trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
Open accessAbstract
Background Dairy consumption is linked to a lower risk of type 2 diabetes, but constituents responsible for this relation are not established. Emerging evidence suggests that trans-palmitoleate (trans 16:1n-7), a fatty acid in dairy and also partially hydrogenated oils, may be associated with a more favorable metabolic profile and less incident diabetes.Objective We investigated the association of trans-palmitoleate with metabolic risk and incident diabetes in a multiethnic US cohort.Design Phospholipid fatty acids and metabolic risk factors were measured in 2000-2002 among 2617 adults in the Multi-Ethnic Study of Atherosclerosis (MESA), a cohort of white, black, Hispanic, and Chinese Americans. In 2281 participants free of baseline diabetes, we also prospectively assessed the risk of new-onset diabetes (205 cases) from baseline to 2005-2007.Results trans-Palmitoleate concentrations correlated positively with self-reported consumption of whole-fat dairy, butter, margarine, and baked desserts and with other circulating biomarkers of both dairy fat and partially hydrogenated oil consumption, which suggested mixed dietary sources. After multivariable adjustment, trans-palmitoleate concentrations were associated with higher LDL cholesterol (quintile 5 compared with quintile 1: +6.4%; P-trend = 0.005), lower triglycerides (-19.1%; P-trend < 0.001), lower fasting insulin (-9.1%; P-trend = 0.002), and lower systolic blood pressure (-2.4 mm Hg; P-trend = 0.01). In prospective analyses, trans-palmitoleate was independently associated with lower incident diabetes (P-trend = 0.02), including a 48% lower risk in quintile 5 compared with quintile 1 (HR: 0.52; 95% CI: 0.32, 0.85). All findings were similar between men and women and between different race-ethnic subgroups.Conclusions Circulating trans-palmitoleate is associated with higher LDL cholesterol but also with lower triglycerides, fasting insulin, blood pressure, and incident diabetes in a multiethnic US cohort. Our findings support the need for further experimental and dietary intervention studies that target circulating trans-palmitoleate. The MESA trial was registered at clinicaltrials.gov as NCT00005487.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dairy fat may have potential benefits for diabetes.
“that dairy fat may have potential benefits for diabetes;59-61”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [60]
In cohorts utilizing objective blood biomarkers, greater dairy fat consumption is associated with lower incidence of diabetes and CHD, with mixed findings for stroke.
“In cohorts utilizing objective blood biomarkers, greater dairy fat consumption is associated with lower incidence of diabetes59-61, 242, 243 and CHD,39, 244, 245 with mixed findings for stroke.246”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [60]
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats
Marella, S., Maddirela, D. R., Badri, K. R., Kumar, M. V. J., & Chippada, A. R. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373954 · Cited by 5,938 · see citing works
Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942 · see citing works
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353 · see citing works
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
Cao, H.-M., Gerhold, K., Mayers, J. R., Wiest, M., Watkins, S., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,142 · see citing works
Maedler, K., Oberholzer, J., Bucher, P., Spinas, G. A., & Donath, M. Y. (2003) · Diabetes · doi:10.2337/diabetes.52.3.726 · Cited by 552 · see citing works
Erbay, E., Babaev, V. R., Mayers, J. R., Makowski, L., Charles, K. N., Snitow, M. E., Fazio, S., Wiest, M. M., Watkins, S. M., Linton, M. F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2067 · Cited by 487 · see citing works
Nettleton, J. A., Steffen, L. M., Mayer-Davis, E. J., Jenny, N. S., Jiang, R., Herrington, D. M., & Jacobs, D. R. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1369 · Cited by 484 · see citing works
Self-citationLaboratory methods and quality assurance in the Cardiovascular Health Study
