Substrate Utilization and Cycling Performance Following Palatinose™ Ingestion: A Randomized, Double-Blind, Controlled Trial
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(1) Objective: To compare the effects of isomaltulose (Palatinose™, PSE) vs. maltodextrin (MDX) ingestion on substrate utilization during endurance exercise and subsequent time trial performance; (2) Methods: 20 male athletes performed two experimental trials with ingestion of either 75 g PSE or MDX 45 min before the start of exercise. The exercise protocol consisted of 90 min cycling (60% VO2max) followed by a time trial; (3) Results: Time trial finishing time (−2.7%, 90% CI: ±3.0%, 89% likely beneficial; p = 0.147) and power output during the final 5 min (+4.6%, 90% CI: ±4.0%, 93% likely beneficial; p = 0.053) were improved with PSE compared with MDX. The blood glucose profile differed between trials (p = 0.013) with PSE resulting in lower glycemia during rest (95%–99% likelihood) and higher blood glucose concentrations during exercise (63%–86% likelihood). In comparison to MDX, fat oxidation was higher (88%–99% likelihood; p = 0.005) and carbohydrate oxidation was lower following PSE intake (85%–96% likelihood; p = 0.002). (4) Conclusion: PSE maintained a more stable blood glucose profile and higher fat oxidation during exercise which resulted in improved cycling performance compared with MDX. These results could be explained by the slower availability and the low-glycemic properties of Palatinose™ allowing a greater reliance on fat oxidation and sparing of glycogen during the initial endurance exercise.
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In endurance-trained athletes (VO2max > 55 mL·kg−1·min−1), isomaltulose ingestion (750 mL, 10% w/v) maintained a more stable blood glucose concentration and increased fat oxidation during exercise, resulting in improved cycling performance compared to maltodextrin consumption.
“At a sporting level, isomaltulose ingestion (750 mL, 10% w/v) maintained a more stable blood glucose concentration and increased fat oxidation during exercise, resulting in improved cycling performance compared to maltodextrin consumption in endurance-trained athletes (VO2max > 55 mL·kg−1·min−1) [50].”
From The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates (2020) · cites this paper as [50]
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- Authors
- König, D., Zdzieblik, D., Holz, A., Theis, S., & Gollhofer, A.
- Affiliations
- University of Freiburg (DE)
- BENEO-Institute, Wormserstrasse 11, Obrigheim 67283, Germany
- Corresponding author
- König, Daniel
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2016-06-23
- Volume
- 8
- Issue
- 7
- Pages
- 390
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC4963866
- OpenAlex
- W2468652589
- Cited by
- 32
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Albert-Ludwigs-Universität Freiburg
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- isomaltulose, palatinose, maltodextrin, endurance exercise, time trial performance, cycling performance, substrate utilization, fat oxidation, carbohydrate oxidation, blood glucose, glycemic index, glycogen sparing, sports nutrition
- MeSH terms
- Adult, Bicycling, Blood Glucose, Body Height, Body Weight, Double-Blind Method, Glycogen, Heart Rate, Humans, Isomaltose, Male, Oxygen Consumption, Physical Endurance, Polysaccharides, Rest, Exercise, Body Mass Index, Cross-Over Studies, Lipid Metabolism, Athletes, Sports Nutritional Physiological Phenomena
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