Diet-microbiota interactions and their implications for healthy living
Open accessAbstract
It is well established that diet influences the health of an individual and that a diet rich in plant-based foods has many advantages in relation to the health and well-being of an individual. What has been unclear until recently is the large contribution of the gut microbiota to this effect. As well as providing basic nutritional requirements, the long-term diet of an animal modifies its gut microbiota. In adults, diets that have a high proportion of fruit and vegetables and a low consumption of meat are associated with a highly diverse microbiota and are defined by a greater abundance of Prevotella compared to Bacteroides, while the reverse is associated with a diet that contains a low proportion of plant-based foods. Furthermore, it is becoming increasingly clear that the effect of the microbial ecology of the gut goes beyond the local gut immune system and is implicated in immune-related disorders, such as IBS, diabetes and inflamm-ageing. In this review, we investigate the evidence that a balanced diet leads to a balanced, diverse microbiota with significant consequences for healthy ageing by focusing on conditions of interest.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Habitual diet is a major determinant of gut microbiota composition and of the microbial metabolites that can affect the host.
“Habitual diet plays a major role in shaping the composition of the gut microbiota, and also determines the repertoire of microbial metabolites that can influence the host.”
From High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome (2016) · cites this paper as [1]
A normal microbiome increases nutrient bioavailability; germ-free mice should be fed a diet of higher nutrient quantity and diversity than conventional mice to maintain their health.
“A normal microbiome increases nutrient bioavailability. In order to maintain their health, GF mice should be fed a diet of higher nutrient quantity and diversity than conventional mice.156”
From The Gut Microbiome and the Brain (2014) · cites this paper as [156]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Self-citationTopping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091 · see citing works
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
Microbial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331 · see citing works
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · cited 1× · see citing works
“In fact, if colonocytes are deprived of butyrate, they undergo autophagy [36].”
BackgroundThe Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
the GIANT Consortium (2009) · Nature Genetics · doi:10.1038/ng.287 · Cited by 1,720 · see citing works
Bacteria as vitamin suppliers to their host: A gut microbiota perspective
LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.08.005 · Cited by 1,613 · cited 1× · see citing works
“A number of other B-group vitamins that are synthesised by members of the microbiota and that may be produced in the gut include riboflavin, vitamin B12, niacin and pyridoxine [58].”
BackgroundMicrobial co-occurrence relationships in the human microbiome
Faust, K., Sathirapongsasuti, J. F., Izard, J., Segata, N., Gevers, D., Raes, J., & Huttenhower, C. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002606 · Cited by 1,527 · see citing works
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works
Immune adaptations that maintain homeostasis with the intestinal microbiota
Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,455 · see citing works
Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375 · see citing works
Common variants near MC4R are associated with fat mass, weight and risk of obesity
The Prostate, L., Loos, R. J. F., KORA, Study, N. H., Initiative, D. G., Study, T. S., The Wellcome Trust Case Control Consortium, FUSION, Lindgren, C. M., Li, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.140 · Cited by 1,325 · see citing works
Jumpertz, R., Le, D. S., Turnbaugh, P. J., Trinidad, C., Bogardus, C., Gordon, J. I., & Krakoff, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010132 · Cited by 1,232 · see citing works
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works
Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation
Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036 · see citing works
Zhang, C., Zhang, M., Wang, S., Han, R., Cao, Y., Hua, W., Mao, Y., Zhang, X., Pang, X., Wei, C., et al. (2010) · The ISME Journal · doi:10.1038/ismej.2009.112 · Cited by 1,024 · see citing works
Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M. C., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1027-1033.2006 · Cited by 1,006 · see citing works
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949 · see citing works
Duchmann, R., Kaiser, I., Hermann, E., Mayet, W.-J., Ewe, K., & BÜSCHENFELDE, K.-H. M. Z. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03836.x · Cited by 938 · see citing works
Towards the human intestinal microbiota phylogenetic core
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works
Gut microbiome, obesity, and metabolic dysfunction
Tilg, H., & Kaser, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58109 · Cited by 860 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Self-citationThe role of pH in determining the species composition of the human colonic microbiota
Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786 · see citing works
Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works
Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome
Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780 · see citing works
Understanding the effects of diet on bacterial metabolism in the large intestine
Louis, P., Scott, K. P., Duncan, S. H., & Flint, H. J. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03322.x · Cited by 775 · see citing works
Effects of short chain fatty acids on gut morphology and function
Scheppach, W. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s35 · Cited by 756 · see citing works
Biesiekierski, J. R., Newnham, E., Irving, P. M., Barrett, J. S., Haines, M. L., Doecke, J. D., Shepherd, S., Muir, J. G., & Gibson, P. R. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.487 · Cited by 712 · see citing works
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children
Cecil, J. E., Tavendale, R., Watt, P., Hetherington, M. M., & Palmer, C. N. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0803839 · Cited by 690 · see citing works
A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism
Samuel, B. S., & Gordon, J. I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602187103 · Cited by 674 · see citing works
Evidence‐based dietary management of functional gastrointestinal symptoms: The FODMAP approach
Gibson, P. R., & Shepherd, S. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.06149.x · Cited by 657 · see citing works
Meyre, D., Delplanque, J., Chèvre, J.-C., Lecœur, C., Lobbens, S., Gallina, S., Durand, E., Vatin, V., Degraeve, F., Cavalcanti-Proença, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.301 · Cited by 648 · see citing works
Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01281.x · Cited by 636 · see citing works
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Sérino, M., Luche, É., Grès, S., Baylac, A., Bergé, M., Cénac, C., Waget, A., Klopp, P., Iacovoni, J. S., Klopp, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301012 · Cited by 617 · see citing works
Scholz-Ahrens, K. E., Ade, P., Marten, B., Weber, P., Timm, W., Asil, Y., Glüer, C.-C., & Schrezenmeir, J. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.3.838s · Cited by 591 · see citing works
Luli, G. W., & Strohl, W. R. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.4.1004-1011.1990 · Cited by 590 · see citing works
Intestinal flora and endogenous vitamin synthesis
Hill, M. J. (1997) · European Journal of Cancer Prevention · doi:10.1097/00008469-199703001-00009 · Cited by 551 · cited 1× · see citing works
“This can be attributed to microbial production of folate and biotin, as well as a number of vitamins, including other water soluble B vitamins and vitamin K [48].”