Cushman, M., Cornell, E. S., Howard, P. R., Bovill, E. G., & Tracy, R. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.264 · Cited by 439 · see citing works
Mozaffarian, D., Cao, H., King, I. B., Lemaitre, R. N., Song, X., Siscovick, D. S., & Hotamisligil, G. S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-12-201012210-00005 · Cited by 363 · see citing works
Self-citationDairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies
Tong, X., Dong, J.-Y., Wu, Z.-W., Li, W., & Qin, L.-Q. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.62 · Cited by 337 · see citing works
A Prospective Study of Dairy Intake and the Risk of Type 2 Diabetes in Women
Liu, S., Choi, H. K., Ford, E., Song, Y., Klevak, A., Buring, J. E., & Manson, J. E. (2006) · Diabetes Care · doi:10.2337/dc06-0256 · Cited by 320 · see citing works
Validity and Reproducibility of a Food Frequency Interview in a Multi-Cultural Epidemiologic Study
Mayer-Davis, E. J., Vitolins, M. Z., Carmichael, S. L., Hemphill, S., Tsaroucha, G., Rushing, J., & Levin, S. (1999) · Annals of Epidemiology · doi:10.1016/s1047-2797(98)00070-2 · Cited by 300 · see citing works
Kröger, J., Zietemann, V., Enzenbach, C., Weikert, C., Jansen, E. H., Döring, F., Joost, H.-G., Boeing, H., & Schulze, M. B. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005447 · Cited by 270 · see citing works
Wolk, A., Furuheim, M., & Vessby, B. O. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.828 · Cited by 250 · see citing works
Dimopoulos, N., Watson, M., Sakamoto, K., & Hundal, H. S. (2006) · Biochemical Journal · doi:10.1042/bj20060244 · Cited by 247 · see citing works
Dietary Calcium and Magnesium, Major Food Sources, and Risk of Type 2 Diabetes in U.S. Black Women
van Dam, R. M., Hu, F. B., Rosenberg, L. A., Krishnan, S., & Palmer, J. R. (2006) · Diabetes Care · doi:10.2337/dc06-1014 · Cited by 244 · see citing works
Patel, P. S., Sharp, S. J., Jansen, E. H. J. M., Luben, R., Khaw, K., Wareham, N. J., & Forouhi, N. G. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29182 · Cited by 227 · see citing works
Evaluation of a biological marker of dairy fat intake
Wolk, A., Vessby, B. O., Ljung, H., & Barrefors, P. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.291 · Cited by 210 · see citing works
Nettleton, J. A., Steffen, L. M., Ni, H., Liu, K., & Jacobs, D. R. (2008) · Diabetes Care · doi:10.2337/dc08-0760 · Cited by 181 · see citing works
Self-citationBrevik, A., Veierød, M. B., Drevon, C. A., & Andersen, L. F. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602256 · Cited by 162 · see citing works
Fatty acid profile of the erythrocyte membrane preceding development of Type 2 diabetes mellitus
Krachler, B., Norberg, M., Eriksson, J. W., Hallmans, G., Johansson, I., Vessby, B. O., Weinehall, L., & Lindahl, B. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.04.005 · Cited by 158 · see citing works
Gluteofemoral Adipose Tissue Plays a Major Role in Production of the Lipokine Palmitoleate in Humans
Pinnick, K. E., Neville, M. J., Fielding, B. A., Frayn, K. N., Karpe, F., & Hodson, L. (2012) · Diabetes · doi:10.2337/db11-1810 · Cited by 98 · see citing works
Micha, R., King, I. B., Lemaître, R. N., Rimm, E. B., Sacks, F. M., Song, X., Siscovick, D. S., & Mozaffarian, D. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28877 · Cited by 94 · see citing works
Self-citationSteffen, B. T., Steffen, L. M., Tracy, R. P., Siscovick, D. S., Jacobs, D. R., Liu, K., He, K., Hanson, N. Q., Nettleton, J. A., & Tsai, M. Y. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.215 · Cited by 64 · see citing works
Self-citationPPAR-γ response element activity in intact primary human adipocytes: effects of fatty acids
Sauma, L., Stenkula, K. G., Kjølhede, P., Strålfors, P., Söderström, M., & Nyström, F. H. (2005) · Nutrition · doi:10.1016/j.nut.2005.04.011 · Cited by 59 · see citing works
Warnet, J., Cambien, F., Vernier, V., Pecoraro, M., Flament, C., Ducimetière, P., Jacqueson, A., Richard, J. L., & Claude, J. (1985) · BMJ · doi:10.1136/bmj.290.6485.1859 · Cited by 27 · see citing works
Dairy Consumption and Risk of Type 2 Diabetes Mellitus in Men: A Prospective Study
Choi, H. K. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.9.997 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
