AMPK, Mitochondrial Function, and Cardiovascular Disease

Cites (278)

Items 201–275 of 275

1. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300
   Zhang, Yuan, Qiu, Jian, Wang, Xiaoming, Zhang, Yuhua, Xia, Min · 2011 · Arteriosclerosis Thrombosis and Vascular Biology
2. Adaptation and maladaptation of the heart in obesity
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3. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice
   Masayoshi Horimoto, Péter Fülöp, Zoltán Derdák, Jack R. Wands, György Baffy · 2004 · Hepatology
4. Expression of Uncoupling Protein-2 in Human Colon Cancer
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5. Sildenafil inhibits the formation of superoxide and the expression of gp47 phox NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells
   Anthony James Koupparis, Jamie Y. Jeremy, Saima Muzaffar · 2005 · British Journal of Urology
6. AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells
   Li, Xiaoxia, Han, Yingying, Pang, Wei, Li, Chenghong, Xie, Xuefen, Shyy, John Y.-J., Zhu, Yi · 2008 · Arteriosclerosis Thrombosis and Vascular Biology
7. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
   Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviçiene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist et al. · 2018 · JCI Insight
8. AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)
   Nerstedt, A., Johansson, A., Andersson, C. X., Cansby, E., Smith, U., Mahlapuu, M. · 2010 · Diabetologia
9. Aldehyde dehydrogenase 2 has cardioprotective effects on myocardial ischaemia/reperfusion injury via suppressing mitophagy
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10. Vascular complications in diabetes: Old messages, new thoughts
    Forbes, Josephine M., Fotheringham, Amelia K. · 2017 · Diabetologia
11. Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction
    Turdi, Subat, Kandadi, Machender R., Zhao, Junxing, Huff, Anna F., Du, Min, Ren, Jun · 2011 · Journal of Molecular and Cellular Cardiology
12. The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission
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13. Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients
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14. Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway
    Xing, Sha-Sha, Yang, Xiao-Yan, Zheng, Tao, Li, Wen-Jing, Wu, Dan, Chi, Jiang-Yang, Bian, Fang, Bai, Xiang-Li, Wu, Guang-Jie, Zhang, You-Zhi et al. · 2015 · Vascular Pharmacology
15. TNF-α Stimulation of MCP-1 Expression Is Mediated by the Akt/PKB Signal Transduction Pathway in Vascular Endothelial Cells
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16. Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion
    Pride, Christelle Kamga, Mo, Li, Quesnelle, Kelly, Dagda, Ruben K., Murillo, Daniel, Geary, Lisa, Corey, Catherine, Portella, Rafael, Zharikov, Sergey, St Croix, Claudette et al. · 2014 · Cardiovascular Research
17. Inhibition of AMP kinase by the protein phosphatase 2a heterotrimer, PP2APpp2r2d
    Joseph, Biny K., Liu, Hsing-Yin, Francisco, Jamie, Pandya, Devanshi, Donigan, Melissa, Gallo-Ebert, Christina, Giordano, Caroline, Bata, Adam, Nickels, Joseph T. · 2015 · Journal of Biological Chemistry
18. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation
    Cao, Ke, Xu, Jie, Pu, Wenjun, Dong, Zhizhong, Sun, Lei, Zang, Weijin, Gao, Feng, Zhang, Yong, Feng, Zhihui, Liu, Jiankang · 2015 · Scientific Reports
19. Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction
    Weir, Robin A.P., Murphy, Charles Aengus, Petrie, Colin J., Martin, Thomas N., Balmain, Sean, Clements, Suzanne, Steedman, Tracey, Wagner, Galen S., Dargie, Henry J., McMurray, John J.V. · 2010 · Circulation Cardiovascular Imaging
20. Thrombin and histamine stimulate endothelial nitric‐oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K‐Akt
    Brynhildur Thors, Haraldur Halldórsson, Guðmundur Þorgeirsson · 2004 · FEBS Letters
21. Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide
    Zhang, Miao, Dong, Yunzhou, Xu, Jian, Xie, Zhonglin, Wu, Yong, Song, Ping, Guzman, Melissa, Wu, Jiliang, Zou, Ming-Hui · 2008 · Circulation Research
22. AMP-activated protein kinase conducts the ischemic stress response orchestra
    Young, Lawrence H. · 2008 · Circulation
23. AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia
    Huagang Zhang, Bo Liu, Tianbo Li, Yun Kai Zhu, Gui-Ping Luo, Yunhan Jiang, Fuqin Tang, Jian Zhao, Yingbin Xiao · 2017 · International Journal of Molecular Medicine
24. Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice
    Young-Eun Cho, Aninda Basu, Anzhi Dai, Michael Heldak, Ayako Makino · 2013 · American Journal of Physiology-Cell Physiology
25. Metformin prevents endotoxin-induced liver injury after partial hepatectomy
    Bergheim, Ina, Luyendyk, James P., Steele, Chad, Russell, Gilandra K., Guo, Luping, Roth, Robert A., Arteel, Gavin E. · 2006 · The Journal of Pharmacology and Experimental Therapeutics