BackgroundCommon genetic variation near MC4R is associated with waist circumference and insulin resistance
Chambers, J. C., Elliott, P., Zabaneh, D., Zhang, W., Li, Y., Froguel, P., Balding, D. J., Scott, J., & Kooner, J. S. (2008) · Nature Genetics · doi:10.1038/ng.156 · Cited by 497 · see citing works
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
Shen, L., Black, E. D., Witkowski, E. D., Lencer, W. I., Guerriero, V., Schneeberger, E. E., & Turner, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.02915 · Cited by 467 · see citing works
A vegan or vegetarian diet substantially alters the human colonic faecal microbiota
Zimmer, J., Lange, B., Frick, J.-S., Sauer, H., Zimmermann, K., Schwiertz, A., Rusch, K., Klosterhalfen, S., & Enck, P. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.141 · Cited by 465 · cited 2× · see citing works
“High amounts of SCFAs may decrease the intestinal pH [41] and prevent the growth of potentially pathogenic bacteria, such as E. coli and other members of the Enterobacteriaceae [42].”
BackgroundStaudacher, H. M., Whelan, K., Irving, P. M., & Lomer, M. C. E. (2011) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2011.01162.x · Cited by 436 · see citing works
Barrett, J. S., Gearry, R. B., Muir, J. G., Irving, P. M., ROSE, R., Rosella, O., Haines, M. L., Shepherd, S., & Gibson, P. G. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04237.x · Cited by 403 · see citing works
Gibson, P. R., & Shepherd, S. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02506.x · Cited by 391 · see citing works
Monsbakken, K. W., Vandvik, P. O., & Farup, P. G. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602367 · Cited by 364 · see citing works
Folate Production by Bifidobacteria as a Potential Probiotic Property
Pompei, A., Cordisco, L., Amaretti, A., Zanoni, S., Matteuzzi, D., & Rossi, M. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01763-06 · Cited by 356 · see citing works
A worldwide correlation of lactase persistence phenotype and genotypes
Itan, Y., Jones, B. L., Ingram, C. J. E., Swallow, D. M., & Thomas, M. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-36 · Cited by 352 · see citing works
Human intestinal microbiota and healthy ageing
Tiihonen, K., Ouwehand, A. C., & Rautonen, N. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.004 · Cited by 346 · see citing works
Selective colonization of insoluble substrates by human faecal bacteria
Leitch, E. C. M., Walker, A. W., Duncan, S. H., Holtrop, G., & Flint, H. J. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01186.x · Cited by 297 · see citing works
Effects of short chain fatty acids on a new human colon carcinoma cell line (LIM1215).
Whitehead, R., Young, G. P., & Bhathal, P. S. (1986) · Gut · doi:10.1136/gut.27.12.1457 · Cited by 297 · see citing works
Allergy and the gastrointestinal system
Vighi, G., Marcucci, F., Sensi, L., Di Cara, G., & Frati, F. (2008) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2008.03713.x · Cited by 291 · see citing works
The impact of nutrition on the human microbiome
Flint, H. J. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00499.x · Cited by 287 · see citing works
The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome
Chang, L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.032 · Cited by 268 · see citing works
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Hansson, G. C., & Johansson, M. (2010) · Gut Microbes · doi:10.4161/gmic.1.1.10470 · Cited by 267 · see citing works
Drescher, L. S., Thiele, S., & Mensink, G. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.647 · Cited by 264 · see citing works
Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives
Salonen, A., de Vos, W. M., & Palva, A. (2010) · Microbiology · doi:10.1099/mic.0.043257-0 · Cited by 264 · see citing works
Review article: fructose malabsorption and the bigger picture
GIBSON, P. R., Newnham, E., Barrett, J. S., Shepherd, S., & Muir, J. G. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03186.x · Cited by 256 · see citing works
Sleeth, M., Thompson, E. L., Ford, H. E., Zac‐Varghese, S., & Frost, G. S. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000089 · Cited by 251 · see citing works
Mäkivuokko, H., Tiihonen, K., Tynkkynen, S., Paulin, L. G., & Rautonen, N. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991553 · Cited by 243 · see citing works
Categorization of the gut microbiota: enterotypes or gradients?
