Biological correlates of complex posttraumatic stress disorder—state of research and future directions
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Complex posttraumatic stress disorder (PTSD) presents with clinical features of full or partial PTSD (re-experiencing a traumatic event, avoiding reminders of the event, and a state of hyperarousal) together with symptoms from three additional clusters (problems in emotional regulation, negative self-concept, and problems in interpersonal relations). Complex PTSD is proposed as a new diagnostic entity in ICD-11 and typically occurs after prolonged and complex trauma. Here we shortly review current knowledge regarding the biological correlates of complex PTSD and compare it to the relevant findings in PTSD. Recent studies provide support to the validity of complex PTSD as a separate diagnostic entity; however, data regarding the biological basis of the disorder are still very limited at this time. Further studies focused on complex PTSD biological correlates and replication of the initial findings are needed, including neuroimaging, neurobiochemical, genetic, and epigenetic investigations. Identification of altered biological pathways in complex PTSD may be critical to further understand the pathophysiology and optimize treatment strategies.
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069 · see citing works
Complex PTSD: A syndrome in survivors of prolonged and repeated trauma
Herman, J. L. (1992) · Journal of Traumatic Stress · doi:10.1002/jts.2490050305 · Cited by 2,609 · see citing works
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610 · see citing works
van der Kolk, B. A. (2005) · Psychiatric Annals · doi:10.3928/00485713-20050501-06 · Cited by 1,609 · see citing works
Cloitre, M., Stolbach, B. C., Herman, J. L., Kolk, B. V. D., Pynoos, R., Wang, J., & Petkova, E. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20444 · Cited by 1,473 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
Posttraumatic stress disorder: the burden to the individual and to society.
Kessler, R. C. (2000) · PubMed · Cited by 1,443 · see citing works
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works
Full and partial posttraumatic stress disorder: findings from a community survey
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.8.1114 · Cited by 1,013 · see citing works
Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.
De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., & Ryan, N. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00045-1 · Cited by 974 · see citing works
A meta-analysis of structural brain abnormalities in PTSD
KARL, A., SCHAEFER, M., MALTA, L., DORFEL, D., ROHLEDER, N., & WERNER, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.03.004 · Cited by 881 · see citing works
Diagnosis and classification of disorders specifically associated with stress: proposals for ICD-11
Maercker, A., Brewin, C. R., Bryant, R. A., Cloitre, M., van Ommeren, M., Jones, L. M., Humayan, A., Kagee, A., Llosa, A. E., Rousseau, C., et al. (2013) · World Psychiatry · doi:10.1002/wps.20057 · Cited by 762 · see citing works
Self-citationEvidence for proposed ICD-11 PTSD and complex PTSD: a latent profile analysis
Cloitre, M., Garvert, D. W., Brewin, C. R., Bryant, R. A., & Maercker, A. (2013) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v4i0.20706 · Cited by 751 · see citing works
Self-citationPost-traumatic stress disorder: the neurobiological impact of psychological trauma
Sherin, J. E., & Nemeroff, C. B. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/jsherin · Cited by 750 · see citing works
Bremner, J. D., Vythilingam, M., Vermetten, E. H. G. J. M., Southwick, S. M., McGlashan, T. H., Nazeer, A., Khan, S., Vaccarino, V., Soufer, R., Garg, P. K., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.924 · Cited by 721 · see citing works
True, W. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820160019002 · Cited by 704 · see citing works
Bremner, J. D., Narayan, M., Staib, L. H., Southwick, S. M., McGlashan, T., & Charney, D. S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1787 · Cited by 701 · see citing works
Cortisol and post-traumatic stress disorder in adults: Systematic review and meta-analysis
Meewisse, M.-L., Reitsma, J. B., De Vries, G.-J., Gersons, B. P. R., & Olff, M. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.024877 · Cited by 661 · see citing works
Shin, L. M., McNally, R. J., Kosslyn, S. M., Thompson, W. L., Rauch, S. L., Alpert, N. M., Metzger, L. J., Lasko, N. B., Orr, S. P., & Pitman, R. K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.575 · Cited by 647 · see citing works
Stein, M. B., Jang, K. L., Taylor, S. J., Vernon, P. A., & Livesley, W. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1675 · Cited by 602 · see citing works
Treatment of complex PTSD: results of the ISTSS expert clinician survey on best practices.