Self-citationde Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T., Uleryk, E., Budylowski, P., Schünemann, H., Beyene, J., et al. (2015) · BMJ · doi:10.1136/bmj.h3978 · Cited by 1,424 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Forouhi, N. G., Koulman, A., Sharp, S. J., Imamura, F., Kröger, J., Schulze, M. B., Crowe, F. L., Huerta, J. M., Guevara, M., Beulens, J. W., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70146-9 · Cited by 557 · see citing works
Aune, D., Norat, T., Romundstad, P., & Vatten, L. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.059030 · Cited by 434 · see citing works
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes
Sobczak, A. I. S., Blindauer, C. A., & Stewart, A. J. (2019) · Nutrients · doi:10.3390/nu11092022 · Cited by 306 · see citing works
Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
Mozaffarian, D., & Wu, J. H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.117.309008 · Cited by 305 · see citing works
Self-citationThe Role of the Novel Lipokine Palmitoleic Acid in Health and Disease
Frigolet, M. E., & Gutiérrez‐Aguilar, R. (2017) · Advances in Nutrition · doi:10.3945/an.115.011130 · Cited by 269 · see citing works
The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease
Ruiz-Núñez, B., Dijck-Brouwer, J., & Muskiet, F. A. J. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.12.007 · Cited by 246 · see citing works
Milk fatty acids and potential health benefits: An updated vision
Gómez‐Cortés, P., Juárez, M., & de la Fuente, M. Á. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.08.014 · Cited by 260 · see citing works
Imamura, F., Fretts, A. M., Marklund, M., Korat, A. V. A., Yang, W.-S., Lankinen, M. A., Qureshi, W., Helmer, C., Chen, T. A., Wong, K., et al. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002670 · Cited by 238 · see citing works
Self-citationGao, D., Ning, N., Wang, C., Wang, Y., Li, Q., Meng, Z., Liu, Y., & Li, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073965 · Cited by 232 · see citing works
Milk, Dairy Products, and Their Functional Effects in Humans: A Narrative Review of Recent Evidence
Visioli, F., & Strata, A. (2014) · Advances in Nutrition · doi:10.3945/an.113.005025 · Cited by 237 · see citing works
Pentadecanoic and Heptadecanoic Acids: Multifaceted Odd-Chain Fatty Acids
Pfeuffer, M., & Jaudszus, A. (2016) · Advances in Nutrition · doi:10.3945/an.115.011387 · Cited by 221 · see citing works
Pimpin, L., Wu, J. H. Y., Haskelberg, H., Gobbo, L. C. D., & Mozaffarian, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158118 · Cited by 212 · see citing works
Self-citationDairy fat and risk of cardiovascular disease in 3 cohorts of US adults
Chen, M., Li, Y., Sun, Q., Pan, A., Manson, J. E., Rexrode, K. M., Willett, W. C., Rimm, E. B., & Hu, F. B. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.134460 · Cited by 182 · see citing works
Ericson, U., Hellstrand, S., Brunkwall, L., Schulz, C.-A., Sonestedt, E., Wallström, P., Gullberg, B., Wirfält, E., & Orho-Melander, M. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.103010 · Cited by 171 · see citing works
Branched-Chain Fatty Acids—An Underexplored Class of Dairy-Derived Fatty Acids
Taormina, V. M., Unger, A. L., Schiksnis, M. R., Torres‐Gonzalez, M., & Kraft, J. (2020) · Nutrients · doi:10.3390/nu12092875 · Cited by 166 · see citing works
Female Fertility and the Nutritional Approach: The Most Essential Aspects
Skoracka, K., Ratajczak, A. E., Rychter, A. M., Dobrowolska, A., & Krela‐Kaźmierczak, I. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab068 · Cited by 151 · see citing works
Santaren, I. D., Watkins, S. M., Liese, A. D., Wagenknecht, L. E., Rewers, M., Haffner, S. M., Lorenzo, C., & Hanley, A. J. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092544 · Cited by 142 · see citing works
Yakoob, M. Y., Shi, P., Willett, W. C., Rexrode, K. M., Campos, H., Orav, E. J., Hu, F. B., & Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018410 · Cited by 140 · see citing works
Self-citationFerreri, C., Masi, A., Sansone, A., Giacometti, G., Larocca, A., Menounou, G., Scanferlato, R., Tortorella, S., Rota, D., Conti, M., et al. (2016) · Diagnostics · doi:10.3390/diagnostics7010001 · Cited by 129 · see citing works
