Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution
Open accessAbstract
Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed.
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Babies fed by infant formulas have a higher number of pathogenic bacteria compared to breast-fed babies.
“The gut microbiota composition is further affected by the diet of the newborn, since babies fed by infant formulas have a higher number of pathogenic bacteria in comparison to breast-fed babies [102].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [102]
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ВПЛИВ ЕНТЕРОСГЕЛЮ ТА ХАРЧОВОЇ ДОБАВКИ КАРБОЛАЙН (АКТИВОВАНЕ ВУГІЛЛЯ) НА МІКРОФЛОРУ КИШЕЧНИКА
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Valverde, M. M. F., Calsavara, L. N., & Zordão, O. P. (2022) · doi:10.22533/at.ed.91522060119
- Authors
- Mejía-León, M., & Barca, A.
- Affiliations
- Centro de Investigación en Alimentación y Desarrollo (MX)
- Corresponding author
- Barca, Ana
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2015-11-06
- Volume
- 7
- Issue
- 11
- Pages
- 9171-9184
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC4663589
- OpenAlex
- W2150164265
- Cited by
- 125
- References
- 72
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 28 · 2021: 8 · 2020: 9 · 2019: 20 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 1 · 2013: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Consejo Nacional de Ciencia y Tecnología (S0008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, gut microbiota, diet, autoimmunity, environmental risk factors, antibiotic use, molecular mechanisms, vascular complications
- MeSH terms
- Gastrointestinal Microbiome, Animals, Autoimmune Diseases, Diabetes Mellitus, Type 1, Diet, Disease Models, Animal, Humans, Immune System, Gastrointestinal Tract
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