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The Gut Microbiome, Aging, and Longevity: A Systematic Review
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Aging is determined by complex interactions among genetic and environmental factors. Increasing evidence suggests that the gut microbiome lies at the core of many age-associated changes, including immune system dysregulation and susceptibility to diseases. The gut microbiota undergoes extensive changes across the lifespan, and age-related processes may influence the gut microbiota and its related metabolic alterations. The aim of this systematic review was to summarize the current literature on aging-associated alterations in diversity, composition, and functional features of the gut microbiota. We identified 27 empirical human studies of normal and successful aging suitable for inclusion. Alpha diversity of microbial taxa, functional pathways, and metabolites was higher in older adults, particularly among the oldest-old adults, compared to younger individuals. Beta diversity distances significantly differed across various developmental stages and were different even between oldest-old and younger-old adults. Differences in taxonomic composition and functional potential varied across studies, but Akkermansia was most consistently reported to be relatively more abundant with aging, whereas Faecalibacterium, Bacteroidaceae, and Lachnospiraceae were relatively reduced. Older adults have reduced pathways related to carbohydrate metabolism and amino acid synthesis; however, oldest-old adults exhibited functional differences that distinguished their microbiota from that of young-old adults, such as greater potential for short-chain fatty acid production and increased butyrate derivatives. Although a definitive interpretation is limited by the cross-sectional design of published reports, we integrated findings of microbial composition and downstream functional pathways and metabolites, offering possible explanations regarding age-related processes.
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![Figure 2 Microbial taxa reported to be differentially abundant in long-living individuals across reviewed studies. Area represents proportion of studies reporting each taxon. Color indicates the direction and net strength of observed findings. Data in this figure are based on nine studies [19,20,21,22,23,24,25,26,34].](/paper-figures/3196547cf8d249b5a06aadaaf7f49a56/the-gut-microbiome-aging-and-longevity-a-systematic-review-figure-2.jpg)
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“Studies in the past decade have demonstrated that gut microbiome composition changes with age, that exceptionally long-lived individuals have a different microbiome composition from average older adults131–133, and that certain microorganisms131,134,135 and the metabolites they produce132,134,136 are beneficial to human health.”
From Measuring biological age using omics data (2022) · cites this paper as [131]
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Self-citationLinking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Self-citationInflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Self-citationInflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Self-citationFormation of propionate and butyrate by the human colonic microbiota
Louis, P., & Flint, H. J. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13589 · Cited by 3,028
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988
Self-citationThe Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755
Adherence to Mediterranean diet and health status: meta-analysis
Sofi, F., Cesari, F., Abbate, R., Gensini, G. F., & Casini, A. (2008) · BMJ · doi:10.1136/bmj.a1344 · Cited by 1,717
Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.-Z., Abe, F., & Osawa, R. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0708-5 · Cited by 1,521
Proteobacteria: A Common Factor in Human Diseases
Rizzatti, G., Lopetuso, L. R., Gibiino, G., Binda, C., & Gasbarrini, A. (2017) · BioMed Research International · doi:10.1155/2017/9351507 · Cited by 1,308
Depp, C. A., & Jeste, D. V. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000192501.03069.bc · Cited by 1,292
Self-citationStability criteria for complex ecosystems
Allesina, S., & Tang, S. (2012) · Nature · doi:10.1038/nature10832 · Cited by 1,232
Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.028 · Cited by 1,174
Gut Microbiota and Extreme Longevity
Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025
Meta‐analyses of human gut microbes associated with obesity and IBD
Walters, W. A., Xu, Z., & Knight, R. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.09.039 · Cited by 836
Self-citationThe human gut bacteria Christensenellaceae are widespread, heritable, and associated with health