Yu, E., & Hu, F. B. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0724-z · Cited by 130 · see citing works
Kleber, M. E., Delgado, G. E., Stefan Lorkowski, A., März, W., & von Schacky, C. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv446 · Cited by 126 · see citing works
Álvarez‐Bueno, C., Cavero‐Redondo, I., Martínez‐Vizcaíno, V., Sotos‐Prieto, M., Ruiz, J. R., & Gil, Á. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy107 · Cited by 126 · see citing works
Cold-induced lipid dynamics and transcriptional programs in white adipose tissue
Xu, Z., You, W., Zhou, Y., Chen, W., Wang, Y., & Shan, T. (2019) · BMC Biology · doi:10.1186/s12915-019-0693-x · Cited by 127 · see citing works
Lemaitre, R. N., Fretts, A. M., Sitlani, C. M., Biggs, M. L., Mukamal, K., King, I. B., Song, X., Djoussé, L., Siscovick, D. S., McKnight, B., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.101857 · Cited by 117 · see citing works
Self-citationDairy foods and health: an umbrella review of observational studies
Godos, J., Tieri, M., Ghelfi, F., Titta, L., Marventano, S., Lafranconi, A., Gambera, A., Alonzo, E., Sciacca, S., Buscemi, S., et al. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1625035 · Cited by 108 · see citing works
Kleber, M. E., Delgado, G. E., Stefan Lorkowski, A., März, W., & von Schacky, C. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.06.049 · Cited by 100 · see citing works
Dietary Fat and Risk for Type 2 Diabetes: a Review of Recent Research
Bradley, B. H. R. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0244-z · Cited by 99 · see citing works
Nestel, P. J., Straznicky, N. E., Mellett, N. A., Wong, G., Souza, D. P. D., Tull, D., Barlow, C. K., Grima, M. T., & Meikle, P. J. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071712 · Cited by 97 · see citing works
How important are fatty acids in human health and can they be used in treating diseases?
Dicks, L. M. T. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2420765 · Cited by 97 · see citing works
Kratz, M., Marcovina, S., Nelson, J. E., Yeh, M. M., Kowdley, K. V., Callahan, H. S., Song, X., Di, C., & Utzschneider, K. M. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.075457 · Cited by 95 · see citing works
Wang, H., Fox, C. S., Troy, L. M., McKeown, N. M., & Jacques, P. F. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003578 · Cited by 97 · see citing works
Li, Z., Lei, H., Jiang, H., Fan, Y., Shi, J., Li, C., Chen, F., Mi, B., Ma, M., Lin, J., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.963471 · Cited by 90 · see citing works
Hirahatake, K. M., Slavin, J. L., Maki, K. C., & Adams, S. H. (2014) · Metabolism · doi:10.1016/j.metabol.2014.02.009 · Cited by 87 · see citing works
Yogurt and Diabetes: Overview of Recent Observational Studies
Salas‐Salvadó, J., Guasch‐Ferré, M., Díaz‐López, A., & Babió, N. (2017) · Journal of Nutrition · doi:10.3945/jn.117.248229 · Cited by 83 · see citing works
Vanderhout, S. M., Aglipay, M., Torabi, N., Jüni, P., da Costa, B. R., Birken, C. S., O’Connor, D. L., Thorpe, K. E., & Maguire, J. L. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz276 · Cited by 79 · see citing works
Huang, L., Lin, J.-S., Aris, I. M., Yang, G., Chen, W., & Li, L. (2019) · Nutrients · doi:10.3390/nu11050998 · Cited by 78 · see citing works
Bernstein, A. M., Roizen, M. F., & Martinez, L. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.08.001 · Cited by 77 · see citing works
RetractedVitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue
Muñoz‐Garach, A., García-Fontana, B., & Muñoz‐Torres, M. (2019) · Nutrients · doi:10.3390/nu11030642 · Cited by 77 · see citing works
Effects of Repeated Heating on Fatty Acid Composition of Plant-Based Cooking Oils
Szabó, Z., Marosvölgyi, T., Szabó, É., Koczka, V., Verzár, Z., Figler, M., & Décsi, T. (2022) · Foods · doi:10.3390/foods11020192 · Cited by 76 · see citing works
Liang, J., Zhou, Q., Amakye, W. K., Su, Y., & Zhang, Z. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1242114 · Cited by 75 · see citing works
