The DOI matches its Crossref record; 49 of the 51 references it cites were found in a registry or an index.
Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans
Open accessAbstract
Background Macronutrient "preloads" can stimulate glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), slow gastric emptying, and reduce postprandial glycemic excursions. After sweet preloads, these effects may be signaled by sodium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both.Objective We determined the effects of 4 sweet preloads on GIP and GLP-1 release, gastric emptying, and postprandial glycemia.Design Ten healthy subjects were studied on 4 separate occasions each. A preload drink containing 40 g glucose, 40 g tagatose/isomalt mixture (TIM), 40 g 3-O-methylglucose (3OMG; a nonmetabolized substrate of SGLT1), or 60 mg sucralose was consumed 15 min before a (13)C-octanoic acid-labeled mashed potato meal. Blood glucose, plasma total GLP-1 and GIP, serum insulin, and gastric emptying were determined.Results Both glucose and 3OMG stimulated GLP-1 and GIP release in advance of the meal (each P < 0.05), whereas TIM and sucralose did not. The overall postprandial GLP-1 response was greater after glucose, 3OMG, and TIM than after sucralose (P < 0.05), albeit later after TIM than the other preloads. The blood glucose and insulin responses in the first 30 min after the meal were greatest after glucose (each P < 0.05). Gastric emptying was slower after both 3OMG and TIM than after sucralose (each P < 0.05).Conclusions In healthy humans, SGLT1 substrates stimulate GLP-1 and GIP and slow gastric emptying, regardless of whether they are metabolized, whereas the artificial sweetener sucralose does not. Poorly absorbed sweet tastants (TIM), which probably expose a greater length of gut to nutrients, result in delayed GLP-1 secretion but not in delayed GIP release. These observations have the potential to optimize the use of preloads for glycemic control. This trial was registered at www.actr.org.au as ACTRN12611000775910.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Our group provided the first evidence that SGLT-1 substrates, even if not metabolized (such as the glucose analog 3-O-methylglucose, 3-OMG), have the capacity to stimulate GLP-1 and GIP secretion in humans (44).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [44]
Citations
Cites
Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
Flint, A., Raben, A., Astrup, A., & Holst, J. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci990 · Cited by 1,402
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1×
“For example, stimulation of sweet taste receptors by sucralose (a noncaloric artificial sweetener) was reported to release GLP-1 from enteroendocrine L cells in vitro (10, 11) but has no effect on GLP-1 secretion and gastric emptying in humans (12).”
BackgroundGhoos, Y. F., Maes, B., Geypens, B. J., Mys, G., Hiele, M. I., Rutgeerts, P. J., & Vantrappen, G. R. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90640-x · Cited by 945
Nauck, M. A., Niedereichholz, U., Ettler, R., Holst, J. J., Ørskov, C., Ritzel, R. A., & Schmiegel, W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.5.e981 · Cited by 834
Glucose Sensing in L Cells: A Primary Cell Study
Reimann, F., Habib, A. M., Tolhurst, G., Parker, H. E., Rogers, G. J., & Gribble, F. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.002 · Cited by 733
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
Holst, J. J., & Gromada, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00545.2003 · Cited by 611
Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects
Horowitz, M., Edelbroek, M. A. L., Wishart, J. M., & Straathof, J. W. (1993) · Diabetologia · doi:10.1007/bf00400362 · Cited by 469
Self-citationSchvarcz, E., Palmer, M., Aman, J., Horowitz, M., Stridsberg, M., & Berne, C. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70080-5 · Cited by 416
Self-citationMa, J., Stevens, J. E., Cukier, K., Maddox, A. F., Wishart, J. M., Jones, K. L., Clifton, P. M., Horowitz, M., & Rayner, C. K. (2009) · Diabetes Care · doi:10.2337/dc09-0723 · Cited by 400
Self-citation
Cited by
Sorted by citations
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Self-citationArtificial sweeteners produce the counterintuitive effect of inducing metabolic derangements
Swithers, S. E. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.05.005 · Cited by 434
Relationships Between Gastric Emptying, Postprandial Glycemia, and Incretin Hormones
Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Diabetes Care · doi:10.2337/dc12-1609 · Cited by 335