Waters, J. L., & Ley, R. E. (2019) · BMC Biology · doi:10.1186/s12915-019-0699-4 · Cited by 818
The microbiome in infectious disease and inflammation
Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
Yoshii, K., Hosomi, K., Sawane, K., & Kunisawa, J. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00048 · Cited by 607
Meslier, V., Laiola, M., Roager, H. M., De Filippis, F., Roume, H., Quinquis, B., Giacco, R., Mennella, I., Ferracane, R., Pons, N., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320438 · Cited by 583
Garcia-Mantrana, I., Selma-Royo, M., Alcantara, C., & Collado, M. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00890 · Cited by 574
An overview of the last advances in probiotic and prebiotic field
Saad, N., Delattre, C., Urdaci, M. C., Schmitter, J., & Bressollier, P. (2012) · LWT · doi:10.1016/j.lwt.2012.05.014 · Cited by 540
Gill, P. A., van Zelm, M. C., Muir, J. G., & Gibson, P. R. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14689 · Cited by 520
Why women live longer than men: Sex differences in longevity
Austad, S. N. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80198-1 · Cited by 512
Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila
Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 506
Composition and temporal stability of the gut microbiota in older persons
Jeffery, I. B., Lynch, D. B., & O’Toole, P. W. (2016) · The ISME Journal · doi:10.1038/ismej.2015.88 · Cited by 421
Xu, Y., Wang, N., Tan, H.-Y., Li, S., Zhang, C., & Feng, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00219 · Cited by 420
Ageing of the human metaorganism: the microbial counterpart
Biagi, E., Candela, M., Fairweather‐Tait, S. J., Franceschi, C., & Brigidi, P. (2011) · AGE · doi:10.1007/s11357-011-9217-5 · Cited by 375
Gut microbiota signatures of longevity
Kong, F., Hua, Y., Zeng, B., Ning, R., Li, Y., & Zhao, J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.015 · Cited by 371
Gorelick, P. B. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05726.x · Cited by 361
Functional metagenomic profiling of intestinal microbiome in extreme ageing
Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P. W., & Brigidi, P. (2013) · Aging · doi:10.18632/aging.100623 · Cited by 359
The effect of heritability and host genetics on the gut microbiota and metabolic syndrome
Lim, M. Y., You, H. J., Yoon, H. S., Kwon, B., Lee, J. Y., Lee, S., Song, Y., Lee, K., Sung, J., & Ko, G. (2016) · Gut · doi:10.1136/gutjnl-2015-311326 · Cited by 349
van den Munckhof, I., Kurilshikov, A., ter Horst, R., Riksen, N. P., Joosten, L. A. B., Zhernakova, A., Fu, J., Keating, S. T., Netea, M. G., Graaf, J. D., et al. (2018) · Obesity Reviews · doi:10.1111/obr.12750 · Cited by 281
The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
Zapata, H. J., & Quagliarello, V. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13310 · Cited by 279
A high menaquinone intake reduces the incidence of coronary heart disease
Herber-Gast, G.-C. M., de Roos, N. M., Sluijs, I., Bots, M. L., Beulens, J. W. J., Geleijnse, J. M., Witteman, J. C. M., Grobbee, D. E., Peeters, P. H. M., & van der Schouw, Y. T. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.10.004 · Cited by 279
Genome-Wide Association Studies of the Human Gut Microbiota
Davenport, E., Cusanovich, D. A., Michelini, K., Barreiro, L. B., Ober, C., & Gilad, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140301 · Cited by 264
Gut microbiota changes in the extreme decades of human life: a focus on centenarians
Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250
Variation in human intestinal microbiota with age
Hopkins, M. J., Sharp, R., & Macfarlane, G. T. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80157-8 · Cited by 249
The gut microbiota of Colombians differs from that of Americans, Europeans and Asians
Escobar, J. S., Klotz, B., Valdés-Duque, B. E., & Agudelo, G. M. (2014) · BMC Microbiology · doi:10.1186/s12866-014-0311-6 · Cited by 232
Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
Lio, D., Scola, L., Crivello, A., Colonna‐Romano, G., Candore, G., Bonafè, M., Cavallone, L., Franceschi, C., & Caruso, C. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363827 · Cited by 227
Genotype Is a Stronger Determinant than Sex of the Mouse Gut Microbiota
Kovacs, A., Ben-Jacob, N., Tayem, H., Halperin, E., Iraqi, F. A., & Gophna, U. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9787-2 · Cited by 226
Host genetic and environmental effects on mouse intestinal microbiota
Campbell, J. H., Foster, C. M., Vishnivetskaya, T. A., Campbell, A. G., Yang, Z. K., Wymore, A. M., Palumbo, A. V., Chesler, E. J., & Podar, M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.54 · Cited by 220