Cloitre, M., Courtois, C. A., Charuvastra, A., Carapezza, R., Stolbach, B. C., & Green, B. L. (2011) · Journal of Traumatic Stress · doi:10.1002/jts.20697 · Cited by 593 · see citing works
Roth, S., Newman, E., Pelcovitz, D., van der Kolk, B., & Mandel, F. S. (1997) · Journal of Traumatic Stress · doi:10.1002/jts.2490100403 · Cited by 581 · see citing works
Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217750110 · Cited by 548 · see citing works
Maercker, A., Brewin, C. R., Bryant, R. A., Cloitre, M., Reed, G. M., van Ommeren, M., Humayun, A., Jones, L. M., Kagee, A., Llosa, A. E., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62191-6 · Cited by 533 · see citing works
Self-citationEpigenetic and immune function profiles associated with posttraumatic stress disorder
Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518 · see citing works
Development of a criteria set and a structured interview for disorders of extreme stress (SIDES)
Pelcovitz, D., van der Kolk, B. A., Roth, S., Mandel, F. S., Kaplan, S. J., & Resick, P. A. (1997) · Journal of Traumatic Stress · doi:10.1023/a:1024800212070 · Cited by 507 · see citing works
American Journal of Psychiatry 1844-1994
(1994) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615376988 · Cited by 507 · see citing works
Lanius, R. A., Brand, B., Vermetten, E., Frewen, P. A., & Spiegel, D. (2012) · Depression and Anxiety · doi:10.1002/da.21889 · Cited by 459 · see citing works
Accumulated childhood trauma and symptom complexity
Briere, J., Kaltman, S., & Green, B. L. (2008) · Journal of Traumatic Stress · doi:10.1002/jts.20317 · Cited by 452 · see citing works
Quantitative meta-analysis of neural activity in posttraumatic stress disorder
Hayes, J. P., Hayes, S. M., & Mikedis, A. M. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-9 · Cited by 452 · see citing works
Abuse-Related Posttraumatic Stress Disorder: Evidence for Chronic Neuroendocrine Activation in Women
Lemieux, A. M., & Coe, C. L. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199503000-00002 · Cited by 411 · see citing works
BREMNER, J. D., VERMETTEN, E., SCHMAHL, C., VACCARINO, V., VYTHILINGAM, M., AFZAL, N., GRILLON, C., & CHARNEY, D. S. (2005) · Psychological Medicine · doi:10.1017/s0033291704003290 · Cited by 370 · see citing works
Yehuda, R., Daskalakis, N. P., Desarnaud, F., Makotkine, I., Lehrner, A. L., Koch, E., Flory, J. D., Buxbaum, J. D., Meaney, M. J., & Bierer, L. M. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00118 · Cited by 358 · see citing works
Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder
Smith, A. K., Conneely, K. N., Kilaru, V., Mercer, K. B., Weiss, T. E., Bradley, B., Tang, Y., Gillespie, C. F., Cubells, J. F., & Ressler, K. J. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31212 · Cited by 355 · see citing works
Stein, M. B., Yehuda, R., Koverola, C., & Hanna, C. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00489-1 · Cited by 345 · see citing works
Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Farrer, L. A., & Gelernter, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.37 · Cited by 327 · see citing works
Transgenerational transmission of cortisol and PTSD risk
Yehuda, R., & Bierer, L. M. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67009-5 · Cited by 306 · see citing works
Bremner, J. D., Vythilingam, M., Vermetten, E., Southwick, S. M., McGlashan, T., Staib, L. H., Soufer, R., & Charney, D. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01891-7 · Cited by 299 · see citing works
Bremner, J. D., Vermetten, E. H. G. J. M., Vythilingam, M., Afzal, N., Schmahl, C. G., Elzinga, B. M., & Charney, D. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.001 · Cited by 279 · see citing works
McLaughlin, K. A., Koenen, K. C., Friedman, M. J., Ruscio, A. M., Karam, E. G., Shahly, V., Stein, D. J., Hill, E. D., Petukhova, M., Alonso, J., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.028 · Cited by 275 · cited 2× · see citing works
“Functional impairment degree and comorbidity rates in partial PTSD have been found to be intermediate between those of traumatized subjects without PTSD symptoms or with full PTSD (McLaughlin et al., 2015).”