Self-citationGlucose transporters in the small intestine in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02439-5 · Cited by 290
Metabolic effects of non-nutritive sweeteners
Pepino, M. Y. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.024 · Cited by 285
Gastric emptying and glycaemia in health and diabetes mellitus
Phillips, L. K., Deane, A. M., Jones, K. L., Rayner, C. K., & Horowitz, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.202 · Cited by 273
Self-citationBauer, P. V., Duca, F. A., Waise, T. M. Z., Rasmussen, B. A., Abraham, M. A., Dranse, H. J., Puri, A., O’Brien, C. A., & Lam, T. K. T. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.019 · Cited by 265
Sucralose affects glycemic and hormonal responses to an oral glucose load
Pepino, M. Y., Tiemann, C. D., Patterson, B. W., Wice, B. M., & Klein, S. (2013) · Diabetes Care · doi:10.2337/dc12-2221 · Cited by 253
The Association Between Artificial Sweeteners and Obesity
Pearlman, M. Y., Obert, J., & Casey, L. C. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0602-9 · Cited by 221
Powell, D. R., Smith, M. G., Greer, J., Harris, A. L., Zhao, S., DaCosta, C. M., Mseeh, F., Shadoan, M. K., Sands, A., Zambrowicz, B., et al. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.203364 · Cited by 189
Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine
Kuhre, R. E., Frost, C. R., Svendsen, B., & Holst, J. J. (2014) · Diabetes · doi:10.2337/db14-0807 · Cited by 177
The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis
Pang, M. D., Goossens, G. H., & Blaak, E. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.598340 · Cited by 180
Critical review of the current literature on the safety of sucralose
Magnuson, B. A., Roberts, A. S., & Nestmann, E. R. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.05.047 · Cited by 170
Dalenberg, J. R., Patel, B. P., Denis, R., Veldhuizen, M. G., Nakamura, Y., Vinke, P. C., Luquet, S. H., & Small, D. M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.014 · Cited by 163
The metabolic role of vagal afferent innervation
Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0062-1 · Cited by 140
Inflammation meets metabolic disease: Gut feeling mediated by GLP-1
Zietek, T., & Rath, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00154 · Cited by 131
Nguyen, N. Q., Debreceni, T. L., Bambrick, J. E., Chia, B., Wishart, J. M., Deane, A. M., Rayner, C. K., Horowitz, M., & Young, R. L. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3144 · Cited by 127
Self-citationRomo-Romo, A., Aguilar-Salinas, C. A., Brito-Córdova, G. X., Díaz, R. A. G., Valentín, D. V., & Almeda‐Valdés, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161264 · Cited by 118
Nichol, A. D., Holle, M. J., & An, R. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0170-6 · Cited by 124
Ahmed, A., Khan, T. A., Ramdath, D. D., Kendall, C. W. C., & Sievenpiper, J. L. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab012 · Cited by 118
Swithers, S. E., Laboy, A. F., Clark, K., Cooper, S., & Davidson, T. L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.024 · Cited by 112
Young, R. L., Chia, B., Isaacs, N. J., Ma, J., Khoo, J., Wu, T., Horowitz, M., & Rayner, C. K. (2013) · Diabetes · doi:10.2337/db13-0581 · Cited by 111
Self-citationGut motility and enteroendocrine secretion
Wu, T., Rayner, C. K., Young, R. L., & Horowitz, M. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.002 · Cited by 112
Self-citationMechanisms controlling hormone secretion in human gut and its relevance to metabolism
Martin, A. M., Sun, E. W. L., & Keating, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0399 · Cited by 117
Dobbins, R. L., Greenway, F. L., Chen, L., Liu, Y., Breed, S. L., Andrews, S. M., Wald, J. A., Walker, A. C., & Smith, C. D. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00286.2014 · Cited by 111
Non-Nutritive Sweeteners and their Role in the Gastrointestinal Tract
Brown, R. J., & Rother, K. I. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1475 · Cited by 110
The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review
Wilk, K., Korytek, W., Pelczyńska, M., Moszak, M., & Bogdański, P. (2022) · Nutrients · doi:10.3390/nu14061261 · Cited by 114
Intestinal SGLT1 in metabolic health and disease
Lehmann, A., & Hornby, P. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00068.2016 · Cited by 104
D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food
Guerrero‐Wyss, M., Durán‐Agüero, S., & Angarita, L. (2018) · BioMed Research International · doi:10.1155/2018/8718053 · Cited by 102
Glucagon-like peptides 1 and 2 in health and disease: A review
Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Peptides · doi:10.1016/j.peptides.2013.01.014 · Cited by 100