Gut microbiota, cognitive frailty and dementia in older individuals: A systematic review
Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215
Bana, B., & Cabreiro, F. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043650 · Cited by 212
Metagenomics and Personalized Medicine
Virgin, H. W., & Todd, J. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.009 · Cited by 205
Wu, L. H., Zeng, T., Zinellu, A., Rubino, S., Kelvin, D. J., & Carru, C. (2019) · mSystems · doi:10.1128/msystems.00325-19 · Cited by 201
Diet-microbiota interactions and their implications for healthy living
Jeffery, I., & O'Toole, P. (2013) · Nutrients · doi:10.3390/nu5010234 · Cited by 199
Age-Related Changes in the Composition of Gut Bifidobacterium Species
Kato, K., Odamaki, T., Mitsuyama, E., Sugahara, H., Xiao, J.-Z., & Osawa, R. (2017) · Current Microbiology · doi:10.1007/s00284-017-1272-4 · Cited by 180
Baggio, G., Donazzan, S., Monti, D., Mari, D., Martini, S., Gabelli, C., Vestra, M. D., Previato, L., Guido, M., Pigozzo, S., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.6.433 · Cited by 178
Anderson, J. R., Carroll, I. M., Azcárate-Peril, M. A., Rochette, A. D., Heinberg, L. J., Peat, C. M., Steffen, K. J., Manderino, L. M., Mitchell, J. E., & Gunstad, J. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.07.018 · Cited by 175
Sartor, R. B. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.036 · Cited by 164
Bischoff, S. C. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000242 · Cited by 164
Sakamoto, M., Takagaki, A., Matsumoto, K., Kato, Y., Gotō, K., & Benno, Y. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.007674-0 · Cited by 163
Gastro-Intestinal and Oral Microbiome Signatures Associated with Healthy Aging
Singh, H., Torralba, M. G., Moncera, K. J., DiLello, L., Petrini, J., Nelson, K. E., & Pieper, R. (2019) · GeroScience · doi:10.1007/s11357-019-00098-8 · Cited by 158
Kim, B. S., Choi, C. W., Shin, H., Jin, S., Bae, J.-S., Han, M., Seo, E. Y., Chun, J., & Chung, J. H. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1811.11023 · Cited by 157
Valentini, L., Pinto, A., Bourdel‐Marchasson, I., Ostan, R., Brigidi, P., Turroni, S., Hrelia, S., Hrelia, P., Bereswill, S., Fischer, A., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.09.023 · Cited by 145
Altitudinal variation of the gut microbiota in wild house mice
Suzuki, T. A., Martins, F. M., & Nachman, M. W. (2018) · Molecular Ecology · doi:10.1111/mec.14905 · Cited by 136
Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan
Odamaki, T., Bottacini, F., Kato, K., Mitsuyama, E., Yoshida, K., Horigome, A., Xiao, J., & van Sinderen, D. (2018) · Scientific Reports · doi:10.1038/s41598-017-18391-x · Cited by 135
Steves, C. J., Bird, S., Williams, F. M. K., & Spector, T. D. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2765 · Cited by 125
Manderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125
Host genetic determinants of the gut microbiota of wild mice
Suzuki, T. A., Phifer‐Rixey, M., Mack, K. L., Sheehan, M. J., Lin, D., Bi, K., & Nachman, M. W. (2019) · Molecular Ecology · doi:10.1111/mec.15139 · Cited by 115
Correlations of Host Genetics and Gut Microbiome Composition
Dąbrowska, K., & Witkiewicz, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01357 · Cited by 113
Hippe, B., Zwielehner, J., Liszt, K. I., Laßl, C., Unger, F. M., & Haslberger, A. G. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02197.x · Cited by 103
Tuikhar, N., Keisam, S., Labala, R. K., Imrat, Ramakrishnan, P., Arunkumar, M. C., Ahmed, G., Biagi, E., & Jeyaram, K. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.02.001 · Cited by 103 · cited 13×
“Publication Country(Rural/Urban) Sample Size (Age Range) Gender (%Female) Sequencing/Genetic Analysis Diversity Patterns Taxonomic Composition Functional Potential and Metabolites Tuikhar et al., 2019 [24] India (R) LL: 30 (97–110) ADT internal: 30 (28–47)ADT external: 30 (22–50) LL: 50.0 ADT internal: 60.0ADT externa…”
BackgroundResultInfluentialZhang, X., Zhang, N., Kan, J., Sun, R., Tang, S., Wang, Z., Chen, M., Liu, J., & Jin, C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.03.111 · Cited by 96
Cultivable and Pyrosequenced Fecal Microflora in Centenarians and Young Subjects
Drago, L., Toscano, M., Rodighiero, V., De Vecchi, E., & Mogna, G. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182693982 · Cited by 92
Functional microbiome deficits associated with ageing: Chronological age threshold
Ruiz‐Ruiz, S., Sánchez-Carrillo, S., Ciordia, S., Mena, M. C., Méndez–García, C., Rojo, D., Bargiela, R., Zubeldia‐Varela, E., Martínez‐Martínez, M., Barbas, C., et al. (2019) · Aging Cell · doi:10.1111/acel.13063 · Cited by 89
Gut Microbiota in Patients with Different Metabolic Statuses: Moscow Study