Jeffery, I. B., Claesson, M. J., O'Toole, P. W., & Shanahan, F. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2859 · Cited by 238 · see citing works
Self-citationThe inflammatory status of old age can be nurtured from the intestinal environment
Guigoz, Y., Dore, J. M., & Schiffrin, E. J. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f2bfdf · Cited by 224 · see citing works
Increasing butyrate concentration in the distal colon by accelerating intestinal transit
Lewis, S. J., & Heaton, K. W. (1997) · Gut · doi:10.1136/gut.41.2.245 · Cited by 213 · see citing works
Differential Expression of Toll-Like Receptors in Patients With Irritable Bowel Syndrome
Brint, E. K., MacSharry, J., Fanning, A., Shanahan, F., & Quigley, E. M. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.438 · Cited by 205 · see citing works
Immunosenescence and Immunogenetics of Human Longevity
Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D., & Franceschi, C. (2008) · NeuroImmunoModulation · doi:10.1159/000156466 · Cited by 188 · see citing works
Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.082 · Cited by 176 · see citing works
Oufir, L. E., Flourié, B., Varannes, S. B. D., Barry, J. L., Cloarec, D., Bornet, F. R. J., & Galmiche, J. P. (1996) · Gut · doi:10.1136/gut.38.6.870 · Cited by 171 · see citing works
Langhorst, J., Junge, A., Rueffer, A., Wehkamp, J., Foell, D., Michalsen, A., Musial, F., & Dobos, G. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.86 · Cited by 167 · see citing works
Production of Menaquinones by Intestinal Anaerobes
Ramotar, K., Conly, J. M., Chubb, H., & Louie, T. (1984) · The Journal of Infectious Diseases · doi:10.1093/infdis/150.2.213 · Cited by 164 · see citing works
Production of Menaquinones by Lactic Acid Bacteria
Morishita, T., Tamura, N., Makino, T., & Kudo, S. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75424-x · Cited by 157 · see citing works
Short-Chain Fatty Acids Stimulate Ileal Motility in Humans
Kamath, P. S., Phillips, S. F., & Zinsmeister, A. R. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80068-4 · Cited by 153 · see citing works
Strozzi, G. P., & Mogna, L. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31818087d8 · Cited by 146 · see citing works
Treem, W. R., Ahsan, N., Kastoff, G., & Hyams, J. S. (1996) · Journal of Pediatric Gastroenterology &amp Nutrition · doi:10.1097/00005176-199610000-00013 · Cited by 146 · see citing works
Ghosh, S., Dai, C., Brown, K., Rajendiran, E., Makarenko, S., Baker, J., Ma, C., Halder, S., Montero, M., Ionescu, V., et al. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00509.2010 · Cited by 144 · see citing works
El‐Salhy, M. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.843 · Cited by 143 · see citing works
Administration of Folate-Producing Bifidobacteria Enhances Folate Status in Wistar Rats ,
Pompei, A., Cordisco, L., Amaretti, A., Zanoni, S., Raimondi, S., Matteuzzi, D., & Rossi, M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.12.2742 · Cited by 120 · see citing works
Said, H. M., Ortiz, A., McCloud, E., Dyer, D. L., Moyer, M. P., & Rubin, S. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.5.c1365 · Cited by 118 · see citing works
The microbiota link to irritable bowel syndrome
Jeffery, I. B., Quigley, E. M. M., Öhman, L., Simrén, M., & O’Toole, P. W. (2012) · Gut Microbes · doi:10.4161/gmic.21772 · Cited by 111 · see citing works
Self-citationA 14-Day Elemental Diet Is Highly Effective in Normalizing the Lactulose Breath Test
Pimentel, M., Constantino, T., Kong, Y., Bajwa, M., Rezaei, A., & Park, S. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000011605.43979.e1 · Cited by 106 · see citing works
Rumessen, J. J., & Gudmand-Höyer, E. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.357 · Cited by 104 · see citing works
Development of healthy gut microbiota early in life
Isolauri, E. (2012) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2012.02489.x · Cited by 88 · see citing works
Short-Chain Fatty Acids and the Irritable Bowel Syndrome: The Effect of Wheat Bran
Mortensen, P. B., Andersen, J. R., Arffmann, S., & KRAG, E. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528708991878 · Cited by 88 · see citing works
Riboflavin uptake by human-derived colonic epithelial NCM460 cells
Said, H. M., Ortiz, A., Moyer, M. P., & Yanagawa, N. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.2.c270 · Cited by 87 · see citing works
Rana, S., Sharma, S., Kaur, J., Sinha, S. K., & Singh, K. (2012) · Digestion · doi:10.1159/000336174 · Cited by 79 · see citing works
Said, H. M., Ortiz, A., Subramanian, V. S., Neufeld, E. J., Moyer, M. P., & Dudeja, P. K. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g144 · Cited by 79 · see citing works
Carroccio, A., Brusca, I., Mansueto, P., Soresi, M., D'Alcamo, A., Ambrosiano, G., Pepe, I., Iacono, G., Lospalluti, M. L., La Chiusa, S. M., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.07.030 · Cited by 75 · see citing works
