Cited by 127Diabetes and associated disordersGut microbiota and healthDiabetes Management and Research

Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution

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Mejía-León, María, Barca, Ana·2015·Nutrients

Abstract

Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed.

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  • Babies fed by infant formulas have a higher number of pathogenic bacteria compared to breast-fed babies.

    “The gut microbiota composition is further affected by the diet of the newborn, since babies fed by infant formulas have a higher number of pathogenic bacteria in comparison to breast-fed babies [102].”

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  1. [64]De Jesus-Laboy K.M. Cox L.M. Rodriguez-Rivera S.M. Rivera-Vinas J. Mendez K. Clemente J.C. Knight R. Dominguez-Bello M.G. Restoring the normal microbiota of cesarean-section born infants Proceedings of American society for microbiology 114th general meeting 18 May 2014 Boston, MA, USA I 741

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Authors
Mejía-León, M., & Barca, A.
Affiliations
Centro de Investigación en Alimentación y Desarrollo (MX)
Corresponding author
Barca, Ana
Venue
Nutrients
Publisher
MDPI AG
Published
2015-11-06
Volume
7
Issue
11
Pages
9171-9184
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2150164265
Cited by
125
References
72
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 28 · 2021: 8 · 2020: 9 · 2019: 20 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 1 · 2013: 1
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Consejo Nacional de Ciencia y Tecnología (S0008)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 1 diabetes, gut microbiota, diet, autoimmunity, environmental risk factors, antibiotic use, molecular mechanisms, vascular complications
MeSH terms
Gastrointestinal Microbiome, Animals, Autoimmune Diseases, Diabetes Mellitus, Type 1, Diet, Disease Models, Animal, Humans, Immune System, Gastrointestinal Tract

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