Krystal, J. H., & Neumeister, A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.044 · Cited by 264 · see citing works
McLean, L. M., & Gallop, R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.369 · Cited by 262 · see citing works
Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder
O'Donovan, A., Epel, E., Lin, J., Wolkowitz, O., Cohen, B., Maguen, S., Metzler, T., Lenoci, M., Blackburn, E., & Neylan, T. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.035 · Cited by 262 · see citing works
A Latent Class Analysis of Dissociation and Posttraumatic Stress Disorder
Wolf, E. J., Miller, M. W., Reardon, A. F., Ryabchenko, K. A., Castillo, D. T., & Freund, R. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1574 · Cited by 253 · see citing works
Logue, M. W., Baldwin, C. T., Guffanti, G., Melista, E., Wolf, E. J., Reardon, A. F., Uddin, M., Wildman, D. E., Galea, S., Koenen, K. C., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.113 · Cited by 238 · see citing works
The long-term sequelae of sexual abuse: Support for a complex posttraumatic stress disorder
Zlotnick, C., Zakriski, A. L., Shea, M. T., Costello, E., Begin, A., Pearlstein, T. B., & Simpson, E. B. (1996) · Journal of Traumatic Stress · doi:10.1007/bf02110655 · Cited by 219 · see citing works
Pietrzak, R. H., Goldstein, R. B., Southwick, S. M., & Grant, B. F. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820d92e7 · Cited by 204 · see citing works
Steuwe, C., Lanius, R. A., & Frewen, P. (2012) · Depression and Anxiety · doi:10.1002/da.21944 · Cited by 182 · see citing works
Cornelis, M. C., Nugent, N. R., Amstadter, A. B., & Koenen, K. C. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0126-6 · Cited by 178 · see citing works
Orr, S. P., Lasko, N. B., Metzger, L. J., Berry, N. J., Ahern, C. E., & Pitman, R. K. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.66.6.906 · Cited by 173 · see citing works
Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04754blu · Cited by 173 · see citing works
Elklit, A., Hyland, P., & Shevlin, M. (2014) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v5.24221 · Cited by 172 · see citing works
Neuroimaging in Posttraumatic Stress Disorder and Other Stress-Related Disorders
Bremner, J. D. (2007) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2007.07.003 · Cited by 166 · see citing works
Briere, J., & Rickards, S. (2007) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0b013e31803044e2 · Cited by 163 · see citing works
Lanius, R. A., Bluhm, R. L., & Frewen, P. A. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01755.x · Cited by 158 · see citing works
Pietrzak, R., Goldstein, R., Southwick, S., & Grant, B. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182303775 · Cited by 146 · see citing works
Schützwohl, M., & Maercker, A. R. A. (1999) · Journal of Traumatic Stress · doi:10.1023/a:1024706702133 · Cited by 143 · see citing works
Self-citationBremner, J. D., Vermetten, E. H. G. J. M., & Kelley, M. E. (2007) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3181594ca0 · Cited by 139 · see citing works
Orr, S. P., Lasko, N. B., Metzger, L. J., et al. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.6.906 · Cited by 139 · see citing works
Rusiecki, J. A., Chen, L., Srikantan, V., Zhang, L., Yan, L., Polin, M., & Baccarelli, A. (2012) · Epigenomics · doi:10.2217/epi.11.116 · Cited by 132 · see citing works
Thomaes, K., Dorrepaal, E., Draijer, N. P. J., de Ruiter, M. B., Elzinga, B. M., van Balkom, A. J., Smoor, P. L. M., Smit, J., & Veltman, D. J. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.03.003 · Cited by 116 · see citing works
Knefel, M., & Lueger‐Schuster, B. (2013) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v4i0.22608 · Cited by 107 · see citing works