A Large Pool of Available Folate Exists in the Large Intestine of Human Infants and Piglets
O’Connor, D. L., Kim, T. H., Yang, J., & Darling, P. B. (2004) · Journal of Nutrition · doi:10.1093/jn/134.6.1389 · Cited by 75 · see citing works
Psychosocial factors and dietary habits associated with vegetable consumption
Satia, J. A., Kristal, A. R., Patterson, R. E., Neuhouser, M. L., & Trudeau, E. (2002) · Nutrition · doi:10.1016/s0899-9007(01)00758-4 · Cited by 73 · see citing works
Bate, J. P., Irving, P. M., Barrett, J. S., & Gibson, P. R. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832b20e8 · Cited by 72 · see citing works
Dietary modification of potential vitamin K supply from enteric bacterial menaquinones in rats
Mathers, J. C., Fernandez, F., Hill, M. J., McCarthy, P. T., Shearer, M. J., & Oxley, A. (1990) · British Journal Of Nutrition · doi:10.1079/bjn19900150 · Cited by 72 · see citing works
Butyrate modulates gene and protein expression in human intestinal endothelial cells
Ogawa, H., Rafiee, P., Fisher, P. J., Johnson, N. A., Otterson, M. F., & Binion, D. G. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.026 · Cited by 70 · see citing works
Dudeja, P. K., Torania, S. A., & Said, H. M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.6.g1408 · Cited by 67 · see citing works
Quigley, E. M. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.009 · Cited by 67 · cited 1× · see citing works
“It is becoming increasingly recognised that low-grade inflammation [67,68] and changes in the gut microbiota are present in a majority of patients, reinforced by observations that probiotic and antibiotic intervention may be effective in reducing the severity of the IBS symptoms [69,70].”
BackgroundMicrobiota and Autoimmune Disease: The Hosted Self
Mathis, D. J., & Benoist, C. O. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.09.007 · Cited by 64 · see citing works
Effects of a Diet Deficient in Tyrosine and Queuine on Germfree Mice
Marks, T. A., & Farkas, W. R. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.5768 · Cited by 62 · see citing works
Guo, H., Jiang, T., Wang, J., Chang, Y., Hai, G., & Zhang, W. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000121 · Cited by 58 · see citing works
Pyridoxine uptake by colonocytes: a specific and regulated carrier-mediated process
Said, Z. M., Subramanian, V. S., Vaziri, N. D., & Said, H. M. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00015.2008 · Cited by 58 · see citing works
Contribution of dialysate acetate to energy metabolism: Metabolic implications
Skutches, C. L., Sigler, M. H., Teehan, B. P., Cooper, J. H., & Reichard, G. (1983) · Kidney International · doi:10.1038/ki.1983.11 · Cited by 37 · see citing works
n-Butyrate absorption in the human colon
Soergel, K. H., Ruppin, H., Bar–Meir, S., Wood, C. M., Schmitt, M. G., Roediger, W. E. W., & Moore, A. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01308130 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Influence of diet on the gut microbiome and implications for human health
Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599 · see citing works
De Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., Serrazanetti, D. I., Di Cagno, R., Ferrocino, I., Lazzi, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309957 · Cited by 1,638 · see citing works
Self-citationExercise and associated dietary extremes impact on gut microbial diversity
Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., Hayes, P., O'Reilly, M., Jeffery, I. B., Wood-Martin, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306541 · Cited by 1,439 · see citing works
Self-citationThe effects of vegetarian and vegan diets on gut microbiota
Tomova, A., Bukovsky, I., Rembert, E., Yonas, W., Alwarith, J., Barnard, N. D., & Kahleova, H. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00047 · Cited by 713 · see citing works
The Gut Microbiome and the Brain
Galland, L. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2014.7000 · Cited by 648 · see citing works
Review article: dietary fibre-microbiota interactions
Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602 · see citing works
Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review
Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0852-y · Cited by 599 · see citing works
The Gut Microbiome, Aging, and Longevity: A Systematic Review
Badal, V. D., Vaccariello, E. D., Murray, E. R., Yu, K. E., Knight, R., Jeste, D. V., & Nguyen, T. T. (2020) · Nutrients · doi:10.3390/nu12123759 · Cited by 551 · see citing works
Brain gut microbiome interactions and functional bowel disorders
Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496 · see citing works
Influence of Mediterranean Diet on Human Gut Microbiota
Merra, G., Noce, A., Marrone, G., Cintoni, M., Tarsitano, M. G., Capacci, A., & De Lorenzo, A. (2020) · Nutrients · doi:10.3390/nu13010007 · Cited by 417 · see citing works