Prada, M., Wittenbecher, C., Eichelmann, F., Wernitz, A., Drouin‐Chartier, J., & Schulze, M. B. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.06.006 · Cited by 76 · see citing works
Hruby, A., Ma, J., Rogers, G. T., Meigs, J. B., & Jacques, P. F. (2017) · Journal of Nutrition · doi:10.3945/jn.117.253401 · Cited by 75 · see citing works
Dietary biomarkers—an update on their validity and applicability in epidemiological studies
Landberg, R., Karra, P., Hoobler, R., Loftfield, E., Huybrechts, I., Rattner, J. I., Noerman, S., Claeys, L., Neveu, V., Vidkjær, N. H., et al. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad119 · Cited by 76 · see citing works
Altered Metabolome of Lipids and Amino Acids Species: A Source of Early Signature Biomarkers of T2DM
Hameed, A., Mojsak, P., Buczyńska, A., Suleria, H. A. R., Kretowski, A. J., & Ciborowski, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072257 · Cited by 71 · see citing works
Biomarker of food intake for assessing the consumption of dairy and egg products
Münger, L. H., Garcia‐Aloy, M., Vázquez‐Fresno, R., Gille, D., Rosana, A. R. R., Passerini, A., Soria-Florido, M. T., Pimentel, G., Sajed, T., Wishart, D. S., et al. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0615-5 · Cited by 68 · see citing works
Guo, J., Givens, D. I., Astrup, A., Bakker, S. J. L., Goossens, G. H., Kratz, M., Marette, A., Pijl, H., & Soedamah‐Muthu, S. S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz050 · Cited by 69 · see citing works
Eussen, S. J. P. M., DONGEN, M. C. J. M. V., Wijckmans, N. E. G., den Biggelaar, L. J. C. J., Elferink, S. J. W. H. O., Singh‐Povel, C. M., Schram, M. T., Sep, S. J. S., Kallen, C., Koster, A., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000313 · Cited by 70 · see citing works
Milk fat biomarkers and cardiometabolic disease
Risérus, U., & Marklund, M. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000381 · Cited by 68 · see citing works
Novel trends and opportunities for microencapsulation of flaxseed oil in foods: A review
Kouamé, K. J. E., Bora, A. F. M., Li, X., Sun, Y., & Liu, L. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104812 · Cited by 68 · see citing works
Liu, Q., Ayoub‐Charette, S., Khan, T. A., Au‐Yeung, F., Blanco Mejia, S., de Souza, R. J., Wolever, T. M. S., Leiter, L. A., Kendall, C. W. C., & Sievenpiper, J. L. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010977 · Cited by 65 · see citing works
Hernandez, E. M. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-247-1.00004-1 · Cited by 66 · see citing works
Raza, G. S., Herzig, K., & Leppäluoto, J. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19649 · Cited by 63 · see citing works
Drehmer, M., Pereira, M. A., Schmidt, M. I., Molina, M. D. C. B., Matos, S. M. A., Lotufo, P. A., & Duncan, B. B. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.102152 · Cited by 62 · see citing works
Otto, M. C. D. O., Lemaître, R. N., Song, X., King, I. B., Siscovick, D. S., & Mozaffarian, D. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy117 · Cited by 62 · see citing works
Self-citationDairy and Cardiovascular Disease: A Review of Recent Observational Research
Rice, B. H. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0076-4 · Cited by 58 · see citing works
Abdullah, M. M. H., Cyr, A., Lépine, M.-C., Labonté, M., Couture, P., Jones, P. J. H., & Lamarche, B. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003894 · Cited by 58 · see citing works
trans Palmitoleic acid arises endogenously from dietary vaccenic acid
Jaudszus, A., Krämer, R., Pfeuffer, M., Röth, A., Jahreis, G., & Kuhnt, K. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076117 · Cited by 58 · see citing works
New data on harmful effects of trans-fatty acids
Ginter, E., & Šimko, V. (2016) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2016_048 · Cited by 63 · see citing works
Dairy food products: good or bad for cardiometabolic disease?
Lovegrove, J. A., & Givens, D. I. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000160 · Cited by 58 · see citing works
Saturated fats, dairy foods and health: A curious paradox?
Givens, D. I. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12283 · Cited by 56 · see citing works
Dairy and cardiovascular health: Friend or foe?