Self-citationMarathe, C. S., Horowitz, M., Trahair, L. G., Wishart, J. M., Bound, M. J., Lange, K. M., Rayner, C. K., & Jones, K. L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2482 · Cited by 99
Self-citationSakurai, M., Nakamura, K., Miura, K., Takamura, T., Yoshita, K., Nagasawa, S., Morikawa, Y., Ishizaki, M., Kido, T., Naruse, Y., et al. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0523-9 · Cited by 104
Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial
Romo-Romo, A., Aguilar-Salinas, C. A., Brito-Córdova, G. X., Gómez-Díaz, R. A., & Almeda‐Valdés, P. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy152 · Cited by 100
Glucose-dependent insulinotropic polypeptide (GIP)
Müller, T. D., Adriaenssens, A. E., Ahrén, B., Blüher, M., Birkenfeld, A. L., Campbell, J. E., Coghlan, M. P., D’Alessio, D. D., Deacon, C. F., DelPrato, S., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102118 · Cited by 103
An application of Pavlovian principles to the problems of obesity and cognitive decline
Davidson, T. L., Sample, C. H., & Swithers, S. E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.014 · Cited by 89
Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture
Goldspink, D. A., Lu, V. B., Miedzybrodzka, E. L., Smith, C. A., Foreman, R. E., Billing, L., Kay, R. G., Reimann, F. M., & Gribble, F. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107833 · Cited by 95
How non-nutritive sweeteners influence hormones and health
Rother, K. I., Conway, E. M., & Sylvetsky, A. C. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.04.010 · Cited by 85
Biological factors controlling starch digestibility in human digestive system
Li, C., Hu, Y., Li, S., Yi, X., Shao, S., Yu, W., & Li, E. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.07.037 · Cited by 81
Federico, A., Dallio, M., Tolone, S., Gravina, A. G., Patrone, V., Romano, M., Tuccillo, C., Mozzillo, A. L., Amoroso, V., Misso, G., et al. (2016) · PubMed · Cited by 77
Role of Intestinal Bitter Sensing in Enteroendocrine Hormone Secretion and Metabolic Control
Xie, C., Wang, X., Young, R. L., Horowitz, M., Rayner, C. K., & Wu, T. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00576 · Cited by 73
Self-citationNeuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners
Moriconi, E., Feraco, A., Marzolla, V., Infante, M., Lombardo, M., Fabbri, A., & Caprio, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00444 · Cited by 77
Taste and move: glucose and peptide transporters in the gastrointestinal tract
Daniel, H., & Zietek, T. (2015) · Experimental Physiology · doi:10.1113/ep085029 · Cited by 67
Grotz, V. L., Pi-Sunyer, X., Porte, D., Roberts, A., & Richard Trout, J. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.05.011 · Cited by 68
Sugar Reduction in Dairy Food: An Overview with Flavoured Milk as an Example
Mahato, D. K., Keast, R., Liem, D. G., Russell, C. G., Cicerale, S., & Gamlath, S. (2020) · Foods · doi:10.3390/foods9101400 · Cited by 76
Do non-nutritive sweeteners influence acute glucose homeostasis in humans? A systematic review
Tucker, R. M., & Tan, S. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.016 · Cited by 68
Xie, C., Jones, K. L., Rayner, C. K., & Wu, T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090790 · Cited by 64
Self-citationSokołowska, E., Sadowska, A. J., Sawicka, D., Kotulska-Bąblińska, I., & Car, H. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895057 · Cited by 64
Effect of sucralose and aspartame on glucose metabolism and gut hormones
Ahmad, S. Y., Friel, J. K., & MacKay, D. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz099 · Cited by 65
Araújo, J. R., Martel, F., & Keating, E. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.09.007 · Cited by 63
Wu, T., Bound, M. J., Zhao, B. R., Standfield, S., Bellon, M., Jones, K. L., Horowitz, M., & Rayner, C. K. (2013) · Diabetes Care · doi:10.2337/dc12-2294 · Cited by 58
Self-citationSmith, K., Azari, E. K., LaMoia, T. E., Hussain, T., Vargova, V., Károlyi, K., Veldhuis, P. P., Arnoletti, J. P., de la Fuente, S. G., Pratley, R. E., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.009 · Cited by 61
Wu, T., Rayner, C. K., & Horowitz, M. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_9 · Cited by 60
Self-citationO'Connor, D., Pang, M. D., Castelnuovo, G., Finlayson, G., Blaak, E. E., Gibbons, C., Navas‐Carretero, S., Almiron‐Roig, E., Harrold, J. A., Raben, A., et al. (2020) · Food & Function · doi:10.1039/d0fo02424d · Cited by 62
Rare sugars: metabolic impacts and mechanisms of action: a scoping review