Didari, T. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i10.3072 · Cited by 356 · see citing works
Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases
Paul, B., Barnes, S., Demark-Wahnefried, W., Morrow, C., Salvador, C., Skibola, C., & Tollefsbol, T. O. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0144-7 · Cited by 306 · see citing works
Nutrition and the gut microbiome in the elderly
Salazar, N., Valdés-Varela, L., González, S., Gueimonde, M., & de los Reyes-Gavilán, C. G. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1256525 · Cited by 282 · see citing works
Imperial, I. C. V. J., & Ibana, J. A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01983 · Cited by 284 · see citing works
Effectiveness of probiotics, prebiotics, and prebiotic‐like components in common functional foods
Peng, M., Tabashsum, Z., Anderson, M., Truong, A., Houser, A., Padilla, J., Akmel, A., Bhatti, J., Rahaman, S. O., & Biswas, D. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12565 · Cited by 258 · see citing works
Williams, B. A., Grant, L. J., Gidley, M. J., & Mikkelsen, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102203 · Cited by 255 · see citing works
The Microbiome–Estrogen Connection and Breast Cancer Risk
Parida, S., & Sharma, D. (2019) · Cells · doi:10.3390/cells8121642 · Cited by 248 · see citing works
Maternal dietary patterns and preterm delivery: results from large prospective cohort study
Englund‐Ögge, L., Brantsæter, A. L., Sengpiel, V., Haugen, M. A., Birgisdóttir, B. E., Myhre, R., Meltzer, H. M., & Jacobsson, B. (2014) · BMJ · doi:10.1136/bmj.g1446 · Cited by 241 · see citing works
Ketogenic diets and chronic disease: weighing the benefits against the risks
Crosby, L., Davis, B., Joshi, S., Jardine, M., Paul, J., Neola, M., & Barnard, N. D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.702802 · Cited by 229 · see citing works
The Health Advantage of a Vegan Diet: Exploring the Gut Microbiota Connection
Glick-Bauer, M., & Yeh, M.-C. (2014) · Nutrients · doi:10.3390/nu6114822 · Cited by 224 · see citing works
Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment
Laborda-Illanes, A., Sánchez‐Alcoholado, L., Domínguez-Recio, M. E., Jiménez-Rodríguez, B., Lavado-Valenzuela, R., Comino‐Méndez, I., Alba, E., & Queipo‐Ortuño, M. I. (2020) · Cancers · doi:10.3390/cancers12092465 · Cited by 208 · see citing works
Oral and nasal microbiota in Parkinson's disease
Pereira, P. A. B., Aho, V. T. E., Paulin, L. G., Pekkonen, E., Auvinen, P., & Scheperjans, F. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.02.026 · Cited by 207 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
In vitro transformation of chlorogenic acid by human gut microbiota
Tomás-Barberán, F. A., Garcı́a-Villalba, R., Quartieri, A., Raimondi, S., Amaretti, A., Leonardi, A., & Rossi, M. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300441 · Cited by 202 · see citing works
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Ostan, R., Lanzarini, C., Pini, E., Scurti, M., Vianello, D., Bertarelli, C., Fabbri, C., Izzi, M., Palmas, M. G., Biondi, F., et al. (2015) · Nutrients · doi:10.3390/nu7042589 · Cited by 194 · see citing works
Gut microbiota and diet in patients with different glucose tolerance
Egshatyan, L. V., Kashtanova, D. A., Popenko, A., Ткачева, О. Н., Tyakht, A., Alexeev, D. G., Karamnova, N., Kostryukova, E., Babenko, V. V., Vakhitova, M. T., et al. (2015) · Endocrine Connections · doi:10.1530/ec-15-0094 · Cited by 186 · see citing works
Microbiota-gut-brain axis and cognitive function
Gareau, M. G. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_16 · Cited by 189 · see citing works
Fusobacterium nucleatum and colorectal cancer: A mechanistic overview
Goradel, N. H., Heidarzadeh, S., Jahangiri, S., Farhood, B., Mortezaee, K., Khanlarkhani, N., & Negahdari, B. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27250 · Cited by 176 · see citing works
Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures
Pang, S., Chen, X., Lu, Z., Meng, L., Huang, Y., Yu, X., Huang, L., Ye, P., Chen, X., Liang, J., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00389-y · Cited by 173 · see citing works
Umu, Ö. C. O., Frank, J. A., Fangel, J. U., Oostindjer, M., da Silva, C. S., Bolhuis, J. E., Bosch, G., Willats, W. G. T., Pope, P. B., & Diep, D. B. (2015) · Microbiome · doi:10.1186/s40168-015-0078-5 · Cited by 154 · see citing works
Modulation of the gut microbiota by prebiotic fibres and bacteriocins
Umu, Ö. C. O., Rudi, K., & Diep, D. B. (2017) · Microbial Ecology in Health and Disease · doi:10.1080/16512235.2017.1348886 · Cited by 151 · see citing works
Kim, B. S., Choi, C. W., Shin, H., Jin, S., Bae, J.-S., Han, M., Seo, E. Y., Chun, J., & Chung, J. H. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1811.11023 · Cited by 151 · see citing works