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., Sjoerds, Z., van Balkom, A. J., Smit, J. H., & Veltman, D. J. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr084 · Cited by 103 · see citing works
Knefel, M., Garvert, D. W., Cloître, M., & Lueger‐Schuster, B. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.25290 · Cited by 99 · see citing works
Thomaes, K., Dorrepaal, E., Draijer, N., de Ruiter, M. B., Elzinga, B. M., van Balkom, A. J. L. M., Smit, J. H., & Veltman, D. J. (2012) · Psychological Medicine · doi:10.1017/s0033291712000499 · Cited by 99 · see citing works
Rusiecki, J. A., Byrne, C., Galdzicki, Z., Srikantan, V., Chen, L., Poulin, M., Yan, L., & Baccarelli, A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00056 · Cited by 99 · see citing works
Meng, Y., Qiu, C., Zhu, H., Lama, S., Lui, S., Gong, Q., & Zhang, W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.021 · Cited by 96 · see citing works
Schaefer, C., Enning, F., Mueller, J. K., Bumb, J. M., Rohleder, C., Odorfer, T. M., Klosterkötter, J., Hellmich, M., Koethe, D., Schmahl, C., et al. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0470-8 · Cited by 92 · see citing works
Phenotype of Blood Lymphocytes in PTSD Suggests Chronic Immune Activation
Wilson, S. N., van der Kolk, B. A., Burbridge, J. A., Fisler, R. E., & Kradin, R. L. (1999) · Psychosomatics · doi:10.1016/s0033-3182(99)71238-7 · Cited by 88 · see citing works
Wolf, E. J., Rasmusson, A. M., Mitchell, K. S., Logue, M. W., Baldwin, C. T., & Miller, M. W. (2014) · Depression and Anxiety · doi:10.1002/da.22260 · Cited by 75 · see citing works
Luterek, J. A., Bittinger, J. N., & Simpson, T. L. (2011) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2011.551504 · Cited by 70 · see citing works
The interaction between stressful life events and leukocyte telomere length is associated with PTSD
Zhang, L., Hu, X.-Z., Benedek, D. M., Fullerton, C. S., Forsten, R. D., Naifeh, J. A., Li, X., Li, H., Benevides, K. N., Smerin, S., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.141 · Cited by 69 · see citing works
The Complexity of Complex PTSD
Bryant, R. A. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10040606 · Cited by 45 · see citing works
Friedman, M. J., Wang, S., Jalowiec, J. E., McHugo, G. J., & McDonagh, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.019 · Cited by 44 · see citing works
Complex posttraumatic stress disorder and survivors of human rights violations
McDonnell, M., Robjant, K., & Katona, C. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835aea9d · Cited by 36 · see citing works
Zerach, G., & Solomon, Z. (2013) · PubMed · Cited by 19 · see citing works
Responsivity to Stress in Chronic Posttraumatic Stress Disorder Due to Childhood Sexual Abuse
Klumpers, U. M. H., Timmerman, L., LOONEN, A. J. M., Tulen, J. H. M., Fekkes, D., & Boomsma, F. (2004) · Psychological Reports · doi:10.2466/pr0.94.2.408-410 · Cited by 11 · see citing works
Transgenerational Effects of PTSD or Traumatic Stress: Do Telomeres Reach Across the Generations?
A, B. A. M. (2014) · Journal of Trauma & Treatment · doi:10.4172/2167-1222.1000204 · Cited by 4 · see citing works
Flagged first, then by citations
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Sorted by citations
Palić, S., Zerach, G., Shevlin, M. E., Zeligman, Z., Elklit, A., & Solomon, Z. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.10.062 · Cited by 99 · see citing works
Giourou, E., Σκώκου, Μ., Andrew, S. P., Alexopoulou, K. I., Gourzis, P., & Jelastopulu, E. (2018) · World Journal of Psychiatry · doi:10.5498/wjp.v8.i1.12 · Cited by 95 · see citing works
A decennial review of psychotraumatology: what did we learn and where are we going?