Smith, A. G., Avery, A., Ford, R., Yang, Q., Goux, A., Mukherjee, I., Neville, D., & Jethwa, P. (2021) · British Journal of Nutrition · doi:10.1017/s0007114521003524 · Cited by 40
Intraduodenal infusion of a combination of tastants decreases food intake in humans
van Avesaat, M. H. P., Troost, F. J., Ripken, D., Peters, J., Hendriks, H., & Masclee, A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.113266 · Cited by 57
Higgins, K., Considine, R. V., & Mattes, R. D. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy021 · Cited by 57
Han, P., Bagenna, B., & Fu, M. (2018) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2018.1492522 · Cited by 55
Ahmad, S. Y., Friel, J. K., & MacKay, D. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0359 · Cited by 56
Sun, L., Tan, K. W. J., Han, C. M. S., Leow, M. K., & Henry, C. J. (2015) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/s00394-015-1059-y · Cited by 53
Role of intestinal glucose absorption in glucose tolerance
Wu, T., Rayner, C. K., Jones, K. L., Xie, C., Marathe, C. S., & Horowitz, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.017 · Cited by 48
Self-citationSaltiel, M. Y., Kuhre, R. E., Christiansen, C. B., Eliasen, R., Conde‐Frieboes, K. W., ROSENKILDE, M. M., & Holst, J. J. (2017) · Nutrients · doi:10.3390/nu9040418 · Cited by 40
Kong, H., Yu, L., Gu, Z., Li, C., Cheng, L., Hong, Y., & Li, Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02828 · Cited by 44
Intestinal nutrient sensing and blood glucose control
Zietek, T., & Daniel, H. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000187 · Cited by 45
Tsuda, T. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400871 · Cited by 44
Wölnerhanssen, B. K., Drewe, J., Verbeure, W., le Roux, C. W., Dellatorre‐Teixeira, L., Rehfeld, J. F., Holst, J. J., Hartmann, B., Tack, J. F., Peterli, R., et al. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14342 · Cited by 44
Gut mechanisms linking intestinal sweet sensing to glycemic control
Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00741 · Cited by 40
“Our group provided the first evidence that SGLT-1 substrates, even if not metabolized (such as the glucose analog 3-O-methylglucose, 3-OMG), have the capacity to stimulate GLP-1 and GIP secretion in humans (44).”
BackgroundSelf-citationIntense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective
Turner, A., Veysey, M. J., Keely, S., Scarlett, C. J., Lucock, M. D., & Beckett, E. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17114094 · Cited by 39
Yunker, A. G., Patel, R., & Page, K. A. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00323-3 · Cited by 38
Wang, X., Xie, C., Marathe, C. S., Malbert, C., Horowitz, M., Jones, K. L., Rayner, C. K., Sun, Z., & Wu, T. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107951 · Cited by 37
Self-citationRisdon, S., Battault, S., Romo-Romo, A., Roustit, M., Briand, L. V., Meyer, G., Almeda‐Valdés, P., & Walther, G. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa185 · Cited by 41
Gastric emptying in health and type 2 diabetes: An evaluation using a 75 g oral glucose drink
Xie, C., Huang, W., Wang, X., Trahair, L. G., Pham, H. T., Marathe, C. S., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108610 · Cited by 34
Self-citationPerspectives on evaluating health effects of starch: Beyond postprandial glycemic response
Kong, H., Yu, L., Li, C., Ban, X., Gu, Z., Liu, L., & Li, Z. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119621 · Cited by 34
Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion
Reimann, F. M., Diakogiannaki, E., Hodge, D., & Gribble, F. M. (2019) · Peptides · doi:10.1016/j.peptides.2019.170206 · Cited by 35
Nichol, A. D., Salamé, C., Rother, K. I., & Pepino, M. Y. (2019) · Nutrients · doi:10.3390/nu12010029 · Cited by 34
Xie, C., Huang, W., Watson, L. E., Soenen, S., Young, R. L., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab828 · Cited by 31
Self-citationJohnston, C. S., Trier, C. M., & Fleming, K. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-35 · Cited by 31
Low calorie sweeteners: Evidence remains lacking for effects on human gut function
Bryant, C. E., & McLaughlin, J. T. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.026 · Cited by 30
Watson, L. E., Phillips, L. K., Wu, T., Bound, M. J., Checklin, H. L., Grivell, J., Jones, K. L., Horowitz, M., & Rayner, C. K. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.014 · Cited by 29
Self-citationOhbayashi, K., Oyama, Y., Yamaguchi, C., Asano, T., Yada, T., & Iwasaki, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.676869 · Cited by 28
Guccio, N., Gribble, F. M., & Reimann, F. M. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-113625 · Cited by 30