Markey, O., Vasilopoulou, D., Givens, D. I., & Lovegrove, J. A. (2014) · Nutrition Bulletin · doi:10.1111/nbu.12086 · Cited by 54 · see citing works
Dairy intake and risk of type 2 diabetes
Talaei, M., Pan, A., Yuan, J., & Koh, W. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.02.022 · Cited by 56 · see citing works
Wang, Q., Imamura, F., Lemaître, R. N., Rimm, E. B., Wang, M., King, I. B., Song, X., Siscovick, D. S., & Mozaffarian, D. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.000914 · Cited by 52 · see citing works
Self-citationMorio, B., Fardet, A., Legrand, P., & Lecerf, J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv043 · Cited by 52 · see citing works
Metabolomics, Nutrition, and Potential Biomarkers of Food Quality, Intake, and Health Status
Sébédio, J. (2017) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.01.001 · Cited by 52 · see citing works
Wang, Q., Imamura, F., Ma, W., Wang, M., Lemaître, R. N., King, I. B., Song, X., Biggs, M. L., Delaney, J. A., Mukamal, K. J., et al. (2015) · Diabetes Care · doi:10.2337/dc14-2101 · Cited by 49 · see citing works
Self-citationEffects of Dairy Protein and Fat on the Metabolic Syndrome and Type 2 Diabetes
Bjørnshave, A., & Hermansen, K. (2014) · The Review of Diabetic Studies · doi:10.1900/rds.2014.11.153 · Cited by 47 · see citing works
JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease
Fujiyoshi, A., Kohsaka, S., Hata, J., Hara, M., Kai, H., Masuda, D., Miyamatsu, N., Nishio, Y., Ogura, M., Sata, M., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0285 · Cited by 47 · see citing works
Natural Rumen‐Derived trans Fatty Acids Are Associated with Metabolic Markers of Cardiac Health
Silva, M. S. D., Julien, P., Përusse, L., Vohl, M., & Rudkowska, I. (2015) · Lipids · doi:10.1007/s11745-015-4055-3 · Cited by 45 · see citing works
The Effects of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients: A Pilot Study
Lee, S., Son, Y., Kim, S., & An, W. S. (2015) · Marine Drugs · doi:10.3390/md13020741 · Cited by 42 · see citing works
Otto, M. C. D. O., Lemaître, R. N., Sun, Q., King, I. B., Wu, J. H. Y., Manichaikul, A. W., Rich, S. S., Tsai, M. Y., Chen, Y. I., Fornage, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196951 · Cited by 41 · see citing works
Self-citationGivens, D. I. (2018) · animal · doi:10.1017/s1751731118000642 · Cited by 41 · see citing works
Mozaffarian, D. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv595 · Cited by 40 · see citing works
Self-citationEffect of Fatty Acids on Glucose Metabolism and Type 2 Diabetes
Sivri, D., & Akdevelıoğlu, Y. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae165 · Cited by 40 · see citing works
Dairy Products and Prevention of Type 2 Diabetes: Implications for Research and Practice
Kalergis, M., Yinko, S. S. L. L., & Nedelcu, R. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00090 · Cited by 40 · see citing works
Yuan, S., & Larsson, S. C. (2019) · Diabetologia · doi:10.1007/s00125-019-05019-0 · Cited by 41 · see citing works
Albani, V., Celis-Morales, C. A., Marsaux, C. F. M., Forster, H., O’Donovan, C. B., Woolhead, C., Macready, A. L., Fallaize, R., Navas‐Carretero, S., San-Cristóbal, R., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500483 · Cited by 38 · see citing works
Some biochemical studies on trans fatty acid-containing diet
El-Aal, Y. A. A., Fattah, D. M. A., & Ahmed, K. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.03.029 · Cited by 39 · see citing works
A systematic review of the effect of yogurt consumption on chronic diseases risk markers in adults
Dumas, A., Lapointe, A., Dugrenier, M., Provencher, V., Lamarche, B., & Desroches, S. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1341-7 · Cited by 38 · see citing works
Saturated fatty acids and type 2 diabetes: more evidence to re-invent dietary guidelines
Mozaffarian, D. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70166-4 · Cited by 37 · see citing works
Self-citationCui, L., Liu, J., Yan, X., & Hu, S. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03232 · Cited by 37 · see citing works
Guillocheau, É., Legrand, P., & Rioux, V. (2019) · OCL · doi:10.1051/ocl/2019047 · Cited by 36 · see citing works
Metabolomics to Explore Impact of Dairy Intake
Zheng, H. X., Clausen, M. R., Dalsgaard, T. K., & Bertram, H. C. (2015) · Nutrients · doi:10.3390/nu7064875 · Cited by 36 · see citing works
Blood Fatty Acid Profiles: New Biomarkers for Cardiometabolic Disease Risk
Jackson, K. H., & Harris, W. S. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0722-1 · Cited by 35 · see citing works
Poudyal, H., & Brown, L. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.07.002 · Cited by 34 · see citing works
Gao, Z. L., Zhang, H., Liu, J., Lau, C. W., Liu, P., Chen, Z., Lee, H. K., Tipoe, G. L., Ho, H., Yao, X., et al. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.009 · Cited by 34 · see citing works
The Regulation of Lipokines by Environmental Factors
Hernández‐Saavedra, D., & Stanford, K. I. (2019) · Nutrients · doi:10.3390/nu11102422 · Cited by 34 · see citing works
Trans-fatty acids and cardiovascular risk: does origin matter?
