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Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential
Open accessAbstract
An intense effort has been focused on new therapeutic approaches and the development of technologies for more efficient and rapid wound healing. The research for plants used for long time in traditional medicine in the treatment of wound has become a promising strategy to obtain drugs therapeutically useful in the acute and chronic wound management. In this context, Centella asiatica (Apiaceae) has been used to treat a variety of skin diseases, such as leprosy, lupus, varicose ulcers, eczema and psoriasis, in Asiatic traditional medicine for thousands of years. Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration and wound repair process by promoting fibroblast proliferation and collagen synthesis. Preliminary findings have shown that the asiatic acid is one of the main active constituents of C. asiatica, directly associated with its healing activity. Thus, this study discusses aspects of the effects of Centella asiatica and its active component, asiatic acid, in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects that contribute to its therapeutic potential.
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“Preclinical studies have demonstrated that these compounds exhibit potent antioxidant and anti-inflammatory activities, promote fibroblast proliferation, enhance collagen synthesis, and protect extracellular matrix integrity [16,17,19,22,23,24].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [17]
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“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
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“Centella asiatica (L.) Urb. is a medicinal plant traditionally used in Asian and Ayurvedic medicine for wound healing and various skin disorders [16,17,18].”
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“The pharmacological activity of C. asiatica is attributed primarily to its secondary metabolites.”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
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In the citing paper
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
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In the citing paper
“These constituents exert complementary actions relevant to skin biology, including stimulation of collagen synthesis and dermal matrix remodeling, modulation of pro-inflammatory signaling, and attenuation of oxidative and glycation stress that collectively underpin benefits in tissue repair and skin-barrier maintenance (Park 2021a; Diniz et al. 2023; Rashid et al. 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Diniz et al. 2023
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Liu, Y.-Q., Zhang, D., Deng, J., Liu, Y., Li, W., & Nie, X. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1419146 · Cited by 14
Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice
Kukula, O., Kırmızıkan, S., Tiryaki, E. S., Çiçekli, M. N., & Günaydın, C. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2048849 · Cited by 14
Chemical composition and biological activity of Centella asiatica essential oil from Nepal
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Antimicrobial and Antioxidant Activities in the Root, Stem and Leaf Extracts of Centella asiatica
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Development of a Novel Herbal Formulation To Inhibit Biofilm Formation in Toxigenic Vibrio cholerae
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Effects of Centella asiatica (L.) Urban extract in TNF-α levels
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Flagged first, then by citations
1 of the 110 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Palani, N., Vijayakumar, P., Monisha, P., Ayyadurai, S., & Rajadesingu, S. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02491-8 · Cited by 125
Witkowska, K., Paczkowska-Walendowska, M., Garbiec, E., & Cielecka-Piontek, J. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16101252 · Cited by 78
Herbal bioactive-loaded biopolymeric formulations for wound healing applications
Jangra, N., Singla, A., Puri, V., Dheer, D., Chopra, H., Malik, T., & Sharma, A. (2025) · RSC Advances · doi:10.1039/d4ra08604j · Cited by 74
Zhang, W., Zhao, S., Guan, Q., Li, P., & Fan, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c14690 · Cited by 45
Novel Functional Dressing Materials for Intraoral Wound Care
Ding, Y., Zhu, Z., Zhang, X., & Wang, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400912 · Cited by 41
Metadata
- Authors
- Diniz, L. R. L., Calado, L. L., Duarte, A. B. S., & de Sousa, D. P.
- Affiliations
- Instituto Nacional do Semiárido (BR)
- Universidade Federal da Paraíba (BR)
- Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-970, Paraíba, Brazil
- Venue
- Metabolites
- Publisher
- MDPI AG
- Published
- 2023-02-14
- Volume
- 13
- Issue
- 2
- Pages
- 276
- ISSN
- 2218-1989 (ISSN-L)
- PMC
- PMC9966672
- OpenAlex
- W4320919855
- Cited by
- 160
- References
- 110
- Citations by year
- 2026: 38 · 2025: 59 · 2024: 50 · 2023: 12
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Metabolites (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Brazilian agencies National Council for Scientific and Technological Development (CNPq) (306729/2019-9, PROEX TERMO AUXPE 0521/2019)
- Coordination for the Improvement of Higher Education Personnel (CAPES) (306729/2019-9, PROEX TERMO AUXPE 0521/2019)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Centella asiatica, asiatic acid, wound healing, skin wounds, traditional medicine, tissue regeneration, fibroblast proliferation, collagen synthesis, cell migration, phytochemicals, antimicrobial activity, chronic wounds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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