Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol
Open accessAbstract
Ageing changes gut microbiota composition and alters immune system function. Probiotics, prebiotics and synbiotics may improve the health status of elderly individuals by modifying the intestinal environment and the microbiota composition, and by stimulating the immune system. In this work, we studied the effects of synbiotic supplementation on the gut microbiota of healthy elderly volunteers. Fifty-one elders were randomly assigned to consume either a synbiotic dietary supplement or a placebo in addition to their usual diet for a 2-week period. The synbiotic product consisted of the probiotic Lactobacillus acidophilus NCFM and the prebiotic lactitol and was ingested twice a day, with a total daily dose of 10 g lactitol and 2 × 10(10) cells of probiotic bacteria. Before, during and after the intervention period fecal quantities of six phylogenetic bacterial groups were determined using quantitative PCR, and relative changes in total microbiota composition were assessed by percent guanine-plus-cytosine profiling. The microbiota profiles showed certain relative changes within the microbial community, and indicated an increase of bifidobacteria levels during synbiotic supplementation. Quantification by PCR confirmed the in changes in the microbiota composition; for example increases in total levels of endogenous bifidobacteria and lactobacilli were recorded. Throughout the 6-week study period there was a decrease unrelated to intervention in the Blautia coccoides-Eubacterium rectale bacterial group levels and Clostridium cluster XIVab levels, but this decrease appeared to be halted during the synbiotic intervention. In conclusion, putatively beneficial changes in microbiota were observed in the elderly subjects supplemented with the synbiotic product.
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The combination of a prebiotic and probiotics has a potentially synergistic effect on intestinal transit.
“The combination of a prebiotic and probiotics would have a potentially synergic effect on the intestinal transit, as has been shown [20].”
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Microbiota: Current Research and Emerging Trends
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- Authors
- Björklund, M., Ouwehand, A. C., Forssten, S. D., Nikkilä, J., Tiihonen, K., Rautonen, N., & Lahtinen, S. J.
- Affiliations
- Pharmatest (Finland) (FI)
- Corresponding author
- Lahtinen, Sampo J.
- Venue
- AGE
- Published
- 2011-08-19
- Volume
- 34
- Issue
- 4
- Pages
- 987-999
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC3682059
- OpenAlex
- W2136172019
- Cited by
- 67
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 7
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- gut microbiota, older adults, synbiotics, Lactobacillus acidophilus NCFM, lactitol, Bifidobacterium, probiotics, prebiotics, aging, immune function, fecal microbiota composition
- MeSH terms
- Aged, Aged, 80 and over, Aging, Analysis of Variance, Anti-Inflammatory Agents, Non-Steroidal, Female, Humans, Lactobacillus acidophilus, Male, Prospective Studies, Reference Values, Sugar Alcohols, Colony Count, Microbial, Linear Models, Treatment Outcome, Probiotics, Gastrointestinal Tract, Metagenome, Prebiotics
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