26. Getting to the Heart of the Matter: Epidemiology of Cyanotic Heart Defects
    Jennifer L. Kornosky, Hamisu Mohammed Salihu · 2008 · Pediatric Cardiology
27. The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 β cells
    Luisa García-Haro, Maria Adelaida García-Gimeno, Dietbert Neumann, Monique Beullens, Mathieu Bollen, Pascual Sanz · 2010 · The FASEB Journal
28. SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress
    Zhang, Mengli, Wu, Jian, Sun, Renqiang, Tao, Xiaoting, Wang, Xiaoxia, Kang, Qi, Wang, Hui, Zhang, Lei, Liu, Peng, Zhang, Jinye et al. · 2019 · PLOS ONE
29. AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases
    Lu, Qingguo, Li, Xuan, Liu, Jia, Sun, Xiaodong, Rousselle, Thomas, Ren, Di, Tong, Nanwei, Li, Ji · 2019 · Bioscience Reports
30. The AMP-Activated Protein Kinase Plays a Role in Antioxidant Defense and Regulation of Vascular Inflammation
    Jansen, Thomas, Kvandová, Miroslava, Daiber, Andreas, Stamm, Paul, Frenis, Katie, Schulz, Eberhard, Münzel, Thomas, Kröller-Schön, Swenja · 2020 · Antioxidants
31. Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure
    Cahill, Thomas J., Leo, Vincenzo, Kelly, Matthew, Stockenhuber, Alexander, Kennedy, Nolan W., Bao, Leyuan, Cereghetti, Grazia, Harper, Andrew R., Czibik, Gabor, Lao, Chunyan et al. · 2015 · Journal of Biological Chemistry
32. Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca2+-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK/SERCA2a pathway
    Cui, Jiasen, Li, Zeng, Zhuang, Shunjiu, Qi, Shaohong, Li, Li, Zhou, Junwen, Zhang, Wan, Zhao, Yun · 2018 · Cell Stress and Chaperones
33. Discovery of MK-8722: A systemic, direct pan-activator of amp-activated protein kinase
    Feng, Danqing, Biftu, Tesfaye, Romero, F. Anthony, Kekec, Ahmet, Dropinski, James, Kassick, Andrew, Xu, Shiyao, Kurtz, Marc M., Gollapudi, Anantha, Shao, Qing et al. · 2018 · ACS Medicinal Chemistry Letters
34. Autophagy and mitochondrial biogenesis impairment contribute to age‐dependent liver injury in experimental sepsis: dysregulation of AMP‐activated protein kinase pathway
    Yu Inata, Satoshi Kikuchi, Ravi Shankar Samraj, Paul W. Hake, Michael O’Connor, John R. Ledford, James O'Connor, Patrick M. Lahni, Vivian Wolfe, Giovanna Piraino et al. · 2017 · The FASEB Journal
35. Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: Potential implications in atherosclerosis
    Karnewar, Santosh, Vasamsetti, Sathish Babu, Gopoju, Raja, Kanugula, Anantha Koteswararao, Ganji, Sai Krishna, Prabhakar, Sripadi, Rangaraj, Nandini, Tupperwar, Nitin, Kumar, Jerald Mahesh, Kotamraju, Srigiridhar · 2016 · Scientific Reports
36. AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6
    Gongol, Brendan, Marin, Traci, Peng, I-Chen, Woo, Brian, Martin, Marcy, King, Stephanie, Sun, Wei, Johnson, David A., Chien, Shu, Shyy, John Y.-J. · 2013 · Proceedings of the National Academy of Sciences
37. Inhibition of mitochondrial fission and NOX2 expression prevent nlrp3 inflammasome activation in the endothelium: The role of corosolic acid action in the amelioration of endothelial dysfunction
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38. ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling
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39. Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure
    Schram, Kristin, Sweeney, Gary · 2008 · Trends in Cardiovascular Medicine
40. Inhibition of Tumor Necrosis Factor α–Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase
    Ewart, Marie-Ann, Kohlhaas, Christine F., Salt, Ian P. · 2008 · Arteriosclerosis Thrombosis and Vascular Biology
41. A protective role of ciglitazone in ox‐ LDL ‐induced rat microvascular endothelial cells via modulating PPAR γ‐dependent AMPK / eNOS pathway
    Lei Xu, Shijun Wang, Bingyu Li, Aijun Sun, Yunzeng Zou, Junbo Ge · 2014 · Journal of Cellular and Molecular Medicine
42. Remodeling of Ca2+ signaling in cancer: Regulation of inositol 1,4,5-trisphosphate receptors through oncogenes and tumor suppressors
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43. The Chemical Interplay between Nitric Oxide and Mitochondrial CytochromecOxidase: Reactions, Effectors and Pathophysiology
    Paolo Sarti, Elena Forte, Alessandro Giuffrè, Daniela Mastronicola, Maria Chiara Magnifico, Marzia Arese · 2012 · International Journal of Cell Biology
44. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation
    Liangpunsakul, Suthat, Wou, Sung-Eun, Zeng, Yan, Ross, Ruth A., Jayaram, Hiremagalur N., Crabb, David W. · 2008 · American Journal of Physiology-Gastrointestinal and Liver Physiology
45. Vildagliptin improves high glucose-induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission
    Liu, Hengdao, Xiang, Hong, Zhao, Shaoli, Sang, Haiqiang, Lv, Fenghua, Chen, Ruifang, Shu, Zhihao, Chen, Alex F., Chen, Shuhua, Lu, Hongwei · 2019 · Journal of Cellular and Molecular Medicine
46. Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via adenosine monophosphate-activated protein kinase signaling pathway
    Wei, Ming, Gan, Lu, Liu, Zheng, Liu, Li, Chang, Jin-Rui, Yin, Da-Chuan, Cao, Hui-Ling, Su, Xing-Li, Smith, Wanli W. · 2020 · Cardiorenal Medicine
47. Biology of endothelium
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48. No-reflow: The next challenge in treatment of ST-elevation acute myocardial infarction
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49. Inhibition of mitochondrial respiration by nitric oxide: Its role in glucose metabolism and neuroprotection
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50. Activation of AMPK attenuates LPS-induced acute lung injury by upregulation of PGC1α and SOD1
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51. Clusterin ameliorates endothelial dysfunction in diabetes by suppressing mitochondrial fragmentation
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52. Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1
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53. Deletion of <i>PRKAA</i> triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L
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54. CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway
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55. The cardioprotective effects of carvedilol on ischemia and reperfusion injury by AMPK signaling pathway
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56. Adiponectin Prevents Reduction of Lipid‐Induced Mitochondrial Biogenesis via AMPK/ACC2 Pathway in Chicken Adipocyte
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57. Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators
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58. Fucoxanthin Protects against oxLDL‐Induced Endothelial Damage via Activating the AMPK‐Akt‐CREB‐PGC1α Pathway
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59. Differential AMP-activated Protein Kinase (AMPK) Recognition mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms
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60. The Role of Hypertriglyceridemia in the Development of Atherosclerosis and Endothelial Dysfunction
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61. Impaired Expression of Uncoupling Protein 2 Causes Defective Postischemic Angiogenesis in Mice Deficient in AMP-Activated Protein Kinase α Subunits
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62. Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes
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63. <i>Ginkgo biloba</i> extract attenuates oxLDL-induced endothelial dysfunction via an AMPK-dependent mechanism
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64. Exercise and MEF2–HDAC interactions
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65. Targeting an energy sensor to treat diabetes
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66. Hypoxia induces PGC-la expression and mitochondrial biogenesis in the myocardium of TOF patients
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67. Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice
    Louwe, Mieke C., van der Hoorn, José W.A., van den Berg, Sjoerd A.A., Jukema, J. Wouter, Romijn, Johannes A., Willems van Dijk, Ko, Rensen, Patrick C.N., Smit, Johannes W.A., Steendijk, Paul · 2012 · Applied Physiology Nutrition and Metabolism
68. Structure-activity relationship of antioxidants for inhibitors of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells
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69. Miglitol, an Anti-diabetic Drug, Inhibits Oxidative Stress^|^ndash;Induced Apoptosis and Mitochondrial ROS Over-Production in Endothelial Cells by Enhancement of AMP-Activated Protein Kinase
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70. Mechanism of thrombin mediated eNOS phosphorylation in endothelial cells is dependent on ATP levels after stimulation
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71. AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues
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72. Homocysteine up-regulates ET B receptors via suppression of autophagy in vascular smooth muscle cells
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73. Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure
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74. TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation
    Wu, Lian-pan, Gong, Zheng-fan, Wang, He, Zhou, Zhong-shu, Zhang, Ming-ming, Liu, Chao, Ren, Hong-mei, Yang, Jian, Han, Yu, Zeng, Chun-yu · 2020 · Acta Pharmacologica Sinica
75. Cardiac β‐adrenergic responsiveness of obese Zucker rats: The role of AMPK
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