Alsunni, A. A. (2020) · International Journal of General Medicine · doi:10.2147/ijgm.s274760 · Cited by 26
Azari, E. K., Smith, K. R., Yi, F., Osborne, T. F., Bizzotto, R., Mari, A., Pratley, R. E., & Kyriazis, G. A. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.146001 · Cited by 26
Bueno-Hernández, N., Vázquez-Frías, R., y Abreu, A. T. A., Almeda‐Valdés, P., Barajas-Nava, L. A., Carmona-Sánchez, R., Chávez-Sáenz, J. A., Consuelo‐Sánchez, A., Espinosa-Flores, A. J., Hernández-Rosiles, V., et al. (2019) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2019.08.001 · Cited by 25
Non-nutritive Sweeteners and Glycaemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0814-6 · Cited by 30
Subhan, F. B., Hashemi, Z., Herrera, M. C. A., Turner, K., Windeler, S., Gänzle, M. G., & Chan, C. B. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103730 · Cited by 25
The Sweetener-Sensing Mechanisms of the Ghrelin Cell
Steensels, S., Vancleef, L., & Depoortere, I. (2016) · Nutrients · doi:10.3390/nu8120795 · Cited by 24
Wu, T., Thazhath, S. S., Marathe, C. S., Bound, M. J., Jones, K. L., Horowitz, M., & Rayner, C. K. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2015.6 · Cited by 24
Self-citationÖRKÜ, Ş. E., Süyen, G. G., & Baş, M. (2022) · Nutrition · doi:10.1016/j.nut.2022.111885 · Cited by 25
Smits, M. M., & Holst, J. J. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3699 · Cited by 22
Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review
Teysseire, F., Bordier, V., Beglinger, C., Wölnerhanssen, B. K., & Meyer‐Gerspach, A. C. (2024) · Nutrients · doi:10.3390/nu16050622 · Cited by 28
Glucose absorption in small intestinal diseases
Thazhath, S. S., Wu, T., Young, R. L., Horowitz, M., & Rayner, C. K. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.887439 · Cited by 23
Self-citationWu, T., Rayner, C. K., & Horowitz, M. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0164 · Cited by 23
Self-citationGut-Based Strategies to Reduce Postprandial Glycaemia in Type 2 Diabetes
Kamruzzaman, M., Horowitz, M., Jones, K. L., & Marathe, C. S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.661877 · Cited by 23
Self-citationGut Sweet Taste Receptors and Their Role in Metabolism
Meyer‐Gerspach, A. C., Wölnerhanssen, B. K., & Beglinger, C. (2014) · Frontiers of hormone research · doi:10.1159/000358321 · Cited by 21
Artificially Sweetened Beverages—Do They Influence Cardiometabolic Risk?
Pereira, M. A., & Odegaard, A. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0375-z · Cited by 22
Trahair, L. G., Nauck, M. A., Wu, T., Stevens, J. E., Buttfield, M., Hatzinikolas, S., Pham, H., Meier, J. J., Rayner, C. K., Horowitz, M., et al. (2022) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1784-6185 · Cited by 20
Self-citationThe Molecular Determinants of Glucagon-like Peptide Secretion by the Intestinal L cell
Brubaker, P. L. (2022) · Endocrinology · doi:10.1210/endocr/bqac159 · Cited by 23
RISING STARS: Endocrine regulation of metabolic homeostasis via the intestine and gut microbiome
Meyer, R. K., & Duca, F. A. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0019 · Cited by 25
Liou, A. P. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5910 · Cited by 21
Romo-Romo, A., Aguilar-Salinas, C. A., López-Carrasco, M. G., Guillén-Pineda, L. E., Brito-Córdova, G. X., Gómez-Díaz, R. A., Gomez-Perez, F. J., & Almeda‐Valdés, P. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.03.018 · Cited by 19
Metadata
- Authors
- Wu, T., Zhao, B. R., Bound, M. J., Checklin, H. L., Bellon, M., Little, T. J., Young, R. L., Jones, K. L., Horowitz, M., & Rayner, C. K.
- Affiliations
- Royal Adelaide Hospital (AU)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 95
- Issue
- 1
- Pages
- 78-83
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2117678516
- Cited by
- 163
- References
- 51
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 17 · 2019: 18 · 2018: 13 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 9 · 2013: 14 · 2012: 5
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- incretin secretion, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, gastric emptying, postprandial blood glucose, sucralose, 3-O-methylglucose, SGLT1, artificial sweeteners, insulin response, glycemic control
- MeSH terms
- Adult, Blood Glucose, Disaccharides, Female, Gastric Emptying, Gastric Inhibitory Polypeptide, Glucose, Hexoses, Humans, Insulin, Male, Sucrose, Sugar Alcohols, Sweetening Agents, Signal Transduction, Dietary Sucrose, Postprandial Period, Sodium-Glucose Transporter 1, Glucagon-Like Peptide 1, Incretins, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review