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Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition
Open accessAbstract
Background Plasma phospholipid fatty acids have been correlated with food intakes in populations with homogeneous dietary patterns. However, few data are available on populations with heterogeneous dietary patterns.Objective The objective was to investigate whether plasma phospholipid fatty acids are suitable biomarkers of dietary intakes across populations involved in a large European multicenter study.Design A cross-sectional study design nested to the European Prospective Investigation into Cancer and Nutrition (EPIC) was conducted to determine plasma fatty acid profiles in >3,000 subjects from 16 centers, who had also completed 24-h dietary recalls and dietary questionnaires. Plasma fatty acids were assessed by capillary gas chromatography. Ecological and individual correlations were calculated between fatty acids and select food groups.Results The most important determinant of plasma fatty acids was region, which suggests that the variations across regions are largely due to different food intakes. Strong ecological correlations were observed between fish intake and long-chain n-3 polyunsaturated fatty acids (r = 0.78, P < 0.01), olive oil and oleic acid (r = 0.73, P < 0.01), and margarine and elaidic acid (r = 0.76, P < 0.01). Individual correlations varied across the regions, particularly between olive oil and oleic acid and between alcohol and the saturation index, as an indicator of stearoyl CoA desaturase activity.Conclusions These findings indicate that specific plasma phospholipid fatty acids are suitable biomarkers of some food intakes in the EPIC Study. Moreover, these findings suggest complex interactions between alcohol intake and fatty acid metabolism, which warrants further attention in epidemiologic studies relating dietary fatty acids to alcohol-related cancers and other chronic diseases.
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“Strong correlations between regional dietary factors and fatty acid concentrations allowed components of the food metabolome to be used as predictor variables in a prospective investigation of gastric cancer in the European Prospective Investigation into Cancer and Nutrition cohort.”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [168]
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“A good example of this approach is given by Saadatian-Elahi et al (168), who correlated food consumption, as determined by 24-h dietary recall, with plasma concentrations of 22 fatty acids determined by gas chromatography in 3000 subjects from the European Prospective Investigation into Cancer and Nutrition cohort.”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [168]
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The food metabolome: a window over dietary exposure
Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519
Biomarkers in nutritional epidemiology: applications, needs and new horizons
Jenab, M., Slimani, N., Bictash, M., Ferrari, P., & Bingham, S. A. (2009) · Human Genetics · doi:10.1007/s00439-009-0662-5 · Cited by 448
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Metadata
- Authors
- Saadatian-Elahi, M., Slimani, N., Chajès, V., Jenab, M., Goudable, J., Biessy, C., Ferrari, P., Byrnes, G., Autier, P., Peeters, P. H., Ocké, M., Bueno de Mesquita, B., Johansson, I., Hallmans, G., Manjer, J., Wirfält, E., González, C. A., Navarro, C., Martinez, C., Amiano, P., Suárez, L. R., Ardanaz, E., Tjønneland, A., Halkjaer, J., Overvad, K., Jakobsen, M. U., Berrino, F., Pala, V., Palli, D., Tumino, R., Vineis, P., Santucci de Magistris, M., Spencer, E. A., Crowe, F. L., Bingham, S., Khaw, K.-T., Linseisen, J., Rohrmann, S., Boeing, H., Noethlings, U., Olsen, K. S., Skeie, G., Lund, E., Trichopoulou, A., Oustoglou, E., Clavel-Chapelon, F., & Riboli, E.
- Affiliations
- Lyon 1 Université (FR)
- Danish Cancer Society (DK)
- Aalborg University (DK)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Istituto per lo Studio e la Prevenzione Oncologica (IT)
- University of Ragusa (IT)
- University of Turin (IT)
- University of Oxford (GB)
- University of Cambridge (GB)
- German Cancer Research Center (DE)
- UiT The Arctic University of Norway (NO)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Slimani, Nadia
- ORCID
- Slimani, Nadia
- Chajès, Véronique
- Jenab, Mazda
- Biessy, Carine
- Ferrari, Pietro
- Byrnes, Graham
- Autier, Philippe
- Peeters, Petra HM
- Ocké, Marga
- Johansson, Ingegerd
- Manjer, Jonas
- Navarro, Carmen
- Amiano, Pilar
- Tjønneland, Anne
- Overvad, Kim
- Jakobsen, Marianne Uhre
- Berrino, Franco
- Pala, Valeria
- Palli, Domenico
- Tumino, Rosario
- Vineis, Paolo
- Crowe, Francesca L
- Khaw, Kay-Tee
- Linseisen, Jakob
- Rohrmann, Sabine
- Boeing, Heiner
- Skeie, Guri
- Lund, Eiliv
- Trichopoulou, Antonia
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 89
- Issue
- 1
- Pages
- 331-346
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2075341416
- Cited by
- 213
- References
- 45
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 13 · 2021: 18 · 2020: 11 · 2019: 13 · 2018: 22 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 10 · 2013: 20 · 2012: 9
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- plasma phospholipid fatty acids, dietary biomarkers, dietary intake, dietary habits, fish consumption, n-3 long-chain polyunsaturated fatty acids, olive oil, oleic acid, margarine, elaidic acid, alcohol consumption, stearoyl-CoA desaturase, fatty acid metabolism, EPIC cohort
- MeSH terms
- Chromatography, Gas, Cross-Sectional Studies, Cross-Cultural Comparison, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Europe, Fatty Acids, Fatty Acids, Unsaturated, Feeding Behavior, Female, Humans, Male, Middle Aged, Neoplasms, Phospholipids, Prospective Studies, Surveys and Questionnaires, Mental Recall, Regression Analysis, Sex Factors, Biomarkers
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