Composition and temporal stability of the gut microbiota in older persons
Open accessAbstract
The composition and function of the human gut microbiota has been linked to health and disease. We previously identified correlations between habitual diet, microbiota composition gradients and health gradients in an unstratified cohort of 178 elderly subjects. To refine our understanding of diet–microbiota associations and differential taxon abundance, we adapted an iterative bi-clustering algorithm (iterative binary bclustering of gene sets (iBBiG)) and applied it to microbiota composition data from 732 faecal samples from 371 ELDERMET cohort subjects, including longitudinal samples. We thus identified distinctive microbiota configurations associated with ageing in both community and long-stay residential care elderly subjects. Mixed-taxa populations were identified that had clinically distinct associations. Microbiota temporal instability was observed in both community-dwelling and long-term care subjects, particularly in those with low initial microbiota diversity. However, the stability of the microbiota of subjects had little impact on the directional change of the microbiota as observed for long-stay subjects who display a gradual shift away from their initial microbiota. This was not observed in community-dwelling subjects. This directional change was associated with duration in long-stay. Changes in these bacterial populations represent the loss of the health-associated and youth-associated microbiota components and gain of an elderly associated microbiota. Interestingly, community-associated microbiota configurations were impacted more by the use of antibiotics than the microbiota of individuals in long-term care, as the community-associated microbiota showed more loss but also more recovery following antibiotic treatment. This improved definition of gut microbiota composition patterns in the elderly will better inform the design of dietary or antibiotic interventions targeting the gut microbiota.
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Advanced age is associated with variations in gut microbiota composition characterized by a loss of diversity of specific taxa.
“Others have found advanced age to be associated with variations in the gut microbiota composition characterized by a loss of diversity of specific taxa46.”
From Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation (2021) · cites this paper as [46]
Data indicate a narrowing of diversity and distinctive microbiota configurations associated with ageing in long-stay care individuals compared with community dwellers.
“Data indicate a narrowing of diversity and distinctive microbiota configurations associated with ageing in long-stay care individuals compared with that of community dwellers (Claesson et al., 2012;Jeffery et al., 2016).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Jeffery et al., 2016
There is greater inter-individual variation in older adults than younger adults (<65 years old) in GM stability.
“Stability begins to decline as we age, and studies suggest that there is greater inter-individual variation in older adults than younger adults (<65 years old) (91, 92)”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [91]
Investigations of age-related changes in gut microbiota describe a bacterial community that is both less diverse and lacking in microorganisms responsible for the production of butyrate, and more abundant in pathogens belonging to the Proteobacteria phylum (e.g., Enterobacteriaceae).
“investigations of age-related changes in gut microbiota describe a bacterial community that is both less diverse and lacking in microorganisms responsible for the production of butyrate (indicative of gastrointestinal health) [15, 84, 98, 99], and more abundant in pathogens belonging to the Proteobacteria phylum (e.g., Enterobacteriaceae) [15, 68, 83].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [99]
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Microbiota y diabetes mellitus tipo 2
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Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases
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Antibiotic-induced collateral damage to the microbiota and associated infections
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Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
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Genomics and metagenomics of trimethylamine-utilizing Archaea in the human gut microbiome
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Toward an improved definition of a healthy microbiome for healthy aging
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Self-citationSynthetic microbial communities (SynComs) of the human gut: design, assembly, and applications
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Age-related changes in intestinal immunity and the microbiome
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New insights into therapeutic strategies for gut microbiota modulation in inflammatory diseases
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Gut microbiota and old age: Modulating factors and interventions for healthy longevity
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Microbiome-health interactions in older people
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Gut microbiota and type 2 diabetes mellitus
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Caenorhabditis elegans: a model to understand host–microbe interactions
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Metagenomic Approaches to Assess Bacteriophages in Various Environmental Niches
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Rethinking Diet to Aid Human–Microbe Symbiosis
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Role of gut microbiota in aging-related health decline: insights from invertebrate models
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Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy
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Self-citationImpact of Melatonin on Skeletal Muscle and Exercise
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The gut microbiota–brain axis in neurological disorders
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The gut microbiota as a key regulator of visceral pain
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Microbiota and Diabetes Mellitus: Role of Lipid Mediators
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The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging
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Evolving trends in next-generation probiotics: a 5W1H perspective
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Microbiota-gut-brain axis and toll-like receptors in Alzheimer’s disease
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Gut microbiota development across the lifespan: Disease links and health‐promoting interventions
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Interventions on Gut Microbiota for Healthy Aging
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The Influence of Nutrition on Intestinal Permeability and the Microbiome in Health and Disease
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Self-citationInfluence of the Mediterranean Diet on Healthy Aging
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The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
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How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives
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Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD
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Composition and richness of the serum microbiome differ by age and link to systemic inflammation
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Gut Microbiota Associations with Metabolic Health and Obesity Status in Older Adults
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- Authors
- Jeffery, I. B., Lynch, D. B., & O’Toole, P. W.
- Affiliations
- University College Cork (IE)
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-06-19
- Volume
- 10
- Issue
- 1
- Pages
- 170-182
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- PMC
- PMC4681863
- OpenAlex
- W1549775244
- Cited by
- 421
- References
- 37
- Citations by year
- 2026: 30 · 2025: 40 · 2024: 49 · 2023: 29 · 2022: 45 · 2021: 66 · 2020: 43 · 2019: 35 · 2018: 26 · 2017: 34 · 2016: 21 · 2015: 3
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The ISME Journal (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-sa)
- Funders
- General Mills
- Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273., 13/SIRG/2128)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- gut microbiota, aging, older adults, temporal stability, microbiota composition, long-term care, community-dwelling older adults, antibiotic use, microbiome diversity, change of direction
- MeSH terms
- Gastrointestinal Microbiome, Aged, Aged, 80 and over, Aging, Bacteria, Diet, Feces, Female, Humans, Male, Phylogeny, Residential Facilities, Gastrointestinal Tract
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