Epigenetics in Cardiac Hypertrophy and Heart Failure
Liu, C., & Tang, W. H. W. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.011 · Cited by 150 · see citing works
Microbiota revolution: How gut microbes regulate our lives
Colella, M., Charitos, I. A., Ballini, A., Cafiero, C., Topi, S., Palmirotta, R., & Santacroce, L. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i28.4368 · Cited by 153 · see citing works
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
Lochlainn, M. N., Bowyer, R. C. E., & Steves, C. J. (2018) · Nutrients · doi:10.3390/nu10070929 · Cited by 138 · see citing works
The Potential of Class II Bacteriocins to Modify Gut Microbiota to Improve Host Health
Umu, Ö. C. O., Bäuerl, C., Oostindjer, M., Pope, P. B., Hernández, P. E., Pérez‐Martínez, G., & Diep, D. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164036 · Cited by 137 · see citing works
Santoro, A., Pini, E., Scurti, M., Palmas, M. G., Berendsen, A. A. M., Brzozowska, A., Pietruszka, B., Szczecińska, A., Cano, N., Meunier, N., et al. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.001 · Cited by 129 · see citing works
Self-citationFrame, L. A., Costa, E., & Jackson, S. A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz106 · Cited by 127 · see citing works
Torjusen, H., Brantsæter, A. L., Haugen, M. A., Alexander, J., Bakketeig, L. S., Lieblein, G., Stigum, H., Næs, T., Swartz, J., Holmboe‐Ottesen, G., et al. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-006143 · Cited by 127 · see citing works
Effects of maternal diets on preterm birth and low birth weight: a systematic review
Gete, D. G., Waller, M., & Mishra, G. D. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519002897 · Cited by 101 · see citing works
Lentinula edodes-Derived Polysaccharide Alters the Spatial Structure of Gut Microbiota in Mice
Xu, X., & Zhang, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115037 · Cited by 98 · see citing works
Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.004 · Cited by 97 · see citing works
Chen, Y., Liang, J., Ouyang, F., Chen, X., Lu, T., Jiang, Z., Li, J., Li, Y., & Zeng, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00661 · Cited by 94 · see citing works
Cattaneo, C., Riso, P., Laureati, M., Gargari, G., & Pagliarini, E. (2019) · Nutrients · doi:10.3390/nu11051167 · Cited by 87 · see citing works
The future of food colloids: Next-generation nanoparticle delivery systems
McClements, D. J. (2016) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2016.12.002 · Cited by 85 · see citing works
Moles, L., & Otaegui, D. (2020) · Nutrients · doi:10.3390/nu12061654 · Cited by 93 · see citing works
Linking Smoking, Coffee, Urate, and Parkinson’s Disease – A Role for Gut Microbiota?
Scheperjans, F., Pekkonen, E., Kaakkola, S., & Auvinen, P. (2015) · Journal of Parkinson’s Disease · doi:10.3233/jpd-150557 · Cited by 83 · see citing works
Microbial Alterations and Risk Factors of Breast Cancer: Connections and Mechanistic Insights
Parida, S., & Sharma, D. (2020) · Cells · doi:10.3390/cells9051091 · Cited by 81 · see citing works
Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice
Gu, J., Thomas‐Ahner, J. M., Riedl, K. M., Bailey, M. T., Vodovotz, Y., Schwartz, S. J., & Clinton, S. K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800636 · Cited by 80 · see citing works
Fruit and Vegetable Intake and Risk of Hip Fracture: A Cohort Study of Swedish Men and Women
Byberg, L., Bellavia, A., Orsini, N., Wolk, A., & Michaëlsson, K. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2384 · Cited by 79 · see citing works
Understanding gut microbiota in elderly's health will enable intervention through probiotics
Pérez‐Martínez, G., Bäuerl, C., & Collado, M. C. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0079 · Cited by 78 · see citing works
Linking microbiota and respiratory disease
Hauptmann, M., & Schaible, U. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12421 · Cited by 75 · see citing works
Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
Rescigno, T., Micolucci, L., Tecce, M. F., & Capasso, A. (2017) · Molecules · doi:10.3390/molecules22010105 · Cited by 73 · see citing works
Pu, G., Li, P., Du, T., Niu, Q., Fan, L., Wang, H., Liu, H., Li, K., Niu, P., Wu, C., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00533 · Cited by 71 · see citing works
Dhillon, J., Li, Z., & Ortiz, R. M. (2019) · Current Developments in Nutrition · doi:10.1093/cdn/nzz079 · Cited by 69 · see citing works
Laddu, D., & Hauser, M. E. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.12.004 · Cited by 67 · see citing works
Birt, D. F., & Phillips, G. J. (2013) · Toxicologic Pathology · doi:10.1177/0192623313506791 · Cited by 66 · see citing works
Interactions between dietary polyphenols and aging gut microbiota: A review
Davinelli, S., & Scapagnini, G. (2021) · BioFactors · doi:10.1002/biof.1785 · Cited by 62 · see citing works
