to processing conditions of fermented soybean

Gao, Y., Fu, Y., Li, N., Jiang, Y., Liu, X., Gao, C., Wang, L., Wu, J., & Zhou, T. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136321 · Cited by 16

A novel heat-stable angiotensin-converting enzyme zinc-binding motif inhibitory peptide identified from corn silk

Hsiang, C., Lo, H., Lu, G., Liao, P.-Y., & Ho, T. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117435 · Cited by 16

Different Strategies for the Biosynthesis of Bioactive Peptide Using Bioengineering Technology in Pichia pastoris: A Review

Hong, K., Rong, Y., Jiang, Y., Yuan, J., Wu, F., Gao, L., & Wu, X. (2025) · Food and Bioprocess Technology · doi:10.1007/s11947-025-03755-3 · Cited by 16

Characterization of Rugulopteryx okamurae algae: A source of bioactive peptides, omega-3 fatty acids, and volatile compounds

Rivero‐Pino, F., la Rosa, T. G., Torrecillas-López, M., Barrera‐Chamorro, L., Rio-Vazquez, J. L. D., Marquez‐Paradas, E., Fernández‐Prior, Á., García‐Vaquero, M., García‐Gómez, J. C., la Paz, S. M., et al. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143084 · Cited by 16

Characteristics of Potential Protein Nutraceuticals of Plant Origin with Antioxidant Activity

Szerszunowicz, I., & Kłobukowski, J. (2020) · Molecules · doi:10.3390/molecules25071621 · Cited by 16

Evaluation of the relationship between the peptide profiles and the lipid-lowering properties of olive seed hydrolysates as a tool for tuning hypocholesterolemic functionality

Prados, I. M., Plaza, M., Marina, M. L., & García, M. C. (2020) · Food & Function · doi:10.1039/d0fo00576b · Cited by 16

A heuristic, computer-driven and top-down approach to identify novel bioactive peptides: A proof-of-principle on angiotensin I converting enzyme inhibitory peptides

Lammi, C., Boschin, G., Bollati, C., Arnoldi, A., Galaverna, G., & Dellafiora, L. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110753 · Cited by 16

Proteomic characterization of pilot scale hot-water extracts from the industrial carrageenan red seaweed Eucheuma denticulatum

Gregersen, S., Pertseva, M., Marcatili, P., Holdt, S. L., Jacobsen, C., García-Moreno, P. J., Hansen, E. B., & Overgaard, M. T. (2022) · Algal Research · doi:10.1016/j.algal.2021.102619 · Cited by 15

Exploration of novel dipeptidyl peptidase-IV inhibitory tetrapeptide from walnut (Juglans sigillata) protein and its effect on diabetes-like phenotypes induced by high-sugar diet in Drosophila melanogaster

Chen, S., Pan, H., Huan, P., Wang, S., Sun, L., Ning, D., Ma, T., & Zhuang, Y. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116487 · Cited by 15

AI-powered de novo architecturing of marine-mimetic antioxidant peptides in yeast synbio factories

Gao, L., Zhou, T., Yuan, J. X., Zhang, S., Hong, K., Zhang, Z., Hau, L. C., Cheang, W. S., Zhou, C.-C., & Wu, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169604 · Cited by 15

Impact of a Shorter Brine Soaking Time on Nutrient Bioaccessibility and Peptide Formation in 30-Months-Ripened Parmigiano Reggiano Cheese

Nunzio, M. D., Loffi, C., Chiarello, E., Dellafiora, L., Picone, G., Antonelli, G., Gregorio, C. D., Capozzi, F., Tedeschi, T., Galaverna, G., et al. (2022) · Molecules · doi:10.3390/molecules27030664 · Cited by 15

Biological activities of whey protein hydrolysate produced by protease from the Antarctic bacterium Lysobacter sp. A03

Millan, G. C. L., Veras, F. F., Stincone, P., Pailliè-Jiménez, M. E., & Brandelli, A. (2022) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2022.102415 · Cited by 15

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Zou, H., & Yin, Z. (2021) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-021-10280-2 · Cited by 15

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Pérez-Polo, S., Imran, M. A. S., Dios, S., Pérez‐Vázquez, J., Barros, L., Carrera, M., & Gestal, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087145 · Cited by 15

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Chen, S., Ding, T., Wang, J., Liang, X., Wang, H., Wang, J., & Xue, M. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.03.017 · Cited by 14

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Lauritano, C., Montuori, E., Falco, G. D., & Carrella, S. (2023) · Antioxidants · doi:10.3390/antiox12030710 · Cited by 15

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Toldrá, F., Reig, M., Gallego, M., & Mora, L. (2023) · Meat and Muscle Biology · doi:10.22175/mmb.16243 · Cited by 14

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Cunha, M. F., Coscueta, E. R., Brassesco, M. E., Marques, R., Neto, J., Almada, F., Gonçalves, D., & Pintado, M. (2023) · Molecules · doi:10.3390/molecules28186458 · Cited by 14

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Li, Z., Jin, J., He, W., Long, W., Yu, H., Gao, X., Nakai, K., Zou, Q., & Wei, L. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad352 · Cited by 14

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Banić, M., Butorac, K., Čuljak, N., Butorac, A., Novak, J., Pavunc, A. L., Rušanac, A., Stanečić, Ž., Lovrić, M., Šušković, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042431 · Cited by 15

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Fan, X., Zhang, L., Sun, Y., Zhou, C., Xia, Q., Du, L., Wu, Z., & Pan, D. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2023.9250041 · Cited by 14

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Zhou, F., Li, D., Hou, Y., Cong, Z., Li, K., Gu, X., & Xiao, G. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298674 · Cited by 15

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Longarela, N. R., Paredes-Ramos, M., & Vilariño, J. M. L. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2367571 · Cited by 14

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Mińkiewicz, P., Iwaniak, A., & Darewicz, M. (2022) · Applied Sciences · doi:10.3390/app12147204 · Cited by 61

BioPepDB: an integrated data platform for food-derived bioactive peptides

Li, Q., Zhang, C., Chen, H., Xue, J., Guo, X., Liang, M., & Chen, M. (2018) · Figshare · doi:10.6084/m9.figshare.5976640

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