Kashtanova, D. A., Ткачева, О. Н., Dudinskaya, Е. N., Strazhesko, I. D., Kotovskaya, Y. V., Popenko, A., Tyakht, A., & Alexeev, D. G. (2018) · Microorganisms · doi:10.3390/microorganisms6040098 · Cited by 88
An investigation into physical frailty as a link between the gut microbiome and cognitive health
Verdi, S., Jackson, M. A., Beaumont, M., Bowyer, R. C. E., Bell, J. T., Spector, T. D., & Steves, C. J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00398 · Cited by 82
Gut microbiota and physical frailty through the mediation of sarcopenia
Casati, M., Ferri, E., Azzolino, D., Cesari, M., & Arosio, B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110639 · Cited by 78
Gangemi, S. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00061-5 · Cited by 73
Björklund, M., Ouwehand, A. C., Forssten, S. D., Nikkilä, J., Tiihonen, K., Rautonen, N., & Lahtinen, S. J. (2012) · AGE · doi:10.1007/s11357-011-9294-5 · Cited by 67
Spaiser, S. J., Culpepper, T., Nieves, C., Ukhanova, M., Mai, V., Percival, S. S., Christman, M. C., & Langkamp-Henken, B. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2014.983249 · Cited by 66
An, R., Wilms, E., Smolinska, A., Hermes, G. D. A., Masclee, A., de Vos, P., Schols, H. A., van Schooten, F., Smidt, H., Jonkers, D. M. A. E., et al. (2019) · Nutrients · doi:10.3390/nu11092193 · Cited by 66
Yu, X., Wu, X., Qiu, L., Wang, D., Gan, M., Chen, X., Wei, H., & Xu, F. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6888-3 · Cited by 56
New insights into the impact of Lactobacillus population on host-bacteria metabolic interplay
Roy, C. I. L., Štšepetova, J., Sepp, E., Songisepp, E., Claus, S. P., & Mikelsaar, M. (2015) · Oncotarget · doi:10.18632/oncotarget.5906 · Cited by 39
Alterations of Gut Microbiome in Rheumatoid Arthritis
Wu, X., Liu, J., Xiao, L., Lü, A., & Zhang, G. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2017.02.484 · Cited by 27
Plant-Based Diets for Healthy Aging
Kahleová, H., Levin, S., & Barnard, N. D. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1790442 · Cited by 19
Pan, Y., Wang, F., Sun, D., & Li, Q. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-6131-7 · Cited by 16
The Microbiome in Neurodegenerative Disease
Brown, E. G., Tanner, C. M., & Goldman, S. M. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0240-6 · Cited by 10
Gut microbiome diversity in Kazakhstani women of different age groups
Kushugulova, A. R., Kozhakhmetov, S., Baiskhanova, D. M., Tynybayeva, I. K., Shapekova, N. L., Kakimova, A. B., Садуахасова, С. А., Shakhabayeva, G. S., Khassenbekova, Z., Nurgozhin, T. S., et al. (2014) · Biotechnology Theory and practice · doi:10.11134/btp.4.2014.1 · Cited by 6
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Sorted by citations
Measuring biological age using omics data
Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570
Chronic inflammation and the hallmarks of aging
Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471
The aging gut microbiome and its impact on host immunity
Bosco, N., & Noti, M. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00126-8 · Cited by 435
Short-chain fatty acids as modulators of redox signaling in health and disease
González‐Bosch, C., Boorman, E., Zunszain, P. A., & Mann, G. E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102165 · Cited by 298
Gut bacterial profiles in Parkinson's disease: A systematic review
Li, Z., Liang, H., Lu, L., Lu, L., Zheng, C., Fan, Y., Wu, B., Zou, T., Luo, X., Xinchun, Z., et al. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13990 · Cited by 224
Metadata
- Authors
- Badal, V. D., Vaccariello, E. D., Murray, E. R., Yu, K. E., Knight, R., Jeste, D. V., & Nguyen, T. T.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Nguyen, Tanya T.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-12-07
- Volume
- 12
- Issue
- 12
- Pages
- 3759
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7762384
- OpenAlex
- W3110715890
- Cited by
- 551
- References
- 91
- Citations by year
- 2026: 108 · 2025: 122 · 2024: 122 · 2023: 96 · 2022: 73 · 2021: 29
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (K23 MH118435-01A1, 5T32 MH019934-24)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, aging, longevity, oldest old, microbial diversity, Akkermansia, Faecalibacterium, Bacteroidaceae, Lachnospiraceae, short-chain fatty acids, butyrate, carbohydrate metabolism, amino acid synthesis, immune dysregulation
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Aged, 80 and over, Aging, Amino Acids, Cross-Sectional Studies, Feces, Female, Humans, Longevity, Male, Middle Aged, Protein Biosynthesis, Signal Transduction, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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