Dawczynski, C., & Stefan Lorkowski, A. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2016.1199956 · Cited by 33 · see citing works
Dietary Fatty Acids: Is it Time to Change the Recommendations?
Nettleton, J. A., Lovegrove, J. A., Mensink, R. P., & Schwab, U. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000446865 · Cited by 32 · see citing works
Self-citationMoslehi, N., Shab‐Bidar, S., Mirmiran, P., Sadeghi, M., & Azizi, F. (2015) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2015.1034249 · Cited by 32 · see citing works
Mitri, J., Tomah, S., Mottalib, A., Salsberg, V., Ashrafzadeh, S., POBER, D. M., Eldib, A. H., Tasabehji, M. W., & Hamdy, O. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa138 · Cited by 32 · see citing works
Jacobs, S., Schiller, K., Jansen, E. H. J. M., Fritsche, A., Weikert, C., di Giuseppe, R., Boeing, H., Schulze, M. B., & Kröger, J. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.36 · Cited by 32 · see citing works
Pranger, I. G., Corpeleijn, E., Muskiet, F. A. J., Kema, I. P., Singh‐Povel, C. M., & Bakker, S. J. L. (2019) · Biomarkers · doi:10.1080/1354750x.2019.1583770 · Cited by 31 · see citing works
Guillocheau, É., Penhoat, C., Drouin, G., Godet, A., Catheline, D., Legrand, P., & Rioux, V. (2020) · Food Chemistry X · doi:10.1016/j.fochx.2020.100081 · Cited by 31 · see citing works
Forouhi, N. G. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv018 · Cited by 30 · see citing works
- Authors
- Mozaffarian, D., de Oliveira Otto, M. C., Lemaitre, R. N., Fretts, A. M., Hotamisligil, G., Tsai, M. Y., Siscovick, D. S., & Nettleton, J. A.
- Affiliations
- Harvard University (US)
- University of Washington (US)
- University of Minnesota (US)
- The University of Texas Health Science Center at Houston (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 97
- Issue
- 4
- Pages
- 854-861
- ISSN
- 0002-9165 (ISSN-L)
- PMC
- PMC3607658
- OpenAlex
- W2151042915
- Cited by
- 270
- References
- 29
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 12 · 2023: 15 · 2022: 26 · 2021: 20 · 2020: 27 · 2019: 32 · 2018: 21 · 2017: 24 · 2016: 26 · 2015: 27 · 2014: 19 · 2013: 6 · 2012: 1
- FWCI
- 24.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc095169-003, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, R01HL085710, N01 HC95169)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK082729)
- National Center for Research Resources (RR024156)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- trans-palmitoleic acid, milk fat, type 2 diabetes, new-onset diabetes, partially hydrogenated oils, LDL cholesterol, triglycerides, fasting insulin, blood pressure, phospholipid fatty acids, dairy consumption, metabolic risk, Multi-Ethnic Study of Atherosclerosis, racial and ethnic differences, dietary biomarkers, butter, margarine
- MeSH terms
- Aged, Blood Pressure, Dairy Products, Diabetes Mellitus, Diet, Dietary Fats, Ethnicity, Fatty Acids, Monounsaturated, Female, Humans, Hydrogenation, Insulin, Lipids, Cholesterol, LDL, Male, Middle Aged, Phospholipids, Prospective Studies, Risk Factors, Triglycerides, United States, Biomarkers, Trans Fatty Acids, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
