Cited by 160Medicinal Plants and NeuroprotectionWound Healing and TreatmentsPhytochemicals and Medicinal Plants

The DOI matches its Crossref record; 109 of the 110 references it cites were found in a registry or an index.

Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential

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Diniz, Lúcio Ricardo Leite, Calado, Leonardo Luiz, Duarte, Allana Brunna Sucupira, de Sousa, Damião Pergentino·2023·Metabolites

Abstract

An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a promising strategy to obtain drugs therapeutically useful in the acute and chronic wound management. In this context, Centella asiatica (Apiaceae) has been used to treat a variety of skin diseases, such as leprosy, lupus, varicose ulcers, eczema and psoriasis, in Asiatic traditional medicine for thousands of years. Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration and wound repair process by promoting fibroblast proliferation and collagen synthesis. Preliminary findings have shown that the asiatic acid is one of the main active constituents of C. asiatica, directly associated with its healing activity. Thus, this study discusses aspects of the effects of Centella asiatica and its active component, asiatic acid, in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects that contribute to its therapeutic potential.

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Crossref · 10.3390/metabo13020276

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Figures

Figure 1 Chemical structure of asiatic acid.
Figure 1 Chemical structure of asiatic acid.CC BY · PubMed Central
Figure 2 Centella asiatica extract (CAE) and its bioactive constituent, asiatic acid (Aa) display a decrease in the wound area and faster healing by increasing collagen synthesis, and cellular proliferation, fibroblast division and re-epithelialization during proliferative and remodeling phases of wound healing. CAE and Aa also act in the inflammatory phase by inhibiting recruitment of immune defense cells, reducing synthesis of pro-inflammatory cytokines (TNF-α, IL-6, and and IL-1β) and growth factors (TGF-β, PDGF and VEGF). Moreover, Aa inhibits the increase of serum levels of IL-17/IL-23. This figure was created with Adobe Illustrator.
Figure 2 Centella asiatica extract (CAE) and its bioactive constituent, asiatic acid (Aa) display a decrease in the wound area and faster healing by increasing collagen synthesis, and cellular proliferation, fibroblast division and re-epithelialization during proliferative and remodeling phases of wound healing. CAE and Aa also act in the inflammatory phase by inhibiting recruitment of immune defense cells, reducing synthesis of pro-inflammatory cytokines (TNF-α, IL-6, and and IL-1β) and growth factors (TGF-β, PDGF and VEGF). Moreover, Aa inhibits the increase of serum levels of IL-17/IL-23. This figure was created with Adobe Illustrator.CC BY · PubMed Central

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Metadata

Authors
Diniz, L. R. L., Calado, L. L., Duarte, A. B. S., & de Sousa, D. P.
Affiliations
  • Instituto Nacional do Semiárido (BR)
  • Universidade Federal da Paraíba (BR)
  • Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-970, Paraíba, Brazil
Venue
Metabolites
Publisher
MDPI AG
Published
2023-02-14
Volume
13
Issue
2
Pages
276
ISSN
2218-1989 (ISSN-L)
OpenAlex
W4320919855
Cited by
160
References
110
Citations by year
2026: 38 · 2025: 59 · 2024: 50 · 2023: 12
FWCI
9.31
Type
journal article
Language
en
Open access
Locations
  • Metabolites (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Brazilian agencies National Council for Scientific and Technological Development (CNPq) (306729/2019-9, PROEX TERMO AUXPE 0521/2019)
  • Coordination for the Improvement of Higher Education Personnel (CAPES) (306729/2019-9, PROEX TERMO AUXPE 0521/2019)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Centella asiatica, asiatic acid, wound healing, skin wounds, traditional medicine, tissue regeneration, fibroblast proliferation, collagen synthesis, cell migration, phytochemicals, antimicrobial activity, chronic wounds

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