Olff, M., Amstadter, A. B., Armour, C., Birkeland, M. S., Bui, É., Cloître, M., Ehlers, A., Ford, J. D., Greene, T., Hansen, M., et al. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1672948 · Cited by 78 · see citing works
Fragkaki, I., Thomaes, K., & Sijbrandij, M. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.30915 · Cited by 54 · see citing works
Olff, M., Hein, I. M., Amstadter, A. B., Armour, C., Birkeland, M. S., Bui, É., Cloître, M., Ehlers, A., Ford, J. D., Greene, T., et al. (2025) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2458406 · Cited by 58 · see citing works
A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health
Wiss, D. A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00193 · Cited by 41 · see citing works
Neurobiological Trajectories Involving Social Isolation in PTSD: A Systematic Review
Vlachos, I. I., Papageorgiou, C., & Margariti, M. M. (2020) · Brain Sciences · doi:10.3390/brainsci10030173 · Cited by 40 · see citing works
Putica, A., & Agathos, J. A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105836 · Cited by 32 · see citing works
Zhang, K., Qu, S., Chang, S., Li, G., Cao, C., Fang, K., Olff, M., Wang, L., & Wang, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.021 · Cited by 28 · see citing works
Lanius, R. A., & Olff, M. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1314165 · Cited by 25 · see citing works
Birze, A., LeBlanc, V. R., Regehr, C., Paradis, E., & Einstein, G. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00604 · Cited by 19 · see citing works
Adaralegbe, N., Okobi, O. E., Omar, Z. T. O., Segun, E. O., Evbayekha, E. O., Abolurin, A., Egberuare, E. O., Ezegbe, H. C., Adegbosin, A., Adedeji, A. G., et al. (2022) · Cureus · doi:10.7759/cureus.31907 · Cited by 21 · see citing works
Chitrala, K. N., Nagarkatti, P. S., & Nagarkatti, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168404 · Cited by 17 · see citing works
Stopyra, M. A., Simon, J. J., Rheude, C., & Nikendei, C. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0014 · Cited by 17 · see citing works
Marinova, Z., Maercker, A. R. A., Grünblatt, E., Wojdacz, T. K., & Walitza, S. (2017) · BMC Research Notes · doi:10.1186/s13104-017-3082-y · Cited by 15 · see citing works
Self-citationAkute und posttraumatische Belastungsstörung
Kapfhammer, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_71 · Cited by 2 · see citing works
Uldall, S. W., Nielsen, M. Ø., Carlsson, J. M., Glenthoj, B. Y., Siebner, H. R., Madsen, K. H., Madsen, C. G., Leffers, A.-M., Nejad, A. B., & Rostrup, E. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1730091 · Cited by 11 · see citing works
Uldall, S. W., Madsen, K. H., Siebner, H. R., Lanius, R. A., Frewen, P., Fischer, E., Madsen, C. G., Leffers, A.-M., Rostrup, E., Carlsson, J. M., et al. (2020) · Chronic Stress · doi:10.1177/2470547020917623 · Cited by 10 · see citing works
de Lange, G. M. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1341824 · Cited by 10 · see citing works
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Ford, J. D., & Greene, C. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-46138-0_5 · Cited by 10 · see citing works
Rheude, C., Nikendei, C., Stopyra, M. A., Bendszus, M., Krämer, B., Gruber, O., Friederich, H., & Simon, J. J. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.110 · Cited by 7 · see citing works
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O’Connor, M. (2017) · Australasian Psychiatry · doi:10.1177/1039856217700464 · Cited by 7 · see citing works
Iffland, B., Eilers, R., Rosner, R., Renneberg, B., Steil, R., & Neuner, F. (2023) · Brain and Behavior · doi:10.1002/brb3.2904 · Cited by 4 · see citing works
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Augsburger, M., & Maercker, A. R. A. (2018) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-0576-6790 · Cited by 5 · see citing works