Dietary Influences on Gut Microbiota with a Focus on Metabolic Syndrome
Thomas, M. S., Blesso, C. N., Calle, M. C., Chun, O. K., Puglisi, M. J., & Fernández, M. L. (2022) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2021.0131 · Cited by 63 · see citing works
Dietary Carbohydrate Constituents Related to Gut Dysbiosis and Health
Seo, Y.-S., Lee, H., Kim, Y., & Park, H. (2020) · Microorganisms · doi:10.3390/microorganisms8030427 · Cited by 60 · see citing works
Tu, A., Wang, X. C., Chen, H., Jia, X., Wang, T., Yi, Y., Liu, B., Xin, W., Lü, X., & Shan, Y. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00865 · Cited by 55 · see citing works
Wassie, T., Lu, Z., Duan, X., Xie, C., Gebeyew, K., Yumei, Z., Yin, Y., & Wu, X. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.783819 · Cited by 56 · see citing works
Impact of diet on the human intestinal microbiota
Tan, H., & O’Toole, P. W. (2015) · Current Opinion in Food Science · doi:10.1016/j.cofs.2015.01.005 · Cited by 50 · see citing works
Self-citationSingh, R., Nieuwdorp, M., ten Berge, I. J. M., Bemelman, F. J., & Geerlings, S. E. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12799 · Cited by 48 · see citing works
The role of the gut microbiota in schizophrenia: Current and future perspectives
Rodrígues-Amorím, D., Baltanás, T. R., Regueiro, B. J., Spuch, C., Heras, M. E. D. L., Méndez, R. V.-N., Nieto-Araujo, M., Barreiro-Villar, C., Olivares, J. M., & Agís‐Balboa, R. C. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1433878 · Cited by 47 · see citing works
The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
Latorre‐Pérez, A., Hernández, M., Iglesias, J. R., Morán, J., Pascual, J., Porcar, M., Vilanova, C., & Yurrita, L. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-01002-1 · Cited by 45 · see citing works
Metagenomics analysis reveals features unique to Indian distal gut microbiota
Kaur, K., Khatri, I., Akhtar, A., Subramanian, S., & Ramya, T. N. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231197 · Cited by 44 · see citing works
Salivary and fecal microbiota and metabolome of celiac children under gluten-free diet
Angelis, M. D., Vannini, L., Cagno, R. D., Cavallo, N., Minervini, F., Francavilla, R., Ercolini, D., & Gobbetti, M. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.07.025 · Cited by 42 · see citing works
on behalf of the Born in Guangzhou Cohort Study Group, Lu, M., He, J., Chen, Q., Lu, J., Wei, X., Zhou, Q., Chan, F., Zhang, L., Chen, N., et al. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0377-3 · Cited by 42 · see citing works
Ghorbani, Y., Schwenger, K. J. P., & Allard, J. P. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02520-4 · Cited by 41 · see citing works
Torregrosa, C., Chorin, F., Beltran, E. E. M., Neuzillet, C., & Cardot‐Ruffino, V. (2022) · Cancers · doi:10.3390/cancers14215402 · Cited by 42 · see citing works
Bovine immunoglobulin protein isolates for the nutritional management of enteropathy
Petschow, B. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i33.11713 · Cited by 40 · see citing works
Dietary macronutrient intake and molecular-bacterial vaginosis: Role of fiber
Shivakoti, R., Tuddenham, S., Caulfield, L. E., Murphy, C., Robinson, C. K., Ravel, J., Ghanem, K. G., & Brotman, R. M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.011 · Cited by 37 · see citing works
Gut microbiota and its roles in the pathogenesis and therapy of endocrine system diseases
Wu, Z., Tian, E., Chen, Y., Dong, Z., & Peng, Q. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127291 · Cited by 39 · see citing works
Cox, N. J., Bowyer, R. C. E., Lochlainn, M. N., Wells, P. M., Roberts, H. C., & Steves, C. J. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12683 · Cited by 37 · see citing works
The interaction between intestinal microenvironment and stroke
Zhao, L., Xiao, J., Li, S., Guo, Y., Fu, R., Hua, S., Du, Y., & Xu, S. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14275 · Cited by 35 · see citing works
Microbial dysbiosis and epigenetics modulation in cancer development – A chemopreventive approach
Haque, S., Raina, R., Afroze, N., Hussain, A., Alsulimani, A., Singh, V., Mishra, B. N., Kaul, S., & Kharwar, R. N. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.024 · Cited by 35 · see citing works
Marinangeli, C. P. F., Harding, S. V., Zafron, M., & Rideout, T. C. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0028 · Cited by 34 · see citing works
Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome
Ni Lochlainn, M., Bowyer, R. C. E., & Steves, C. J. (2018) · doi:10.20944/preprints201806.0152.v1 · Cited by 138 · see citing works
Cuervo, A., Hevia, A., López, P., Suárez, A., Diaz, C., Sánchez, B., Margolles, A., & González, S. (2016) · Food & Function · doi:10.1039/c5fo00853k · Cited by 32 · see citing works
Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