Self-citationMaercker, A. R. A. (2019) · Springer eBooks · doi:10.1007/978-3-662-58470-5_3 · Cited by 4 · see citing works
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Daniel, D. R., & Zolnikov, T. R. (2023) · American Journal of Qualitative Research · doi:10.29333/ajqr/13596 · Cited by 4 · see citing works
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Barani, F. (2019) · Theory & Psychology · doi:10.1177/0959354319842949 · Cited by 3 · see citing works
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Tsuji-Lyons, A., & White, M. B. (2023) · NeuroRegulation · doi:10.15540/nr.10.4.220 · Cited by 3 · see citing works
Maercker, A. R. A. (2022) · Springer eBooks · doi:10.1007/978-3-662-64057-9_3 · Cited by 1 · see citing works
Self-citationShiota, S., Oura, S.-I., & MATSUMOTO, M. (2024) · Environment and Social Psychology · doi:10.59429/esp.v9i7.2079 · Cited by 1 · see citing works
Lim, T. H. B., Reay, W. R., Gustin, S. M., & Quidé, Y. (2026) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2026.04.002 · Cited by 1 · see citing works
Song, X., Ge, J., Ben, S., & Peng, Y. (2025) · Basic and Applied Social Psychology · doi:10.1080/01973533.2025.2585406 · Cited by 1 · see citing works
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Panayi, P., Varese, F., PETERS, E. R., Bentall, R. P., Hardy, A., Berry, K., Sellwood, W., Underwood, R., Steel, C., Mason, L., et al. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112182 · Cited by 1 · see citing works
Steardo, L., Fornaro, M., D’Angelo, M., Stefano, V. D., Monaco, F., Scuderi, C., Steardo, L., & Valenza, M. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111337 · Cited by 1 · see citing works
Thomas, E., Hemmings, S. M. J., Spies, G., Nöthling, J., & Seedat, S. (2018) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2018.02.002 · Cited by 1 · see citing works
FAMILY ENVIRONMENT AND ATTACHMENT IN RELATION TO COMPLEX TRAUMA AND C-PTSD
Ocean, S. E. (2020) · The Mathematics Enthusiast · Cited by 1 · see citing works
Post-traumatic Stress Risk among COVID-19 Survivors in ColombiaPreprint
Campo‐Arias, A., Pedrozo‐Pupo, J. C., & Herazo, E. (2021) · medRxiv · doi:10.1101/2021.12.02.21267210 · Cited by 1 · see citing works
Akute und posttraumatische Belastungsstörung
Kapfhammer, H. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_71-1
Post-Traumatic Stress Risk Among COVID-19 Survivors in Colombia
Herazo, E., Pedrozo‐Pupo, J. C., & Campo‐Arias, A. (2023) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2023.11.007
Post-Traumatic Stress Risk Among COVID-19 Survivors in Colombia
Herazo, E., Pedrozo‐Pupo, J. C., & Campo‐Arias, A. (2025) · Revista Colombiana de Psiquiatría (English ed ) · doi:10.1016/j.rcpeng.2025.11.011
Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives
Rajkumar, R. P. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1786811
- Authors
- Marinova, Z., & Maercker, A.
- Affiliations
- University of Zurich (CH)
- Department of Psychology, Division of Psychopathology and Clinical Intervention, University of Zürich, Zürich, Switzerland
- Corresponding author
- Marinova, Zoya
- Venue
- European Journal of Psychotraumatology
- Publisher
- Informa UK Limited
- Published
- 2015-04-16
- Volume
- 6
- Issue
- 1
- Pages
- 25913-25913
- ISSN
- 2000-8066 (ISSN-L)
- PMC
- PMC4401823
- OpenAlex
- W1989606600
- Cited by
- 42
- References
- 78
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- European Journal of Psychotraumatology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Figshare (cc-by)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- complex PTSD, biological correlates, emotional dysregulation, negative self-concept, interpersonal problems, ICD-11 diagnostic criteria, neuroimaging, neurochemistry, epigenetics, pathophysiology, hyperarousal
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