Rammos, C., Hendgen-Cotta, U. B., Pohl, J., Totzeck, M., Luedike, P., Schulze, V. T., Kelm, M., & Rassaf, T. (2014) · BioMed Research International · doi:10.1155/2014/582586 · Cited by 31 · see citing works
Zhang, J., Jian, S., Chen, X., Nie, C., Zhao, J., Guan, W., Lei, L.-H., He, T., Chen, Y., Johnston, L. J., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03091 · Cited by 31 · see citing works
Zhu, Y., Hedderson, M. M., Brown, S. D., Badon, S. E., Feng, J., Quesenberry, C. P., & Ferrara, A. M. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab089 · Cited by 33 · see citing works
The Effect of a Planetary Health Diet on the Human Gut Microbiome: A Descriptive Analysis
Rehner, J., Schmartz, G. P., Kramer, T., Keller, V., Keller, A., & Becker, S. L. (2023) · Nutrients · doi:10.3390/nu15081924 · Cited by 30 · see citing works
Rothenberg, S. E., Wagner, C. L., Hamidi, B., Alekseyenko, A. V., & Azcárate-Peril, M. A. (2019) · Environmental Research · doi:10.1016/j.envres.2019.01.014 · Cited by 30 · see citing works
Dietary patterns and longitudinal change in hip bone mineral density among older men
Rogers, T., Harrison, S. L., Judd, S. E., ORWOLL, E. S., Marshall, L. M., Shannon, J., Langsetmo, L., Lane, N. E., & Shikany, J. M. (2018) · Osteoporosis International · doi:10.1007/s00198-018-4388-x · Cited by 29 · see citing works
Potential applications of gut microbiota to control human physiology
Umu, Ö. C. O., Oostindjer, M., Pope, P. B., Svihus, B., Egelandsdal, B., Nes, I. F., & Diep, D. B. (2013) · Antonie van Leeuwenhoek · doi:10.1007/s10482-013-0008-0 · Cited by 28 · see citing works
Prete, R., Tofalo, R., Federici, E., Ciarrocchi, A., Cenci, G., & Corsetti, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02349 · Cited by 27 · see citing works
Role of Maternal Microbiota and Nutrition in Early-Life Neurodevelopmental Disorders
Daliry, A., & Pereira, E. N. G. D. S. (2021) · Nutrients · doi:10.3390/nu13103533 · Cited by 28 · see citing works
Human microbiome versus food-borne pathogens: friend or foe
Josephs‐Spaulding, J., Beeler, E., & Singh, O. V. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7523-7 · Cited by 27 · see citing works
Nutrigenetics and nutrigenomics—A personalized approach to nutrition
Ahluwalia, M. K. (2021) · Advances in genetics · doi:10.1016/bs.adgen.2021.08.005 · Cited by 26 · see citing works
Sex- and age-specific variation of gut microbiota in Brandt’s voles
Xu, X., & Zhang, Z. (2021) · PeerJ · doi:10.7717/peerj.11434 · Cited by 26 · see citing works
Zheng, J., Xiao, X., Zhang, Q., Yu, M., Xu, J., Qi, C., & Wang, T. (2016) · Bioscience Reports · doi:10.1042/bsr20160103 · Cited by 26 · see citing works
Killinger, B., Whidbey, C., Sadler, N., DeLeon, A. J., Munoz, N. M., Kim, Y., & Wright, A. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00313-z · Cited by 24 · see citing works
Li, Y., Li, W., Wang, X., Ding, C., Liu, J., Li, Y., Li, W., & Sun, Y. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900965 · Cited by 23 · see citing works
Adithya, K. K., Rajeev, R., Selvin, J., & Kiran, G. S. (2021) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.0c00075 · Cited by 22 · see citing works
Chen, L., Wang, B., Liu, J., Wu, X., Xu, X., Cao, H., Ji, X., Zhang, P., Li, X., Hou, Z., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.974694 · Cited by 22 · see citing works
Wassie, T., Cheng, B., Zhou, T., Gao, L., Lu, Z., Xie, C., & Wu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.996897 · Cited by 22 · see citing works
Ford, A. C., & Moayyedi, P. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328365d45d · Cited by 21 · see citing works
Summer, M., Sajjad, A., Ali, S., & Hussain, T. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03868-x · Cited by 19 · see citing works
- Authors
- Jeffery, I., & O'Toole, P.
- Affiliations
- University College Cork (IE)
- Department of Microbiology, University College Cork, College Road, Cork, Ireland
- Corresponding author
- Jeffery, Ian
- ORCID
- Jeffery, Ian
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2013-01-17
- Volume
- 5
- Issue
- 1
- Pages
- 234-252
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC3571646
- OpenAlex
- W2052419633
- Cited by
- 199
- References
- 119
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 9 · 2023: 13 · 2022: 20 · 2021: 21 · 2020: 22 · 2019: 16 · 2018: 9 · 2017: 16 · 2016: 14 · 2015: 15 · 2014: 20 · 2013: 11
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science Foundation Ireland
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota diversity, plant-based diet, fruit and vegetable intake, meat consumption, Prevotella, Bacteroides, immune-related diseases, inflammatory bowel disease, diabetes mellitus, healthy aging
- MeSH terms
- Adult, Aging, Animals, Child, Diabetes Mellitus, Diet, Feces, Humans, Nutritional Requirements, Obesity, Inflammatory Bowel Diseases, Gastrointestinal Tract, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
